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P07943

- ALDR_RAT

UniProt

P07943 - ALDR_RAT

Protein

Aldose reductase

Gene

Akr1b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

    Catalytic activityi

    Alditol + NAD(P)+ = aldose + NAD(P)H.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton donorBy similarity
    Sitei78 – 781Lowers pKa of active site TyrBy similarity
    Binding sitei111 – 1111SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 1910NADPSequence Analysis
    Nucleotide bindingi211 – 27363NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. alditol:NADP+ 1-oxidoreductase activity Source: RGD

    GO - Biological processi

    1. cellular response to hydrogen peroxide Source: RGD
    2. cellular response to methylglyoxal Source: RGD
    3. cellular response to peptide Source: RGD
    4. inner medullary collecting duct development Source: RGD
    5. maternal process involved in female pregnancy Source: RGD
    6. monosaccharide metabolic process Source: RGD
    7. naphthalene metabolic process Source: RGD
    8. norepinephrine metabolic process Source: RGD
    9. positive regulation of JAK-STAT cascade Source: RGD
    10. positive regulation of smooth muscle cell proliferation Source: RGD
    11. response to organic substance Source: RGD
    12. response to thyroid hormone Source: RGD
    13. response to water deprivation Source: RGD
    14. sorbitol biosynthetic process Source: RGD
    15. stress-activated protein kinase signaling cascade Source: RGD
    16. tissue homeostasis Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    SABIO-RKP07943.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldose reductase (EC:1.1.1.21)
    Short name:
    AR
    Alternative name(s):
    Aldehyde reductase
    Gene namesi
    Name:Akr1b1
    Synonyms:Akr1b4, Aldr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi2092. Akr1b1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell projection cytoplasm Source: RGD
    2. cytosol Source: RGD
    3. extracellular space Source: RGD
    4. mast cell granule Source: RGD
    5. paranodal junction Source: RGD
    6. perinuclear region of cytoplasm Source: RGD
    7. Schmidt-Lanterman incisure Source: RGD
    8. Schwann cell microvillus Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 316315Aldose reductasePRO_0000124627Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei95 – 951N6-acetyllysineBy similarity
    Modified residuei222 – 2221N6-acetyllysineBy similarity
    Modified residuei263 – 2631N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP07943.
    PRIDEiP07943.

    PTM databases

    PhosphoSiteiP07943.

    Expressioni

    Gene expression databases

    GenevestigatoriP07943.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi246382. 2 interactions.
    STRINGi10116.ENSRNOP00000012879.

    Structurei

    3D structure databases

    ProteinModelPortaliP07943.
    SMRiP07943. Positions 1-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG0656.
    GeneTreeiENSGT00670000097881.
    HOGENOMiHOG000250272.
    HOVERGENiHBG000020.
    InParanoidiP07943.
    KOiK00011.
    OMAiDFLDTWT.
    OrthoDBiEOG70KGQF.
    PhylomeDBiP07943.
    TreeFamiTF106492.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000097. AKR. 1 hit.
    PRINTSiPR00069. ALDKETRDTASE.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07943-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASHLELNNG TKMPTLGLGT WKSPPGQVTE AVKVAIDMGY RHIDCAQVYQ    50
    NEKEVGVALQ EKLKEQVVKR QDLFIVSKLW CTFHDQSMVK GACQKTLSDL 100
    QLDYLDLYLI HWPTGFKPGP DYFPLDASGN VIPSDTDFVD TWTAMEQLVD 150
    EGLVKAIGVS NFNPLQIERI LNKPGLKYKP AVNQIECHPY LTQEKLIEYC 200
    HCKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKEIAAK YNKTTAQVLI 250
    RFPIQRNLVV IPKSVTPARI AENFKVFDFE LSNEDMATLL SYNRNWRVCA 300
    LMSCAKHKDY PFHAEV 316
    Length:316
    Mass (Da):35,797
    Last modified:January 23, 2007 - v3
    Checksum:iD6D07843B6850002
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05884 mRNA. Translation: CAA29308.1.
    M60322 Genomic DNA. Translation: AAA40721.1.
    BC062034 mRNA. Translation: AAH62034.1.
    PIRiA60603.
    RefSeqiNP_036630.1. NM_012498.1.
    UniGeneiRn.107801.

    Genome annotation databases

    EnsembliENSRNOT00000012879; ENSRNOP00000012879; ENSRNOG00000009513.
    GeneIDi24192.
    KEGGirno:24192.
    UCSCiRGD:2092. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05884 mRNA. Translation: CAA29308.1 .
    M60322 Genomic DNA. Translation: AAA40721.1 .
    BC062034 mRNA. Translation: AAH62034.1 .
    PIRi A60603.
    RefSeqi NP_036630.1. NM_012498.1.
    UniGenei Rn.107801.

    3D structure databases

    ProteinModelPortali P07943.
    SMRi P07943. Positions 1-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246382. 2 interactions.
    STRINGi 10116.ENSRNOP00000012879.

    Chemistry

    BindingDBi P07943.
    ChEMBLi CHEMBL2622.

    PTM databases

    PhosphoSitei P07943.

    Proteomic databases

    PaxDbi P07943.
    PRIDEi P07943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000012879 ; ENSRNOP00000012879 ; ENSRNOG00000009513 .
    GeneIDi 24192.
    KEGGi rno:24192.
    UCSCi RGD:2092. rat.

    Organism-specific databases

    CTDi 231.
    RGDi 2092. Akr1b1.

    Phylogenomic databases

    eggNOGi COG0656.
    GeneTreei ENSGT00670000097881.
    HOGENOMi HOG000250272.
    HOVERGENi HBG000020.
    InParanoidi P07943.
    KOi K00011.
    OMAi DFLDTWT.
    OrthoDBi EOG70KGQF.
    PhylomeDBi P07943.
    TreeFami TF106492.

    Enzyme and pathway databases

    SABIO-RK P07943.

    Miscellaneous databases

    NextBioi 602571.
    PROi P07943.

    Gene expression databases

    Genevestigatori P07943.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000097. AKR. 1 hit.
    PRINTSi PR00069. ALDKETRDTASE.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aldose reductase and p-crystallin belong to the same protein superfamily as aldehyde reductase."
      Carper D., Nishimura C., Shinohara T., Dietzchold B., Wistow G., Craft C., Kador P., Kinoshita J.H.
      FEBS Lett. 220:209-213(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, PARTIAL PROTEIN SEQUENCE.
      Strain: Sprague-Dawley.
      Tissue: Lens.
    2. "Characterization of the aldose reductase-encoding gene family in rat."
      Graham C.E., Szpirer C., Levan G., Carper D.
      Gene 107:259-267(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    4. Lubec G., Afjehi-Sadat L.
      Submitted (NOV-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 42-53; 156-169; 178-195; 276-294 AND 307-316, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Spinal cord.
    5. "Long-term induction of an aldose reductase protein by basic fibroblast growth factor in rat astrocytes in vitro."
      Laeng P., Bouillon P., Taupenot L., Labourdette G.
      Electrophoresis 16:1240-1250(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 156-169 AND 205-210.
      Tissue: Astrocyte.

    Entry informationi

    Entry nameiALDR_RAT
    AccessioniPrimary (citable) accession number: P07943
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3