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P07943 (ALDR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose reductase

Short name=AR
EC=1.1.1.21
Alternative name(s):
Aldehyde reductase
Gene names
Name:Akr1b1
Synonyms:Akr1b4, Aldr1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Catalytic activity

Alditol + NAD(P)+ = aldose + NAD(P)H.

Subunit structure

Monomer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to hydrogen peroxide

Inferred from direct assay PubMed 9039961. Source: RGD

cellular response to methylglyoxal

Inferred from direct assay PubMed 12604218. Source: RGD

cellular response to peptide

Inferred from expression pattern PubMed 17490626. Source: RGD

inner medullary collecting duct development

Inferred from direct assay PubMed 1401064. Source: RGD

maternal process involved in female pregnancy

Inferred from expression pattern PubMed 2121099. Source: RGD

monosaccharide metabolic process

Inferred from direct assay PubMed 2119895. Source: RGD

naphthalene metabolic process

Inferred from direct assay PubMed 8407226. Source: RGD

norepinephrine metabolic process

Inferred from direct assay PubMed 10424772. Source: RGD

positive regulation of JAK-STAT cascade

Inferred from mutant phenotype PubMed 15746188. Source: RGD

positive regulation of smooth muscle cell proliferation

Inferred from mutant phenotype PubMed 16648138. Source: RGD

response to organic substance

Inferred from direct assay PubMed 16567803. Source: RGD

response to thyroid hormone

Inferred from expression pattern PubMed 19422879. Source: RGD

response to water deprivation

Inferred from direct assay PubMed 8785398. Source: RGD

sorbitol biosynthetic process

Inferred from mutant phenotype PubMed 21376710PubMed 6690344. Source: RGD

stress-activated protein kinase signaling cascade

Inferred from mutant phenotype PubMed 16669970. Source: RGD

tissue homeostasis

Inferred from mutant phenotype PubMed 21376710. Source: RGD

   Cellular_componentSchmidt-Lanterman incisure

Inferred from direct assay PubMed 1650113. Source: RGD

Schwann cell microvillus

Inferred from direct assay PubMed 1650113. Source: RGD

cell projection cytoplasm

Inferred from direct assay PubMed 8150024. Source: RGD

cytosol

Inferred from direct assay PubMed 11716357. Source: RGD

extracellular space

Inferred from direct assay PubMed 16332428. Source: RGD

mast cell granule

Inferred from direct assay PubMed 1650113. Source: RGD

paranodal junction

Inferred from direct assay PubMed 1650113. Source: RGD

perinuclear region of cytoplasm

Inferred from direct assay PubMed 8150024. Source: RGD

   Molecular_functionalditol:NADP+ 1-oxidoreductase activity

Inferred from direct assay PubMed 2114645. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 316315Aldose reductase
PRO_0000124627

Regions

Nucleotide binding10 – 1910NADP Potential
Nucleotide binding211 – 27363NADP By similarity

Sites

Active site491Proton donor By similarity
Binding site1111Substrate By similarity
Site781Lowers pKa of active site Tyr By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue951N6-acetyllysine By similarity
Modified residue2221N6-acetyllysine By similarity
Modified residue2631N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P07943 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D6D07843B6850002

FASTA31635,797
        10         20         30         40         50         60 
MASHLELNNG TKMPTLGLGT WKSPPGQVTE AVKVAIDMGY RHIDCAQVYQ NEKEVGVALQ 

        70         80         90        100        110        120 
EKLKEQVVKR QDLFIVSKLW CTFHDQSMVK GACQKTLSDL QLDYLDLYLI HWPTGFKPGP 

       130        140        150        160        170        180 
DYFPLDASGN VIPSDTDFVD TWTAMEQLVD EGLVKAIGVS NFNPLQIERI LNKPGLKYKP 

       190        200        210        220        230        240 
AVNQIECHPY LTQEKLIEYC HCKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKEIAAK 

       250        260        270        280        290        300 
YNKTTAQVLI RFPIQRNLVV IPKSVTPARI AENFKVFDFE LSNEDMATLL SYNRNWRVCA 

       310 
LMSCAKHKDY PFHAEV 

« Hide

References

« Hide 'large scale' references
[1]"Aldose reductase and p-crystallin belong to the same protein superfamily as aldehyde reductase."
Carper D., Nishimura C., Shinohara T., Dietzchold B., Wistow G., Craft C., Kador P., Kinoshita J.H.
FEBS Lett. 220:209-213(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, PARTIAL PROTEIN SEQUENCE.
Strain: Sprague-Dawley.
Tissue: Lens.
[2]"Characterization of the aldose reductase-encoding gene family in rat."
Graham C.E., Szpirer C., Levan G., Carper D.
Gene 107:259-267(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[4]Lubec G., Afjehi-Sadat L.
Submitted (NOV-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 42-53; 156-169; 178-195; 276-294 AND 307-316, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Spinal cord.
[5]"Long-term induction of an aldose reductase protein by basic fibroblast growth factor in rat astrocytes in vitro."
Laeng P., Bouillon P., Taupenot L., Labourdette G.
Electrophoresis 16:1240-1250(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 156-169 AND 205-210.
Tissue: Astrocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05884 mRNA. Translation: CAA29308.1.
M60322 Genomic DNA. Translation: AAA40721.1.
BC062034 mRNA. Translation: AAH62034.1.
PIRA60603.
RefSeqNP_036630.1. NM_012498.1.
UniGeneRn.107801.

3D structure databases

ProteinModelPortalP07943.
SMRP07943. Positions 1-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid246382. 2 interactions.
STRING10116.ENSRNOP00000012879.

Chemistry

BindingDBP07943.
ChEMBLCHEMBL2622.

PTM databases

PhosphoSiteP07943.

Proteomic databases

PaxDbP07943.
PRIDEP07943.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000012879; ENSRNOP00000012879; ENSRNOG00000009513.
GeneID24192.
KEGGrno:24192.
UCSCRGD:2092. rat.

Organism-specific databases

CTD231.
RGD2092. Akr1b1.

Phylogenomic databases

eggNOGCOG0656.
GeneTreeENSGT00670000097881.
HOGENOMHOG000250272.
HOVERGENHBG000020.
InParanoidP07943.
KOK00011.
OMADFLDTWT.
OrthoDBEOG70KGQF.
PhylomeDBP07943.
TreeFamTF106492.

Enzyme and pathway databases

SABIO-RKP07943.

Gene expression databases

GenevestigatorP07943.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio602571.
PROP07943.

Entry information

Entry nameALDR_RAT
AccessionPrimary (citable) accession number: P07943
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families