Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aldose reductase

Gene

Akr1b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton donorBy similarity1
Sitei78Lowers pKa of active site TyrBy similarity1
Binding sitei111SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 19NADPSequence analysis10
Nucleotide bindingi211 – 273NADPBy similarityAdd BLAST63

GO - Molecular functioni

GO - Biological processi

  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to methylglyoxal Source: RGD
  • cellular response to peptide Source: RGD
  • daunorubicin metabolic process Source: Ensembl
  • doxorubicin metabolic process Source: Ensembl
  • inner medullary collecting duct development Source: RGD
  • maternal process involved in female pregnancy Source: RGD
  • monosaccharide metabolic process Source: RGD
  • naphthalene metabolic process Source: RGD
  • norepinephrine metabolic process Source: RGD
  • positive regulation of JAK-STAT cascade Source: RGD
  • positive regulation of smooth muscle cell proliferation Source: RGD
  • response to organic substance Source: RGD
  • response to thyroid hormone Source: RGD
  • response to water deprivation Source: RGD
  • sorbitol biosynthetic process Source: RGD
  • stress-activated protein kinase signaling cascade Source: RGD
  • tissue homeostasis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.21. 5301.
ReactomeiR-RNO-196108. Pregnenolone biosynthesis.
R-RNO-5652227. Fructose biosynthesis.
SABIO-RKP07943.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase (EC:1.1.1.21)
Short name:
AR
Alternative name(s):
Aldehyde reductase
Gene namesi
Name:Akr1b1
Synonyms:Akr1b4, Aldr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2092. Akr1b1.

Subcellular locationi

GO - Cellular componenti

  • cell projection cytoplasm Source: RGD
  • cytosol Source: RGD
  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD
  • mast cell granule Source: RGD
  • nucleoplasm Source: Ensembl
  • paranodal junction Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • Schmidt-Lanterman incisure Source: RGD
  • Schwann cell microvillus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001246272 – 316Aldose reductaseAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineCombined sources1
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei222N6-acetyllysineBy similarity1
Modified residuei263N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP07943.
PRIDEiP07943.

PTM databases

iPTMnetiP07943.
PhosphoSitePlusiP07943.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009513.
GenevisibleiP07943. RN.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi246382. 2 interactors.
STRINGi10116.ENSRNOP00000012879.

Chemistry databases

BindingDBiP07943.

Structurei

3D structure databases

ProteinModelPortaliP07943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiP07943.
KOiK00011.
OMAiCALMSCA.
OrthoDBiEOG091G0D69.
PhylomeDBiP07943.
TreeFamiTF106492.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHLELNNG TKMPTLGLGT WKSPPGQVTE AVKVAIDMGY RHIDCAQVYQ
60 70 80 90 100
NEKEVGVALQ EKLKEQVVKR QDLFIVSKLW CTFHDQSMVK GACQKTLSDL
110 120 130 140 150
QLDYLDLYLI HWPTGFKPGP DYFPLDASGN VIPSDTDFVD TWTAMEQLVD
160 170 180 190 200
EGLVKAIGVS NFNPLQIERI LNKPGLKYKP AVNQIECHPY LTQEKLIEYC
210 220 230 240 250
HCKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKEIAAK YNKTTAQVLI
260 270 280 290 300
RFPIQRNLVV IPKSVTPARI AENFKVFDFE LSNEDMATLL SYNRNWRVCA
310
LMSCAKHKDY PFHAEV
Length:316
Mass (Da):35,797
Last modified:January 23, 2007 - v3
Checksum:iD6D07843B6850002
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05884 mRNA. Translation: CAA29308.1.
M60322 Genomic DNA. Translation: AAA40721.1.
BC062034 mRNA. Translation: AAH62034.1.
PIRiA60603.
RefSeqiNP_036630.1. NM_012498.1.
UniGeneiRn.107801.

Genome annotation databases

EnsembliENSRNOT00000012879; ENSRNOP00000012879; ENSRNOG00000009513.
GeneIDi24192.
KEGGirno:24192.
UCSCiRGD:2092. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05884 mRNA. Translation: CAA29308.1.
M60322 Genomic DNA. Translation: AAA40721.1.
BC062034 mRNA. Translation: AAH62034.1.
PIRiA60603.
RefSeqiNP_036630.1. NM_012498.1.
UniGeneiRn.107801.

3D structure databases

ProteinModelPortaliP07943.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246382. 2 interactors.
STRINGi10116.ENSRNOP00000012879.

Chemistry databases

BindingDBiP07943.
ChEMBLiCHEMBL2622.

PTM databases

iPTMnetiP07943.
PhosphoSitePlusiP07943.

Proteomic databases

PaxDbiP07943.
PRIDEiP07943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012879; ENSRNOP00000012879; ENSRNOG00000009513.
GeneIDi24192.
KEGGirno:24192.
UCSCiRGD:2092. rat.

Organism-specific databases

CTDi231.
RGDi2092. Akr1b1.

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
GeneTreeiENSGT00760000119041.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiP07943.
KOiK00011.
OMAiCALMSCA.
OrthoDBiEOG091G0D69.
PhylomeDBiP07943.
TreeFamiTF106492.

Enzyme and pathway databases

BRENDAi1.1.1.21. 5301.
ReactomeiR-RNO-196108. Pregnenolone biosynthesis.
R-RNO-5652227. Fructose biosynthesis.
SABIO-RKP07943.

Miscellaneous databases

PROiP07943.

Gene expression databases

BgeeiENSRNOG00000009513.
GenevisibleiP07943. RN.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALDR_RAT
AccessioniPrimary (citable) accession number: P07943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.