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P07940 (SIGNS_REOVL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein sigma-NS

Short name=SigmaNS
Gene names
Name:S3
OrganismReovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) [Reference proteome]
Taxonomic identifier10884 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostMammalia [TaxID: 40674]

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein that binds to ssRNA and may be involved in genome packaging. Ref.3

Subunit structure

Homomultimer Probable. Interacts with protein mu-NS; in viral inclusions. Ref.3 Ref.4

Sequence similarities

Belongs to the orthoreovirus sigma-NS protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Protein sigma-NS
PRO_0000222761

Regions

Region1 – 1111Important for ssRNA-binding and formation of complexes

Experimental info

Sequence conflict2501V → I in AAA47281. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P07940 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: B9172A6A9251CC9A

FASTA36641,189
        10         20         30         40         50         60 
MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVTTKVVRNV VEYQIRTGGF FSCLAMLRPL 

        70         80         90        100        110        120 
QYAKRERLLG QRNLERISTR DILQTRDLHS LCMPTPDAPM SNHQAATMRE LICSYFKVDH 

       130        140        150        160        170        180 
TDGLKYIPMD ERYSPSSLAR LFTMGMAGLH ITTEPSYKRV PIMHLAADLD CMTLALPYMI 

       190        200        210        220        230        240 
TLDGDTVVPV APTLSAEQLL DDGLKGLACM DISYGCEVDA SNRSAGDQSM DSSRCINELY 

       250        260        270        280        290        300 
CEETAEAICV LKTCLVLNCM QFKLEMDDLA HNATELDKIQ MMIPFSERVF RMASSFATID 

       310        320        330        340        350        360 
AQCFRFCVMM KDKNLKIDMR ETMRLWTRSA LDDSVVTSSL SISLDRGRWV AADATDARLL 


VFPIRV 

« Hide

References

[1]"Biosynthesis of reovirus-specified polypeptides. Molecular cDNA cloning and nucleotide sequence of the reovirus serotype 1 Lang strain s3 mRNA which encodes the nonstructural RNA-binding protein sigma NS."
George C.X., Atwater J.A., Samuel C.E.
Biochem. Biophys. Res. Commun. 139:845-851(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Comparison of the reovirus serotype 1, 2, and 3 S3 genome segments encoding the nonstructural protein sigma NS."
Wiener J.R., Joklik W.K.
Virology 161:332-339(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Amino terminus of reovirus nonstructural protein sigma NS is important for ssRNA binding and nucleoprotein complex formation."
Gillian A.L., Nibert M.L.
Virology 240:1-11(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[4]"Reovirus sigma NS protein localizes to inclusions through an association requiring the mu NS amino terminus."
Miller C.L., Broering T.J., Parker J.S.L., Arnold M.M., Nibert M.L.
J. Virol. 77:4566-4576(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PROTEIN MU-NS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M14325 Genomic RNA. Translation: AAA47273.1.
M18389 Genomic RNA. Translation: AAA47281.1.
PIRMNXRST. A25068.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002507. Reovirus_polyG_pol.
[Graphical view]
PfamPF01518. PolyG_pol. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSIGNS_REOVL
AccessionPrimary (citable) accession number: P07940
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families