SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P07940

- SIGNS_REOVL

UniProt

P07940 - SIGNS_REOVL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein sigma-NS
Gene
S3
Organism
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Protein that binds to ssRNA and may be involved in genome packaging.1 Publication

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: InterPro
  2. single-stranded RNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein sigma-NS
    Short name:
    SigmaNS
    Gene namesi
    Name:S3
    OrganismiReovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)
    Taxonomic identifieri10884 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
    Virus hostiMammalia [TaxID: 40674]
    ProteomesiUP000007253: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Protein sigma-NS
    PRO_0000222761Add
    BLAST

    Interactioni

    Subunit structurei

    Homomultimer Inferred. Interacts with protein mu-NS; in viral inclusions.2 Publications

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1111Important for ssRNA-binding and formation of complexes
    Add
    BLAST

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR002507. Reovirus_polyG_pol.
    [Graphical view]
    PfamiPF01518. PolyG_pol. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P07940-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVTTKVVRNV VEYQIRTGGF    50
    FSCLAMLRPL QYAKRERLLG QRNLERISTR DILQTRDLHS LCMPTPDAPM 100
    SNHQAATMRE LICSYFKVDH TDGLKYIPMD ERYSPSSLAR LFTMGMAGLH 150
    ITTEPSYKRV PIMHLAADLD CMTLALPYMI TLDGDTVVPV APTLSAEQLL 200
    DDGLKGLACM DISYGCEVDA SNRSAGDQSM DSSRCINELY CEETAEAICV 250
    LKTCLVLNCM QFKLEMDDLA HNATELDKIQ MMIPFSERVF RMASSFATID 300
    AQCFRFCVMM KDKNLKIDMR ETMRLWTRSA LDDSVVTSSL SISLDRGRWV 350
    AADATDARLL VFPIRV 366
    Length:366
    Mass (Da):41,189
    Last modified:August 1, 1988 - v1
    Checksum:iB9172A6A9251CC9A
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti250 – 2501V → I in AAA47281. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14325 Genomic RNA. Translation: AAA47273.1.
    M18389 Genomic RNA. Translation: AAA47281.1.
    PIRiA25068. MNXRST.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14325 Genomic RNA. Translation: AAA47273.1 .
    M18389 Genomic RNA. Translation: AAA47281.1 .
    PIRi A25068. MNXRST.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002507. Reovirus_polyG_pol.
    [Graphical view ]
    Pfami PF01518. PolyG_pol. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Biosynthesis of reovirus-specified polypeptides. Molecular cDNA cloning and nucleotide sequence of the reovirus serotype 1 Lang strain s3 mRNA which encodes the nonstructural RNA-binding protein sigma NS."
      George C.X., Atwater J.A., Samuel C.E.
      Biochem. Biophys. Res. Commun. 139:845-851(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Comparison of the reovirus serotype 1, 2, and 3 S3 genome segments encoding the nonstructural protein sigma NS."
      Wiener J.R., Joklik W.K.
      Virology 161:332-339(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Amino terminus of reovirus nonstructural protein sigma NS is important for ssRNA binding and nucleoprotein complex formation."
      Gillian A.L., Nibert M.L.
      Virology 240:1-11(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    4. "Reovirus sigma NS protein localizes to inclusions through an association requiring the mu NS amino terminus."
      Miller C.L., Broering T.J., Parker J.S.L., Arnold M.M., Nibert M.L.
      J. Virol. 77:4566-4576(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PROTEIN MU-NS.

    Entry informationi

    Entry nameiSIGNS_REOVL
    AccessioniPrimary (citable) accession number: P07940
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: April 16, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi