P07938 (SIG1S_REOVL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein sigma-1-small
Short name=Sigma1s

Alternative name(s):
Sigma-s
Sigma1NS
Sigma1bNS
p14

Gene names

Name:

S1

Organism

Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) [Reference proteome]

Taxonomic identifier

10884 [NCBI]

Taxonomic lineage

Viruses › dsRNA viruses › Reoviridae › Spinareovirinae › Orthoreovirus › Mammalian orthoreovirus › Mammalian orthoreovirus 1

Virus host

Mammalia [TaxID: 40674]

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the orthoreovirus sigma-1s protein family.

Ontologies

Keywords
Biological process	Host G2/M cell cycle arrest by virus Host-virus interaction Modulation of host cell cycle by virus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	suppression by virus of G2/M transition of host mitotic cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Protein sigma-1-small		PRO_0000222757
Experimental info
	Sequence conflict	71	1	V → L in AAA47243. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P07938 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: D6EEE53353BC6190	FASTA	119	13,989
	10 20 30 40 50 60 MAPSQKKSRK SRNKSRSTLM ISGLPILNST DLEDRLLTSA IASQPLSQDW VRWIIDLWVS 70 80 90 100 110 RVRSRNYLTQ VARTLRAYPH WVTESMLSNH ELTVWIRSRL ISLDEHPLWR QMLEAYGQN

References

[1]	"Sequences of the S1 genes of the three serotypes of reovirus." Cashdollar L.W., Chmelo R.A., Wiener J.R., Joklik W.K. Proc. Natl. Acad. Sci. U.S.A. 82:24-28(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Biosynthesis of reovirus-specified polypeptides. Molecular cDNA cloning and nucleotide sequence of the reovirus serotype 1 Lang strain bicistronic s1 mRNA which encodes the minor capsid polypeptide sigma 1a and the nonstructural polypeptide sigma 1bNS." Munemitsu S.M., Atwater J.A., Samuel C.E. Biochem. Biophys. Res. Commun. 140:508-514(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]	"Structure of the reovirus cell-attachment protein: a model for the domain organization of sigma 1." Nibert M.L., Dermody T.S., Fields B.N. J. Virol. 64:2976-2989(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M10260 Genomic RNA. Translation: AAA66878.1. M14779 Genomic RNA. Translation: AAA47277.1. M35963 Genomic RNA. Translation: AAA47243.1.
PIR	MNXR1B. B26436. B34829.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003478. Capsid_sigma_1s. [Graphical view]
Pfam	PF02454. Sigma_1s. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIG1S_REOVL

Accession

Primary (citable) accession number: P07938

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program