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Protein

Neuromodulin

Gene

Gap43

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).By similarity

GO - Molecular functioni

  • lysophosphatidic acid binding Source: RGD
  • phosphatidylinositol phosphate binding Source: RGD
  • phosphatidylserine binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Growth regulation, Neurogenesis

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromodulin
Alternative name(s):
Axonal membrane protein GAP-43
Growth-associated protein 43
Protein F1
Gene namesi
Name:Gap43
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi62071. Gap43.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: RGD
  • filopodium membrane Source: UniProtKB-SubCell
  • growth cone Source: RGD
  • growth cone membrane Source: UniProtKB-SubCell
  • postsynaptic density Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226NeuromodulinPRO_0000159599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteineBy similarity
Lipidationi4 – 41S-palmitoyl cysteineBy similarity
Modified residuei41 – 411Phosphoserine; by PHK and PKC2 Publications
Modified residuei86 – 861PhosphoserineCombined sources
Modified residuei96 – 961PhosphoserineCombined sources1 Publication
Modified residuei142 – 1421PhosphoserineBy similarity
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei145 – 1451PhosphoserineBy similarity
Modified residuei172 – 1721PhosphothreonineCombined sources2 Publications
Modified residuei191 – 1911PhosphoserineCombined sources
Modified residuei192 – 1921PhosphoserineCombined sources

Post-translational modificationi

Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity).By similarity
Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.3 Publications

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP07936.
PRIDEiP07936.

PTM databases

iPTMnetiP07936.
PhosphoSiteiP07936.
SwissPalmiP07936.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001528.
GenevisibleiP07936. RN.

Interactioni

Subunit structurei

Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca2+ than in its presence.By similarity

Protein-protein interaction databases

BioGridi248071. 4 interactions.
STRINGi10116.ENSRNOP00000002091.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 6030IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 44Important for membrane bindingBy similarity

Sequence similaritiesi

Belongs to the neuromodulin family.Curated
Contains 1 IQ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IVZP. Eukaryota.
ENOG411256P. LUCA.
GeneTreeiENSGT00730000111265.
HOGENOMiHOG000013014.
HOVERGENiHBG006468.
InParanoidiP07936.
KOiK20041.
OMAiPEADQEH.
OrthoDBiEOG091G0Z3Z.
PhylomeDBiP07936.
TreeFamiTF333213.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001422. Neuromodulin.
IPR017454. Neuromodulin_C.
IPR018947. Neuromodulin_gap-junction_N.
IPR033137. Neuromodulin_P_site.
IPR018243. Neuromodulin_palmitoyl_site.
[Graphical view]
PANTHERiPTHR10699:SF15. PTHR10699:SF15. 1 hit.
PfamiPF00612. IQ. 1 hit.
PF06614. Neuromodulin. 1 hit.
PF10580. Neuromodulin_N. 1 hit.
[Graphical view]
PRINTSiPR00215. NEUROMODULIN.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
PS00412. NEUROMODULIN_1. 1 hit.
PS00413. NEUROMODULIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCCMRRTKQ VEKNDEDQKI EQDGVKPEDK AHKAATKIQA SFRGHITRKK
60 70 80 90 100
LKDEKKGDAP AAEAEAKEKD DAPVADGVEK KEGDGSATTD AAPATSPKAE
110 120 130 140 150
EPSKAGDAPS EEKKGEGDAA PSEEKAGSAE TESAAKATTD NSPSSKAEDG
160 170 180 190 200
PAKEEPKQAD VPAAVTDAAA TTPAAEDAAK AAQPPTETAE SSQAEEEKEA
210 220
VDEAKPKESA RQDEGKEDPE ADQEHA
Length:226
Mass (Da):23,603
Last modified:August 1, 1988 - v1
Checksum:i1314B2CDC61DB746
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16228 mRNA. Translation: AAA41190.1.
M16736 mRNA. Translation: AAA41192.1.
X06338 mRNA. Translation: CAA29644.1.
L21192, L21190, L21191 Genomic DNA. Translation: AAA41189.1.
BC127502 mRNA. Translation: AAI27503.1.
PIRiA26964.
RefSeqiNP_058891.1. NM_017195.3.
UniGeneiRn.10928.

Genome annotation databases

EnsembliENSRNOT00000002091; ENSRNOP00000002091; ENSRNOG00000001528.
GeneIDi29423.
KEGGirno:29423.
UCSCiRGD:62071. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16228 mRNA. Translation: AAA41190.1.
M16736 mRNA. Translation: AAA41192.1.
X06338 mRNA. Translation: CAA29644.1.
L21192, L21190, L21191 Genomic DNA. Translation: AAA41189.1.
BC127502 mRNA. Translation: AAI27503.1.
PIRiA26964.
RefSeqiNP_058891.1. NM_017195.3.
UniGeneiRn.10928.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248071. 4 interactions.
STRINGi10116.ENSRNOP00000002091.

PTM databases

iPTMnetiP07936.
PhosphoSiteiP07936.
SwissPalmiP07936.

Proteomic databases

PaxDbiP07936.
PRIDEiP07936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002091; ENSRNOP00000002091; ENSRNOG00000001528.
GeneIDi29423.
KEGGirno:29423.
UCSCiRGD:62071. rat.

Organism-specific databases

CTDi2596.
RGDi62071. Gap43.

Phylogenomic databases

eggNOGiENOG410IVZP. Eukaryota.
ENOG411256P. LUCA.
GeneTreeiENSGT00730000111265.
HOGENOMiHOG000013014.
HOVERGENiHBG006468.
InParanoidiP07936.
KOiK20041.
OMAiPEADQEH.
OrthoDBiEOG091G0Z3Z.
PhylomeDBiP07936.
TreeFamiTF333213.

Miscellaneous databases

PROiP07936.

Gene expression databases

BgeeiENSRNOG00000001528.
GenevisibleiP07936. RN.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001422. Neuromodulin.
IPR017454. Neuromodulin_C.
IPR018947. Neuromodulin_gap-junction_N.
IPR033137. Neuromodulin_P_site.
IPR018243. Neuromodulin_palmitoyl_site.
[Graphical view]
PANTHERiPTHR10699:SF15. PTHR10699:SF15. 1 hit.
PfamiPF00612. IQ. 1 hit.
PF06614. Neuromodulin. 1 hit.
PF10580. Neuromodulin_N. 1 hit.
[Graphical view]
PRINTSiPR00215. NEUROMODULIN.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
PS00412. NEUROMODULIN_1. 1 hit.
PS00413. NEUROMODULIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEUM_RAT
AccessioniPrimary (citable) accession number: P07936
Secondary accession number(s): A0JPM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 7, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.