Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (URA5)
  2. Orotidine 5'-phosphate decarboxylase (URA3)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37SubstrateBy similarity1
Active sitei93Proton donorPROSITE-ProRule annotation1
Binding sitei217SubstrateBy similarity1
Binding sitei235SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
Ordered Locus Names:KLLA0E22902g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome E

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346631 – 267Orotidine 5'-phosphate decarboxylaseAdd BLAST267

Proteomic databases

PRIDEiP07922.

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_454981.1.

Structurei

3D structure databases

ProteinModelPortaliP07922.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 61Substrate bindingBy similarity3
Regioni91 – 100Substrate bindingBy similarity10

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.
HOGENOMiHOG000213905.
InParanoidiP07922.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG092C3SZ1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKSYTSRA ETHASPVASK LLRLMDEKKT NLCASLDVRS TDELLKLVET
60 70 80 90 100
LGPYICLLKT HVDILDDFSY EGTVVPLKAL AEKYKFLIFE DRKFADIGNT
110 120 130 140 150
VKLQYTSGVY RIAEWSDITN AHGVTGAGIV AGLKQGAQEV TKEPRGLLML
160 170 180 190 200
AELSSKGSLA HGEYTKGTVD IAKSDKDFVI GFIAQNDMGG REEGFDWLIM
210 220 230 240 250
TPGVGLDDKG DALGQQYRTV DEVVSGGSDI IIVGRGLFAK GRDPKVEGER
260
YRNAGWEAYQ KRISAPH
Length:267
Mass (Da):29,241
Last modified:August 1, 1988 - v1
Checksum:iC55224B57BC0D544
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00454 Genomic DNA. Translation: CAA68509.1.
D00431 Genomic DNA. Translation: BAA00333.1.
CR382125 Genomic DNA. Translation: CAH00068.1.
PIRiA27836. DCVKOP.
RefSeqiXP_454981.1. XM_454981.1.

Genome annotation databases

EnsemblFungiiCAH00068; CAH00068; KLLA0_E22771g.
GeneIDi2894282.
KEGGikla:KLLA0E22771g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00454 Genomic DNA. Translation: CAA68509.1.
D00431 Genomic DNA. Translation: BAA00333.1.
CR382125 Genomic DNA. Translation: CAH00068.1.
PIRiA27836. DCVKOP.
RefSeqiXP_454981.1. XM_454981.1.

3D structure databases

ProteinModelPortaliP07922.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_454981.1.

Proteomic databases

PRIDEiP07922.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAH00068; CAH00068; KLLA0_E22771g.
GeneIDi2894282.
KEGGikla:KLLA0E22771g.

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.
HOGENOMiHOG000213905.
InParanoidiP07922.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG092C3SZ1.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRF_KLULA
AccessioniPrimary (citable) accession number: P07922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 5, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.