Reviewed, UniProtKB/Swiss-Prot P07919 (QCR6_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
    Ubiquinol-cytochrome c reductase complex 11 kDa protein
    Cytochrome c1 non-heme 11 kDa protein
    Mitochondrial hinge protein
    Complex III subunit VIII
    Complex III subunit 6

Gene names

Name:

UQCRH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	91 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
Subunit structure	The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the UQCRH/QCR6 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Transit peptide
PTM	Acetylation Disulfide bond Phosphoprotein
Gene Ontology (GO)
Biological process	aerobic respiration Ref.1 Traceable author statement. Source: ProtInc mitochondrial electron transport, ubiquinol to cytochrome c Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial respiratory chain Ref.1 Traceable author statement. Source: ProtInc
Molecular function	ubiquinol-cytochrome-c reductase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 13	13	Mitochondrion
	Chain	14 – 91	78	Cytochrome b-c1 complex subunit 6, mitochondrial		PRO_0000035990
Regions
	Compositional bias	17 – 25	9	Poly-Glu
Amino acid modifications
	Modified residue	42	1	N6-acetyllysine By similarity
	Modified residue	61	1	Phosphoserine Ref.6
	Modified residue	63	1	Phosphothreonine By similarity
	Disulfide bond	37 ↔ 81		By similarity
	Disulfide bond	53 ↔ 67		By similarity
Natural variations
	Natural variant	51	1	E → Q: dbSNP rs34813470.		VAR_034579
Experimental info
	Sequence conflict	57	1	V → D in AAA36317. Ref.1
	Sequence conflict	57	1	V → D in CAA68733. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P07919-1 [UniParc]. Last modified May 2, 2002. Version 2. Checksum: 499B5D069E738F4C	FASTA	91	10,739
	10 20 30 40 50 60 MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL ELCDERVSSR 70 80 90 SHTEEDCTEE LFDFLHARDH CVAHKLFNNL K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein." Ohta S., Goto K., Arai H., Kagawa Y. FEBS Lett. 226:171-175(1987) [PubMed: 2826252] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung, Pancreas and Placenta.
[5]	"Elevated expression of the human mitochondrial hinge protein gene in cancer." Liu A.Y., Bradner R.C. Cancer Res. 53:2460-2465(1993) [PubMed: 7684318] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M36647 mRNA. Translation: AAA36317.1. Y00764 mRNA. Translation: CAA68733.1. BT007070 mRNA. Translation: AAP35733.1. AL122001 Genomic DNA. Translation: CAI21963.1. BC001426 mRNA. Translation: AAH01426.1. BC001934 mRNA. Translation: AAH01934.1. BC015177 mRNA. Translation: AAH15177.1. BC107703 mRNA. Translation: AAI07704.1. S61826 Genomic DNA. Translation: AAD13930.1.
IPI	IPI00296022.
PIR	S00219.
RefSeq	NP_005995.2.
UniGene	Hs.481571
3D structure databases
SMR	P07919. Positions 14-91.
ModBase	Search...
PTM databases
PhosphoSite	P07919.
Proteomic databases
PRIDE	P07919.
Genome annotation databases
Ensembl	ENSG00000173660. Homo sapiens. [Contig view]
GeneID	7388.
KEGG	hsa:7388.
NMPDR	fig|9606.3.peg.1090.
Organism-specific databases
GeneCards	GC01M016007. GC01P046541.
H-InvDB	HIX0000548. HIX0023863.
HGNC	HGNC:12590. UQCRH.
PharmGKB	PA37220.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P07919.
HOVERGEN	P07919.
OMA	P07919. HKLFNSL.
Enzyme and pathway databases
Reactome	REACT_6305. Electron Transport Chain.
Gene expression databases
Bgee	P07919.
CleanEx	HS_UQCRH.
GermOnline	ENSG00000173660. Homo sapiens.
Family and domain databases
InterPro	IPR003422. Ubol_cytC_Rdtase_hinge. [Graphical view]
PANTHER	PTHR15336. UCR_hinge. 1 hit.
Pfam	PF02320. UCR_hinge. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	28926.

Entry information

Entry name

QCR6_HUMAN

Accession

Primary (citable) accession number: P07919
Secondary accession number(s): Q5TDF6, Q6LDB8, Q9BQ91

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	May 2, 2002
Last modified:	June 16, 2009
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)