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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

UQCRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

  1. ubiquinol-cytochrome-c reductase activity Source: ProtInc

GO - Biological processi

  1. aerobic respiration Source: ProtInc
  2. cellular metabolic process Source: Reactome
  3. hydrogen ion transmembrane transport Source: GOC
  4. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
  5. oxidation-reduction process Source: ProtInc
  6. oxidative phosphorylation Source: ProtInc
  7. respiratory electron transport chain Source: Reactome
  8. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:UQCRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12590. UQCRH.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial respiratory chain Source: ProtInc
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313MitochondrionAdd
BLAST
Chaini14 – 9178Cytochrome b-c1 complex subunit 6, mitochondrialPRO_0000035990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 81By similarity
Modified residuei42 – 421N6-acetyllysineBy similarity
Disulfide bondi53 ↔ 67By similarity
Modified residuei85 – 851N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

MaxQBiP07919.
PaxDbiP07919.
PRIDEiP07919.

PTM databases

PhosphoSiteiP07919.

Expressioni

Gene expression databases

BgeeiP07919.
CleanExiHS_UQCRH.
GenevestigatoriP07919.

Organism-specific databases

HPAiHPA042574.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

BioGridi113234. 16 interactions.
IntActiP07919. 3 interactions.
MINTiMINT-3006002.
STRINGi9606.ENSP00000309565.

Structurei

3D structure databases

ProteinModelPortaliP07919.
SMRiP07919. Positions 26-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 259Poly-Glu

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG312125.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP07919.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG7PK92F.
PhylomeDBiP07919.
TreeFamiTF105036.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL
60 70 80 90
ELCDERVSSR SHTEEDCTEE LFDFLHARDH CVAHKLFNNL K
Length:91
Mass (Da):10,739
Last modified:May 2, 2002 - v2
Checksum:i499B5D069E738F4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571V → D in AAA36317 (PubMed:2826252).Curated
Sequence conflicti57 – 571V → D in CAA68733 (PubMed:2826252).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511E → Q.
Corresponds to variant rs34813470 [ dbSNP | Ensembl ].
VAR_034579

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36647 mRNA. Translation: AAA36317.1.
Y00764 mRNA. Translation: CAA68733.1.
BT007070 mRNA. Translation: AAP35733.1.
AK311967 mRNA. Translation: BAG34906.1.
AL122001 Genomic DNA. Translation: CAI21963.1.
CH471059 Genomic DNA. Translation: EAX06922.1.
CH471059 Genomic DNA. Translation: EAX06924.1.
BC001426 mRNA. Translation: AAH01426.1.
BC001934 mRNA. Translation: AAH01934.1.
BC015177 mRNA. Translation: AAH15177.1.
BC107703 mRNA. Translation: AAI07704.1.
S61826 Genomic DNA. Translation: AAD13930.1.
CCDSiCCDS30704.1.
PIRiS00219.
RefSeqiNP_005995.2. NM_006004.3.
UniGeneiHs.481571.

Genome annotation databases

EnsembliENST00000311672; ENSP00000309565; ENSG00000173660.
GeneIDi7388.
KEGGihsa:7388.
UCSCiuc001cpp.3. human.

Polymorphism databases

DMDMi20455515.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36647 mRNA. Translation: AAA36317.1.
Y00764 mRNA. Translation: CAA68733.1.
BT007070 mRNA. Translation: AAP35733.1.
AK311967 mRNA. Translation: BAG34906.1.
AL122001 Genomic DNA. Translation: CAI21963.1.
CH471059 Genomic DNA. Translation: EAX06922.1.
CH471059 Genomic DNA. Translation: EAX06924.1.
BC001426 mRNA. Translation: AAH01426.1.
BC001934 mRNA. Translation: AAH01934.1.
BC015177 mRNA. Translation: AAH15177.1.
BC107703 mRNA. Translation: AAI07704.1.
S61826 Genomic DNA. Translation: AAD13930.1.
CCDSiCCDS30704.1.
PIRiS00219.
RefSeqiNP_005995.2. NM_006004.3.
UniGeneiHs.481571.

3D structure databases

ProteinModelPortaliP07919.
SMRiP07919. Positions 26-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113234. 16 interactions.
IntActiP07919. 3 interactions.
MINTiMINT-3006002.
STRINGi9606.ENSP00000309565.

PTM databases

PhosphoSiteiP07919.

Polymorphism databases

DMDMi20455515.

Proteomic databases

MaxQBiP07919.
PaxDbiP07919.
PRIDEiP07919.

Protocols and materials databases

DNASUi7388.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311672; ENSP00000309565; ENSG00000173660.
GeneIDi7388.
KEGGihsa:7388.
UCSCiuc001cpp.3. human.

Organism-specific databases

CTDi7388.
GeneCardsiGC01P046769.
H-InvDBHIX0023863.
HGNCiHGNC:12590. UQCRH.
HPAiHPA042574.
MIMi613844. gene.
neXtProtiNX_P07919.
PharmGKBiPA37220.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG312125.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP07919.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG7PK92F.
PhylomeDBiP07919.
TreeFamiTF105036.

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiUQCRH. human.
GeneWikiiUQCRH.
GenomeRNAii7388.
NextBioi28926.
PROiP07919.
SOURCEiSearch...

Gene expression databases

BgeeiP07919.
CleanExiHS_UQCRH.
GenevestigatoriP07919.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein."
    Ohta S., Goto K., Arai H., Kagawa Y.
    FEBS Lett. 226:171-175(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung, Pancreas and Placenta.
  7. "Elevated expression of the human mitochondrial hinge protein gene in cancer."
    Liu A.Y., Bradner R.C.
    Cancer Res. 53:2460-2465(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQCR6_HUMAN
AccessioniPrimary (citable) accession number: P07919
Secondary accession number(s): B2R4V9
, D3DQ18, Q5TDF6, Q6LDB8, Q9BQ91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 2, 2002
Last modified: March 4, 2015
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.