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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

UQCRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

  • ubiquinol-cytochrome-c reductase activity Source: ProtInc

GO - Biological processi

  • aerobic respiration Source: ProtInc
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: Reactome
  • oxidation-reduction process Source: ProtInc
  • oxidative phosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciZFISH:HS10708-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:UQCRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12590. UQCRH.

Subcellular locationi

  • Mitochondrion inner membrane By similarity

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial respiratory chain Source: ProtInc
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7388.
OpenTargetsiENSG00000173660.
PharmGKBiPA37220.

Polymorphism and mutation databases

BioMutaiUQCRH.
DMDMi20455515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13MitochondrionBy similarityAdd BLAST13
ChainiPRO_000003599014 – 91Cytochrome b-c1 complex subunit 6, mitochondrialAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 81By similarity
Modified residuei42N6-acetyllysineBy similarity1
Disulfide bondi53 ↔ 67By similarity
Modified residuei85N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP07919.
MaxQBiP07919.
PaxDbiP07919.
PeptideAtlasiP07919.
PRIDEiP07919.
TopDownProteomicsiP07919.

PTM databases

iPTMnetiP07919.
PhosphoSitePlusiP07919.

Expressioni

Gene expression databases

BgeeiENSG00000173660.
CleanExiHS_UQCRH.
ExpressionAtlasiP07919. baseline and differential.
GenevisibleiP07919. HS.

Organism-specific databases

HPAiHPA042574.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL8AQ96BM95EBI-1224427,EBI-4401082
FAM189BQ96H713EBI-1224427,EBI-10195448
RNF24Q9Y2253EBI-1224427,EBI-10195462

Protein-protein interaction databases

BioGridi113234. 42 interactors.
IntActiP07919. 10 interactors.
MINTiMINT-3006002.
STRINGi9606.ENSP00000309565.

Structurei

3D structure databases

ProteinModelPortaliP07919.
SMRiP07919.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 25Poly-Glu9

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4763. Eukaryota.
ENOG411247S. LUCA.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP07919.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG091G13DH.
PhylomeDBiP07919.
TreeFamiTF105036.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL
60 70 80 90
ELCDERVSSR SHTEEDCTEE LFDFLHARDH CVAHKLFNNL K
Length:91
Mass (Da):10,739
Last modified:May 2, 2002 - v2
Checksum:i499B5D069E738F4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57V → D in AAA36317 (PubMed:2826252).Curated1
Sequence conflicti57V → D in CAA68733 (PubMed:2826252).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03457951E → Q.Corresponds to variant rs34813470dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36647 mRNA. Translation: AAA36317.1.
Y00764 mRNA. Translation: CAA68733.1.
BT007070 mRNA. Translation: AAP35733.1.
AK311967 mRNA. Translation: BAG34906.1.
AL122001 Genomic DNA. Translation: CAI21963.1.
CH471059 Genomic DNA. Translation: EAX06922.1.
CH471059 Genomic DNA. Translation: EAX06924.1.
BC001426 mRNA. Translation: AAH01426.1.
BC001934 mRNA. Translation: AAH01934.1.
BC015177 mRNA. Translation: AAH15177.1.
BC107703 mRNA. Translation: AAI07704.1.
S61826 Genomic DNA. Translation: AAD13930.1.
CCDSiCCDS30704.1.
PIRiS00219.
RefSeqiNP_005995.2. NM_006004.3.
UniGeneiHs.481571.

Genome annotation databases

EnsembliENST00000311672; ENSP00000309565; ENSG00000173660.
GeneIDi7388.
KEGGihsa:7388.
UCSCiuc001cpp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36647 mRNA. Translation: AAA36317.1.
Y00764 mRNA. Translation: CAA68733.1.
BT007070 mRNA. Translation: AAP35733.1.
AK311967 mRNA. Translation: BAG34906.1.
AL122001 Genomic DNA. Translation: CAI21963.1.
CH471059 Genomic DNA. Translation: EAX06922.1.
CH471059 Genomic DNA. Translation: EAX06924.1.
BC001426 mRNA. Translation: AAH01426.1.
BC001934 mRNA. Translation: AAH01934.1.
BC015177 mRNA. Translation: AAH15177.1.
BC107703 mRNA. Translation: AAI07704.1.
S61826 Genomic DNA. Translation: AAD13930.1.
CCDSiCCDS30704.1.
PIRiS00219.
RefSeqiNP_005995.2. NM_006004.3.
UniGeneiHs.481571.

3D structure databases

ProteinModelPortaliP07919.
SMRiP07919.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113234. 42 interactors.
IntActiP07919. 10 interactors.
MINTiMINT-3006002.
STRINGi9606.ENSP00000309565.

PTM databases

iPTMnetiP07919.
PhosphoSitePlusiP07919.

Polymorphism and mutation databases

BioMutaiUQCRH.
DMDMi20455515.

Proteomic databases

EPDiP07919.
MaxQBiP07919.
PaxDbiP07919.
PeptideAtlasiP07919.
PRIDEiP07919.
TopDownProteomicsiP07919.

Protocols and materials databases

DNASUi7388.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311672; ENSP00000309565; ENSG00000173660.
GeneIDi7388.
KEGGihsa:7388.
UCSCiuc001cpp.4. human.

Organism-specific databases

CTDi7388.
DisGeNETi7388.
GeneCardsiUQCRH.
H-InvDBHIX0023863.
HGNCiHGNC:12590. UQCRH.
HPAiHPA042574.
MIMi613844. gene.
neXtProtiNX_P07919.
OpenTargetsiENSG00000173660.
PharmGKBiPA37220.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4763. Eukaryota.
ENOG411247S. LUCA.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP07919.
KOiK00416.
OMAiSQTEEDC.
OrthoDBiEOG091G13DH.
PhylomeDBiP07919.
TreeFamiTF105036.

Enzyme and pathway databases

BioCyciZFISH:HS10708-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiUQCRH. human.
GeneWikiiUQCRH.
GenomeRNAii7388.
PROiP07919.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173660.
CleanExiHS_UQCRH.
ExpressionAtlasiP07919. baseline and differential.
GenevisibleiP07919. HS.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQCR6_HUMAN
AccessioniPrimary (citable) accession number: P07919
Secondary accession number(s): B2R4V9
, D3DQ18, Q5TDF6, Q6LDB8, Q9BQ91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 2, 2002
Last modified: November 30, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.