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P07919

- QCR6_HUMAN

UniProt

P07919 - QCR6_HUMAN

Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

UQCRH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

    GO - Molecular functioni

    1. ubiquinol-cytochrome-c reductase activity Source: ProtInc

    GO - Biological processi

    1. aerobic respiration Source: ProtInc
    2. cellular metabolic process Source: Reactome
    3. hydrogen ion transmembrane transport Source: GOC
    4. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
    5. oxidation-reduction process Source: ProtInc
    6. oxidative phosphorylation Source: ProtInc
    7. protein heterooligomerization Source: Ensembl
    8. respiratory electron transport chain Source: Reactome
    9. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b-c1 complex subunit 6, mitochondrial
    Alternative name(s):
    Complex III subunit 6
    Complex III subunit VIII
    Cytochrome c1 non-heme 11 kDa protein
    Mitochondrial hinge protein
    Ubiquinol-cytochrome c reductase complex 11 kDa protein
    Gene namesi
    Name:UQCRH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:12590. UQCRH.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Reactome
    2. mitochondrial respiratory chain Source: ProtInc
    3. mitochondrial respiratory chain complex III Source: Ensembl
    4. mitochondrion Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37220.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1313MitochondrionAdd
    BLAST
    Chaini14 – 9178Cytochrome b-c1 complex subunit 6, mitochondrialPRO_0000035990Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi37 ↔ 81By similarity
    Modified residuei42 – 421N6-acetyllysineBy similarity
    Disulfide bondi53 ↔ 67By similarity
    Modified residuei85 – 851N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Disulfide bond

    Proteomic databases

    MaxQBiP07919.
    PaxDbiP07919.
    PRIDEiP07919.

    PTM databases

    PhosphoSiteiP07919.

    Expressioni

    Gene expression databases

    BgeeiP07919.
    CleanExiHS_UQCRH.
    GenevestigatoriP07919.

    Organism-specific databases

    HPAiHPA042574.

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

    Protein-protein interaction databases

    BioGridi113234. 11 interactions.
    IntActiP07919. 3 interactions.
    MINTiMINT-3006002.
    STRINGi9606.ENSP00000309565.

    Structurei

    3D structure databases

    ProteinModelPortaliP07919.
    SMRiP07919. Positions 26-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi17 – 259Poly-Glu

    Sequence similaritiesi

    Belongs to the UQCRH/QCR6 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG312125.
    HOGENOMiHOG000243673.
    HOVERGENiHBG001487.
    InParanoidiP07919.
    KOiK00416.
    OMAiRYRARPL.
    OrthoDBiEOG7PK92F.
    PhylomeDBiP07919.
    TreeFamiTF105036.

    Family and domain databases

    Gene3Di1.10.287.20. 1 hit.
    InterProiIPR003422. Cyt_b-c1_6.
    IPR023184. Ubol_cytC_Rdtase_hinge_dom.
    [Graphical view]
    PANTHERiPTHR15336. PTHR15336. 1 hit.
    PfamiPF02320. UCR_hinge. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000019. Bc1_11K. 1 hit.
    SUPFAMiSSF81531. SSF81531. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07919-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL   50
    ELCDERVSSR SHTEEDCTEE LFDFLHARDH CVAHKLFNNL K 91
    Length:91
    Mass (Da):10,739
    Last modified:May 2, 2002 - v2
    Checksum:i499B5D069E738F4C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571V → D in AAA36317. (PubMed:2826252)Curated
    Sequence conflicti57 – 571V → D in CAA68733. (PubMed:2826252)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511E → Q.
    Corresponds to variant rs34813470 [ dbSNP | Ensembl ].
    VAR_034579

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36647 mRNA. Translation: AAA36317.1.
    Y00764 mRNA. Translation: CAA68733.1.
    BT007070 mRNA. Translation: AAP35733.1.
    AK311967 mRNA. Translation: BAG34906.1.
    AL122001 Genomic DNA. Translation: CAI21963.1.
    CH471059 Genomic DNA. Translation: EAX06922.1.
    CH471059 Genomic DNA. Translation: EAX06924.1.
    BC001426 mRNA. Translation: AAH01426.1.
    BC001934 mRNA. Translation: AAH01934.1.
    BC015177 mRNA. Translation: AAH15177.1.
    BC107703 mRNA. Translation: AAI07704.1.
    S61826 Genomic DNA. Translation: AAD13930.1.
    CCDSiCCDS30704.1.
    PIRiS00219.
    RefSeqiNP_005995.2. NM_006004.2.
    UniGeneiHs.481571.

    Genome annotation databases

    EnsembliENST00000311672; ENSP00000309565; ENSG00000173660.
    GeneIDi7388.
    KEGGihsa:7388.
    UCSCiuc001cpp.3. human.

    Polymorphism databases

    DMDMi20455515.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36647 mRNA. Translation: AAA36317.1 .
    Y00764 mRNA. Translation: CAA68733.1 .
    BT007070 mRNA. Translation: AAP35733.1 .
    AK311967 mRNA. Translation: BAG34906.1 .
    AL122001 Genomic DNA. Translation: CAI21963.1 .
    CH471059 Genomic DNA. Translation: EAX06922.1 .
    CH471059 Genomic DNA. Translation: EAX06924.1 .
    BC001426 mRNA. Translation: AAH01426.1 .
    BC001934 mRNA. Translation: AAH01934.1 .
    BC015177 mRNA. Translation: AAH15177.1 .
    BC107703 mRNA. Translation: AAI07704.1 .
    S61826 Genomic DNA. Translation: AAD13930.1 .
    CCDSi CCDS30704.1.
    PIRi S00219.
    RefSeqi NP_005995.2. NM_006004.2.
    UniGenei Hs.481571.

    3D structure databases

    ProteinModelPortali P07919.
    SMRi P07919. Positions 26-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113234. 11 interactions.
    IntActi P07919. 3 interactions.
    MINTi MINT-3006002.
    STRINGi 9606.ENSP00000309565.

    PTM databases

    PhosphoSitei P07919.

    Polymorphism databases

    DMDMi 20455515.

    Proteomic databases

    MaxQBi P07919.
    PaxDbi P07919.
    PRIDEi P07919.

    Protocols and materials databases

    DNASUi 7388.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311672 ; ENSP00000309565 ; ENSG00000173660 .
    GeneIDi 7388.
    KEGGi hsa:7388.
    UCSCi uc001cpp.3. human.

    Organism-specific databases

    CTDi 7388.
    GeneCardsi GC01P046769.
    H-InvDB HIX0023863.
    HGNCi HGNC:12590. UQCRH.
    HPAi HPA042574.
    MIMi 613844. gene.
    neXtProti NX_P07919.
    PharmGKBi PA37220.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312125.
    HOGENOMi HOG000243673.
    HOVERGENi HBG001487.
    InParanoidi P07919.
    KOi K00416.
    OMAi RYRARPL.
    OrthoDBi EOG7PK92F.
    PhylomeDBi P07919.
    TreeFami TF105036.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi UQCRH. human.
    GeneWikii UQCRH.
    GenomeRNAii 7388.
    NextBioi 28926.
    PROi P07919.
    SOURCEi Search...

    Gene expression databases

    Bgeei P07919.
    CleanExi HS_UQCRH.
    Genevestigatori P07919.

    Family and domain databases

    Gene3Di 1.10.287.20. 1 hit.
    InterProi IPR003422. Cyt_b-c1_6.
    IPR023184. Ubol_cytC_Rdtase_hinge_dom.
    [Graphical view ]
    PANTHERi PTHR15336. PTHR15336. 1 hit.
    Pfami PF02320. UCR_hinge. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000019. Bc1_11K. 1 hit.
    SUPFAMi SSF81531. SSF81531. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein."
      Ohta S., Goto K., Arai H., Kagawa Y.
      FEBS Lett. 226:171-175(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung, Pancreas and Placenta.
    7. "Elevated expression of the human mitochondrial hinge protein gene in cancer."
      Liu A.Y., Bradner R.C.
      Cancer Res. 53:2460-2465(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-85, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQCR6_HUMAN
    AccessioniPrimary (citable) accession number: P07919
    Secondary accession number(s): B2R4V9
    , D3DQ18, Q5TDF6, Q6LDB8, Q9BQ91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: May 2, 2002
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3