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P07919

- QCR6_HUMAN

UniProt

P07919 - QCR6_HUMAN

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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

UQCRH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

  1. ubiquinol-cytochrome-c reductase activity Source: ProtInc

GO - Biological processi

  1. aerobic respiration Source: ProtInc
  2. cellular metabolic process Source: Reactome
  3. hydrogen ion transmembrane transport Source: GOC
  4. mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
  5. oxidation-reduction process Source: ProtInc
  6. oxidative phosphorylation Source: ProtInc
  7. protein heterooligomerization Source: Ensembl
  8. respiratory electron transport chain Source: Reactome
  9. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:UQCRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:12590. UQCRH.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial respiratory chain Source: ProtInc
  3. mitochondrial respiratory chain complex III Source: Ensembl
  4. mitochondrion Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313MitochondrionAdd
BLAST
Chaini14 – 9178Cytochrome b-c1 complex subunit 6, mitochondrialPRO_0000035990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 81By similarity
Modified residuei42 – 421N6-acetyllysineBy similarity
Disulfide bondi53 ↔ 67By similarity
Modified residuei85 – 851N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

MaxQBiP07919.
PaxDbiP07919.
PRIDEiP07919.

PTM databases

PhosphoSiteiP07919.

Expressioni

Gene expression databases

BgeeiP07919.
CleanExiHS_UQCRH.
GenevestigatoriP07919.

Organism-specific databases

HPAiHPA042574.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

BioGridi113234. 13 interactions.
IntActiP07919. 3 interactions.
MINTiMINT-3006002.
STRINGi9606.ENSP00000309565.

Structurei

3D structure databases

ProteinModelPortaliP07919.
SMRiP07919. Positions 26-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 259Poly-Glu

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG312125.
GeneTreeiENSGT00390000003860.
HOGENOMiHOG000243673.
HOVERGENiHBG001487.
InParanoidiP07919.
KOiK00416.
OMAiRYRARPL.
OrthoDBiEOG7PK92F.
PhylomeDBiP07919.
TreeFamiTF105036.

Family and domain databases

Gene3Di1.10.287.20. 1 hit.
InterProiIPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view]
PANTHERiPTHR15336. PTHR15336. 1 hit.
PfamiPF02320. UCR_hinge. 1 hit.
[Graphical view]
PIRSFiPIRSF000019. Bc1_11K. 1 hit.
SUPFAMiSSF81531. SSF81531. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07919-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL
60 70 80 90
ELCDERVSSR SHTEEDCTEE LFDFLHARDH CVAHKLFNNL K
Length:91
Mass (Da):10,739
Last modified:May 2, 2002 - v2
Checksum:i499B5D069E738F4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571V → D in AAA36317. (PubMed:2826252)Curated
Sequence conflicti57 – 571V → D in CAA68733. (PubMed:2826252)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511E → Q.
Corresponds to variant rs34813470 [ dbSNP | Ensembl ].
VAR_034579

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36647 mRNA. Translation: AAA36317.1.
Y00764 mRNA. Translation: CAA68733.1.
BT007070 mRNA. Translation: AAP35733.1.
AK311967 mRNA. Translation: BAG34906.1.
AL122001 Genomic DNA. Translation: CAI21963.1.
CH471059 Genomic DNA. Translation: EAX06922.1.
CH471059 Genomic DNA. Translation: EAX06924.1.
BC001426 mRNA. Translation: AAH01426.1.
BC001934 mRNA. Translation: AAH01934.1.
BC015177 mRNA. Translation: AAH15177.1.
BC107703 mRNA. Translation: AAI07704.1.
S61826 Genomic DNA. Translation: AAD13930.1.
CCDSiCCDS30704.1.
PIRiS00219.
RefSeqiNP_005995.2. NM_006004.3.
UniGeneiHs.481571.

Genome annotation databases

EnsembliENST00000311672; ENSP00000309565; ENSG00000173660.
GeneIDi7388.
KEGGihsa:7388.
UCSCiuc001cpp.3. human.

Polymorphism databases

DMDMi20455515.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36647 mRNA. Translation: AAA36317.1 .
Y00764 mRNA. Translation: CAA68733.1 .
BT007070 mRNA. Translation: AAP35733.1 .
AK311967 mRNA. Translation: BAG34906.1 .
AL122001 Genomic DNA. Translation: CAI21963.1 .
CH471059 Genomic DNA. Translation: EAX06922.1 .
CH471059 Genomic DNA. Translation: EAX06924.1 .
BC001426 mRNA. Translation: AAH01426.1 .
BC001934 mRNA. Translation: AAH01934.1 .
BC015177 mRNA. Translation: AAH15177.1 .
BC107703 mRNA. Translation: AAI07704.1 .
S61826 Genomic DNA. Translation: AAD13930.1 .
CCDSi CCDS30704.1.
PIRi S00219.
RefSeqi NP_005995.2. NM_006004.3.
UniGenei Hs.481571.

3D structure databases

ProteinModelPortali P07919.
SMRi P07919. Positions 26-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113234. 13 interactions.
IntActi P07919. 3 interactions.
MINTi MINT-3006002.
STRINGi 9606.ENSP00000309565.

PTM databases

PhosphoSitei P07919.

Polymorphism databases

DMDMi 20455515.

Proteomic databases

MaxQBi P07919.
PaxDbi P07919.
PRIDEi P07919.

Protocols and materials databases

DNASUi 7388.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311672 ; ENSP00000309565 ; ENSG00000173660 .
GeneIDi 7388.
KEGGi hsa:7388.
UCSCi uc001cpp.3. human.

Organism-specific databases

CTDi 7388.
GeneCardsi GC01P046769.
H-InvDB HIX0023863.
HGNCi HGNC:12590. UQCRH.
HPAi HPA042574.
MIMi 613844. gene.
neXtProti NX_P07919.
PharmGKBi PA37220.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312125.
GeneTreei ENSGT00390000003860.
HOGENOMi HOG000243673.
HOVERGENi HBG001487.
InParanoidi P07919.
KOi K00416.
OMAi RYRARPL.
OrthoDBi EOG7PK92F.
PhylomeDBi P07919.
TreeFami TF105036.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSi UQCRH. human.
GeneWikii UQCRH.
GenomeRNAii 7388.
NextBioi 28926.
PROi P07919.
SOURCEi Search...

Gene expression databases

Bgeei P07919.
CleanExi HS_UQCRH.
Genevestigatori P07919.

Family and domain databases

Gene3Di 1.10.287.20. 1 hit.
InterProi IPR003422. Cyt_b-c1_6.
IPR023184. Ubol_cytC_Rdtase_hinge_dom.
[Graphical view ]
PANTHERi PTHR15336. PTHR15336. 1 hit.
Pfami PF02320. UCR_hinge. 1 hit.
[Graphical view ]
PIRSFi PIRSF000019. Bc1_11K. 1 hit.
SUPFAMi SSF81531. SSF81531. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein."
    Ohta S., Goto K., Arai H., Kagawa Y.
    FEBS Lett. 226:171-175(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung, Pancreas and Placenta.
  7. "Elevated expression of the human mitochondrial hinge protein gene in cancer."
    Liu A.Y., Bradner R.C.
    Cancer Res. 53:2460-2465(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-85, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQCR6_HUMAN
AccessioniPrimary (citable) accession number: P07919
Secondary accession number(s): B2R4V9
, D3DQ18, Q5TDF6, Q6LDB8, Q9BQ91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 2, 2002
Last modified: October 29, 2014
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3