Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heterogeneous nuclear ribonucleoproteins C1/C2

Gene

HNRNPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).5 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • mRNA 3'-UTR binding Source: UniProtKB
  • N6-methyladenosine-containing RNA binding Source: UniProtKB
  • nucleosomal DNA binding Source: UniProtKB
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • poly(U) RNA binding Source: UniProtKB
  • RNA binding Source: HGNC
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
  • telomerase RNA binding Source: BHF-UCL

GO - Biological processi

  • 3'-UTR-mediated mRNA stabilization Source: UniProtKB
  • ATP-dependent chromatin remodeling Source: UniProtKB
  • gene expression Source: Reactome
  • mRNA splicing, via spliceosome Source: UniProtKB
  • negative regulation of telomere maintenance via telomerase Source: BHF-UCL
  • osteoblast differentiation Source: UniProtKB
  • protein sumoylation Source: Reactome
  • RNA splicing Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.
SIGNORiP07910.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoproteins C1/C2
Short name:
hnRNP C1/C2
Gene namesi
Name:HNRNPC
Synonyms:HNRPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:5035. HNRNPC.

Subcellular locationi

  • Nucleus

  • Note: Component of ribonucleosomes.

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nuclear chromatin Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • pronucleus Source: Ensembl
  • protein complex Source: UniProtKB
  • spliceosomal complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi197 – 1971K → R: No effect on sumoylation. 1 Publication
Mutagenesisi250 – 2501K → R: Loss of sumoylation. 1 Publication

Organism-specific databases

PharmGKBiPA162391217.

Chemistry

ChEMBLiCHEMBL2216742.

Polymorphism and mutation databases

BioMutaiHNRNPC.
DMDMi108935845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 306305Heterogeneous nuclear ribonucleoproteins C1/C2PRO_0000081844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources1 Publication
Cross-linki50 – 50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki89 – 89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki94 – 94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei109 – 1091PhosphothreonineCombined sources
Modified residuei113 – 1131PhosphoserineCombined sources
Modified residuei115 – 1151PhosphoserineCombined sources
Modified residuei121 – 1211PhosphoserineBy similarity
Modified residuei162 – 1621PhosphoserineCombined sources
Modified residuei166 – 1661PhosphoserineCombined sources
Modified residuei176 – 1761N6-acetyllysine; alternateBy similarity
Cross-linki176 – 176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki223 – 223Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki229 – 229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki232 – 232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki232 – 232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei233 – 2331PhosphoserineCombined sources
Modified residuei238 – 2381PhosphoserineCombined sources
Modified residuei239 – 2391PhosphoserineCombined sources
Modified residuei241 – 2411PhosphoserineCombined sources
Cross-linki243 – 243Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki244 – 244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki250 – 250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei253 – 2531PhosphoserineCombined sources1 Publication
Modified residuei260 – 2601PhosphoserineCombined sources1 Publication
Modified residuei299 – 2991PhosphoserineCombined sources1 Publication
Modified residuei306 – 3061PhosphoserineCombined sources
Isoform C1 (identifier: P07910-2)
Modified residuei107 – 1071PhosphoserineCombined sources
Modified residuei108 – 1081PhosphoserineCombined sources
Isoform 4 (identifier: P07910-4)
Modified residuei107 – 1071PhosphoserineCombined sources
Modified residuei108 – 1081PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.1 Publication
Sumoylated. Sumoylation reduces affinity for mRNA.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP07910.
MaxQBiP07910.
PaxDbiP07910.
PeptideAtlasiP07910.
PRIDEiP07910.
TopDownProteomicsiP07910-1. [P07910-1]
P07910-2. [P07910-2]

2D gel databases

SWISS-2DPAGEP07910.

PTM databases

iPTMnetiP07910.
PhosphoSiteiP07910.
SwissPalmiP07910.

Expressioni

Gene expression databases

BgeeiENSG00000092199.
ExpressionAtlasiP07910. baseline and differential.
GenevisibleiP07910. HS.

Organism-specific databases

HPAiCAB005223.
CAB075755.
CAB075756.
HPA051075.

Interactioni

Subunit structurei

Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-357966,EBI-357966
G2XKQ03EBI-357966,EBI-10175576
EPS8Q129293EBI-357966,EBI-375576
KPNA2Q6NVW73EBI-357966,EBI-9377406
KPNA3Q8IYQ95EBI-357966,EBI-742146
KPNA4O006293EBI-357966,EBI-396343
LMO2P257913EBI-357966,EBI-739696
RALYLQ86SE57EBI-357966,EBI-741520
RBM41Q96IZ55EBI-357966,EBI-740773
SDCBPO005603EBI-357966,EBI-727004
SRPK2P783622EBI-357966,EBI-593303
SUMO1P631653EBI-357966,EBI-80140
UBE2IQ7KZS03EBI-357966,EBI-10180829
YWHAZP631042EBI-357966,EBI-347088
ZFYVE26Q96H433EBI-357966,EBI-10286915

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • nucleosomal DNA binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109424. 177 interactions.
DIPiDIP-29854N.
IntActiP07910. 93 interactions.
MINTiMINT-4999718.
STRINGi9606.ENSP00000319690.

Structurei

Secondary structure

1
306
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni11 – 133Combined sources
Beta strandi18 – 236Combined sources
Turni25 – 273Combined sources
Helixi30 – 356Combined sources
Turni38 – 403Combined sources
Beta strandi43 – 497Combined sources
Beta strandi51 – 599Combined sources
Helixi60 – 689Combined sources
Turni69 – 724Combined sources
Beta strandi81 – 844Combined sources
Beta strandi94 – 963Combined sources
Helixi194 – 21623Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TXPNMR-A/B/C/D194-220[»]
1WF2NMR-A8-92[»]
2MXYNMR-A2-106[»]
2MZ1NMR-A2-106[»]
3LN4X-ray1.30C102-117[»]
ProteinModelPortaliP07910.
SMRiP07910. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07910.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 8772RRMPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili190 – 23849Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi155 – 1617Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 303123Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the RRM HNRPC family. RALY subfamily.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00390000006718.
HOVERGENiHBG002302.
InParanoidiP07910.
KOiK12884.
OMAiPVEMKND.
OrthoDBiEOG091G0O1Q.
PhylomeDBiP07910.
TreeFamiTF330974.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR017347. hnRNP_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037992. hnRNP-C_Raly. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C2 (identifier: P07910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK
60 70 80 90 100
GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS
110 120 130 140 150
AAEMYGSVTE HPSPSPLLSS SFDLDYDFQR DYYDRMYSYP ARVPPPPPIA
160 170 180 190 200
RAVVPSKRQR VSGNTSRRGK SGFNSKSGQR GSSKSGKLKG DDLQAIKKEL
210 220 230 240 250
TQIKQKVDSL LENLEKIEKE QSKQAVEMKN DKSEEEQSSS SVKKDETNVK
260 270 280 290 300
MESEGGADDS AEEGDLLDDD DNEDRGDDQL ELIKDDEKEA EEGEDDRDSA

NGEDDS
Length:306
Mass (Da):33,670
Last modified:June 13, 2006 - v4
Checksum:i17BBC78690C69C5C
GO
Isoform C1 (identifier: P07910-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.

Show »
Length:293
Mass (Da):32,338
Checksum:iB90DDFD06A77FEE8
GO
Isoform 3 (identifier: P07910-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-119: KYGKIVGCSV...EHPSPSPLLS → N

Show »
Length:226
Mass (Da):25,230
Checksum:iBE6EC8C7A9FD7114
GO
Isoform 4 (identifier: P07910-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.
     153-195: Missing.

Show »
Length:250
Mass (Da):27,822
Checksum:i543388C3EC431836
GO

Sequence cautioni

The sequence BAD92764 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101E → G in AAH08423 (PubMed:15489334).Curated
Sequence conflicti217 – 2171I → M (PubMed:2557628).Curated
Sequence conflicti217 – 2171I → M (PubMed:3110598).Curated
Sequence conflicti224 – 2241Q → R in AAH08364 (PubMed:15489334).Curated
Sequence conflicti244 – 2441K → R in AAH08364 (PubMed:15489334).Curated
Sequence conflicti254 – 2541E → G in AAH07052 (PubMed:15489334).Curated
Sequence conflicti303 – 3064EDDS → G (PubMed:2557628).Curated
Sequence conflicti303 – 3064EDDS → G (PubMed:3110598).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671R → Q.
Corresponds to variant rs3272 [ dbSNP | Ensembl ].
VAR_052224

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 11981KYGKI…SPLLS → N in isoform 3. 1 PublicationVSP_019225Add
BLAST
Alternative sequencei108 – 12013Missing in isoform C1 and isoform 4. 3 PublicationsVSP_005831Add
BLAST
Alternative sequencei153 – 19543Missing in isoform 4. 1 PublicationVSP_019226Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29063 mRNA. Translation: AAA36576.1.
M16342 mRNA. Translation: AAA52680.1.
BX161480 mRNA. Translation: CAD61934.1.
BX247961 mRNA. Translation: CAD62300.1.
BX247992 mRNA. Translation: CAD62326.1.
AB209527 mRNA. Translation: BAD92764.1. Different initiation.
AK223517 mRNA. Translation: BAD97237.1.
CH471078 Genomic DNA. Translation: EAW66392.1.
CH471078 Genomic DNA. Translation: EAW66393.1.
CH471078 Genomic DNA. Translation: EAW66394.1.
CH471078 Genomic DNA. Translation: EAW66395.1.
CH471078 Genomic DNA. Translation: EAW66396.1.
CH471078 Genomic DNA. Translation: EAW66399.1.
CH471078 Genomic DNA. Translation: EAW66400.1.
BC003394 mRNA. Translation: AAH03394.1.
BC007052 mRNA. Translation: AAH07052.1.
BC008364 mRNA. Translation: AAH08364.1.
BC008423 mRNA. Translation: AAH08423.1.
BC066932 mRNA. Translation: AAH66932.1.
BC089438 mRNA. Translation: AAH89438.1.
BC108658 mRNA. Translation: AAI08659.1.
BC103758 mRNA. Translation: AAI03759.1.
CCDSiCCDS41915.1. [P07910-1]
CCDS45079.1. [P07910-2]
PIRiA26885.
C34504.
RefSeqiNP_001070910.1. NM_001077442.1. [P07910-1]
NP_001070911.1. NM_001077443.1. [P07910-2]
NP_004491.2. NM_004500.3. [P07910-2]
NP_112604.2. NM_031314.2. [P07910-1]
XP_006720188.1. XM_006720125.2. [P07910-2]
XP_011535010.1. XM_011536708.1. [P07910-1]
XP_011535011.1. XM_011536709.2. [P07910-1]
XP_011535012.1. XM_011536710.2. [P07910-1]
XP_011535013.1. XM_011536711.2. [P07910-1]
XP_011535014.1. XM_011536712.1. [P07910-2]
UniGeneiHs.508848.
Hs.675546.

Genome annotation databases

EnsembliENST00000420743; ENSP00000404848; ENSG00000092199. [P07910-1]
ENST00000430246; ENSP00000442816; ENSG00000092199. [P07910-2]
ENST00000553300; ENSP00000450544; ENSG00000092199. [P07910-2]
ENST00000554455; ENSP00000451291; ENSG00000092199. [P07910-1]
ENST00000554969; ENSP00000450725; ENSG00000092199. [P07910-2]
ENST00000555883; ENSP00000450629; ENSG00000092199. [P07910-4]
ENST00000556628; ENSP00000451652; ENSG00000092199. [P07910-3]
ENST00000556897; ENSP00000451176; ENSG00000092199. [P07910-2]
ENST00000557201; ENSP00000452276; ENSG00000092199. [P07910-1]
GeneIDi3183.
KEGGihsa:3183.
UCSCiuc001vzw.5. human. [P07910-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29063 mRNA. Translation: AAA36576.1.
M16342 mRNA. Translation: AAA52680.1.
BX161480 mRNA. Translation: CAD61934.1.
BX247961 mRNA. Translation: CAD62300.1.
BX247992 mRNA. Translation: CAD62326.1.
AB209527 mRNA. Translation: BAD92764.1. Different initiation.
AK223517 mRNA. Translation: BAD97237.1.
CH471078 Genomic DNA. Translation: EAW66392.1.
CH471078 Genomic DNA. Translation: EAW66393.1.
CH471078 Genomic DNA. Translation: EAW66394.1.
CH471078 Genomic DNA. Translation: EAW66395.1.
CH471078 Genomic DNA. Translation: EAW66396.1.
CH471078 Genomic DNA. Translation: EAW66399.1.
CH471078 Genomic DNA. Translation: EAW66400.1.
BC003394 mRNA. Translation: AAH03394.1.
BC007052 mRNA. Translation: AAH07052.1.
BC008364 mRNA. Translation: AAH08364.1.
BC008423 mRNA. Translation: AAH08423.1.
BC066932 mRNA. Translation: AAH66932.1.
BC089438 mRNA. Translation: AAH89438.1.
BC108658 mRNA. Translation: AAI08659.1.
BC103758 mRNA. Translation: AAI03759.1.
CCDSiCCDS41915.1. [P07910-1]
CCDS45079.1. [P07910-2]
PIRiA26885.
C34504.
RefSeqiNP_001070910.1. NM_001077442.1. [P07910-1]
NP_001070911.1. NM_001077443.1. [P07910-2]
NP_004491.2. NM_004500.3. [P07910-2]
NP_112604.2. NM_031314.2. [P07910-1]
XP_006720188.1. XM_006720125.2. [P07910-2]
XP_011535010.1. XM_011536708.1. [P07910-1]
XP_011535011.1. XM_011536709.2. [P07910-1]
XP_011535012.1. XM_011536710.2. [P07910-1]
XP_011535013.1. XM_011536711.2. [P07910-1]
XP_011535014.1. XM_011536712.1. [P07910-2]
UniGeneiHs.508848.
Hs.675546.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TXPNMR-A/B/C/D194-220[»]
1WF2NMR-A8-92[»]
2MXYNMR-A2-106[»]
2MZ1NMR-A2-106[»]
3LN4X-ray1.30C102-117[»]
ProteinModelPortaliP07910.
SMRiP07910. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109424. 177 interactions.
DIPiDIP-29854N.
IntActiP07910. 93 interactions.
MINTiMINT-4999718.
STRINGi9606.ENSP00000319690.

Chemistry

ChEMBLiCHEMBL2216742.

PTM databases

iPTMnetiP07910.
PhosphoSiteiP07910.
SwissPalmiP07910.

Polymorphism and mutation databases

BioMutaiHNRNPC.
DMDMi108935845.

2D gel databases

SWISS-2DPAGEP07910.

Proteomic databases

EPDiP07910.
MaxQBiP07910.
PaxDbiP07910.
PeptideAtlasiP07910.
PRIDEiP07910.
TopDownProteomicsiP07910-1. [P07910-1]
P07910-2. [P07910-2]

Protocols and materials databases

DNASUi3183.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420743; ENSP00000404848; ENSG00000092199. [P07910-1]
ENST00000430246; ENSP00000442816; ENSG00000092199. [P07910-2]
ENST00000553300; ENSP00000450544; ENSG00000092199. [P07910-2]
ENST00000554455; ENSP00000451291; ENSG00000092199. [P07910-1]
ENST00000554969; ENSP00000450725; ENSG00000092199. [P07910-2]
ENST00000555883; ENSP00000450629; ENSG00000092199. [P07910-4]
ENST00000556628; ENSP00000451652; ENSG00000092199. [P07910-3]
ENST00000556897; ENSP00000451176; ENSG00000092199. [P07910-2]
ENST00000557201; ENSP00000452276; ENSG00000092199. [P07910-1]
GeneIDi3183.
KEGGihsa:3183.
UCSCiuc001vzw.5. human. [P07910-1]

Organism-specific databases

CTDi3183.
GeneCardsiHNRNPC.
HGNCiHGNC:5035. HNRNPC.
HPAiCAB005223.
CAB075755.
CAB075756.
HPA051075.
MIMi164020. gene.
neXtProtiNX_P07910.
PharmGKBiPA162391217.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00390000006718.
HOVERGENiHBG002302.
InParanoidiP07910.
KOiK12884.
OMAiPVEMKND.
OrthoDBiEOG091G0O1Q.
PhylomeDBiP07910.
TreeFamiTF330974.

Enzyme and pathway databases

ReactomeiR-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.
SIGNORiP07910.

Miscellaneous databases

ChiTaRSiHNRNPC. human.
EvolutionaryTraceiP07910.
GeneWikiiHNRNPC.
GenomeRNAii3183.
PROiP07910.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000092199.
ExpressionAtlasiP07910. baseline and differential.
GenevisibleiP07910. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR017347. hnRNP_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037992. hnRNP-C_Raly. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRPC_HUMAN
AccessioniPrimary (citable) accession number: P07910
Secondary accession number(s): D3DS19
, D3DS22, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 13, 2006
Last modified: September 7, 2016
This is version 207 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.