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Protein

Heterogeneous nuclear ribonucleoproteins C1/C2

Gene

HNRNPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).5 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • mRNA 3'-UTR binding Source: UniProtKB
  • N6-methyladenosine-containing RNA binding Source: UniProtKB
  • nucleosomal DNA binding Source: UniProtKB
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • poly(U) RNA binding Source: UniProtKB
  • RNA binding Source: HGNC
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
  • telomerase RNA binding Source: BHF-UCL

GO - Biological processi

  • 3'-UTR-mediated mRNA stabilization Source: UniProtKB
  • ATP-dependent chromatin remodeling Source: UniProtKB
  • gene expression Source: Reactome
  • mRNA splicing, via spliceosome Source: UniProtKB
  • negative regulation of telomere maintenance via telomerase Source: BHF-UCL
  • osteoblast differentiation Source: UniProtKB
  • protein sumoylation Source: Reactome
  • RNA splicing Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000092199-MONOMER.
ReactomeiR-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.
SIGNORiP07910.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoproteins C1/C2
Short name:
hnRNP C1/C2
Gene namesi
Name:HNRNPC
Synonyms:HNRPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:5035. HNRNPC.

Subcellular locationi

  • Nucleus

  • Note: Component of ribonucleosomes.

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nuclear chromatin Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • protein complex Source: UniProtKB
  • spliceosomal complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi197K → R: No effect on sumoylation. 1 Publication1
Mutagenesisi250K → R: Loss of sumoylation. 1 Publication1

Organism-specific databases

DisGeNETi3183.
OpenTargetsiENSG00000092199.
PharmGKBiPA162391217.

Chemistry databases

ChEMBLiCHEMBL2216742.

Polymorphism and mutation databases

BioMutaiHNRNPC.
DMDMi108935845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000818442 – 306Heterogeneous nuclear ribonucleoproteins C1/C2Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei109PhosphothreonineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei121PhosphoserineBy similarity1
Modified residuei162PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei176N6-acetyllysine; alternateBy similarity1
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki223Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei233PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Cross-linki243Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Modified residuei253PhosphoserineCombined sources1 Publication1
Modified residuei260PhosphoserineCombined sources1 Publication1
Modified residuei299PhosphoserineCombined sources1 Publication1
Modified residuei306PhosphoserineCombined sources1
Isoform C1 (identifier: P07910-2)
Modified residuei107PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Isoform 4 (identifier: P07910-4)
Modified residuei107PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.1 Publication
Sumoylated. Sumoylation reduces affinity for mRNA.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP07910.
MaxQBiP07910.
PaxDbiP07910.
PeptideAtlasiP07910.
PRIDEiP07910.
TopDownProteomicsiP07910-1. [P07910-1]
P07910-2. [P07910-2]

2D gel databases

SWISS-2DPAGEP07910.

PTM databases

iPTMnetiP07910.
PhosphoSitePlusiP07910.
SwissPalmiP07910.

Expressioni

Gene expression databases

BgeeiENSG00000092199.
ExpressionAtlasiP07910. baseline and differential.
GenevisibleiP07910. HS.

Organism-specific databases

HPAiCAB005223.
CAB075755.
CAB075756.
HPA051075.

Interactioni

Subunit structurei

Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself7EBI-357966,EBI-357966
G2XKQ05EBI-357966,EBI-10175576
EPS8Q129293EBI-357966,EBI-375576
KPNA2Q6NVW73EBI-357966,EBI-9377406
KPNA3Q8IYQ95EBI-357966,EBI-742146
KPNA4O006295EBI-357966,EBI-396343
LMO2P257913EBI-357966,EBI-739696
RALYLQ86SE57EBI-357966,EBI-741520
RBM41Q96IZ55EBI-357966,EBI-740773
SDCBPO005605EBI-357966,EBI-727004
SRPK2P783622EBI-357966,EBI-593303
SUMO1P631653EBI-357966,EBI-80140
UBE2IQ7KZS03EBI-357966,EBI-10180829
YWHAZP631042EBI-357966,EBI-347088
ZFYVE26Q96H433EBI-357966,EBI-10286915

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi109424. 177 interactors.
DIPiDIP-29854N.
IntActiP07910. 99 interactors.
MINTiMINT-4999718.
STRINGi9606.ENSP00000319690.

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 13Combined sources3
Beta strandi18 – 23Combined sources6
Turni25 – 27Combined sources3
Helixi30 – 35Combined sources6
Turni38 – 40Combined sources3
Beta strandi43 – 49Combined sources7
Beta strandi51 – 59Combined sources9
Helixi60 – 68Combined sources9
Turni69 – 72Combined sources4
Beta strandi81 – 84Combined sources4
Beta strandi94 – 96Combined sources3
Helixi194 – 216Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TXPNMR-A/B/C/D194-220[»]
1WF2NMR-A8-92[»]
2MXYNMR-A2-106[»]
2MZ1NMR-A2-106[»]
3LN4X-ray1.30C102-117[»]
ProteinModelPortaliP07910.
SMRiP07910.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07910.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 87RRMPROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 238Sequence analysisAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi155 – 161Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 303Asp/Glu-rich (acidic)Add BLAST123

Sequence similaritiesi

Belongs to the RRM HNRPC family. RALY subfamily.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00390000006718.
HOVERGENiHBG002302.
InParanoidiP07910.
KOiK12884.
OMAiPVEMKND.
OrthoDBiEOG091G0O1Q.
PhylomeDBiP07910.
TreeFamiTF330974.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR017347. hnRNP_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037992. hnRNP-C_Raly. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C2 (identifier: P07910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK
60 70 80 90 100
GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS
110 120 130 140 150
AAEMYGSVTE HPSPSPLLSS SFDLDYDFQR DYYDRMYSYP ARVPPPPPIA
160 170 180 190 200
RAVVPSKRQR VSGNTSRRGK SGFNSKSGQR GSSKSGKLKG DDLQAIKKEL
210 220 230 240 250
TQIKQKVDSL LENLEKIEKE QSKQAVEMKN DKSEEEQSSS SVKKDETNVK
260 270 280 290 300
MESEGGADDS AEEGDLLDDD DNEDRGDDQL ELIKDDEKEA EEGEDDRDSA

NGEDDS
Length:306
Mass (Da):33,670
Last modified:June 13, 2006 - v4
Checksum:i17BBC78690C69C5C
GO
Isoform C1 (identifier: P07910-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.

Show »
Length:293
Mass (Da):32,338
Checksum:iB90DDFD06A77FEE8
GO
Isoform 3 (identifier: P07910-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-119: KYGKIVGCSV...EHPSPSPLLS → N

Show »
Length:226
Mass (Da):25,230
Checksum:iBE6EC8C7A9FD7114
GO
Isoform 4 (identifier: P07910-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.
     153-195: Missing.

Show »
Length:250
Mass (Da):27,822
Checksum:i543388C3EC431836
GO

Sequence cautioni

The sequence BAD92764 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110E → G in AAH08423 (PubMed:15489334).Curated1
Sequence conflicti217I → M (PubMed:2557628).Curated1
Sequence conflicti217I → M (PubMed:3110598).Curated1
Sequence conflicti224Q → R in AAH08364 (PubMed:15489334).Curated1
Sequence conflicti244K → R in AAH08364 (PubMed:15489334).Curated1
Sequence conflicti254E → G in AAH07052 (PubMed:15489334).Curated1
Sequence conflicti303 – 306EDDS → G (PubMed:2557628).Curated4
Sequence conflicti303 – 306EDDS → G (PubMed:3110598).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052224167R → Q.Corresponds to variant rs3272dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01922539 – 119KYGKI…SPLLS → N in isoform 3. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_005831108 – 120Missing in isoform C1 and isoform 4. 3 PublicationsAdd BLAST13
Alternative sequenceiVSP_019226153 – 195Missing in isoform 4. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29063 mRNA. Translation: AAA36576.1.
M16342 mRNA. Translation: AAA52680.1.
BX161480 mRNA. Translation: CAD61934.1.
BX247961 mRNA. Translation: CAD62300.1.
BX247992 mRNA. Translation: CAD62326.1.
AB209527 mRNA. Translation: BAD92764.1. Different initiation.
AK223517 mRNA. Translation: BAD97237.1.
CH471078 Genomic DNA. Translation: EAW66392.1.
CH471078 Genomic DNA. Translation: EAW66393.1.
CH471078 Genomic DNA. Translation: EAW66394.1.
CH471078 Genomic DNA. Translation: EAW66395.1.
CH471078 Genomic DNA. Translation: EAW66396.1.
CH471078 Genomic DNA. Translation: EAW66399.1.
CH471078 Genomic DNA. Translation: EAW66400.1.
BC003394 mRNA. Translation: AAH03394.1.
BC007052 mRNA. Translation: AAH07052.1.
BC008364 mRNA. Translation: AAH08364.1.
BC008423 mRNA. Translation: AAH08423.1.
BC066932 mRNA. Translation: AAH66932.1.
BC089438 mRNA. Translation: AAH89438.1.
BC108658 mRNA. Translation: AAI08659.1.
BC103758 mRNA. Translation: AAI03759.1.
CCDSiCCDS41915.1. [P07910-1]
CCDS45079.1. [P07910-2]
PIRiA26885.
C34504.
RefSeqiNP_001070910.1. NM_001077442.1. [P07910-1]
NP_001070911.1. NM_001077443.1. [P07910-2]
NP_004491.2. NM_004500.3. [P07910-2]
NP_112604.2. NM_031314.2. [P07910-1]
XP_006720188.1. XM_006720125.2. [P07910-2]
XP_011535010.1. XM_011536708.1. [P07910-1]
XP_011535011.1. XM_011536709.2. [P07910-1]
XP_011535012.1. XM_011536710.2. [P07910-1]
XP_011535013.1. XM_011536711.2. [P07910-1]
XP_011535014.1. XM_011536712.1. [P07910-2]
XP_016876741.1. XM_017021252.1. [P07910-2]
XP_016876742.1. XM_017021253.1. [P07910-2]
UniGeneiHs.508848.
Hs.675546.

Genome annotation databases

EnsembliENST00000420743; ENSP00000404848; ENSG00000092199. [P07910-1]
ENST00000430246; ENSP00000442816; ENSG00000092199. [P07910-2]
ENST00000553300; ENSP00000450544; ENSG00000092199. [P07910-2]
ENST00000554455; ENSP00000451291; ENSG00000092199. [P07910-1]
ENST00000554969; ENSP00000450725; ENSG00000092199. [P07910-2]
ENST00000555883; ENSP00000450629; ENSG00000092199. [P07910-4]
ENST00000556628; ENSP00000451652; ENSG00000092199. [P07910-3]
ENST00000556897; ENSP00000451176; ENSG00000092199. [P07910-2]
ENST00000557201; ENSP00000452276; ENSG00000092199. [P07910-1]
GeneIDi3183.
KEGGihsa:3183.
UCSCiuc001vzw.5. human. [P07910-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29063 mRNA. Translation: AAA36576.1.
M16342 mRNA. Translation: AAA52680.1.
BX161480 mRNA. Translation: CAD61934.1.
BX247961 mRNA. Translation: CAD62300.1.
BX247992 mRNA. Translation: CAD62326.1.
AB209527 mRNA. Translation: BAD92764.1. Different initiation.
AK223517 mRNA. Translation: BAD97237.1.
CH471078 Genomic DNA. Translation: EAW66392.1.
CH471078 Genomic DNA. Translation: EAW66393.1.
CH471078 Genomic DNA. Translation: EAW66394.1.
CH471078 Genomic DNA. Translation: EAW66395.1.
CH471078 Genomic DNA. Translation: EAW66396.1.
CH471078 Genomic DNA. Translation: EAW66399.1.
CH471078 Genomic DNA. Translation: EAW66400.1.
BC003394 mRNA. Translation: AAH03394.1.
BC007052 mRNA. Translation: AAH07052.1.
BC008364 mRNA. Translation: AAH08364.1.
BC008423 mRNA. Translation: AAH08423.1.
BC066932 mRNA. Translation: AAH66932.1.
BC089438 mRNA. Translation: AAH89438.1.
BC108658 mRNA. Translation: AAI08659.1.
BC103758 mRNA. Translation: AAI03759.1.
CCDSiCCDS41915.1. [P07910-1]
CCDS45079.1. [P07910-2]
PIRiA26885.
C34504.
RefSeqiNP_001070910.1. NM_001077442.1. [P07910-1]
NP_001070911.1. NM_001077443.1. [P07910-2]
NP_004491.2. NM_004500.3. [P07910-2]
NP_112604.2. NM_031314.2. [P07910-1]
XP_006720188.1. XM_006720125.2. [P07910-2]
XP_011535010.1. XM_011536708.1. [P07910-1]
XP_011535011.1. XM_011536709.2. [P07910-1]
XP_011535012.1. XM_011536710.2. [P07910-1]
XP_011535013.1. XM_011536711.2. [P07910-1]
XP_011535014.1. XM_011536712.1. [P07910-2]
XP_016876741.1. XM_017021252.1. [P07910-2]
XP_016876742.1. XM_017021253.1. [P07910-2]
UniGeneiHs.508848.
Hs.675546.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TXPNMR-A/B/C/D194-220[»]
1WF2NMR-A8-92[»]
2MXYNMR-A2-106[»]
2MZ1NMR-A2-106[»]
3LN4X-ray1.30C102-117[»]
ProteinModelPortaliP07910.
SMRiP07910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109424. 177 interactors.
DIPiDIP-29854N.
IntActiP07910. 99 interactors.
MINTiMINT-4999718.
STRINGi9606.ENSP00000319690.

Chemistry databases

ChEMBLiCHEMBL2216742.

PTM databases

iPTMnetiP07910.
PhosphoSitePlusiP07910.
SwissPalmiP07910.

Polymorphism and mutation databases

BioMutaiHNRNPC.
DMDMi108935845.

2D gel databases

SWISS-2DPAGEP07910.

Proteomic databases

EPDiP07910.
MaxQBiP07910.
PaxDbiP07910.
PeptideAtlasiP07910.
PRIDEiP07910.
TopDownProteomicsiP07910-1. [P07910-1]
P07910-2. [P07910-2]

Protocols and materials databases

DNASUi3183.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420743; ENSP00000404848; ENSG00000092199. [P07910-1]
ENST00000430246; ENSP00000442816; ENSG00000092199. [P07910-2]
ENST00000553300; ENSP00000450544; ENSG00000092199. [P07910-2]
ENST00000554455; ENSP00000451291; ENSG00000092199. [P07910-1]
ENST00000554969; ENSP00000450725; ENSG00000092199. [P07910-2]
ENST00000555883; ENSP00000450629; ENSG00000092199. [P07910-4]
ENST00000556628; ENSP00000451652; ENSG00000092199. [P07910-3]
ENST00000556897; ENSP00000451176; ENSG00000092199. [P07910-2]
ENST00000557201; ENSP00000452276; ENSG00000092199. [P07910-1]
GeneIDi3183.
KEGGihsa:3183.
UCSCiuc001vzw.5. human. [P07910-1]

Organism-specific databases

CTDi3183.
DisGeNETi3183.
GeneCardsiHNRNPC.
HGNCiHGNC:5035. HNRNPC.
HPAiCAB005223.
CAB075755.
CAB075756.
HPA051075.
MIMi164020. gene.
neXtProtiNX_P07910.
OpenTargetsiENSG00000092199.
PharmGKBiPA162391217.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00390000006718.
HOVERGENiHBG002302.
InParanoidiP07910.
KOiK12884.
OMAiPVEMKND.
OrthoDBiEOG091G0O1Q.
PhylomeDBiP07910.
TreeFamiTF330974.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000092199-MONOMER.
ReactomeiR-HSA-4570464. SUMOylation of RNA binding proteins.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.
SIGNORiP07910.

Miscellaneous databases

ChiTaRSiHNRNPC. human.
EvolutionaryTraceiP07910.
GeneWikiiHNRNPC.
GenomeRNAii3183.
PROiP07910.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000092199.
ExpressionAtlasiP07910. baseline and differential.
GenevisibleiP07910. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR017347. hnRNP_C.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037992. hnRNP-C_Raly. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRPC_HUMAN
AccessioniPrimary (citable) accession number: P07910
Secondary accession number(s): D3DS19
, D3DS22, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 13, 2006
Last modified: November 30, 2016
This is version 210 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.