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Protein

Heterogeneous nuclear ribonucleoprotein A1

Gene

Hrb98DE

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is a component of ribonucleosomes.

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: FlyBase
  • mRNA binding Source: FlyBase
  • nucleotide binding Source: InterPro
  • sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • compound eye morphogenesis Source: FlyBase
  • female germ-line stem cell population maintenance Source: FlyBase
  • negative regulation of RNA splicing Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of translation Source: FlyBase
  • regulation of alternative mRNA splicing, via spliceosome Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • sensory perception of pain Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-DME-6803529. FGFR2 alternative splicing.
R-DME-72163. mRNA Splicing - Major Pathway.
R-DME-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A1
Short name:
hnRNP A1
Alternative name(s):
PEN repeat clone P9
hnRNP core protein A1-A
Gene namesi
Name:Hrb98DE
Synonyms:Pen9
ORF Names:CG9983
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001215. Hrb98DE.

Subcellular locationi

GO - Cellular componenti

  • intracellular ribonucleoprotein complex Source: FlyBase
  • nucleus Source: FlyBase
  • polytene chromosome puff Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818341 – 365Heterogeneous nuclear ribonucleoprotein A1Add BLAST365

Proteomic databases

PaxDbiP07909.
PRIDEiP07909.

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Highest zygotic expression found in adult females and pupae.1 Publication

Gene expression databases

BgeeiFBgn0001215.
ExpressionAtlasiP07909. baseline.
GenevisibleiP07909. DM.

Interactioni

Protein-protein interaction databases

BioGridi68261. 13 interactors.
DIPiDIP-19217N.
IntActiP07909. 7 interactors.
MINTiMINT-764040.
STRINGi7227.FBpp0084669.

Structurei

3D structure databases

ProteinModelPortaliP07909.
SMRiP07909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 107RRM 1PROSITE-ProRule annotationAdd BLAST77
Domaini122 – 199RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi206 – 365Gly-richAdd BLAST160

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
InParanoidiP07909.
KOiK12741.
OMAiHDEQCIR.
OrthoDBiEOG091G1CPI.
PhylomeDBiP07909.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P07909-1) [UniParc]FASTAAdd to basket
Also known as: C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVNSNQNQNG NSNGHDDDFP QDSITEPEHM RKLFIGGLDY RTTDENLKAH
60 70 80 90 100
FEKWGNIVDV VVMKDPRTKR SRGFGFITYS HSSMIDEAQK SRPHKIDGRV
110 120 130 140 150
VEPKRAVPRQ DIDSPNAGAT VKKLFVGALK DDHDEQSIRD YFQHFGNIVD
160 170 180 190 200
INIVIDKETG KKRGFAFVEF DDYDPVDKVV LQKQHQLNGK MVDVKKALPK
210 220 230 240 250
QNDQQGGGGG RGGPGGRAGG NRGNMGGGNY GNQNGGGNWN NGGNNWGNNR
260 270 280 290 300
GGNDNWGNNS FGGGGGGGGG YGGGNNSWGN NNPWDNGNGG GNFGGGGNNW
310 320 330 340 350
NNGGNDFGGY QQNYGGGPQR GGGNFNNNRM QPYQGGGGFK AGGGNQGNYG
360
GNNQGFNNGG NNRRY
Length:365
Mass (Da):39,038
Last modified:August 1, 1988 - v1
Checksum:iBCC707CA2A2EC580
GO
Isoform A (identifier: P07909-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MVNSNQNQNGNSNGHD → MGGHDNWNNGQNEEQ

Show »
Length:364
Mass (Da):39,038
Checksum:i7653D03DBB79E364
GO
Isoform E (identifier: P07909-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MVNSNQNQNGNSNGHDDDFPQ → MGGHDNWNNGQNEEQD

Show »
Length:360
Mass (Da):38,550
Checksum:i0997302969DE0623
GO
Isoform D (identifier: P07909-4) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     18-21: Missing.

Show »
Length:361
Mass (Da):38,550
Checksum:i08C016CDF6D9918C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0058281 – 21MVNSN…DDFPQ → MGGHDNWNNGQNEEQD in isoform E. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0058271 – 16MVNSN…SNGHD → MGGHDNWNNGQNEEQ in isoform A. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_00582918 – 21Missing in isoform D. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15766 mRNA. Translation: AAA70426.1.
M25545
, M28871, M28872, M33955, M31560 Genomic DNA. Translation: AAA28621.1.
M25545
, M28870, M28872, M33955, M31560 Genomic DNA. Translation: AAA28622.1.
M25545
, M28870, M28872, M33955, M31560 Genomic DNA. Translation: AAA28623.1.
M25545
, M28871, M28872, M33955, M31560 Genomic DNA. Translation: AAA28624.1.
AE014297 Genomic DNA. Translation: AAF56800.2.
AE014297 Genomic DNA. Translation: AAF56801.1.
AE014297 Genomic DNA. Translation: AAN14141.1.
AE014297 Genomic DNA. Translation: AAN14143.1.
AY061448 mRNA. Translation: AAL28996.1.
PIRiA26459.
RefSeqiNP_524543.1. NM_079819.3. [P07909-1]
NP_733249.1. NM_170370.2. [P07909-2]
NP_733250.1. NM_170371.2. [P07909-3]
NP_733251.1. NM_170372.2. [P07909-1]
NP_733252.1. NM_170373.2. [P07909-4]
NP_733253.1. NM_170374.2. [P07909-4]
UniGeneiDm.7147.

Genome annotation databases

EnsemblMetazoaiFBtr0085300; FBpp0084669; FBgn0001215. [P07909-1]
FBtr0085301; FBpp0084670; FBgn0001215. [P07909-1]
GeneIDi43385.
KEGGidme:Dmel_CG9983.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15766 mRNA. Translation: AAA70426.1.
M25545
, M28871, M28872, M33955, M31560 Genomic DNA. Translation: AAA28621.1.
M25545
, M28870, M28872, M33955, M31560 Genomic DNA. Translation: AAA28622.1.
M25545
, M28870, M28872, M33955, M31560 Genomic DNA. Translation: AAA28623.1.
M25545
, M28871, M28872, M33955, M31560 Genomic DNA. Translation: AAA28624.1.
AE014297 Genomic DNA. Translation: AAF56800.2.
AE014297 Genomic DNA. Translation: AAF56801.1.
AE014297 Genomic DNA. Translation: AAN14141.1.
AE014297 Genomic DNA. Translation: AAN14143.1.
AY061448 mRNA. Translation: AAL28996.1.
PIRiA26459.
RefSeqiNP_524543.1. NM_079819.3. [P07909-1]
NP_733249.1. NM_170370.2. [P07909-2]
NP_733250.1. NM_170371.2. [P07909-3]
NP_733251.1. NM_170372.2. [P07909-1]
NP_733252.1. NM_170373.2. [P07909-4]
NP_733253.1. NM_170374.2. [P07909-4]
UniGeneiDm.7147.

3D structure databases

ProteinModelPortaliP07909.
SMRiP07909.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68261. 13 interactors.
DIPiDIP-19217N.
IntActiP07909. 7 interactors.
MINTiMINT-764040.
STRINGi7227.FBpp0084669.

Proteomic databases

PaxDbiP07909.
PRIDEiP07909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085300; FBpp0084669; FBgn0001215. [P07909-1]
FBtr0085301; FBpp0084670; FBgn0001215. [P07909-1]
GeneIDi43385.
KEGGidme:Dmel_CG9983.

Organism-specific databases

CTDi43385.
FlyBaseiFBgn0001215. Hrb98DE.

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00760000118873.
InParanoidiP07909.
KOiK12741.
OMAiHDEQCIR.
OrthoDBiEOG091G1CPI.
PhylomeDBiP07909.

Enzyme and pathway databases

ReactomeiR-DME-6803529. FGFR2 alternative splicing.
R-DME-72163. mRNA Splicing - Major Pathway.
R-DME-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

ChiTaRSiHrb98DE. fly.
GenomeRNAii43385.
PROiP07909.

Gene expression databases

BgeeiFBgn0001215.
ExpressionAtlasiP07909. baseline.
GenevisibleiP07909. DM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROA1_DROME
AccessioniPrimary (citable) accession number: P07909
Secondary accession number(s): Q24359
, Q24360, Q99361, Q9VAU7, Q9VAU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.