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Protein

DNA excision repair protein ERCC-1

Gene

Ercc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi134 – 156Sequence analysisAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • cell development Source: MGI
  • cell proliferation Source: MGI
  • cellular response to DNA damage stimulus Source: MGI
  • chromosome organization Source: MGI
  • DNA recombination Source: MGI
  • DNA repair Source: MGI
  • double-strand break repair Source: MGI
  • double-strand break repair via nonhomologous end joining Source: MGI
  • embryonic organ development Source: Ensembl
  • germ cell development Source: MGI
  • interstrand cross-link repair Source: MGI
  • isotype switching Source: MGI
  • male gonad development Source: MGI
  • meiotic mismatch repair Source: GO_Central
  • mitotic recombination Source: MGI
  • multicellular organism aging Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of protection from non-homologous end joining at telomere Source: MGI
  • negative regulation of telomere maintenance Source: MGI
  • nucleotide-excision repair Source: MGI
  • nucleotide-excision repair, DNA incision, 3'-to lesion Source: MGI
  • nucleotide-excision repair, DNA incision, 5'-to lesion Source: MGI
  • oogenesis Source: MGI
  • positive regulation of t-circle formation Source: BHF-UCL
  • post-embryonic hemopoiesis Source: MGI
  • pyrimidine dimer repair by nucleotide-excision repair Source: MGI
  • replicative cell aging Source: MGI
  • response to cadmium ion Source: Ensembl
  • response to immobilization stress Source: Ensembl
  • response to nutrient Source: Ensembl
  • response to oxidative stress Source: MGI
  • response to sucrose Source: Ensembl
  • response to X-ray Source: MGI
  • spermatogenesis Source: MGI
  • syncytium formation Source: MGI
  • t-circle formation Source: BHF-UCL
  • telomeric DNA-containing double minutes formation Source: MGI
  • UV-damage excision repair Source: GO_Central
  • UV protection Source: MGI

Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-5696395 Formation of Incision Complex in GG-NER
R-MMU-5696400 Dual Incision in GG-NER
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6783310 Fanconi Anemia Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
DNA excision repair protein ERCC-1
Gene namesi
Name:Ercc1
Synonyms:Ercc-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95412 Ercc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000870071 – 298DNA excision repair protein ERCC-1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki243Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP07903
PaxDbiP07903
PeptideAtlasiP07903
PRIDEiP07903

PTM databases

iPTMnetiP07903
PhosphoSitePlusiP07903

Expressioni

Gene expression databases

BgeeiENSMUSG00000003549
ExpressionAtlasiP07903 baseline and differential
GenevisibleiP07903 MM

Interactioni

Subunit structurei

Heterodimer composed of ERCC1 and XPF/ERRC4.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199499, 3 interactors
ComplexPortaliCPX-491 Ercc1-Xpf endonuclease complex
STRINGi10090.ENSMUSP00000003645

Structurei

3D structure databases

ProteinModelPortaliP07903
SMRiP07903
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni220 – 298HhH2, dimerization with ERCC4By similarityAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi17 – 23Nuclear localization signalSequence analysis7

Sequence similaritiesi

Belongs to the ERCC1/RAD10/SWI10 family.Curated

Phylogenomic databases

eggNOGiKOG2841 Eukaryota
COG5241 LUCA
GeneTreeiENSGT00390000011275
HOGENOMiHOG000037440
HOVERGENiHBG051497
InParanoidiP07903
KOiK10849
OMAiLNPDYIC
OrthoDBiEOG091G0IRO
TreeFamiTF101231

Family and domain databases

InterProiView protein in InterPro
IPR004579 ERCC1/RAD10/SWI10
IPR011335 Restrct_endonuc-II-like
IPR010994 RuvA_2-like
PANTHERiPTHR12749 PTHR12749, 1 hit
PfamiView protein in Pfam
PF03834 Rad10, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013585 DNA_repair_Rad10, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF52980 SSF52980, 1 hit
TIGRFAMsiTIGR00597 rad10, 1 hit

Sequencei

Sequence statusi: Complete.

P07903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGKDEESR PQPSGPPTRR KFVIPLEEEE VPCAGVKPLF RSSRNPTIPA
60 70 80 90 100
TSAHVAPQTY AEYAITQPPG GAGATVPTGS EPAAGENPSQ TLKTGAKSNS
110 120 130 140 150
IIVSPRQRGN PVLKFVRNVP WEFGEVIPDY VLGQSTCALF LSLRYHNLHP
160 170 180 190 200
DYIHERLQSL GKNFALRVLL VQVDVKDPQQ ALKELAKMCI LADCTLVLAW
210 220 230 240 250
SAEEAGRYLE TYKAYEQKPA DLLMEKLEQN FLSRATECLT TVKSVNKTDS
260 270 280 290
QTLLATFGSL EQLFTASRED LALCPGLGPQ KARRLFEVLH EPFLKVPR
Length:298
Mass (Da):32,910
Last modified:October 3, 2012 - v2
Checksum:i264DF6865A3ED847
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55V → M in CAA30310 (PubMed:3290851).Curated1
Sequence conflicti213K → R in CAA30310 (PubMed:3290851).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07414 mRNA Translation: CAA30310.1
X07413 Genomic DNA No translation available.
AK088271 mRNA Translation: BAC40249.1
AK136733 mRNA Translation: BAE23112.1
AC148988 Genomic DNA No translation available.
CH466639 Genomic DNA Translation: EDL23137.1
BC011224 mRNA Translation: AAH11224.1
CCDSiCCDS20898.1
PIRiS01202
RefSeqiNP_001120796.1, NM_001127324.1
NP_031974.2, NM_007948.2
UniGeneiMm.280913

Genome annotation databases

EnsembliENSMUST00000003645; ENSMUSP00000003645; ENSMUSG00000003549
GeneIDi13870
KEGGimmu:13870
UCSCiuc009flm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiERCC1_MOUSE
AccessioniPrimary (citable) accession number: P07903
Secondary accession number(s): Q91VP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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