P07903 (ERCC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA excision repair protein ERCC-1

Gene names

Name:	Ercc1
Synonyms:	Ercc-1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair.
Subunit structure	Heterodimer composed of ERCC1 and XPF/ERRC4.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the ERCC1/RAD10/SWI10 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	UV protection Inferred from mutant phenotype PubMed 10454634PubMed 16682947PubMed 8275084. Source: MGI cell proliferation Inferred from mutant phenotype PubMed 15692571. Source: MGI chromosome organization Inferred from mutant phenotype PubMed 15199134. Source: MGI double-strand break repair Inferred from mutant phenotype PubMed 15199134PubMed 17912366. Source: MGI embryonic organ development Inferred from electronic annotation. Source: Compara germ cell development Inferred from mutant phenotype PubMed 17912366. Source: MGI isotype switching Inferred from mutant phenotype PubMed 15280420. Source: MGI male gonad development Inferred from mutant phenotype PubMed 17912366. Source: MGI mitotic recombination Inferred from electronic annotation. Source: Compara multicellular organism growth Inferred from mutant phenotype PubMed 17183314PubMed 22323595. Source: MGI multicellular organismal aging Inferred from mutant phenotype PubMed 17183314. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 17912366. Source: MGI negative regulation of telomere maintenance Inferred from electronic annotation. Source: Compara nucleotide-excision repair, DNA incision, 3'-to lesion Inferred from electronic annotation. Source: Compara nucleotide-excision repair, DNA incision, 5'-to lesion Inferred from electronic annotation. Source: Compara oogenesis Inferred from mutant phenotype PubMed 12466203. Source: MGI post-embryonic hemopoiesis Inferred from mutant phenotype PubMed 15692571. Source: MGI pyrimidine dimer repair by nucleotide-excision repair Inferred from mutant phenotype PubMed 10454634. Source: MGI replicative cell aging Inferred from mutant phenotype PubMed 17173483PubMed 9197240. Source: MGI response to X-ray Inferred from mutant phenotype PubMed 15979950. Source: MGI response to nutrient Inferred from electronic annotation. Source: Compara response to oxidative stress Inferred from electronic annotation. Source: Compara response to sucrose stimulus Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from mutant phenotype PubMed 12466203. Source: MGI syncytium formation Inferred from mutant phenotype PubMed 10834928. Source: MGI
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nuclear chromosome, telomeric region Inferred from electronic annotation. Source: Compara nucleotide-excision repair complex Inferred from sequence or structural similarity. Source: UniProtKB transcription factor TFIID complex Inferred from direct assay PubMed 22323595. Source: MGI
Molecular_function	TFIID-class transcription factor binding Inferred from direct assay PubMed 22323595. Source: MGI damaged DNA binding Inferred from electronic annotation. Source: Compara single-stranded DNA binding Inferred from electronic annotation. Source: Compara single-stranded DNA specific endodeoxyribonuclease activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	DNA excision repair protein ERCC-1		PRO_0000087007
Regions
	DNA binding	134 – 156	23	Potential
	Motif	17 – 23	7	Nuclear localization signal Potential
Experimental info
	Sequence conflict	55	1	V → M in CAA30310. Ref.1
	Sequence conflict	213	1	K → R in CAA30310. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P07903 [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 264DF6865A3ED847	FASTA	298	32,910
	10 20 30 40 50 60 MDPGKDEESR PQPSGPPTRR KFVIPLEEEE VPCAGVKPLF RSSRNPTIPA TSAHVAPQTY 70 80 90 100 110 120 AEYAITQPPG GAGATVPTGS EPAAGENPSQ TLKTGAKSNS IIVSPRQRGN PVLKFVRNVP 130 140 150 160 170 180 WEFGEVIPDY VLGQSTCALF LSLRYHNLHP DYIHERLQSL GKNFALRVLL VQVDVKDPQQ 190 200 210 220 230 240 ALKELAKMCI LADCTLVLAW SAEEAGRYLE TYKAYEQKPA DLLMEKLEQN FLSRATECLT 250 260 270 280 290 TVKSVNKTDS QTLLATFGSL EQLFTASRED LALCPGLGPQ KARRLFEVLH EPFLKVPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolution and mutagenesis of the mammalian excision repair gene ERCC-1." van Duin M., van den Tol J., Warmerdam P., Odijk H., Meijer D., Westerveld A., Hoeijmakers J.H.J. Nucleic Acids Res. 16:5305-5322(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Epididymis and Thymus.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X07414 mRNA. Translation: CAA30310.1. X07413 Genomic DNA. No translation available. AK088271 mRNA. Translation: BAC40249.1. AK136733 mRNA. Translation: BAE23112.1. AC148988 Genomic DNA. No translation available. CH466639 Genomic DNA. Translation: EDL23137.1. BC011224 mRNA. Translation: AAH11224.1.
IPI	IPI00133914. IPI00895992.
PIR	S01202.
RefSeq	NP_001120796.1. NM_001127324.1. NP_031974.2. NM_007948.2.
UniGene	Mm.280913.
3D structure databases
ProteinModelPortal	P07903.
SMR	P07903. Positions 99-297.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000003645.
PTM databases
PhosphoSite	P07903.
Proteomic databases
PaxDb	P07903.
PRIDE	P07903.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000003645; ENSMUSP00000003645; ENSMUSG00000003549.
GeneID	13870.
KEGG	mmu:13870.
UCSC	uc009flm.2. mouse.
Organism-specific databases
CTD	2067.
MGI	MGI:95412. Ercc1.
Phylogenomic databases
eggNOG	COG5241.
GeneTree	ENSGT00390000011275.
HOGENOM	HOG000037440.
HOVERGEN	HBG051497.
InParanoid	P07903.
KO	K10849.
OMA	HPDYIHQ.
OrthoDB	EOG4R23VJ.
Gene expression databases
Genevestigator	P07903.
GermOnline	ENSMUSG00000003549. Mus musculus.
Family and domain databases
InterPro	IPR004579. DNA_repair_Rad10. IPR000445. HhH_motif. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR011335. Restrct_endonuc-II-like. IPR010994. RuvA_2-like. [Graphical view]
Pfam	PF00633. HHH. 1 hit. PF03834. Rad10. 1 hit. [Graphical view]
ProDom	PD013585. DNA_repair_Rad10. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00278. HhH1. 1 hit. [Graphical view]
SUPFAM	SSF52980. Restrict_endonuc_II-like_core. 1 hit. SSF47781. RuvA_2_like. 1 hit.
TIGRFAMs	TIGR00597. rad10. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	ERCC1. mouse.
NextBio	284784.
SOURCE	Search...

Entry information

Entry name

ERCC1_MOUSE

Accession

Primary (citable) accession number: P07903
Secondary accession number(s): Q91VP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	October 3, 2012
Last modified:	May 29, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program