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P07903

- ERCC1_MOUSE

UniProt

P07903 - ERCC1_MOUSE

Protein

DNA excision repair protein ERCC-1

Gene

Ercc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi134 – 15623Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. damaged DNA binding Source: InterPro
    2. protein binding Source: MGI
    3. single-stranded DNA binding Source: Ensembl
    4. single-stranded DNA endodeoxyribonuclease activity Source: Ensembl
    5. TBP-class protein binding Source: MGI
    6. TFIID-class transcription factor binding Source: MGI

    GO - Biological processi

    1. cell development Source: MGI
    2. cell proliferation Source: MGI
    3. cellular response to DNA damage stimulus Source: MGI
    4. chromosome organization Source: MGI
    5. DNA recombination Source: MGI
    6. DNA repair Source: MGI
    7. double-strand break repair Source: MGI
    8. embryonic organ development Source: Ensembl
    9. germ cell development Source: MGI
    10. interstrand cross-link repair Source: MGI
    11. isotype switching Source: MGI
    12. male gonad development Source: MGI
    13. mitotic recombination Source: Ensembl
    14. multicellular organismal aging Source: MGI
    15. multicellular organism growth Source: MGI
    16. negative regulation of telomere maintenance Source: Ensembl
    17. nucleotide-excision repair Source: UniProtKB
    18. nucleotide-excision repair, DNA incision, 3'-to lesion Source: Ensembl
    19. nucleotide-excision repair, DNA incision, 5'-to lesion Source: Ensembl
    20. oogenesis Source: MGI
    21. post-embryonic hemopoiesis Source: MGI
    22. pyrimidine dimer repair by nucleotide-excision repair Source: MGI
    23. replicative cell aging Source: MGI
    24. response to nutrient Source: Ensembl
    25. response to oxidative stress Source: Ensembl
    26. response to sucrose Source: Ensembl
    27. response to X-ray Source: MGI
    28. spermatogenesis Source: MGI
    29. syncytium formation Source: MGI
    30. UV protection Source: MGI

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA excision repair protein ERCC-1
    Gene namesi
    Name:Ercc1
    Synonyms:Ercc-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:95412. Ercc1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear chromosome, telomeric region Source: Ensembl
    3. nucleotide-excision repair complex Source: UniProtKB
    4. transcription factor TFIID complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298DNA excision repair protein ERCC-1PRO_0000087007Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP07903.
    PRIDEiP07903.

    PTM databases

    PhosphoSiteiP07903.

    Expressioni

    Gene expression databases

    ArrayExpressiP07903.
    GenevestigatoriP07903.

    Interactioni

    Subunit structurei

    Heterodimer composed of ERCC1 and XPF/ERRC4.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000003645.

    Structurei

    3D structure databases

    ProteinModelPortaliP07903.
    SMRiP07903. Positions 99-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni220 – 29879HhH2, dimerization with ERCC4By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi17 – 237Nuclear localization signalSequence Analysis

    Sequence similaritiesi

    Belongs to the ERCC1/RAD10/SWI10 family.Curated

    Phylogenomic databases

    eggNOGiCOG5241.
    GeneTreeiENSGT00390000011275.
    HOGENOMiHOG000037440.
    HOVERGENiHBG051497.
    InParanoidiP07903.
    KOiK10849.
    OMAiHPDYIHQ.
    OrthoDBiEOG7XH6Q8.
    TreeFamiTF101231.

    Family and domain databases

    InterProiIPR004579. DNA_repair_Rad10.
    IPR000445. HhH_motif.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR011335. Restrct_endonuc-II-like.
    IPR010994. RuvA_2-like.
    [Graphical view]
    PfamiPF00633. HHH. 1 hit.
    PF03834. Rad10. 1 hit.
    [Graphical view]
    ProDomiPD013585. DNA_repair_Rad10. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00278. HhH1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47781. SSF47781. 1 hit.
    SSF52980. SSF52980. 1 hit.
    TIGRFAMsiTIGR00597. rad10. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P07903-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPGKDEESR PQPSGPPTRR KFVIPLEEEE VPCAGVKPLF RSSRNPTIPA    50
    TSAHVAPQTY AEYAITQPPG GAGATVPTGS EPAAGENPSQ TLKTGAKSNS 100
    IIVSPRQRGN PVLKFVRNVP WEFGEVIPDY VLGQSTCALF LSLRYHNLHP 150
    DYIHERLQSL GKNFALRVLL VQVDVKDPQQ ALKELAKMCI LADCTLVLAW 200
    SAEEAGRYLE TYKAYEQKPA DLLMEKLEQN FLSRATECLT TVKSVNKTDS 250
    QTLLATFGSL EQLFTASRED LALCPGLGPQ KARRLFEVLH EPFLKVPR 298
    Length:298
    Mass (Da):32,910
    Last modified:October 3, 2012 - v2
    Checksum:i264DF6865A3ED847
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 551V → M in CAA30310. (PubMed:3290851)Curated
    Sequence conflicti213 – 2131K → R in CAA30310. (PubMed:3290851)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07414 mRNA. Translation: CAA30310.1.
    X07413 Genomic DNA. No translation available.
    AK088271 mRNA. Translation: BAC40249.1.
    AK136733 mRNA. Translation: BAE23112.1.
    AC148988 Genomic DNA. No translation available.
    CH466639 Genomic DNA. Translation: EDL23137.1.
    BC011224 mRNA. Translation: AAH11224.1.
    CCDSiCCDS20898.1.
    PIRiS01202.
    RefSeqiNP_001120796.1. NM_001127324.1.
    NP_031974.2. NM_007948.2.
    UniGeneiMm.280913.

    Genome annotation databases

    EnsembliENSMUST00000003645; ENSMUSP00000003645; ENSMUSG00000003549.
    GeneIDi13870.
    KEGGimmu:13870.
    UCSCiuc009flm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07414 mRNA. Translation: CAA30310.1 .
    X07413 Genomic DNA. No translation available.
    AK088271 mRNA. Translation: BAC40249.1 .
    AK136733 mRNA. Translation: BAE23112.1 .
    AC148988 Genomic DNA. No translation available.
    CH466639 Genomic DNA. Translation: EDL23137.1 .
    BC011224 mRNA. Translation: AAH11224.1 .
    CCDSi CCDS20898.1.
    PIRi S01202.
    RefSeqi NP_001120796.1. NM_001127324.1.
    NP_031974.2. NM_007948.2.
    UniGenei Mm.280913.

    3D structure databases

    ProteinModelPortali P07903.
    SMRi P07903. Positions 99-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000003645.

    PTM databases

    PhosphoSitei P07903.

    Proteomic databases

    PaxDbi P07903.
    PRIDEi P07903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003645 ; ENSMUSP00000003645 ; ENSMUSG00000003549 .
    GeneIDi 13870.
    KEGGi mmu:13870.
    UCSCi uc009flm.2. mouse.

    Organism-specific databases

    CTDi 2067.
    MGIi MGI:95412. Ercc1.

    Phylogenomic databases

    eggNOGi COG5241.
    GeneTreei ENSGT00390000011275.
    HOGENOMi HOG000037440.
    HOVERGENi HBG051497.
    InParanoidi P07903.
    KOi K10849.
    OMAi HPDYIHQ.
    OrthoDBi EOG7XH6Q8.
    TreeFami TF101231.

    Enzyme and pathway databases

    Reactomei REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.

    Miscellaneous databases

    ChiTaRSi ERCC1. mouse.
    NextBioi 284784.
    PROi P07903.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07903.
    Genevestigatori P07903.

    Family and domain databases

    InterProi IPR004579. DNA_repair_Rad10.
    IPR000445. HhH_motif.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR011335. Restrct_endonuc-II-like.
    IPR010994. RuvA_2-like.
    [Graphical view ]
    Pfami PF00633. HHH. 1 hit.
    PF03834. Rad10. 1 hit.
    [Graphical view ]
    ProDomi PD013585. DNA_repair_Rad10. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00278. HhH1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47781. SSF47781. 1 hit.
    SSF52980. SSF52980. 1 hit.
    TIGRFAMsi TIGR00597. rad10. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Epididymis and Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiERCC1_MOUSE
    AccessioniPrimary (citable) accession number: P07903
    Secondary accession number(s): Q91VP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3