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P07903 (ERCC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA excision repair protein ERCC-1
Gene names
Name:Ercc1
Synonyms:Ercc-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 By similarity.

Subunit structure

Heterodimer composed of ERCC1 and XPF/ERRC4.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the ERCC1/RAD10/SWI10 family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA recombination

Inferred from mutant phenotype PubMed 11707424. Source: MGI

DNA repair

Inferred from mutant phenotype PubMed 12466203. Source: MGI

UV protection

Inferred from mutant phenotype PubMed 10454634PubMed 16682947PubMed 8275084. Source: MGI

cell development

Inferred from mutant phenotype PubMed 10834928. Source: MGI

cell proliferation

Inferred from mutant phenotype PubMed 15692571. Source: MGI

cellular response to DNA damage stimulus

Inferred from mutant phenotype PubMed 11707424PubMed 15692571PubMed 15979950PubMed 9197240. Source: MGI

chromosome organization

Inferred from mutant phenotype PubMed 15199134. Source: MGI

double-strand break repair

Inferred from mutant phenotype PubMed 15199134PubMed 17912366. Source: MGI

embryonic organ development

Inferred from electronic annotation. Source: Ensembl

germ cell development

Inferred from mutant phenotype PubMed 17912366. Source: MGI

interstrand cross-link repair

Inferred from mutant phenotype PubMed 23637614. Source: MGI

isotype switching

Inferred from mutant phenotype PubMed 15280420. Source: MGI

male gonad development

Inferred from mutant phenotype PubMed 17912366. Source: MGI

mitotic recombination

Inferred from electronic annotation. Source: Ensembl

multicellular organism growth

Inferred from mutant phenotype PubMed 17183314PubMed 22323595. Source: MGI

multicellular organismal aging

Inferred from mutant phenotype PubMed 17183314. Source: MGI

negative regulation of telomere maintenance

Inferred from electronic annotation. Source: Ensembl

nucleotide-excision repair

Inferred from sequence or structural similarity. Source: UniProtKB

nucleotide-excision repair, DNA incision, 3'-to lesion

Inferred from electronic annotation. Source: Ensembl

nucleotide-excision repair, DNA incision, 5'-to lesion

Inferred from electronic annotation. Source: Ensembl

oogenesis

Inferred from mutant phenotype PubMed 12466203. Source: MGI

post-embryonic hemopoiesis

Inferred from mutant phenotype PubMed 15692571. Source: MGI

pyrimidine dimer repair by nucleotide-excision repair

Inferred from mutant phenotype PubMed 10454634. Source: MGI

replicative cell aging

Inferred from mutant phenotype PubMed 17173483PubMed 9197240. Source: MGI

response to X-ray

Inferred from mutant phenotype PubMed 15979950. Source: MGI

response to nutrient

Inferred from electronic annotation. Source: Ensembl

response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

response to sucrose

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from mutant phenotype PubMed 12466203. Source: MGI

syncytium formation

Inferred from mutant phenotype PubMed 10834928. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nuclear chromosome, telomeric region

Inferred from electronic annotation. Source: Ensembl

nucleotide-excision repair complex

Inferred from sequence or structural similarity. Source: UniProtKB

transcription factor TFIID complex

Inferred from direct assay PubMed 22323595. Source: MGI

   Molecular_functionTBP-class protein binding

Inferred from physical interaction PubMed 22323595. Source: MGI

TFIID-class transcription factor binding

Inferred from direct assay PubMed 22323595. Source: MGI

damaged DNA binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 22234173. Source: MGI

single-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

single-stranded DNA endodeoxyribonuclease activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298DNA excision repair protein ERCC-1
PRO_0000087007

Regions

DNA binding134 – 15623 Potential
Region220 – 29879HhH2, dimerization with ERCC4 By similarity
Motif17 – 237Nuclear localization signal Potential

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict551V → M in CAA30310. Ref.1
Sequence conflict2131K → R in CAA30310. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P07903 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 264DF6865A3ED847

FASTA29832,910
        10         20         30         40         50         60 
MDPGKDEESR PQPSGPPTRR KFVIPLEEEE VPCAGVKPLF RSSRNPTIPA TSAHVAPQTY 

        70         80         90        100        110        120 
AEYAITQPPG GAGATVPTGS EPAAGENPSQ TLKTGAKSNS IIVSPRQRGN PVLKFVRNVP 

       130        140        150        160        170        180 
WEFGEVIPDY VLGQSTCALF LSLRYHNLHP DYIHERLQSL GKNFALRVLL VQVDVKDPQQ 

       190        200        210        220        230        240 
ALKELAKMCI LADCTLVLAW SAEEAGRYLE TYKAYEQKPA DLLMEKLEQN FLSRATECLT 

       250        260        270        280        290 
TVKSVNKTDS QTLLATFGSL EQLFTASRED LALCPGLGPQ KARRLFEVLH EPFLKVPR 

« Hide

References

« Hide 'large scale' references
[1]"Evolution and mutagenesis of the mammalian excision repair gene ERCC-1."
van Duin M., van den Tol J., Warmerdam P., Odijk H., Meijer D., Westerveld A., Hoeijmakers J.H.J.
Nucleic Acids Res. 16:5305-5322(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Epididymis and Thymus.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07414 mRNA. Translation: CAA30310.1.
X07413 Genomic DNA. No translation available.
AK088271 mRNA. Translation: BAC40249.1.
AK136733 mRNA. Translation: BAE23112.1.
AC148988 Genomic DNA. No translation available.
CH466639 Genomic DNA. Translation: EDL23137.1.
BC011224 mRNA. Translation: AAH11224.1.
CCDSCCDS20898.1.
PIRS01202.
RefSeqNP_001120796.1. NM_001127324.1.
NP_031974.2. NM_007948.2.
UniGeneMm.280913.

3D structure databases

ProteinModelPortalP07903.
SMRP07903. Positions 99-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000003645.

PTM databases

PhosphoSiteP07903.

Proteomic databases

PaxDbP07903.
PRIDEP07903.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003645; ENSMUSP00000003645; ENSMUSG00000003549.
GeneID13870.
KEGGmmu:13870.
UCSCuc009flm.2. mouse.

Organism-specific databases

CTD2067.
MGIMGI:95412. Ercc1.

Phylogenomic databases

eggNOGCOG5241.
GeneTreeENSGT00390000011275.
HOGENOMHOG000037440.
HOVERGENHBG051497.
InParanoidP07903.
KOK10849.
OMAHPDYIHQ.
OrthoDBEOG7XH6Q8.
TreeFamTF101231.

Gene expression databases

ArrayExpressP07903.
GenevestigatorP07903.

Family and domain databases

InterProIPR004579. DNA_repair_Rad10.
IPR000445. HhH_motif.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR011335. Restrct_endonuc-II-like.
IPR010994. RuvA_2-like.
[Graphical view]
PfamPF00633. HHH. 1 hit.
PF03834. Rad10. 1 hit.
[Graphical view]
ProDomPD013585. DNA_repair_Rad10. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMSSF47781. SSF47781. 1 hit.
SSF52980. SSF52980. 1 hit.
TIGRFAMsTIGR00597. rad10. 1 hit.
ProtoNetSearch...

Other

ChiTaRSERCC1. mouse.
NextBio284784.
PROP07903.
SOURCESearch...

Entry information

Entry nameERCC1_MOUSE
AccessionPrimary (citable) accession number: P07903
Secondary accession number(s): Q91VP3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot