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P07895

- SODM_RAT

UniProt

P07895 - SODM_RAT

Protein

Superoxide dismutase [Mn], mitochondrial

Gene

Sod2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (01 May 1992)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.1 Publication

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi50 – 501ManganeseBy similarity
    Metal bindingi98 – 981ManganeseBy similarity
    Metal bindingi183 – 1831ManganeseBy similarity
    Metal bindingi187 – 1871ManganeseBy similarity

    GO - Molecular functioni

    1. DNA binding Source: RGD
    2. identical protein binding Source: RGD
    3. manganese ion binding Source: UniProtKB
    4. oxygen binding Source: RGD
    5. protein binding Source: RGD
    6. superoxide dismutase activity Source: UniProtKB

    GO - Biological processi

    1. age-dependent response to reactive oxygen species Source: UniProtKB
    2. aging Source: RGD
    3. cellular response to ethanol Source: RGD
    4. detection of oxygen Source: Ensembl
    5. erythrophore differentiation Source: Ensembl
    6. glutathione metabolic process Source: Ensembl
    7. heart development Source: Ensembl
    8. hemopoiesis Source: Ensembl
    9. hydrogen peroxide biosynthetic process Source: RGD
    10. hydrogen peroxide metabolic process Source: RGD
    11. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    12. intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
    13. iron ion homeostasis Source: Ensembl
    14. liver development Source: Ensembl
    15. locomotory behavior Source: Ensembl
    16. negative regulation of apoptotic process Source: RGD
    17. negative regulation of fat cell differentiation Source: Ensembl
    18. negative regulation of fibroblast proliferation Source: Ensembl
    19. negative regulation of neuron apoptotic process Source: Ensembl
    20. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
    21. neuron development Source: Ensembl
    22. oxygen homeostasis Source: Ensembl
    23. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    24. post-embryonic development Source: Ensembl
    25. protein homooligomerization Source: RGD
    26. protein homotetramerization Source: Ensembl
    27. regulation of catalytic activity Source: Ensembl
    28. regulation of mitochondrial membrane potential Source: Ensembl
    29. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    30. release of cytochrome c from mitochondria Source: Ensembl
    31. removal of superoxide radicals Source: RGD
    32. respiratory electron transport chain Source: Ensembl
    33. response to activity Source: RGD
    34. response to axon injury Source: Ensembl
    35. response to cadmium ion Source: RGD
    36. response to cold Source: RGD
    37. response to drug Source: RGD
    38. response to electrical stimulus Source: RGD
    39. response to gamma radiation Source: Ensembl
    40. response to hydrogen peroxide Source: RGD
    41. response to hyperoxia Source: Ensembl
    42. response to hypoxia Source: RGD
    43. response to immobilization stress Source: RGD
    44. response to isolation stress Source: RGD
    45. response to L-ascorbic acid Source: RGD
    46. response to lipopolysaccharide Source: RGD
    47. response to magnetism Source: RGD
    48. response to manganese ion Source: RGD
    49. response to nutrient levels Source: RGD
    50. response to oxidative stress Source: RGD
    51. response to radiation Source: RGD
    52. response to selenium ion Source: RGD
    53. response to silicon dioxide Source: RGD
    54. response to zinc ion Source: RGD
    55. superoxide anion generation Source: Ensembl
    56. superoxide metabolic process Source: UniProtKB
    57. vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_213899. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
    Gene namesi
    Name:Sod2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi3732. Sod2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. mitochondrial inner membrane Source: Ensembl
    3. mitochondrial nucleoid Source: RGD
    4. mitochondrion Source: RGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionAdd
    BLAST
    Chaini25 – 222198Superoxide dismutase [Mn], mitochondrialPRO_0000032874Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei58 – 581Nitrated tyrosine2 Publications
    Modified residuei68 – 681N6-acetyllysine; alternateBy similarity
    Modified residuei68 – 681N6-succinyllysine; alternateBy similarity
    Modified residuei75 – 751N6-acetyllysine; alternateBy similarity
    Modified residuei75 – 751N6-succinyllysine; alternateBy similarity
    Modified residuei114 – 1141N6-acetyllysineBy similarity
    Modified residuei122 – 1221N6-acetyllysine; alternateBy similarity
    Modified residuei122 – 1221N6-succinyllysine; alternateBy similarity
    Modified residuei130 – 1301N6-acetyllysine; alternateBy similarity
    Modified residuei130 – 1301N6-succinyllysine; alternateBy similarity
    Modified residuei202 – 2021N6-acetyllysineBy similarity

    Post-translational modificationi

    Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.2 Publications
    Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting By similarity.By similarity

    Keywords - PTMi

    Acetylation, Nitration

    Proteomic databases

    PaxDbiP07895.
    PRIDEiP07895.

    2D gel databases

    World-2DPAGE0004:P07895.

    PTM databases

    PhosphoSiteiP07895.

    Expressioni

    Gene expression databases

    GenevestigatoriP07895.

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    IntActiP07895. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP07895.
    SMRiP07895. Positions 25-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0605.
    GeneTreeiENSGT00390000011877.
    HOGENOMiHOG000013583.
    HOVERGENiHBG004451.
    InParanoidiP07895.
    KOiK04564.
    OMAiMAIRCVA.
    OrthoDBiEOG7FV3R5.
    PhylomeDBiP07895.
    TreeFamiTF105132.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07895-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLCRAACSAG RRLGPAASTA GSRHKHSLPD LPYDYGALEP HINAQIMQLH    50
    HSKHHATYVN NLNVTEEKYH EALAKGDVTT QVALQPALKF NGGGHINHSI 100
    FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL 150
    GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY 200
    LKAIWNVINW ENVSQRYIVC KK 222
    Length:222
    Mass (Da):24,674
    Last modified:May 1, 1992 - v2
    Checksum:i8CCC1E0E857B3138
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti167 – 1671Q → H in CAA68549. (PubMed:3697077)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00497 mRNA. Translation: CAA68549.1.
    X56600 Genomic DNA. Translation: CAA39937.1.
    BC070913 mRNA. Translation: AAH70913.1.
    PIRiS21661. DSRTN.
    RefSeqiNP_058747.1. NM_017051.2.
    UniGeneiRn.10488.

    Genome annotation databases

    EnsembliENSRNOT00000025794; ENSRNOP00000025794; ENSRNOG00000019048.
    GeneIDi24787.
    KEGGirno:24787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00497 mRNA. Translation: CAA68549.1 .
    X56600 Genomic DNA. Translation: CAA39937.1 .
    BC070913 mRNA. Translation: AAH70913.1 .
    PIRi S21661. DSRTN.
    RefSeqi NP_058747.1. NM_017051.2.
    UniGenei Rn.10488.

    3D structure databases

    ProteinModelPortali P07895.
    SMRi P07895. Positions 25-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P07895. 1 interaction.

    PTM databases

    PhosphoSitei P07895.

    2D gel databases

    World-2DPAGE 0004:P07895.

    Proteomic databases

    PaxDbi P07895.
    PRIDEi P07895.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025794 ; ENSRNOP00000025794 ; ENSRNOG00000019048 .
    GeneIDi 24787.
    KEGGi rno:24787.

    Organism-specific databases

    CTDi 6648.
    RGDi 3732. Sod2.

    Phylogenomic databases

    eggNOGi COG0605.
    GeneTreei ENSGT00390000011877.
    HOGENOMi HOG000013583.
    HOVERGENi HBG004451.
    InParanoidi P07895.
    KOi K04564.
    OMAi MAIRCVA.
    OrthoDBi EOG7FV3R5.
    PhylomeDBi P07895.
    TreeFami TF105132.

    Enzyme and pathway databases

    Reactomei REACT_213899. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    NextBioi 604412.
    PROi P07895.

    Gene expression databases

    Genevestigatori P07895.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of cDNAs coding for rat manganese-containing superoxide dismutase."
      Ho Y.-S., Crapo J.D.
      Nucleic Acids Res. 15:10070-10070(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "Molecular structure of a functional rat gene for manganese-containing superoxide dismutase."
      Ho Y.-S., Howard A.J., Crapo J.D.
      Am. J. Respir. Cell Mol. Biol. 4:278-286(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    4. Lubec G., Afjehi-Sadat L., Diao W., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 54-68; 76-108; 135-154 AND 203-216, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain, Hippocampus and Spinal cord.
    5. "Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidney."
      Guo W., Adachi T., Matsui R., Xu S., Jiang B., Zou M.H., Kirber M., Lieberthal W., Cohen R.A.
      Am. J. Physiol. 285:H1396-H1403(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NITRATION, FUNCTION DURING OXIDATIVE STRESS.
    6. "Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging."
      Xu S., Ying J., Jiang B., Guo W., Adachi T., Sharov V., Lazar H., Menzoian J., Knyushko T.V., Bigelow D., Schoeneich C., Cohen R.A.
      Am. J. Physiol. 290:H2220-H2227(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NITRATION AT TYR-58.

    Entry informationi

    Entry nameiSODM_RAT
    AccessioniPrimary (citable) accession number: P07895
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3