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P07895

- SODM_RAT

UniProt

P07895 - SODM_RAT

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Protein

Superoxide dismutase [Mn], mitochondrial

Gene

Sod2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.1 Publication

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 manganese ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi50 – 501ManganeseBy similarity
Metal bindingi98 – 981ManganeseBy similarity
Metal bindingi183 – 1831ManganeseBy similarity
Metal bindingi187 – 1871ManganeseBy similarity

GO - Molecular functioni

  1. DNA binding Source: RGD
  2. identical protein binding Source: RGD
  3. manganese ion binding Source: UniProtKB
  4. oxygen binding Source: RGD
  5. superoxide dismutase activity Source: UniProtKB

GO - Biological processi

  1. age-dependent response to reactive oxygen species Source: UniProtKB
  2. aging Source: RGD
  3. cellular response to ethanol Source: RGD
  4. detection of oxygen Source: Ensembl
  5. erythrophore differentiation Source: Ensembl
  6. glutathione metabolic process Source: Ensembl
  7. heart development Source: Ensembl
  8. hemopoiesis Source: Ensembl
  9. hydrogen peroxide biosynthetic process Source: RGD
  10. hydrogen peroxide metabolic process Source: RGD
  11. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  12. intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
  13. iron ion homeostasis Source: Ensembl
  14. liver development Source: Ensembl
  15. locomotory behavior Source: Ensembl
  16. negative regulation of apoptotic process Source: RGD
  17. negative regulation of fat cell differentiation Source: Ensembl
  18. negative regulation of fibroblast proliferation Source: Ensembl
  19. negative regulation of neuron apoptotic process Source: Ensembl
  20. negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
  21. neuron development Source: Ensembl
  22. oxygen homeostasis Source: Ensembl
  23. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  24. post-embryonic development Source: Ensembl
  25. protein homooligomerization Source: RGD
  26. protein homotetramerization Source: Ensembl
  27. regulation of catalytic activity Source: Ensembl
  28. regulation of mitochondrial membrane potential Source: Ensembl
  29. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  30. release of cytochrome c from mitochondria Source: Ensembl
  31. removal of superoxide radicals Source: RGD
  32. respiratory electron transport chain Source: Ensembl
  33. response to activity Source: RGD
  34. response to axon injury Source: Ensembl
  35. response to cadmium ion Source: RGD
  36. response to cold Source: RGD
  37. response to drug Source: RGD
  38. response to electrical stimulus Source: RGD
  39. response to gamma radiation Source: Ensembl
  40. response to hydrogen peroxide Source: RGD
  41. response to hyperoxia Source: Ensembl
  42. response to hypoxia Source: RGD
  43. response to immobilization stress Source: RGD
  44. response to isolation stress Source: RGD
  45. response to L-ascorbic acid Source: RGD
  46. response to lipopolysaccharide Source: RGD
  47. response to magnetism Source: RGD
  48. response to manganese ion Source: RGD
  49. response to nutrient levels Source: RGD
  50. response to oxidative stress Source: RGD
  51. response to radiation Source: RGD
  52. response to selenium ion Source: RGD
  53. response to silicon dioxide Source: RGD
  54. response to zinc ion Source: RGD
  55. superoxide anion generation Source: Ensembl
  56. superoxide metabolic process Source: UniProtKB
  57. vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_213899. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Gene namesi
Name:Sod2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi3732. Sod2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular vesicular exosome Source: Ensembl
  3. mitochondrial inner membrane Source: Ensembl
  4. mitochondrial nucleoid Source: RGD
  5. mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionAdd
BLAST
Chaini25 – 222198Superoxide dismutase [Mn], mitochondrialPRO_0000032874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Nitrated tyrosine1 Publication
Modified residuei68 – 681N6-acetyllysine; alternateBy similarity
Modified residuei68 – 681N6-succinyllysine; alternateBy similarity
Modified residuei75 – 751N6-acetyllysine; alternateBy similarity
Modified residuei75 – 751N6-succinyllysine; alternateBy similarity
Modified residuei114 – 1141N6-acetyllysineBy similarity
Modified residuei122 – 1221N6-acetyllysine; alternateBy similarity
Modified residuei122 – 1221N6-succinyllysine; alternateBy similarity
Modified residuei130 – 1301N6-acetyllysine; alternateBy similarity
Modified residuei130 – 1301N6-succinyllysine; alternateBy similarity
Modified residuei202 – 2021N6-acetyllysineBy similarity

Post-translational modificationi

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.2 Publications
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting By similarity.By similarity

Keywords - PTMi

Acetylation, Nitration

Proteomic databases

PaxDbiP07895.
PRIDEiP07895.

2D gel databases

World-2DPAGE0004:P07895.

PTM databases

PhosphoSiteiP07895.

Expressioni

Gene expression databases

ExpressionAtlasiP07895. baseline and differential.
GenevestigatoriP07895.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

IntActiP07895. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP07895.
SMRiP07895. Positions 25-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0605.
GeneTreeiENSGT00390000011877.
HOGENOMiHOG000013583.
HOVERGENiHBG004451.
InParanoidiP07895.
KOiK04564.
OMAiMAIRCVA.
OrthoDBiEOG7FV3R5.
PhylomeDBiP07895.
TreeFamiTF105132.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07895-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLCRAACSAG RRLGPAASTA GSRHKHSLPD LPYDYGALEP HINAQIMQLH
60 70 80 90 100
HSKHHATYVN NLNVTEEKYH EALAKGDVTT QVALQPALKF NGGGHINHSI
110 120 130 140 150
FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL
160 170 180 190 200
GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY
210 220
LKAIWNVINW ENVSQRYIVC KK
Length:222
Mass (Da):24,674
Last modified:May 1, 1992 - v2
Checksum:i8CCC1E0E857B3138
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671Q → H in CAA68549. (PubMed:3697077)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00497 mRNA. Translation: CAA68549.1.
X56600 Genomic DNA. Translation: CAA39937.1.
BC070913 mRNA. Translation: AAH70913.1.
PIRiS21661. DSRTN.
RefSeqiNP_058747.1. NM_017051.2.
UniGeneiRn.10488.

Genome annotation databases

EnsembliENSRNOT00000025794; ENSRNOP00000025794; ENSRNOG00000019048.
GeneIDi24787.
KEGGirno:24787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00497 mRNA. Translation: CAA68549.1 .
X56600 Genomic DNA. Translation: CAA39937.1 .
BC070913 mRNA. Translation: AAH70913.1 .
PIRi S21661. DSRTN.
RefSeqi NP_058747.1. NM_017051.2.
UniGenei Rn.10488.

3D structure databases

ProteinModelPortali P07895.
SMRi P07895. Positions 25-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P07895. 1 interaction.

PTM databases

PhosphoSitei P07895.

2D gel databases

World-2DPAGE 0004:P07895.

Proteomic databases

PaxDbi P07895.
PRIDEi P07895.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025794 ; ENSRNOP00000025794 ; ENSRNOG00000019048 .
GeneIDi 24787.
KEGGi rno:24787.

Organism-specific databases

CTDi 6648.
RGDi 3732. Sod2.

Phylogenomic databases

eggNOGi COG0605.
GeneTreei ENSGT00390000011877.
HOGENOMi HOG000013583.
HOVERGENi HBG004451.
InParanoidi P07895.
KOi K04564.
OMAi MAIRCVA.
OrthoDBi EOG7FV3R5.
PhylomeDBi P07895.
TreeFami TF105132.

Enzyme and pathway databases

Reactomei REACT_213899. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

NextBioi 604412.
PROi P07895.

Gene expression databases

ExpressionAtlasi P07895. baseline and differential.
Genevestigatori P07895.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequences of cDNAs coding for rat manganese-containing superoxide dismutase."
    Ho Y.-S., Crapo J.D.
    Nucleic Acids Res. 15:10070-10070(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Molecular structure of a functional rat gene for manganese-containing superoxide dismutase."
    Ho Y.-S., Howard A.J., Crapo J.D.
    Am. J. Respir. Cell Mol. Biol. 4:278-286(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  4. Lubec G., Afjehi-Sadat L., Diao W., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 54-68; 76-108; 135-154 AND 203-216, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain, Hippocampus and Spinal cord.
  5. "Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidney."
    Guo W., Adachi T., Matsui R., Xu S., Jiang B., Zou M.H., Kirber M., Lieberthal W., Cohen R.A.
    Am. J. Physiol. 285:H1396-H1403(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NITRATION, FUNCTION DURING OXIDATIVE STRESS.
  6. "Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging."
    Xu S., Ying J., Jiang B., Guo W., Adachi T., Sharov V., Lazar H., Menzoian J., Knyushko T.V., Bigelow D., Schoeneich C., Cohen R.A.
    Am. J. Physiol. 290:H2220-H2227(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NITRATION AT TYR-58.

Entry informationi

Entry nameiSODM_RAT
AccessioniPrimary (citable) accession number: P07895
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3