Probable copper-transporting ATPase synA - Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)

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Reviewed, UniProtKB/Swiss-Prot P07893 (ATSY_SYNP6)

Last modified June 16, 2009. Version 81. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Probable copper-transporting ATPase synA
EC=3.6.3.4

Gene names

Name:	synA
Synonyms:	ctaA
Ordered Locus Names:	syc1785_d

Organism

Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans) [Complete proteome] [HAMAP]

Taxonomic identifier

269084 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

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Protein attributes

Sequence length	790 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Involved in copper transport.
Catalytic activity	ATP + H₂O + Cu²⁺(In) = ADP + phosphate + Cu²⁺(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IB subfamily. Contains 1 HMA domain.

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Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Copper Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro copper ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 790

790

Probable copper-transporting ATPase synA

PRO_0000046157

Regions

Topological domain

1 – 105

105

Cytoplasmic Potential

Transmembrane

106 – 125

Potential

Topological domain

126 – 134

Extracellular Potential

Transmembrane

135 – 154

Potential

Topological domain

155 – 166

Cytoplasmic Potential

Transmembrane

167 – 189

Potential

Topological domain

190 – 193

Extracellular Potential

Transmembrane

194 – 211

Potential

Topological domain

212 – 357

146

Cytoplasmic Potential

Transmembrane

358 – 380

Potential

Topological domain

381 – 416

Extracellular Potential

Transmembrane

417 – 439

Potential

Topological domain

440 – 726

287

Cytoplasmic Potential

Transmembrane

727 – 749

Potential

Topological domain

750 – 753

Extracellular Potential

Transmembrane

754 – 776

Potential

Topological domain

777 – 790

Cytoplasmic Potential

Domain

15 – 82

HMA

Sites

Active site

476

4-aspartylphosphate intermediate By similarity

Metal binding

Copper Potential

Metal binding

Copper Potential

Metal binding

669

Magnesium By similarity

Metal binding

673

Magnesium By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

P07893-1 [UniParc].

Last modified August 1, 1988. Version 2.
Checksum: 822B3A9A3F139CDF
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FASTA

790

83,657

        10         20         30         40         50         60 
MPAAIVHSAD PSSTSILVEV EGMKCAGCVA AVERRLQQTA GVEAVSVNLI TRLAKVDYDA 

        70         80         90        100        110        120 
ALIEDPTVLT TEITGLGFRA QLRQDDNPLT LPIAEIPPLQ QQRLQLAIAA FLLIVSSWGH 

       130        140        150        160        170        180 
LGHWLDHPLP GTDQLWFHAL LAIWALLGPG RSILQAGWQG LRCGAPNMNS LVLLGTGSAY 

       190        200        210        220        230        240 
LASLVALLWP QLGWVCFLDE PVMLLGFILL GRTLEEQARF RSQAALQNLL ALQPETTQLL 

       250        260        270        280        290        300 
TAPSSIAPQD LLEAPAQIWP VAQLRAGDYV QVLPGVRIPV DGCIVAGQST LDTAMLTGEP 

       310        320        330        340        350        360 
LPQPCQVGDR VCAGTLNLSH RLVIRAEQTG SQTRLAAIVR CVAEAQQRKA PVQRFADAIA 

       370        380        390        400        410        420 
GRFVYGVCAI AALTFGFWAT LGSRWWPQVL QQPLPGLLIH APHHGMEMAH PHSHSPLLLA 

       430        440        450        460        470        480 
LTLAISVLVV ACPCALGLAT PTAILVATGL AAEQGILVRG GDVLEQLARI KHFVFDKTGT 

       490        500        510        520        530        540 
LTQGQFELIE IQPLADVDPD RLLQWAAALE ADSRHPLATA LQTAAQAANL APIAASDRQQ 

       550        560        570        580        590        600 
VPGLGVSGTC DGRSLRLGNP TWVQVATAKL PTGSAAATSI WLADDQQLLA CFWLQDQPRP 

       610        620        630        640        650        660 
EAAEVVQALR SRGATVQILS GDRQTTAVAL AQQLGLESET VVAEVLPEDK AAAIAALQSQ 

       670        680        690        700        710        720 
GDAVAMIGDG INDAPALATA AVGISLAAGS DIAQDSAGLL LSRDRLDSVL VAWNLSQMGL 

       730        740        750        760        770        780 
RTIRQNLTWA LGYNVVMLPL AAGAFLPAYG LALTPAIAGA CMAVSSLAVV SNSLLLRYWF 

       790 
RRSLNHSVSV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization." Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M. Photosyn. Res. 93:55-67(2007) [PubMed: 17211581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The organization and sequence of the genes for ATP synthase subunits in the cyanobacterium Synechococcus 6301. Support for an endosymbiotic origin of chloroplasts." Cozens A.L., Walker J.E. J. Mol. Biol. 194:359-383(1987) [PubMed: 3041005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 498-790.

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Cross-references

Sequence databases
	AP008231 Genomic DNA. Translation: BAD79975.1. X05925 Genomic DNA. Translation: CAA29364.1.
RefSeq	YP_172495.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3197979.
GenomeReviews	Gene locus syc1785_d in contig AP008231_GR.
KEGG	syc:syc1785_d.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P07893.
OMA	P07893. IENEETK.
Enzyme and pathway databases
BioCyc	SELO269084:SYC1785_D-MON.
Family and domain databases
InterPro	IPR001877. ATPase1_Cu-transp. IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_phosphor_site. IPR005834. Dehalogen-like_hydro. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe_transpt. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00942. CUATPASEI.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

ATSY_SYNP6

Accession

Primary (citable) accession number: P07893
Secondary accession number(s): Q5N145

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	June 16, 2009
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents