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Protein

3-ketoacyl-CoA thiolase B, peroxisomal

Gene

Acaa1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There exist at least 2 rat liver peroxisomal 3-ketoacyl-CoA thiolases.

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei123Acyl-thioester intermediateBy similarity1
Active sitei377Proton acceptorPROSITE-ProRule annotation1
Active sitei408Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

SABIO-RKP07871
UniPathwayiUPA00199

Chemistry databases

SwissLipidsiSLP:000001213

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolase B, peroxisomal (EC:2.3.1.16)
Alternative name(s):
Acetyl-CoA acyltransferase B
Beta-ketothiolase B
Peroxisomal 3-oxoacyl-CoA thiolase B
Gene namesi
Name:Acaa1b
Synonyms:Acaa1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1562373 Acaa1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26Peroxisome1 PublicationAdd BLAST26
ChainiPRO_000003407127 – 4243-ketoacyl-CoA thiolase B, peroxisomalAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173N6-acetyllysineBy similarity1
Modified residuei234N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP07871

PTM databases

iPTMnetiP07871
PhosphoSitePlusiP07871

Expressioni

Inductioni

Peroxisomal thiolase is markedly induced (at the level of transcription) by various hypolipidemic compounds in parallel with the other two enzymes of the peroxisomal beta-oxidation system.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP07871, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP07871
SMRiP07871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000012239
HOVERGENiHBG003112
InParanoidiP07871
KOiK07513
PhylomeDBiP07871

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRLQVVLGH LAGRSESSSA LQAAPCSAGF PQASASDVVV VHGRRTPIGR
60 70 80 90 100
AGRGGFKDTT PDELLSAVLT AVLQDVKLKP ECLGDISVGN VLQPGAGAAM
110 120 130 140 150
ARIAQFLSGI PETVPLSAVN RQCSSGLQAV ANIAGGIRNG SYDIGMACGV
160 170 180 190 200
ESMTLSERGN PGNISSRLLE NEKARDCLIP MGITSENVAE RFGISRQKQD
210 220 230 240 250
AFALASQQKA ASAQSKGCFR AEIVPVTTTV LDDKGDRKTI TVSQDEGVRP
260 270 280 290 300
STTMEGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI
310 320 330 340 350
LGVLRSYAVV GVPPDIMGIG PAYAIPAALQ KAGLTVNDID IFEINEAFAS
360 370 380 390 400
QALYCVEKLG IPAEKVNPLG GAIALGHPLG CTGARQVVTL LNELKRRGRR
410 420
AYGVVSMCIG TGMGAAAVFE YPGN
Length:424
Mass (Da):43,820
Last modified:May 1, 1991 - v2
Checksum:iE1D41A3C65477D77
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44R → Q in AAA41497 (PubMed:3036803).Curated1
Sequence conflicti78L → P in AAA41497 (PubMed:3036803).Curated1
Sequence conflicti359L → V in BAA14107 (PubMed:2307679).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02749 mRNA Translation: AAA41497.1
D90063 Genomic DNA Translation: BAA14107.1
BC098757 mRNA Translation: AAH98757.1
PIRiB35725 XURTAB
RefSeqiNP_001035108.1, NM_001040019.1
UniGeneiRn.154995

Genome annotation databases

GeneIDi501072
KEGGirno:501072
UCSCiRGD:1562373 rat

Similar proteinsi

Entry informationi

Entry nameiTHIKB_RAT
AccessioniPrimary (citable) accession number: P07871
Secondary accession number(s): Q4G049
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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