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P07864 (LDHC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 151. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase C chain

Short name=LDH-C
EC=1.1.1.27
Alternative name(s):
Cancer/testis antigen 32
Short name=CT32
LDH testis subunit
LDH-X
Gene names
Name:LDHC
Synonyms:LDH3, LDHX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possible role in sperm motility. Ref.4

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH. HAMAP-Rule MF_00488

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. HAMAP-Rule MF_00488

Subunit structure

Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 By similarity.

Subcellular location

Cytoplasm HAMAP-Rule MF_00488.

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 332331L-lactate dehydrogenase C chain HAMAP-Rule MF_00488
PRO_0000168479

Regions

Nucleotide binding29 – 5729NAD By similarity

Sites

Active site1931Proton acceptor By similarity
Binding site991NAD By similarity
Binding site1061Substrate By similarity
Binding site1381NAD or substrate By similarity
Binding site1691Substrate By similarity
Binding site2481Substrate By similarity

Amino acid modifications

Modified residue3011Phosphoserine Ref.7

Natural variations

Natural variant2851E → Q.
Corresponds to variant rs2230150 [ dbSNP | Ensembl ].
VAR_034068

Experimental info

Sequence conflict771I → V in AAA59507. Ref.1
Sequence conflict771I → V in AAA59508. Ref.2
Sequence conflict821D → G in AAP37402. Ref.4
Sequence conflict1191S → I in AAA59507. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P07864 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: DF7047FF5BCB101B

FASTA33236,311
        10         20         30         40         50         60 
MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL VDVALDKLKG 

        70         80         90        100        110        120 
EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ QEGETRLALV QRNVAIMKSI 

       130        140        150        160        170        180 
IPAIVHYSPD CKILVVSNPV DILTYIVWKI SGLPVTRVIG SGCNLDSARF RYLIGEKLGV 

       190        200        210        220        230        240 
HPTSCHGWII GEHGDSSVPL WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE 

       250        260        270        280        290        300 
IIKLKGYTSW AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV 

       310        320        330 
SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF 

« Hide

References

« Hide 'large scale' references
[1]"Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence."
Millan J.L., Driscoll C.E., Goldberg E.
Proc. Natl. Acad. Sci. U.S.A. 84:5311-5315(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Human testicular lactate dehydrogenase-C gene is interrupted by six introns at positions homologous to those of LDH-A (muscle) and LDH-B (heart) genes."
Takano T., Li S.S.-L.
Biochem. Biophys. Res. Commun. 159:579-583(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Human testicular lactate dehydrogenase-C gene: cDNA sequence and putative alternative splicing at the 5' noncoding region."
Wu K., Li S.S.-L.
J. Genet. Mol. Biol. 1:72-76(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications."
Wang H., Zhou Z., Xu M., Li J., Xiao J., Xu Z.-Y., Sha J.
J. Mol. Med. 82:317-324(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION.
Tissue: Testis.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Web resources

Wikipedia

Lactate dehydrogenase entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02938 mRNA. Translation: AAA59507.1.
AH002865 Genomic DNA. Translation: AAA59508.1.
U13680 mRNA. Translation: AAA21348.1.
AY286300 mRNA. Translation: AAP37402.1.
CH471064 Genomic DNA. Translation: EAW68392.1.
CH471064 Genomic DNA. Translation: EAW68394.1.
BC019249 mRNA. Translation: AAH19249.3.
BC064388 mRNA. Translation: AAH64388.1.
BC090043 mRNA. Translation: AAH90043.1.
CCDSCCDS7840.1.
PIRDEHULC. A30933.
RefSeqNP_002292.1. NM_002301.4.
NP_059144.1. NM_017448.3.
UniGeneHs.654377.

3D structure databases

ProteinModelPortalP07864.
SMRP07864. Positions 2-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110140. 5 interactions.
STRING9606.ENSP00000280704.

Chemistry

BindingDBP07864.
DrugBankDB00157. NADH.

PTM databases

PhosphoSiteP07864.

Polymorphism databases

DMDM76363520.

Proteomic databases

MaxQBP07864.
PaxDbP07864.
PRIDEP07864.

Protocols and materials databases

DNASU3948.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280704; ENSP00000280704; ENSG00000166796.
ENST00000541669; ENSP00000437783; ENSG00000166796.
GeneID3948.
KEGGhsa:3948.
UCSCuc001mom.4. human.

Organism-specific databases

CTD3948.
GeneCardsGC11P018433.
HGNCHGNC:6544. LDHC.
HPAHPA045442.
MIM150150. gene.
neXtProtNX_P07864.
PharmGKBPA30328.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213793.
HOVERGENHBG000462.
InParanoidP07864.
KOK00016.
OMADSDKDQW.
OrthoDBEOG7X0VH3.
PhylomeDBP07864.
TreeFamTF314963.

Enzyme and pathway databases

UniPathwayUPA00554; UER00611.

Gene expression databases

ArrayExpressP07864.
BgeeP07864.
CleanExHS_LDHC.
GenevestigatorP07864.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00488. Lactate_dehydrog.
InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLDHC. human.
GenomeRNAi3948.
NextBio15487.
PROP07864.
SOURCESearch...

Entry information

Entry nameLDHC_HUMAN
AccessionPrimary (citable) accession number: P07864
Secondary accession number(s): D3DQY4, Q6GSG8, Q7Z7J4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 151 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM