L-lactate dehydrogenase C chain - Homo sapiens (Human)

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P07864 (LDHC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 125. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
L-lactate dehydrogenase C chain
Short name=LDH-C
EC=1.1.1.27

Alternative name(s):
Cancer/testis antigen 32
Short name=CT32
LDH testis subunit
LDH-X

Gene names

Name:	LDHC
Synonyms:	LDH3, LDHX

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Possible role in sperm motility. Ref.4
Catalytic activity	(S)-lactate + NAD⁺ = pyruvate + NADH.
Pathway	Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Subunit structure	Homotetramer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the LDH/MDH superfamily. LDH family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-lactate dehydrogenase activity Traceable author statement. Source: ProtInc nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed

Chain

2 – 332

331

L-lactate dehydrogenase C chain

PRO_0000168479

Regions

Nucleotide binding

29 – 57

NAD By similarity

Sites

Active site

193

Proton acceptor By similarity

Binding site

NAD By similarity

Binding site

106

Substrate By similarity

Binding site

138

NAD or substrate By similarity

Binding site

169

Substrate By similarity

Binding site

248

Substrate By similarity

Natural variations

Natural variant

285

E → Q.
Corresponds to variant rs2230150 [ dbSNP | Ensembl ].

VAR_034068

Experimental info

Sequence conflict

I → V in AAA59507. Ref.1

Sequence conflict

I → V in AAA59508. Ref.2

Sequence conflict

D → G in AAP37402. Ref.4

Sequence conflict

119

S → I in AAA59507. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P07864 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: DF7047FF5BCB101B
Show »

FASTA

332

36,311

        10         20         30         40         50         60 
MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL VDVALDKLKG 

        70         80         90        100        110        120 
EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ QEGETRLALV QRNVAIMKSI 

       130        140        150        160        170        180 
IPAIVHYSPD CKILVVSNPV DILTYIVWKI SGLPVTRVIG SGCNLDSARF RYLIGEKLGV 

       190        200        210        220        230        240 
HPTSCHGWII GEHGDSSVPL WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE 

       250        260        270        280        290        300 
IIKLKGYTSW AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV 

       310        320        330 
SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence." Millan J.L., Driscoll C.E., Goldberg E. Proc. Natl. Acad. Sci. U.S.A. 84:5311-5315(1987) [PubMed: 2440048] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Human testicular lactate dehydrogenase-C gene is interrupted by six introns at positions homologous to those of LDH-A (muscle) and LDH-B (heart) genes." Takano T., Li S.S.-L. Biochem. Biophys. Res. Commun. 159:579-583(1989) [PubMed: 2930531] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Human testicular lactate dehydrogenase-C gene: cDNA sequence and putative alternative splicing at the 5' noncoding region." Wu K., Li S.S.-L. J. Genet. Mol. Biol. 1:72-76(1990) Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications." Wang H., Zhou Z., Xu M., Li J., Xiao J., Xu Z.-Y., Sha J. J. Mol. Med. 82:317-324(2004) [PubMed: 14985855] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION. Tissue: Testis.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Testis.
+	Additional computationally mapped references.

Web resources

GeneReviews

Wikipedia

Lactate dehydrogenase entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02938 mRNA. Translation: AAA59507.1. M24515 , M24510, M24511, M24512, M24513, M24514 Genomic DNA. Translation: AAA59508.1. U13680 mRNA. Translation: AAA21348.1. AY286300 mRNA. Translation: AAP37402.1. CH471064 Genomic DNA. Translation: EAW68392.1. CH471064 Genomic DNA. Translation: EAW68394.1. BC019249 mRNA. Translation: AAH19249.3. BC064388 mRNA. Translation: AAH64388.1. BC090043 mRNA. Translation: AAH90043.1.
IPI	IPI00554498.
PIR	DEHULC. A30933.
RefSeq	NP_002292.1. NM_002301.4. NP_059144.1. NM_017448.3.
UniGene	Hs.654377.
3D structure databases
ProteinModelPortal	P07864.
SMR	P07864. Positions 2-332.
ModBase	Search...
Protein-protein interaction databases
STRING	P07864.
PTM databases
PhosphoSite	P07864.
Polymorphism databases
DMDM	76363520.
Proteomic databases
PRIDE	P07864.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000280704; ENSP00000280704; ENSG00000166796. ENST00000396215; ENSP00000379518; ENSG00000166796.
GeneID	3948.
KEGG	hsa:3948.
UCSC	uc001mom.2. human.
Organism-specific databases
CTD	3948.
GeneCards	GC11P018433.
H-InvDB	HIX0201629.
HGNC	HGNC:6544. LDHC.
HPA	HPA045442.
MIM	150150. gene.
neXtProt	NX_P07864.
PharmGKB	PA30328.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11524.
GeneTree	ENSGT00550000074541.
HOGENOM	HBG566126.
HOVERGEN	HBG000462.
InParanoid	P07864.
OMA	FRKELAT.
OrthoDB	EOG4Z36F6.
PhylomeDB	P07864.
Gene expression databases
ArrayExpress	P07864.
Bgee	P07864.
CleanEx	HS_LDHC.
Genevestigator	P07864.
GermOnline	ENSG00000166796. Homo sapiens.
Family and domain databases
InterPro	IPR001557. L-lactate/malate_DH. IPR011304. L-lactate_DH. IPR018177. L-lactate_DH_AS. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00016.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
PRINTS	PR00086. LLDHDRGNASE.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01771. L-LDH-NAD. 1 hit.
PROSITE	PS00064. L_LDH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00157. NADH.
NextBio	15487.
SOURCE	Search...

Entry information

Entry name

LDHC_HUMAN

Accession

Primary (citable) accession number: P07864
Secondary accession number(s): D3DQY4, Q6GSG8, Q7Z7J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 125 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 11: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents