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P07864

- LDHC_HUMAN

UniProt

P07864 - LDHC_HUMAN

Protein

L-lactate dehydrogenase C chain

Gene

LDHC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Possible role in sperm motility.

    Catalytic activityi

    (S)-lactate + NAD+ = pyruvate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991NADBy similarity
    Binding sitei106 – 1061SubstrateBy similarity
    Binding sitei138 – 1381NAD or substrateBy similarity
    Binding sitei169 – 1691SubstrateBy similarity
    Active sitei193 – 1931Proton acceptorBy similarity
    Binding sitei248 – 2481SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 5729NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. L-lactate dehydrogenase activity Source: ProtInc

    GO - Biological processi

    1. ATP biosynthetic process Source: Ensembl
    2. cellular carbohydrate metabolic process Source: InterPro
    3. glycolytic process Source: UniProtKB-KW
    4. lactate biosynthetic process from pyruvate Source: Ensembl
    5. lactate oxidation Source: Ensembl
    6. sperm motility Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00554; UER00611.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-lactate dehydrogenase C chain (EC:1.1.1.27)
    Short name:
    LDH-C
    Alternative name(s):
    Cancer/testis antigen 32
    Short name:
    CT32
    LDH testis subunit
    LDH-X
    Gene namesi
    Name:LDHC
    Synonyms:LDH3, LDHX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6544. LDHC.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. motile cilium Source: Ensembl
    3. nucleus Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30328.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 332331L-lactate dehydrogenase C chainPRO_0000168479Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei301 – 3011Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP07864.
    PaxDbiP07864.
    PRIDEiP07864.

    PTM databases

    PhosphoSiteiP07864.

    Expressioni

    Gene expression databases

    ArrayExpressiP07864.
    BgeeiP07864.
    CleanExiHS_LDHC.
    GenevestigatoriP07864.

    Organism-specific databases

    HPAiHPA045442.

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi110140. 5 interactions.
    STRINGi9606.ENSP00000280704.

    Structurei

    3D structure databases

    ProteinModelPortaliP07864.
    SMRiP07864. Positions 2-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. LDH family.Curated

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213793.
    HOVERGENiHBG000462.
    InParanoidiP07864.
    KOiK00016.
    OMAiDSDKDQW.
    OrthoDBiEOG7X0VH3.
    PhylomeDBiP07864.
    TreeFamiTF314963.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00488. Lactate_dehydrog.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR011304. L-lactate_DH.
    IPR018177. L-lactate_DH_AS.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
    PROSITEiPS00064. L_LDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07864-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL    50
    VDVALDKLKG EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ 100
    QEGETRLALV QRNVAIMKSI IPAIVHYSPD CKILVVSNPV DILTYIVWKI 150
    SGLPVTRVIG SGCNLDSARF RYLIGEKLGV HPTSCHGWII GEHGDSSVPL 200
    WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE IIKLKGYTSW 250
    AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV 300
    SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF 332
    Length:332
    Mass (Da):36,311
    Last modified:January 23, 2007 - v4
    Checksum:iDF7047FF5BCB101B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 771I → V in AAA59507. (PubMed:2440048)Curated
    Sequence conflicti77 – 771I → V in AAA59508. (PubMed:2930531)Curated
    Sequence conflicti82 – 821D → G in AAP37402. (PubMed:14985855)Curated
    Sequence conflicti119 – 1191S → I in AAA59507. (PubMed:2440048)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti285 – 2851E → Q.
    Corresponds to variant rs2230150 [ dbSNP | Ensembl ].
    VAR_034068

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02938 mRNA. Translation: AAA59507.1.
    AH002865 Genomic DNA. Translation: AAA59508.1.
    U13680 mRNA. Translation: AAA21348.1.
    AY286300 mRNA. Translation: AAP37402.1.
    CH471064 Genomic DNA. Translation: EAW68392.1.
    CH471064 Genomic DNA. Translation: EAW68394.1.
    BC019249 mRNA. Translation: AAH19249.3.
    BC064388 mRNA. Translation: AAH64388.1.
    BC090043 mRNA. Translation: AAH90043.1.
    CCDSiCCDS7840.1.
    PIRiA30933. DEHULC.
    RefSeqiNP_002292.1. NM_002301.4.
    NP_059144.1. NM_017448.3.
    UniGeneiHs.654377.

    Genome annotation databases

    EnsembliENST00000280704; ENSP00000280704; ENSG00000166796.
    ENST00000541669; ENSP00000437783; ENSG00000166796.
    GeneIDi3948.
    KEGGihsa:3948.
    UCSCiuc001mom.4. human.

    Polymorphism databases

    DMDMi76363520.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Lactate dehydrogenase entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02938 mRNA. Translation: AAA59507.1 .
    AH002865 Genomic DNA. Translation: AAA59508.1 .
    U13680 mRNA. Translation: AAA21348.1 .
    AY286300 mRNA. Translation: AAP37402.1 .
    CH471064 Genomic DNA. Translation: EAW68392.1 .
    CH471064 Genomic DNA. Translation: EAW68394.1 .
    BC019249 mRNA. Translation: AAH19249.3 .
    BC064388 mRNA. Translation: AAH64388.1 .
    BC090043 mRNA. Translation: AAH90043.1 .
    CCDSi CCDS7840.1.
    PIRi A30933. DEHULC.
    RefSeqi NP_002292.1. NM_002301.4.
    NP_059144.1. NM_017448.3.
    UniGenei Hs.654377.

    3D structure databases

    ProteinModelPortali P07864.
    SMRi P07864. Positions 2-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110140. 5 interactions.
    STRINGi 9606.ENSP00000280704.

    Chemistry

    BindingDBi P07864.
    DrugBanki DB00157. NADH.

    PTM databases

    PhosphoSitei P07864.

    Polymorphism databases

    DMDMi 76363520.

    Proteomic databases

    MaxQBi P07864.
    PaxDbi P07864.
    PRIDEi P07864.

    Protocols and materials databases

    DNASUi 3948.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280704 ; ENSP00000280704 ; ENSG00000166796 .
    ENST00000541669 ; ENSP00000437783 ; ENSG00000166796 .
    GeneIDi 3948.
    KEGGi hsa:3948.
    UCSCi uc001mom.4. human.

    Organism-specific databases

    CTDi 3948.
    GeneCardsi GC11P018433.
    HGNCi HGNC:6544. LDHC.
    HPAi HPA045442.
    MIMi 150150. gene.
    neXtProti NX_P07864.
    PharmGKBi PA30328.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213793.
    HOVERGENi HBG000462.
    InParanoidi P07864.
    KOi K00016.
    OMAi DSDKDQW.
    OrthoDBi EOG7X0VH3.
    PhylomeDBi P07864.
    TreeFami TF314963.

    Enzyme and pathway databases

    UniPathwayi UPA00554 ; UER00611 .

    Miscellaneous databases

    ChiTaRSi LDHC. human.
    GenomeRNAii 3948.
    NextBioi 15487.
    PROi P07864.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07864.
    Bgeei P07864.
    CleanExi HS_LDHC.
    Genevestigatori P07864.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00488. Lactate_dehydrog.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR011304. L-lactate_DH.
    IPR018177. L-lactate_DH_AS.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01771. L-LDH-NAD. 1 hit.
    PROSITEi PS00064. L_LDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence."
      Millan J.L., Driscoll C.E., Goldberg E.
      Proc. Natl. Acad. Sci. U.S.A. 84:5311-5315(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Human testicular lactate dehydrogenase-C gene is interrupted by six introns at positions homologous to those of LDH-A (muscle) and LDH-B (heart) genes."
      Takano T., Li S.S.-L.
      Biochem. Biophys. Res. Commun. 159:579-583(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Human testicular lactate dehydrogenase-C gene: cDNA sequence and putative alternative splicing at the 5' noncoding region."
      Wu K., Li S.S.-L.
      J. Genet. Mol. Biol. 1:72-76(1990)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications."
      Wang H., Zhou Z., Xu M., Li J., Xiao J., Xu Z.-Y., Sha J.
      J. Mol. Med. 82:317-324(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION.
      Tissue: Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Testis.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiLDHC_HUMAN
    AccessioniPrimary (citable) accession number: P07864
    Secondary accession number(s): D3DQY4, Q6GSG8, Q7Z7J4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 152 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3