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P07864

- LDHC_HUMAN

UniProt

P07864 - LDHC_HUMAN

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Protein

L-lactate dehydrogenase C chain

Gene

LDHC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Possible role in sperm motility.

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991NADBy similarity
Binding sitei106 – 1061SubstrateBy similarity
Binding sitei138 – 1381NAD or substrateBy similarity
Binding sitei169 – 1691SubstrateBy similarity
Active sitei193 – 1931Proton acceptorBy similarity
Binding sitei248 – 2481SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 5729NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. L-lactate dehydrogenase activity Source: ProtInc

GO - Biological processi

  1. ATP biosynthetic process Source: Ensembl
  2. cellular carbohydrate metabolic process Source: InterPro
  3. lactate biosynthetic process from pyruvate Source: Ensembl
  4. lactate oxidation Source: Ensembl
  5. sperm motility Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase C chain (EC:1.1.1.27)
Short name:
LDH-C
Alternative name(s):
Cancer/testis antigen 32
Short name:
CT32
LDH testis subunit
LDH-X
Gene namesi
Name:LDHC
Synonyms:LDH3, LDHX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6544. LDHC.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProtKB
  3. motile cilium Source: Ensembl
  4. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 332331L-lactate dehydrogenase C chainPRO_0000168479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei301 – 3011Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP07864.
PaxDbiP07864.
PRIDEiP07864.

PTM databases

PhosphoSiteiP07864.

Expressioni

Gene expression databases

BgeeiP07864.
CleanExiHS_LDHC.
ExpressionAtlasiP07864. baseline and differential.
GenevestigatoriP07864.

Organism-specific databases

HPAiHPA045442.

Interactioni

Subunit structurei

Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 By similarity.By similarity

Protein-protein interaction databases

BioGridi110140. 5 interactions.
STRINGi9606.ENSP00000280704.

Structurei

3D structure databases

ProteinModelPortaliP07864.
SMRiP07864. Positions 2-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiCOG0039.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiP07864.
KOiK00016.
OMAiDSDKDQW.
OrthoDBiEOG7X0VH3.
PhylomeDBiP07864.
TreeFamiTF314963.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07864-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL
60 70 80 90 100
VDVALDKLKG EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ
110 120 130 140 150
QEGETRLALV QRNVAIMKSI IPAIVHYSPD CKILVVSNPV DILTYIVWKI
160 170 180 190 200
SGLPVTRVIG SGCNLDSARF RYLIGEKLGV HPTSCHGWII GEHGDSSVPL
210 220 230 240 250
WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE IIKLKGYTSW
260 270 280 290 300
AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV
310 320 330
SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF
Length:332
Mass (Da):36,311
Last modified:January 23, 2007 - v4
Checksum:iDF7047FF5BCB101B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771I → V in AAA59507. (PubMed:2440048)Curated
Sequence conflicti77 – 771I → V in AAA59508. (PubMed:2930531)Curated
Sequence conflicti82 – 821D → G in AAP37402. (PubMed:14985855)Curated
Sequence conflicti119 – 1191S → I in AAA59507. (PubMed:2440048)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti285 – 2851E → Q.
Corresponds to variant rs2230150 [ dbSNP | Ensembl ].
VAR_034068

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02938 mRNA. Translation: AAA59507.1.
AH002865 Genomic DNA. Translation: AAA59508.1.
U13680 mRNA. Translation: AAA21348.1.
AY286300 mRNA. Translation: AAP37402.1.
CH471064 Genomic DNA. Translation: EAW68392.1.
CH471064 Genomic DNA. Translation: EAW68394.1.
BC019249 mRNA. Translation: AAH19249.3.
BC064388 mRNA. Translation: AAH64388.1.
BC090043 mRNA. Translation: AAH90043.1.
CCDSiCCDS7840.1.
PIRiA30933. DEHULC.
RefSeqiNP_002292.1. NM_002301.4.
NP_059144.1. NM_017448.3.
UniGeneiHs.654377.

Genome annotation databases

EnsembliENST00000280704; ENSP00000280704; ENSG00000166796.
ENST00000541669; ENSP00000437783; ENSG00000166796.
GeneIDi3948.
KEGGihsa:3948.
UCSCiuc001mom.4. human.

Polymorphism databases

DMDMi76363520.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Lactate dehydrogenase entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02938 mRNA. Translation: AAA59507.1 .
AH002865 Genomic DNA. Translation: AAA59508.1 .
U13680 mRNA. Translation: AAA21348.1 .
AY286300 mRNA. Translation: AAP37402.1 .
CH471064 Genomic DNA. Translation: EAW68392.1 .
CH471064 Genomic DNA. Translation: EAW68394.1 .
BC019249 mRNA. Translation: AAH19249.3 .
BC064388 mRNA. Translation: AAH64388.1 .
BC090043 mRNA. Translation: AAH90043.1 .
CCDSi CCDS7840.1.
PIRi A30933. DEHULC.
RefSeqi NP_002292.1. NM_002301.4.
NP_059144.1. NM_017448.3.
UniGenei Hs.654377.

3D structure databases

ProteinModelPortali P07864.
SMRi P07864. Positions 2-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110140. 5 interactions.
STRINGi 9606.ENSP00000280704.

Chemistry

BindingDBi P07864.

PTM databases

PhosphoSitei P07864.

Polymorphism databases

DMDMi 76363520.

Proteomic databases

MaxQBi P07864.
PaxDbi P07864.
PRIDEi P07864.

Protocols and materials databases

DNASUi 3948.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280704 ; ENSP00000280704 ; ENSG00000166796 .
ENST00000541669 ; ENSP00000437783 ; ENSG00000166796 .
GeneIDi 3948.
KEGGi hsa:3948.
UCSCi uc001mom.4. human.

Organism-specific databases

CTDi 3948.
GeneCardsi GC11P018433.
HGNCi HGNC:6544. LDHC.
HPAi HPA045442.
MIMi 150150. gene.
neXtProti NX_P07864.
PharmGKBi PA30328.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0039.
GeneTreei ENSGT00550000074541.
HOGENOMi HOG000213793.
HOVERGENi HBG000462.
InParanoidi P07864.
KOi K00016.
OMAi DSDKDQW.
OrthoDBi EOG7X0VH3.
PhylomeDBi P07864.
TreeFami TF314963.

Enzyme and pathway databases

UniPathwayi UPA00554 ; UER00611 .

Miscellaneous databases

ChiTaRSi LDHC. human.
GenomeRNAii 3948.
NextBioi 15487.
PROi P07864.
SOURCEi Search...

Gene expression databases

Bgeei P07864.
CleanExi HS_LDHC.
ExpressionAtlasi P07864. baseline and differential.
Genevestigatori P07864.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00488. Lactate_dehydrog.
InterProi IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01771. L-LDH-NAD. 1 hit.
PROSITEi PS00064. L_LDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence."
    Millan J.L., Driscoll C.E., Goldberg E.
    Proc. Natl. Acad. Sci. U.S.A. 84:5311-5315(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Human testicular lactate dehydrogenase-C gene is interrupted by six introns at positions homologous to those of LDH-A (muscle) and LDH-B (heart) genes."
    Takano T., Li S.S.-L.
    Biochem. Biophys. Res. Commun. 159:579-583(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Human testicular lactate dehydrogenase-C gene: cDNA sequence and putative alternative splicing at the 5' noncoding region."
    Wu K., Li S.S.-L.
    J. Genet. Mol. Biol. 1:72-76(1990)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications."
    Wang H., Zhou Z., Xu M., Li J., Xiao J., Xu Z.-Y., Sha J.
    J. Mol. Med. 82:317-324(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION.
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiLDHC_HUMAN
AccessioniPrimary (citable) accession number: P07864
Secondary accession number(s): D3DQY4, Q6GSG8, Q7Z7J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 153 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3