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Protein

Non-specific lipid-transfer protein

Gene

SCP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.

Catalytic activityi

3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA.

GO - Molecular functioni

GO - Biological processi

  • lipid hydroperoxide transport Source: UniProtKB
  • phospholipid transport Source: GO_Central
  • positive regulation of intracellular cholesterol transport Source: UniProtKB
  • steroid biosynthetic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific lipid-transfer protein (EC:2.3.1.176)
Short name:
NSL-TP
Alternative name(s):
Propanoyl-CoA C-acyltransferase
SCP-chi
SCPX
Sterol carrier protein 2
Short name:
SCP-2
Sterol carrier protein X
Short name:
SCP-X
Gene namesi
Name:SCP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm
  • Mitochondrion

  • Note: Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.
Isoform SCPx :
  • Peroxisome By similarity

  • Note: Interaction with PEX5 is essential for peroxisomal import.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Non-specific lipid-transfer proteinPRO_0000045842Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei39 – 391N6-succinyllysineBy similarity
Modified residuei167 – 1671N6-succinyllysineBy similarity
Modified residuei172 – 1721N6-acetyllysineBy similarity
Modified residuei182 – 1821N6-acetyllysine; alternateBy similarity
Modified residuei182 – 1821N6-succinyllysine; alternateBy similarity
Modified residuei281 – 2811N6-succinyllysineBy similarity
Modified residuei340 – 3401N6-acetyllysine; alternateBy similarity
Modified residuei340 – 3401N6-succinyllysine; alternateBy similarity
Modified residuei428 – 4281N6-acetyllysine; alternateBy similarity
Modified residuei428 – 4281N6-succinyllysine; alternateBy similarity
Modified residuei434 – 4341N6-acetyllysine; alternateBy similarity
Modified residuei434 – 4341N6-succinyllysine; alternateBy similarity
Modified residuei439 – 4391N6-acetyllysine; alternateBy similarity
Modified residuei439 – 4391N6-succinyllysine; alternateBy similarity
Modified residuei449 – 4491N6-acetyllysine; alternateBy similarity
Modified residuei449 – 4491N6-succinyllysine; alternateBy similarity
Modified residuei460 – 4601N6-succinyllysineBy similarity
Modified residuei466 – 4661N6-acetyllysine; alternateBy similarity
Modified residuei466 – 4661N6-succinyllysine; alternateBy similarity
Modified residuei475 – 4751N6-succinyllysineBy similarity
Modified residuei487 – 4871N6-acetyllysineBy similarity
Modified residuei488 – 4881N6-succinyllysineBy similarity
Modified residuei507 – 5071N6-succinyllysineBy similarity
Modified residuei518 – 5181N6-succinyllysineBy similarity
Modified residuei530 – 5301N6-succinyllysineBy similarity
Modified residuei540 – 5401N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP07857.
PeptideAtlasiP07857.
PRIDEiP07857.

Interactioni

Subunit structurei

Interacts with PEX5.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004879.

Structurei

3D structure databases

ProteinModelPortaliP07857.
SMRiP07857. Positions 421-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini429 – 539111SCP2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi541 – 5433Microbody targeting signalSequence analysis

Sequence similaritiesi

Contains 1 SCP2 domain.Curated

Phylogenomic databases

eggNOGiKOG1406. Eukaryota.
KOG4170. Eukaryota.
ENOG410XPRW. LUCA.
HOGENOMiHOG000221741.
HOVERGENiHBG006506.
InParanoidiP07857.
KOiK08764.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.47.10. 4 hits.
InterProiIPR003033. SCP2_sterol-bd_dom.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02036. SCP2. 1 hit.
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
SSF55718. SSF55718. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform SCPx (identifier: P07857-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVASQSPL RNRVFVVGVG MTKFTKPGVE NRDYPDLAKE AGQKALADAQ
60 70 80 90 100
IPYSAVEQAC IGYVYGDSTS GQRAIYHSLG LTGIPIINVN NNCSTGSTAL
110 120 130 140 150
FMARQLIQGG LADCVLALGF EKMVKGPIAV NIQDKANPID KHIEVMVNKY
160 170 180 190 200
GLSPSPVAPQ MFGNAGKEHM EKYGTTLEHF AKIGWKNHKH SVNNPYSQFQ
210 220 230 240 250
KEYSLDEVMT SRKIFDFLTV LQCCPTSDGA AAAILASEAF VQKHNLKPKA
260 270 280 290 300
VEILAQEMVT DMPSSFEGKS IIKMVGFDMS KEAARRCYEK SGLRPSDIDV
310 320 330 340 350
IELHDCFSAN ELITYEALGL CPEGQGGKLV ERGDNTYGGK WVINPSGGLI
360 370 380 390 400
SKGHPLGATG LAQCVELCWH LRGEAGKRQV PGAKVALQHN IGIGGAVVVT
410 420 430 440 450
LYKMGFPEAA RTHQIEAAPT SSSVDGFKAN LVFKEIEKKL EDEGEQFVKK
460 470 480 490 500
IGGIFAFKVK DGPGGKEATW VVDVKNGKGS VLPNSDKKAD CTITMADSDL
510 520 530 540
LALMTGKMNP QTAFFQGKLK INGNMGLAMK LQNLQLQPGK AKL
Length:543
Mass (Da):58,577
Last modified:January 24, 2006 - v2
Checksum:i4EFAE214F4A2CA99
GO
Isoform SCP2 (identifier: P07857-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-403: Missing.

Note: Mitochondrial precursor. Contains a mitochondrial transit peptide at position 1-17 (Potential).Curated
Show »
Length:140
Mass (Da):15,072
Checksum:iBE9BC6494FE95C03
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 403403Missing in isoform SCP2. CuratedVSP_018894Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103370 mRNA. Translation: AAI03371.1.
RefSeqiNP_001029162.2. NM_001033990.3. [P07857-1]
UniGeneiBt.11188.

Genome annotation databases

GeneIDi508918.
KEGGibta:508918.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103370 mRNA. Translation: AAI03371.1.
RefSeqiNP_001029162.2. NM_001033990.3. [P07857-1]
UniGeneiBt.11188.

3D structure databases

ProteinModelPortaliP07857.
SMRiP07857. Positions 421-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004879.

Proteomic databases

PaxDbiP07857.
PeptideAtlasiP07857.
PRIDEiP07857.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi508918.
KEGGibta:508918.

Organism-specific databases

CTDi6342.

Phylogenomic databases

eggNOGiKOG1406. Eukaryota.
KOG4170. Eukaryota.
ENOG410XPRW. LUCA.
HOGENOMiHOG000221741.
HOVERGENiHBG006506.
InParanoidiP07857.
KOiK08764.

Family and domain databases

Gene3Di3.30.1050.10. 1 hit.
3.40.47.10. 4 hits.
InterProiIPR003033. SCP2_sterol-bd_dom.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02036. SCP2. 1 hit.
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
SSF55718. SSF55718. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLTP_BOVIN
AccessioniPrimary (citable) accession number: P07857
Secondary accession number(s): Q3SYV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 24, 2006
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.