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Protein

Fatty acid synthase

Gene

FASN

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Catalytic activityi

Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid synthase (EC:2.3.1.85)
Gene namesi
Name:FASN
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000180278‹1 – ›64Fatty acid synthaseAdd BLAST›64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38O-(pantetheine 4'-phosphoryl)serine; alternatePROSITE-ProRule annotation1 Publication1
Modified residuei38Phosphoserine; alternateBy similarity1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Subunit structurei

Homodimer which is arranged in a head to tail fashion (By similarity). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP07855.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 64CarrierPROSITE-ProRule annotationAdd BLAST64

Phylogenomic databases

InParanoidiP07855.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiView protein in InterPro
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
PfamiView protein in Pfam
PF00550. PP-binding. 1 hit.
SMARTiView protein in SMART
SM00823. PKS_PP. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiView protein in PROSITE
PS50075. CARRIER. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.

Sequencei

Sequence statusi: Fragment.

P07855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AEGEGQRDLL KAVAHILGIR DLAGINLDSS LADLGLDSLM GVEVRQTLER
60
EHDLVLSMRE VRQL
Length:64
Mass (Da):7,037
Last modified:August 1, 1988 - v1
Checksum:i7CECE99D8A76B42D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei641

Sequence databases

PIRiS07221.

Cross-referencesi

Sequence databases

PIRiS07221.

3D structure databases

ProteinModelPortaliP07855.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiP07855.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiView protein in InterPro
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
PfamiView protein in Pfam
PF00550. PP-binding. 1 hit.
SMARTiView protein in SMART
SM00823. PKS_PP. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiView protein in PROSITE
PS50075. CARRIER. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFAS_RABIT
AccessioniPrimary (citable) accession number: P07855
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: February 15, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Multifunctional enzyme, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.