P07855 (FAS_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fatty acid synthase
EC=2.3.1.85

Gene names

Name:

FASN

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	64 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Catalytic activity	Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.
Subunit structure	Homodimer which is arranged in a head to tail fashion.
Subcellular location	Cytoplasm By similarity. Melanosome By similarity.
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Ligand	NAD NADP Phosphopantetheine
Molecular function	Transferase
Technical term	Complete proteome Direct protein sequencing Multifunctional enzyme Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	fatty acid synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›64	›64	Fatty acid synthase		PRO_0000180278
Regions
	Domain	5 – 64	60	Acyl carrier
Amino acid modifications
	Modified residue	38	1	O-(pantetheine 4'-phosphoryl)serine Ref.1
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	64	1

Sequences

	Sequence		Length	Mass (Da)
	P07855 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: 7CECE99D8A76B42D	FASTA	64	7,037
	10 20 30 40 50 60 AEGEGQRDLL KAVAHILGIR DLAGINLDSS LADLGLDSLM GVEVRQTLER EHDLVLSMRE VRQL

References

[1]	"The multifunctional polypeptide chain of rabbit mammary fatty acid synthase contains a domain homologous with the acyl carrier protein of Escherichia coli." McCarthy A.D., Aitken A., Hardie D.G. Eur. J. Biochem. 136:501-508(1983) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	S07221.
3D structure databases
ProteinModelPortal	P07855.
SMR	P07855. Positions 1-64.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.1200.10. 1 hit.
InterPro	IPR009081. Acyl_carrier_prot-like. IPR006162. PPantetheine_attach_site. [Graphical view]
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00606. B_KETOACYL_SYNTHASE. Partial match. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FAS_RABIT

Accession

Primary (citable) accession number: P07855

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program