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P07855 (FAS_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty acid synthase

EC=2.3.1.85
Gene names
Name:FASN
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length64 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Catalytic activity

Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.

Subunit structure

Homodimer which is arranged in a head to tail fashion.

Subcellular location

Cytoplasm By similarity. Melanosome By similarity.

Sequence similarities

Contains 1 acyl carrier domain.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentCytoplasm
   LigandNAD
NADP
   Molecular functionTransferase
   PTMPhosphopantetheine
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Multifunctional enzyme
Reference proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmelanosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfatty acid synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›64›64Fatty acid synthase
PRO_0000180278

Regions

Domain5 – 6460Acyl carrier

Amino acid modifications

Modified residue381O-(pantetheine 4'-phosphoryl)serine Ref.1

Experimental info

Non-terminal residue11
Non-terminal residue641

Sequences

Sequence LengthMass (Da)Tools
P07855 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 7CECE99D8A76B42D

FASTA647,037
        10         20         30         40         50         60 
AEGEGQRDLL KAVAHILGIR DLAGINLDSS LADLGLDSLM GVEVRQTLER EHDLVLSMRE 


VRQL 

« Hide

References

[1]"The multifunctional polypeptide chain of rabbit mammary fatty acid synthase contains a domain homologous with the acyl carrier protein of Escherichia coli."
McCarthy A.D., Aitken A., Hardie D.G.
Eur. J. Biochem. 136:501-508(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, PHOSPHOPANTETHEINYLATION AT SER-38.

Cross-references

Sequence databases

PIRS07221.

3D structure databases

ProteinModelPortalP07855.
SMRP07855. Positions 1-64.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.1200.10. 1 hit.
InterProIPR009081. Acyl_carrier_prot-like.
IPR006162. PPantetheine_attach_site.
[Graphical view]
PfamPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMSSF47336. SSF47336. 1 hit.
PROSITEPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFAS_RABIT
AccessionPrimary (citable) accession number: P07855
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families