Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P07850

- SUOX_CHICK

UniProt

P07850 - SUOX_CHICK

Protein

Sulfite oxidase

Gene

SUOX

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (22 Feb 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Sulfite + O2 + H2O = sulfate + H2O2.

    Cofactori

    Binds 1 heme B (iron-protoporphyrin IX) group non-covalently per subunit.1 Publication
    Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi40 – 401Iron (heme axial ligand)
    Metal bindingi65 – 651Iron (heme axial ligand)
    Binding sitei69 – 691Heme b1 Publication
    Metal bindingi185 – 1851Molybdenum
    Binding sitei244 – 2441Molybdopterin
    Binding sitei283 – 2831Molybdopterin
    Binding sitei288 – 2881Molybdopterin

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. heme binding Source: InterPro
    3. molybdenum ion binding Source: InterPro
    4. molybdopterin cofactor binding Source: InterPro
    5. sulfite oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sulfur compound metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, Molybdenum

    Enzyme and pathway databases

    UniPathwayiUPA00096.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfite oxidase (EC:1.8.3.1)
    Gene namesi
    Name:SUOX
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 459459Sulfite oxidasePRO_0000166076Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Structurei

    Secondary structure

    1
    459
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 124
    Turni18 – 203
    Beta strandi21 – 266
    Beta strandi29 – 324
    Turni34 – 396
    Helixi44 – 474
    Helixi48 – 503
    Beta strandi53 – 553
    Helixi56 – 616
    Helixi63 – 664
    Helixi68 – 758
    Beta strandi78 – 825
    Beta strandi92 – 943
    Turni96 – 994
    Beta strandi107 – 1115
    Turni112 – 1154
    Beta strandi116 – 1183
    Helixi121 – 1244
    Beta strandi126 – 1294
    Turni132 – 1343
    Turni148 – 1503
    Beta strandi152 – 1565
    Turni158 – 1603
    Beta strandi163 – 1664
    Helixi167 – 1737
    Beta strandi177 – 1848
    Turni186 – 1894
    Helixi190 – 1945
    Beta strandi208 – 21811
    Helixi219 – 2257
    Beta strandi237 – 2459
    Beta strandi251 – 2577
    Helixi258 – 2625
    Helixi264 – 2663
    Beta strandi269 – 2746
    Helixi281 – 2833
    Turni284 – 2863
    Beta strandi288 – 2903
    Helixi296 – 2983
    Beta strandi301 – 31111
    Helixi316 – 3194
    Beta strandi320 – 3223
    Turni331 – 3333
    Helixi336 – 3383
    Beta strandi348 – 3547
    Beta strandi362 – 37211
    Beta strandi379 – 39113
    Beta strandi396 – 3983
    Beta strandi411 – 4199
    Beta strandi424 – 43310
    Helixi444 – 4463

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SOXX-ray1.90A/B1-459[»]
    2A99X-ray2.20A95-459[»]
    2A9AX-ray2.00A/B95-459[»]
    2A9BX-ray2.50A95-459[»]
    2A9CX-ray2.50A/B95-459[»]
    2A9DX-ray1.70A/B95-459[»]
    3HBGX-ray1.90A1-459[»]
    3HBPX-ray2.40A1-459[»]
    3HBQX-ray2.80A1-459[»]
    3R18X-ray2.40A1-459[»]
    3R19X-ray2.10A1-459[»]
    ProteinModelPortaliP07850.
    SMRiP07850. Positions 3-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07850.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 8380Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni86 – 9510Hinge
    Regioni96 – 323228Moco domainAdd
    BLAST
    Regioni136 – 1405Molybdopterin-binding
    Regioni299 – 3013Molybdopterin-binding
    Regioni324 – 459136HomodimerizationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG017865.
    PhylomeDBiP07850.

    Family and domain databases

    Gene3Di2.60.40.650. 1 hit.
    3.10.120.10. 1 hit.
    3.90.420.10. 1 hit.
    InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
    IPR018506. Cyt_B5_heme-BS.
    IPR014756. Ig_E-set.
    IPR005066. MoCF_OxRdtse_dimer.
    IPR008335. Mopterin_OxRdtase_euk.
    IPR000572. OxRdtase_Mopterin-bd_dom.
    IPR022407. OxRdtase_Mopterin_BS.
    [Graphical view]
    PfamiPF00173. Cyt-b5. 1 hit.
    PF03404. Mo-co_dimer. 1 hit.
    PF00174. Oxidored_molyb. 1 hit.
    [Graphical view]
    PRINTSiPR00363. CYTOCHROMEB5.
    PR00407. EUMOPTERIN.
    SUPFAMiSSF55856. SSF55856. 1 hit.
    SSF56524. SSF56524. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
    PS50255. CYTOCHROME_B5_2. 1 hit.
    PS00559. MOLYBDOPTERIN_EUK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P07850-1 [UniParc]FASTAAdd to Basket

    « Hide

    APSYPRYTRE EVGRHRSPEE RVWVTHGTDV FDVTDFVELH PGGPDKILLA    50
    AGGALEPFWA LYAVHGEPHV LELLQQYKVG ELSPDEAPAA PDAQDPFAGD 100
    PPRHPGLRVN SQKPFNAEPP AELLAERFLT PNELFFTRNH LPVPAVEPSS 150
    YRLRVDGPGG RTLSLSLAEL RSRFPKHEVT ATLQCAGNRR SEMSRVRPVK 200
    GLPWDIGAIS TARWGGASLR DVLLHAGFPE ELQGGEHVCF EGLDADPGGA 250
    PYGASIPYGR ALSPAADVLL AYEMNGTELP RDHRFPVRVV VPGVVGARSV 300
    KWLRRVAVSP DESPSRWQQN DYKGFSPCVD WDTVDYRTAP AIQELPVQSA 350
    VTQPRPGAAV PPGELTVKGY AWSGGGREVV RVDVSLDGGR TWKVARLMGD 400
    KAPPGRAWAW ALWELTVPVE AGTELEIVCK AVDSSYNVQP DSVAPIWNLR 450
    GVLSTAWHR 459
    Length:459
    Mass (Da):50,205
    Last modified:February 22, 2003 - v3
    Checksum:i7AA222AD7E4E77F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521R → RR AA sequence (PubMed:2687265)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52559 mRNA. Translation: CAA36793.1.
    PIRiA34180.
    UniGeneiGga.741.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52559 mRNA. Translation: CAA36793.1 .
    PIRi A34180.
    UniGenei Gga.741.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SOX X-ray 1.90 A/B 1-459 [» ]
    2A99 X-ray 2.20 A 95-459 [» ]
    2A9A X-ray 2.00 A/B 95-459 [» ]
    2A9B X-ray 2.50 A 95-459 [» ]
    2A9C X-ray 2.50 A/B 95-459 [» ]
    2A9D X-ray 1.70 A/B 95-459 [» ]
    3HBG X-ray 1.90 A 1-459 [» ]
    3HBP X-ray 2.40 A 1-459 [» ]
    3HBQ X-ray 2.80 A 1-459 [» ]
    3R18 X-ray 2.40 A 1-459 [» ]
    3R19 X-ray 2.10 A 1-459 [» ]
    ProteinModelPortali P07850.
    SMRi P07850. Positions 3-459.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG017865.
    PhylomeDBi P07850.

    Enzyme and pathway databases

    UniPathwayi UPA00096 .

    Miscellaneous databases

    EvolutionaryTracei P07850.

    Family and domain databases

    Gene3Di 2.60.40.650. 1 hit.
    3.10.120.10. 1 hit.
    3.90.420.10. 1 hit.
    InterProi IPR001199. Cyt_B5-like_heme/steroid-bd.
    IPR018506. Cyt_B5_heme-BS.
    IPR014756. Ig_E-set.
    IPR005066. MoCF_OxRdtse_dimer.
    IPR008335. Mopterin_OxRdtase_euk.
    IPR000572. OxRdtase_Mopterin-bd_dom.
    IPR022407. OxRdtase_Mopterin_BS.
    [Graphical view ]
    Pfami PF00173. Cyt-b5. 1 hit.
    PF03404. Mo-co_dimer. 1 hit.
    PF00174. Oxidored_molyb. 1 hit.
    [Graphical view ]
    PRINTSi PR00363. CYTOCHROMEB5.
    PR00407. EUMOPTERIN.
    SUPFAMi SSF55856. SSF55856. 1 hit.
    SSF56524. SSF56524. 1 hit.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00191. CYTOCHROME_B5_1. 1 hit.
    PS50255. CYTOCHROME_B5_2. 1 hit.
    PS00559. MOLYBDOPTERIN_EUK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conserved domains in molybdenum hydroxylases. The amino acid sequence of chicken hepatic sulfite oxidase."
      Neame P.J., Barber M.J.
      J. Biol. Chem. 264:20894-20901(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Liver.
    2. "Amino acid sequence of the 'b5-like' heme-binding domain from chicken sulfite oxidase."
      Guiard B., Lederer F.
      Eur. J. Biochem. 100:441-453(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-97.
      Tissue: Liver.
    3. Binder C.M., Irminger J.C., Jaussi R.
      Submitted (MAR-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-96.
      Strain: White leghorn.
      Tissue: Liver.
    4. "Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase."
      Kisker C., Schindelin H., Pacheco A., Wehbi W.A., Garrett R.M., Rajagopalan K.V., Enemark J.H., Rees D.C.
      Cell 91:973-983(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 152, X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH HEME AND MO-MOLYBDOPTERIN, COFACTOR.
      Tissue: Liver.

    Entry informationi

    Entry nameiSUOX_CHICK
    AccessioniPrimary (citable) accession number: P07850
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: February 22, 2003
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3