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Protein

Sulfite oxidase

Gene

SUOX

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Sulfite + O2 + H2O = sulfate + H2O2.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: sulfur metabolism

This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Iron (heme axial ligand)1
Metal bindingi65Iron (heme axial ligand)1
Binding sitei69Heme b1 Publication1
Metal bindingi185Molybdenum1
Binding sitei244Molybdopterin1
Binding sitei283Molybdopterin1
Binding sitei288Molybdopterin1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, Molybdenum

Enzyme and pathway databases

BRENDAi1.8.2.1. 1306.
1.8.3.1. 1306.
UniPathwayiUPA00096.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite oxidase (EC:1.8.3.1)
Gene namesi
Name:SUOX
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660761 – 459Sulfite oxidaseAdd BLAST459

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1459
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 12Combined sources4
Turni18 – 20Combined sources3
Beta strandi21 – 26Combined sources6
Beta strandi29 – 32Combined sources4
Turni34 – 39Combined sources6
Helixi44 – 47Combined sources4
Helixi48 – 50Combined sources3
Beta strandi53 – 55Combined sources3
Helixi56 – 61Combined sources6
Helixi63 – 66Combined sources4
Helixi68 – 75Combined sources8
Beta strandi78 – 82Combined sources5
Beta strandi92 – 94Combined sources3
Turni96 – 99Combined sources4
Beta strandi107 – 111Combined sources5
Turni112 – 115Combined sources4
Beta strandi116 – 118Combined sources3
Helixi121 – 124Combined sources4
Beta strandi126 – 129Combined sources4
Turni132 – 134Combined sources3
Turni148 – 150Combined sources3
Beta strandi152 – 156Combined sources5
Turni158 – 160Combined sources3
Beta strandi163 – 166Combined sources4
Helixi167 – 173Combined sources7
Beta strandi177 – 184Combined sources8
Turni186 – 189Combined sources4
Helixi190 – 194Combined sources5
Beta strandi208 – 218Combined sources11
Helixi219 – 225Combined sources7
Beta strandi237 – 245Combined sources9
Beta strandi251 – 257Combined sources7
Helixi258 – 262Combined sources5
Helixi264 – 266Combined sources3
Beta strandi269 – 274Combined sources6
Helixi281 – 283Combined sources3
Turni284 – 286Combined sources3
Beta strandi288 – 290Combined sources3
Helixi296 – 298Combined sources3
Beta strandi301 – 311Combined sources11
Helixi316 – 319Combined sources4
Beta strandi320 – 322Combined sources3
Turni331 – 333Combined sources3
Helixi336 – 338Combined sources3
Beta strandi348 – 354Combined sources7
Beta strandi362 – 372Combined sources11
Beta strandi379 – 391Combined sources13
Beta strandi396 – 398Combined sources3
Beta strandi411 – 419Combined sources9
Beta strandi424 – 433Combined sources10
Helixi444 – 446Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SOXX-ray1.90A/B1-459[»]
2A99X-ray2.20A95-459[»]
2A9AX-ray2.00A/B95-459[»]
2A9BX-ray2.50A95-459[»]
2A9CX-ray2.50A/B95-459[»]
2A9DX-ray1.70A/B95-459[»]
3HBGX-ray1.90A1-459[»]
3HBPX-ray2.40A1-459[»]
3HBQX-ray2.80A1-459[»]
3R18X-ray2.40A1-459[»]
3R19X-ray2.10A1-459[»]
ProteinModelPortaliP07850.
SMRiP07850.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07850.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 83Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 95Hinge10
Regioni96 – 323Moco domainAdd BLAST228
Regioni136 – 140Molybdopterin-binding5
Regioni299 – 301Molybdopterin-binding3
Regioni324 – 459HomodimerizationAdd BLAST136

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG017865.
InParanoidiP07850.
PhylomeDBiP07850.

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSiPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
APSYPRYTRE EVGRHRSPEE RVWVTHGTDV FDVTDFVELH PGGPDKILLA
60 70 80 90 100
AGGALEPFWA LYAVHGEPHV LELLQQYKVG ELSPDEAPAA PDAQDPFAGD
110 120 130 140 150
PPRHPGLRVN SQKPFNAEPP AELLAERFLT PNELFFTRNH LPVPAVEPSS
160 170 180 190 200
YRLRVDGPGG RTLSLSLAEL RSRFPKHEVT ATLQCAGNRR SEMSRVRPVK
210 220 230 240 250
GLPWDIGAIS TARWGGASLR DVLLHAGFPE ELQGGEHVCF EGLDADPGGA
260 270 280 290 300
PYGASIPYGR ALSPAADVLL AYEMNGTELP RDHRFPVRVV VPGVVGARSV
310 320 330 340 350
KWLRRVAVSP DESPSRWQQN DYKGFSPCVD WDTVDYRTAP AIQELPVQSA
360 370 380 390 400
VTQPRPGAAV PPGELTVKGY AWSGGGREVV RVDVSLDGGR TWKVARLMGD
410 420 430 440 450
KAPPGRAWAW ALWELTVPVE AGTELEIVCK AVDSSYNVQP DSVAPIWNLR

GVLSTAWHR
Length:459
Mass (Da):50,205
Last modified:February 22, 2003 - v3
Checksum:i7AA222AD7E4E77F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152R → RR AA sequence (PubMed:2687265).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52559 mRNA. Translation: CAA36793.1.
PIRiA34180.
UniGeneiGga.741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52559 mRNA. Translation: CAA36793.1.
PIRiA34180.
UniGeneiGga.741.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SOXX-ray1.90A/B1-459[»]
2A99X-ray2.20A95-459[»]
2A9AX-ray2.00A/B95-459[»]
2A9BX-ray2.50A95-459[»]
2A9CX-ray2.50A/B95-459[»]
2A9DX-ray1.70A/B95-459[»]
3HBGX-ray1.90A1-459[»]
3HBPX-ray2.40A1-459[»]
3HBQX-ray2.80A1-459[»]
3R18X-ray2.40A1-459[»]
3R19X-ray2.10A1-459[»]
ProteinModelPortaliP07850.
SMRiP07850.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG017865.
InParanoidiP07850.
PhylomeDBiP07850.

Enzyme and pathway databases

UniPathwayiUPA00096.
BRENDAi1.8.2.1. 1306.
1.8.3.1. 1306.

Miscellaneous databases

EvolutionaryTraceiP07850.

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSiPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUOX_CHICK
AccessioniPrimary (citable) accession number: P07850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 22, 2003
Last modified: November 2, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.