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P07850 (SUOX_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sulfite oxidase
EC=1.8.3.1
Gene names
Name:SUOX
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Sulfite + O2 + H2O = sulfate + H2O2.

Cofactor

Binds 1 protoheme group.

Molybdenum (molybdopterin).

Pathway

Energy metabolism; sulfur metabolism.

Subunit structure

Homodimer.

Subcellular location

Mitochondrion intermembrane space.

Sequence similarities

Contains 1 cytochrome b5 heme-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459Sulfite oxidase
PRO_0000166076

Regions

Domain4 – 8380Cytochrome b5 heme-binding
Region86 – 10217Hinge
Region103 – 459357Molybdenum-pterin domain
Region136 – 1405Molybdenum-pterin-binding By similarity
Region242 – 2443Molybdenum-pterin-binding By similarity
Region288 – 30114Molybdenum-pterin-binding By similarity

Sites

Metal binding401Iron (heme axial ligand) By similarity
Metal binding651Iron (heme axial ligand) By similarity
Metal binding1851Molybdenum-pterin Ref.4
Metal binding2391Molybdenum-pterin By similarity

Experimental info

Sequence conflict1521R → RR AA sequence Ref.1

Secondary structure

1 ............................................................................................ 459
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P07850 [UniParc].

Last modified February 22, 2003. Version 3.
Checksum: 7AA222AD7E4E77F1

FASTA45950,205
        10         20         30         40         50         60 
APSYPRYTRE EVGRHRSPEE RVWVTHGTDV FDVTDFVELH PGGPDKILLA AGGALEPFWA 

        70         80         90        100        110        120 
LYAVHGEPHV LELLQQYKVG ELSPDEAPAA PDAQDPFAGD PPRHPGLRVN SQKPFNAEPP 

       130        140        150        160        170        180 
AELLAERFLT PNELFFTRNH LPVPAVEPSS YRLRVDGPGG RTLSLSLAEL RSRFPKHEVT 

       190        200        210        220        230        240 
ATLQCAGNRR SEMSRVRPVK GLPWDIGAIS TARWGGASLR DVLLHAGFPE ELQGGEHVCF 

       250        260        270        280        290        300 
EGLDADPGGA PYGASIPYGR ALSPAADVLL AYEMNGTELP RDHRFPVRVV VPGVVGARSV 

       310        320        330        340        350        360 
KWLRRVAVSP DESPSRWQQN DYKGFSPCVD WDTVDYRTAP AIQELPVQSA VTQPRPGAAV 

       370        380        390        400        410        420 
PPGELTVKGY AWSGGGREVV RVDVSLDGGR TWKVARLMGD KAPPGRAWAW ALWELTVPVE 

       430        440        450 
AGTELEIVCK AVDSSYNVQP DSVAPIWNLR GVLSTAWHR

« Hide

References

[1]"Conserved domains in molybdenum hydroxylases. The amino acid sequence of chicken hepatic sulfite oxidase."
Neame P.J., Barber M.J.
J. Biol. Chem. 264:20894-20901(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Liver.
[2]"Amino acid sequence of the 'b5-like' heme-binding domain from chicken sulfite oxidase."
Guiard B., Lederer F.
Eur. J. Biochem. 100:441-453(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-97.
Tissue: Liver.
[3]Binder C.M., Irminger J.C., Jaussi R.
Submitted (MAR-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-96.
Strain: White leghorn.
Tissue: Liver.
[4]"Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase."
Kisker C., Schindelin H., Pacheco A., Wehbi W.A., Garrett R.M., Rajagopalan K.V., Enemark J.H., Rees D.C.
Cell 91:973-983(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS), SEQUENCE REVISION TO 152.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X52559 mRNA. Translation: CAA36793.1.
IPIIPI00572263.
PIRA34180.
UniGeneGga.741.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SOXX-ray1.90A/B1-459[»]
2A99X-ray2.20A95-459[»]
2A9AX-ray2.00A/B95-459[»]
2A9BX-ray2.50A95-459[»]
2A9CX-ray2.50A/B95-459[»]
2A9DX-ray1.70A/B95-459[»]
3HBGX-ray1.90A1-459[»]
3HBPX-ray2.40A1-459[»]
3HBQX-ray2.80A1-459[»]
3R18X-ray2.40A1-459[»]
3R19X-ray2.10A1-459[»]
ProteinModelPortalP07850.
SMRP07850. Positions 3-459.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG017865.

Enzyme and pathway databases

UniPathwayUPA00096.

Family and domain databases

Gene3D2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SUPFAMSSF55856. Cyt_B5. 1 hit.
SSF81296. Ig_E-set. 1 hit.
SSF56524. Oxidored_molyb. 1 hit.
PROSITEPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP07850.

Entry information

Entry nameSUOX_CHICK
AccessionPrimary (citable) accession number: P07850
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 22, 2003
Last modified: April 3, 2013
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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