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P07850

- SUOX_CHICK

UniProt

P07850 - SUOX_CHICK

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Protein

Sulfite oxidase

Gene

SUOX

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Sulfite + O2 + H2O = sulfate + H2O2.

Cofactori

Binds 1 heme B (iron-protoporphyrin IX) group non-covalently per subunit.1 Publication
Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi40 – 401Iron (heme axial ligand)
Metal bindingi65 – 651Iron (heme axial ligand)
Binding sitei69 – 691Heme b1 Publication
Metal bindingi185 – 1851Molybdenum
Binding sitei244 – 2441Molybdopterin
Binding sitei283 – 2831Molybdopterin
Binding sitei288 – 2881Molybdopterin

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. molybdenum ion binding Source: InterPro
  4. molybdopterin cofactor binding Source: InterPro
  5. sulfite oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. sulfur compound metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, Molybdenum

Enzyme and pathway databases

UniPathwayiUPA00096.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite oxidase (EC:1.8.3.1)
Gene namesi
Name:SUOX
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Sulfite oxidasePRO_0000166076Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1
459
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 124
Turni18 – 203
Beta strandi21 – 266
Beta strandi29 – 324
Turni34 – 396
Helixi44 – 474
Helixi48 – 503
Beta strandi53 – 553
Helixi56 – 616
Helixi63 – 664
Helixi68 – 758
Beta strandi78 – 825
Beta strandi92 – 943
Turni96 – 994
Beta strandi107 – 1115
Turni112 – 1154
Beta strandi116 – 1183
Helixi121 – 1244
Beta strandi126 – 1294
Turni132 – 1343
Turni148 – 1503
Beta strandi152 – 1565
Turni158 – 1603
Beta strandi163 – 1664
Helixi167 – 1737
Beta strandi177 – 1848
Turni186 – 1894
Helixi190 – 1945
Beta strandi208 – 21811
Helixi219 – 2257
Beta strandi237 – 2459
Beta strandi251 – 2577
Helixi258 – 2625
Helixi264 – 2663
Beta strandi269 – 2746
Helixi281 – 2833
Turni284 – 2863
Beta strandi288 – 2903
Helixi296 – 2983
Beta strandi301 – 31111
Helixi316 – 3194
Beta strandi320 – 3223
Turni331 – 3333
Helixi336 – 3383
Beta strandi348 – 3547
Beta strandi362 – 37211
Beta strandi379 – 39113
Beta strandi396 – 3983
Beta strandi411 – 4199
Beta strandi424 – 43310
Helixi444 – 4463

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SOXX-ray1.90A/B1-459[»]
2A99X-ray2.20A95-459[»]
2A9AX-ray2.00A/B95-459[»]
2A9BX-ray2.50A95-459[»]
2A9CX-ray2.50A/B95-459[»]
2A9DX-ray1.70A/B95-459[»]
3HBGX-ray1.90A1-459[»]
3HBPX-ray2.40A1-459[»]
3HBQX-ray2.80A1-459[»]
3R18X-ray2.40A1-459[»]
3R19X-ray2.10A1-459[»]
ProteinModelPortaliP07850.
SMRiP07850. Positions 3-459.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07850.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8380Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 9510Hinge
Regioni96 – 323228Moco domainAdd
BLAST
Regioni136 – 1405Molybdopterin-binding
Regioni299 – 3013Molybdopterin-binding
Regioni324 – 459136HomodimerizationAdd
BLAST

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG017865.
InParanoidiP07850.
PhylomeDBiP07850.

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PRINTSiPR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07850-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
APSYPRYTRE EVGRHRSPEE RVWVTHGTDV FDVTDFVELH PGGPDKILLA
60 70 80 90 100
AGGALEPFWA LYAVHGEPHV LELLQQYKVG ELSPDEAPAA PDAQDPFAGD
110 120 130 140 150
PPRHPGLRVN SQKPFNAEPP AELLAERFLT PNELFFTRNH LPVPAVEPSS
160 170 180 190 200
YRLRVDGPGG RTLSLSLAEL RSRFPKHEVT ATLQCAGNRR SEMSRVRPVK
210 220 230 240 250
GLPWDIGAIS TARWGGASLR DVLLHAGFPE ELQGGEHVCF EGLDADPGGA
260 270 280 290 300
PYGASIPYGR ALSPAADVLL AYEMNGTELP RDHRFPVRVV VPGVVGARSV
310 320 330 340 350
KWLRRVAVSP DESPSRWQQN DYKGFSPCVD WDTVDYRTAP AIQELPVQSA
360 370 380 390 400
VTQPRPGAAV PPGELTVKGY AWSGGGREVV RVDVSLDGGR TWKVARLMGD
410 420 430 440 450
KAPPGRAWAW ALWELTVPVE AGTELEIVCK AVDSSYNVQP DSVAPIWNLR

GVLSTAWHR
Length:459
Mass (Da):50,205
Last modified:February 22, 2003 - v3
Checksum:i7AA222AD7E4E77F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521R → RR AA sequence (PubMed:2687265)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52559 mRNA. Translation: CAA36793.1.
PIRiA34180.
UniGeneiGga.741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52559 mRNA. Translation: CAA36793.1 .
PIRi A34180.
UniGenei Gga.741.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SOX X-ray 1.90 A/B 1-459 [» ]
2A99 X-ray 2.20 A 95-459 [» ]
2A9A X-ray 2.00 A/B 95-459 [» ]
2A9B X-ray 2.50 A 95-459 [» ]
2A9C X-ray 2.50 A/B 95-459 [» ]
2A9D X-ray 1.70 A/B 95-459 [» ]
3HBG X-ray 1.90 A 1-459 [» ]
3HBP X-ray 2.40 A 1-459 [» ]
3HBQ X-ray 2.80 A 1-459 [» ]
3R18 X-ray 2.40 A 1-459 [» ]
3R19 X-ray 2.10 A 1-459 [» ]
ProteinModelPortali P07850.
SMRi P07850. Positions 3-459.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG017865.
InParanoidi P07850.
PhylomeDBi P07850.

Enzyme and pathway databases

UniPathwayi UPA00096 .

Miscellaneous databases

EvolutionaryTracei P07850.

Family and domain databases

Gene3Di 2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProi IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
[Graphical view ]
Pfami PF00173. Cyt-b5. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view ]
PRINTSi PR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
SUPFAMi SSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conserved domains in molybdenum hydroxylases. The amino acid sequence of chicken hepatic sulfite oxidase."
    Neame P.J., Barber M.J.
    J. Biol. Chem. 264:20894-20901(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Liver.
  2. "Amino acid sequence of the 'b5-like' heme-binding domain from chicken sulfite oxidase."
    Guiard B., Lederer F.
    Eur. J. Biochem. 100:441-453(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-97.
    Tissue: Liver.
  3. Binder C.M., Irminger J.C., Jaussi R.
    Submitted (MAR-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-96.
    Strain: White leghorn.
    Tissue: Liver.
  4. "Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase."
    Kisker C., Schindelin H., Pacheco A., Wehbi W.A., Garrett R.M., Rajagopalan K.V., Enemark J.H., Rees D.C.
    Cell 91:973-983(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 152, X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH HEME AND MO-MOLYBDOPTERIN, COFACTOR.
    Tissue: Liver.

Entry informationi

Entry nameiSUOX_CHICK
AccessioniPrimary (citable) accession number: P07850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 22, 2003
Last modified: October 29, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3