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Protein

Sorbitol dehydrogenase

Gene

SORD

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.By similarity

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43Zinc; catalytic1 Publication1
Binding sitei49Substrate1 Publication1
Metal bindingi67Zinc; catalytic1 Publication1
Metal bindingi68Zinc; catalytic1 Publication1
Binding sitei153Substrate1 Publication1
Binding sitei296Substrate1 Publication1
Binding sitei297Substrate1 Publication1

GO - Molecular functioni

  • L-iditol 2-dehydrogenase activity Source: UniProtKB
  • NAD binding Source: AgBase
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • flagellated sperm motility Source: UniProtKB
  • fructose biosynthetic process Source: AgBase
  • sorbitol catabolic process Source: AgBase

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

SABIO-RKiP07846

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase (EC:1.1.1.14)
Alternative name(s):
L-iditol 2-dehydrogenase
Gene namesi
Name:SORD
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075154

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001608191 – 354Sorbitol dehydrogenaseAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208PhosphoserineBy similarity1
Modified residuei222PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP07846

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

Secondary structure

1354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 14Combined sources7
Beta strandi17 – 22Combined sources6
Beta strandi32 – 42Combined sources11
Helixi44 – 51Combined sources8
Beta strandi52 – 54Combined sources3
Beta strandi68 – 76Combined sources9
Beta strandi88 – 91Combined sources4
Beta strandi93 – 95Combined sources3
Helixi101 – 104Combined sources4
Helixi108 – 110Combined sources3
Beta strandi127 – 133Combined sources7
Helixi134 – 136Combined sources3
Beta strandi137 – 139Combined sources3
Helixi146 – 165Combined sources20
Beta strandi172 – 176Combined sources5
Helixi180 – 191Combined sources12
Beta strandi195 – 202Combined sources8
Helixi204 – 213Combined sources10
Beta strandi216 – 220Combined sources5
Helixi226 – 237Combined sources12
Beta strandi242 – 246Combined sources5
Helixi251 – 260Combined sources10
Beta strandi266 – 269Combined sources4
Helixi281 – 286Combined sources6
Beta strandi290 – 293Combined sources4
Helixi301 – 309Combined sources9
Helixi316 – 318Combined sources3
Beta strandi319 – 324Combined sources6
Helixi325 – 327Combined sources3
Helixi328 – 337Combined sources10
Beta strandi339 – 346Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SDGmodel-A1-347[»]
3QE3X-ray1.90A1-354[»]
ProteinModelPortaliP07846
SMRiP07846
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07846

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005484

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P07846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKPAAENLSL VVHGPGDLRL ENYPIPEPGP NEVLLKMHSV GICGSDVHYW
60 70 80 90 100
QGRIGDFVVK KPMVLGHEAS GTVVKVGSLV RHLQPGDRVA IQPGAPRQTD
110 120 130 140 150
EFCKIGRYNL SPTIFFCATP PDDGNLCRFY KHNANFCYKL PDNVTFEEGA
160 170 180 190 200
LIEPLSVGIH ACRRAGVTLG NKVLVCGAGP IGLVNLLAAK AMGAAQVVVT
210 220 230 240 250
DLSASRLSKA KEVGADFILE ISNESPEEIA KKVEGLLGSK PEVTIECTGV
260 270 280 290 300
ETSIQAGIYA THSGGTLVLV GLGSEMTSVP LVHAATREVD IKGVFRYCNT
310 320 330 340 350
WPMAISMLAS KSVNVKPLVT HRFPLEKALE AFETSKKGLG LKVMIKCDPS

DQNP
Length:354
Mass (Da):37,831
Last modified:August 1, 1988 - v1
Checksum:iD5FE56BC06F87389
GO

Sequence databases

PIRiS10065

Similar proteinsi

Entry informationi

Entry nameiDHSO_SHEEP
AccessioniPrimary (citable) accession number: P07846
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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