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Protein

Sorbitol dehydrogenase

Gene

SORD

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.By similarity

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43Zinc; catalytic1 Publication1
Binding sitei49Substrate1 Publication1
Metal bindingi67Zinc; catalytic1 Publication1
Metal bindingi68Zinc; catalytic1 Publication1
Binding sitei153Substrate1 Publication1
Binding sitei296Substrate1 Publication1
Binding sitei297Substrate1 Publication1

GO - Molecular functioni

  • L-iditol 2-dehydrogenase activity Source: UniProtKB
  • NAD binding Source: AgBase
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • flagellated sperm motility Source: UniProtKB
  • fructose biosynthetic process Source: AgBase
  • sorbitol catabolic process Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

SABIO-RKP07846.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase (EC:1.1.1.14)
Alternative name(s):
L-iditol 2-dehydrogenase
Gene namesi
Name:SORD
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

  • Mitochondrion membrane By similarity; Peripheral membrane protein By similarity
  • Cell projectionciliumflagellum By similarity

  • Note: Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.By similarity

GO - Cellular componenti

  • macromolecular complex Source: AgBase
  • mitochondrial membrane Source: UniProtKB-SubCell
  • motile cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075154.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001608191 – 354Sorbitol dehydrogenaseAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei208PhosphoserineBy similarity1
Modified residuei222PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP07846.

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

Secondary structure

1354
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 14Combined sources7
Beta strandi17 – 22Combined sources6
Beta strandi32 – 42Combined sources11
Helixi44 – 51Combined sources8
Beta strandi52 – 54Combined sources3
Beta strandi68 – 76Combined sources9
Beta strandi88 – 91Combined sources4
Beta strandi93 – 95Combined sources3
Helixi101 – 104Combined sources4
Helixi108 – 110Combined sources3
Beta strandi127 – 133Combined sources7
Helixi134 – 136Combined sources3
Beta strandi137 – 139Combined sources3
Helixi146 – 165Combined sources20
Beta strandi172 – 176Combined sources5
Helixi180 – 191Combined sources12
Beta strandi195 – 202Combined sources8
Helixi204 – 213Combined sources10
Beta strandi216 – 220Combined sources5
Helixi226 – 237Combined sources12
Beta strandi242 – 246Combined sources5
Helixi251 – 260Combined sources10
Beta strandi266 – 269Combined sources4
Helixi281 – 286Combined sources6
Beta strandi290 – 293Combined sources4
Helixi301 – 309Combined sources9
Helixi316 – 318Combined sources3
Beta strandi319 – 324Combined sources6
Helixi325 – 327Combined sources3
Helixi328 – 337Combined sources10
Beta strandi339 – 346Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SDGmodel-A1-347[»]
3QE3X-ray1.90A1-354[»]
ProteinModelPortaliP07846.
SMRiP07846.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07846.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005484.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKPAAENLSL VVHGPGDLRL ENYPIPEPGP NEVLLKMHSV GICGSDVHYW
60 70 80 90 100
QGRIGDFVVK KPMVLGHEAS GTVVKVGSLV RHLQPGDRVA IQPGAPRQTD
110 120 130 140 150
EFCKIGRYNL SPTIFFCATP PDDGNLCRFY KHNANFCYKL PDNVTFEEGA
160 170 180 190 200
LIEPLSVGIH ACRRAGVTLG NKVLVCGAGP IGLVNLLAAK AMGAAQVVVT
210 220 230 240 250
DLSASRLSKA KEVGADFILE ISNESPEEIA KKVEGLLGSK PEVTIECTGV
260 270 280 290 300
ETSIQAGIYA THSGGTLVLV GLGSEMTSVP LVHAATREVD IKGVFRYCNT
310 320 330 340 350
WPMAISMLAS KSVNVKPLVT HRFPLEKALE AFETSKKGLG LKVMIKCDPS

DQNP
Length:354
Mass (Da):37,831
Last modified:August 1, 1988 - v1
Checksum:iD5FE56BC06F87389
GO

Sequence databases

PIRiS10065.

Cross-referencesi

Sequence databases

PIRiS10065.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SDGmodel-A1-347[»]
3QE3X-ray1.90A1-354[»]
ProteinModelPortaliP07846.
SMRiP07846.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL1075154.

Proteomic databases

PRIDEiP07846.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005484.

Enzyme and pathway databases

SABIO-RKP07846.

Miscellaneous databases

EvolutionaryTraceiP07846.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHSO_SHEEP
AccessioniPrimary (citable) accession number: P07846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.