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Protein

Major actin

Gene

act1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • myosin binding Source: dictyBase
  • structural constituent of cytoskeleton Source: dictyBase

GO - Biological processi

  • cell morphogenesis Source: dictyBase
  • chemotaxis Source: dictyBase
  • endocytosis Source: dictyBase
  • hyperosmotic response Source: dictyBase
  • mitotic cytokinesis Source: dictyBase
  • phagocytosis Source: dictyBase
  • phototaxis Source: dictyBase
  • vesicle-mediated transport Source: dictyBase
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Major actin
Alternative name(s):
Actin A1
Actin A12
Actin A8
Actin III
Actin M6
Actin-1
Actin-11
Actin-12
Actin-13
Actin-14
Actin-15
Actin-16
Actin-19
Actin-2
Actin-2-sub 1
Actin-20
Actin-21
Actin-3a
Actin-4
Actin-5
Actin-6
Actin-7
Actin-8
Actin-9
Actin-IEL1
Gene namesi
Name:act1
Synonyms:act1a
ORF Names:DDB_G0289553
AND
Name:act2
Synonyms:act2-1
ORF Names:DDB_G0274133
AND
Name:act4
ORF Names:DDB_G0289005
AND
Name:act5
ORF Names:DDB_G0289663
AND
Name:act6
ORF Names:DDB_G0274135
AND
Name:act7
ORF Names:DDB_G0280545
AND
Name:act8
Synonyms:actA8
ORF Names:DDB_G0269234
AND
Name:act9
ORF Names:DDB_G0274601
AND
Name:act11
ORF Names:DDB_G0288879
AND
Name:act12
ORF Names:DDB_G0274129
AND
Name:act13
ORF Names:DDB_G0274599
AND
Name:act14
Synonyms:actB1
ORF Names:DDB_G0274137
AND
Name:act15
Synonyms:actA1
ORF Names:DDB_G0272520
AND
Name:act16
Synonyms:actM6
ORF Names:DDB_G0272248
AND
Name:act19
ORF Names:DDB_G0274727
AND
Name:act20
ORF Names:DDB_G0274285
AND
Name:act21
ORF Names:DDB_G0274561
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Chromosome 2, Chromosome 3, Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289553. act1.
DDB_G0288879. act11.
DDB_G0274129. act12.
DDB_G0274599. act13.
DDB_G0274137. act14.
DDB_G0272520. act15.
DDB_G0272248. act16.
DDB_G0274727. act19.
DDB_G0274133. act2.
DDB_G0274285. act20.
DDB_G0274561. act21.
DDB_G0289005. act4.
DDB_G0289663. act5.
DDB_G0274135. act6.
DDB_G0280545. act7.
DDB_G0269234. act8.
DDB_G0274601. act9.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: dictyBase
  • actin filament Source: dictyBase
  • cell leading edge Source: dictyBase
  • cell pole Source: dictyBase
  • cortical actin cytoskeleton Source: dictyBase
  • early phagosome Source: dictyBase
  • phagocytic cup Source: dictyBase
  • phagocytic vesicle Source: dictyBase
  • phagolysosome Source: dictyBase
  • pseudopodium Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 376375Major actinPRO_0000088926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP07830.
PRIDEiP07830.

2D gel databases

SWISS-2DPAGEP07830.

PTM databases

iPTMnetiP07830.

Interactioni

GO - Molecular functioni

  • myosin binding Source: dictyBase

Protein-protein interaction databases

DIPiDIP-40989N.
MINTiMINT-121645.
STRINGi44689.DDB0220456.

Structurei

Secondary structure

1
376
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63Combined sources
Beta strandi9 – 135Combined sources
Beta strandi15 – 228Combined sources
Beta strandi25 – 273Combined sources
Beta strandi29 – 335Combined sources
Beta strandi36 – 405Combined sources
Beta strandi43 – 453Combined sources
Helixi57 – 615Combined sources
Turni62 – 654Combined sources
Beta strandi66 – 694Combined sources
Beta strandi71 – 733Combined sources
Helixi80 – 9213Combined sources
Turni93 – 953Combined sources
Helixi99 – 1013Combined sources
Beta strandi104 – 1085Combined sources
Helixi114 – 12613Combined sources
Beta strandi131 – 1377Combined sources
Helixi138 – 1458Combined sources
Beta strandi149 – 1568Combined sources
Beta strandi161 – 1677Combined sources
Helixi173 – 1753Combined sources
Beta strandi177 – 1804Combined sources
Helixi183 – 19614Combined sources
Helixi204 – 21714Combined sources
Helixi224 – 23310Combined sources
Beta strandi235 – 2373Combined sources
Beta strandi239 – 2424Combined sources
Beta strandi244 – 2463Combined sources
Beta strandi248 – 2514Combined sources
Helixi254 – 26310Combined sources
Helixi265 – 2684Combined sources
Helixi275 – 28410Combined sources
Helixi288 – 2903Combined sources
Helixi291 – 2955Combined sources
Beta strandi298 – 3025Combined sources
Helixi303 – 3053Combined sources
Helixi310 – 32112Combined sources
Helixi336 – 3383Combined sources
Helixi339 – 34911Combined sources
Helixi353 – 3553Combined sources
Beta strandi357 – 3593Combined sources
Helixi360 – 3667Combined sources
Helixi368 – 3703Combined sources
Helixi371 – 3744Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C0FX-ray2.40A2-376[»]
1C0GX-ray2.00A2-376[»]
1DEJX-ray2.40A2-376[»]
1NLVX-ray1.80A2-376[»]
1NM1X-ray1.80A2-376[»]
1NMDX-ray1.90A2-376[»]
3A5LX-ray2.40C2-376[»]
3A5MX-ray2.40C2-376[»]
3A5NX-ray2.36C2-376[»]
3A5OX-ray2.40C2-376[»]
3CHWX-ray2.30A2-376[»]
3CI5X-ray1.70A2-376[»]
3CIPX-ray1.60A2-376[»]
ProteinModelPortaliP07830.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07830.

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
InParanoidiP07830.
KOiK10355.
OMAiMAENEDI.
PhylomeDBiP07830.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGEDVQALV IDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HTGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVMDSGDGV SHTVPIYEGY ALPHAILRLD LAGRDLTDYM MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLAYV ALDFEAEMQT AASSSALEKS YELPDGQVIT
260 270 280 290 300
IGNERFRCPE ALFQPSFLGM ESAGIHETTY NSIMKCDVDI RKDLYGNVVL
310 320 330 340 350
SGGTTMFPGI ADRMNKELTA LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK EEYDESGPSI VHRKCF
Length:376
Mass (Da):41,733
Last modified:January 23, 2007 - v2
Checksum:i3610737F3B525123
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311V → L in CAA23479 (PubMed:293714).Curated
Sequence conflicti32 – 321F → S in CAA27032 (PubMed:3003365).Curated
Sequence conflicti41 – 411H → Y in CAA23479 (PubMed:293714).Curated
Sequence conflicti57 – 571D → E in CAA27032 (PubMed:3003365).Curated
Sequence conflicti109 – 1091A → G in CAA27032 (PubMed:3003365).Curated
Sequence conflicti140 – 1401V → A in CAA27032 (PubMed:3003365).Curated
Sequence conflicti145 – 1451A → E in AAA74186 (Ref. 5) Curated
Sequence conflicti226 – 2261A → Q AA sequence (PubMed:6892652).Curated
Sequence conflicti228 – 2281M → I in AAA74186 (Ref. 5) Curated
Sequence conflicti229 – 2291Q → A AA sequence (PubMed:6892652).Curated
Sequence conflicti313 – 3131R → G in AAA51619 (PubMed:6276562).Curated
Sequence conflicti313 – 3131R → G in AAA33148 (PubMed:6276562).Curated
Sequence conflicti313 – 3131R → G in AAA33157 (PubMed:6276562).Curated
Sequence conflicti357 – 3571W → L in AAA33152 (PubMed:6276562).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03281 Genomic DNA. Translation: CAA27031.1.
X03282 Genomic DNA. Translation: CAA27032.1.
M14146 Genomic DNA. Translation: AAA33145.1.
AAFI02000005 Genomic DNA. Translation: EAL71967.1.
AAFI02000008 Genomic DNA. Translation: EAL71184.1.
AAFI02000008 Genomic DNA. Translation: EAL71276.1.
AAFI02000012 Genomic DNA. Translation: EAL69957.1.
AAFI02000012 Genomic DNA. Translation: EAL69959.1.
AAFI02000012 Genomic DNA. Translation: EAL69960.1.
AAFI02000012 Genomic DNA. Translation: EAL69961.1.
AAFI02000012 Genomic DNA. Translation: EAL70035.1.
AAFI02000012 Genomic DNA. Translation: EAL70173.1.
AAFI02000012 Genomic DNA. Translation: EAL70192.1.
AAFI02000012 Genomic DNA. Translation: EAL70193.1.
AAFI02000012 Genomic DNA. Translation: EAL70256.1.
AAFI02000037 Genomic DNA. Translation: EAL67074.1.
AAFI02000126 Genomic DNA. Translation: EAL62963.1.
AAFI02000129 Genomic DNA. Translation: EAL62918.1.
AAFI02000142 Genomic DNA. Translation: EAL62666.1.
AAFI02000148 Genomic DNA. Translation: EAL62543.1.
U25660 Genomic DNA. Translation: AAA74186.1.
V00183 Genomic DNA. Translation: CAA23479.1.
V00186 Genomic DNA. Translation: CAA23482.1.
V00188 mRNA. Translation: CAA23484.1.
J01267 Genomic DNA. Translation: AAA33147.1.
J01273 Genomic DNA. Translation: AAA33151.1.
J01274 Genomic DNA. Translation: AAA33153.1.
J01276 Genomic DNA. Translation: AAA51618.1.
J01279 Genomic DNA. Translation: AAA33146.1.
J01265 mRNA. Translation: AAA33158.1.
J01270 mRNA. Translation: AAA33159.1.
J01272 Genomic DNA. Translation: AAA33160.1.
K02954 Genomic DNA. Translation: AAA33148.1.
K02958 Genomic DNA. Translation: AAA33152.1.
K02960 Genomic DNA. Translation: AAA51619.1.
J01278 mRNA. Translation: AAA33157.1.
PIRiA25084.
A39239.
A93223. ATDO.
B23412.
RefSeqiXP_636088.1. XM_630996.1.
XP_636169.1. XM_631077.1.
XP_636425.1. XM_631333.1.
XP_636507.1. XM_631415.1.
XP_641146.1. XM_636054.1.
XP_643986.1. XM_638894.1.
XP_643988.1. XM_638896.1.
XP_643989.1. XM_638897.1.
XP_643990.1. XM_638898.1.
XP_644132.1. XM_639040.1.
XP_644146.1. XM_639054.1.
XP_644157.1. XM_639065.1.
XP_644244.1. XM_639152.1.
XP_644246.1. XM_639154.1.
XP_645099.1. XM_640007.1.
XP_645262.1. XM_640170.1.
XP_646688.1. XM_641596.1.

Genome annotation databases

EnsemblProtistsiDDB0185015; DDB0185015; DDB_G0272520.
DDB0185124; DDB0185124; DDB_G0274133.
DDB0185126; DDB0185126; DDB_G0274135.
DDB0185127; DDB0185127; DDB_G0272248.
DDB0216213; DDB0216213; DDB_G0269234.
DDB0216214; DDB0216214; DDB_G0274129.
DDB0220444; DDB0220444; DDB_G0289553.
DDB0220445; DDB0220445; DDB_G0280545.
DDB0220446; DDB0220446; DDB_G0274727.
DDB0220447; DDB0220447; DDB_G0289663.
DDB0220448; DDB0220448; DDB_G0289005.
DDB0220449; DDB0220449; DDB_G0288879.
DDB0220450; DDB0220450; DDB_G0274285.
DDB0220451; DDB0220451; DDB_G0274561.
DDB0220454; DDB0220454; DDB_G0274599.
DDB0220455; DDB0220455; DDB_G0274137.
DDB0220456; DDB0220456; DDB_G0274601.
GeneIDi8617663.
8618428.
8618493.
8619412.
8619414.
8619415.
8619416.
8619562.
8619575.
8619586.
8619672.
8619674.
8622703.
8626890.
8626916.
8627198.
8627300.
KEGGiddi:DDB_G0269234.
ddi:DDB_G0272248.
ddi:DDB_G0272520.
ddi:DDB_G0274129.
ddi:DDB_G0274133.
ddi:DDB_G0274135.
ddi:DDB_G0274137.
ddi:DDB_G0274285.
ddi:DDB_G0274561.
ddi:DDB_G0274599.
ddi:DDB_G0274601.
ddi:DDB_G0274727.
ddi:DDB_G0280545.
ddi:DDB_G0288879.
ddi:DDB_G0289005.
ddi:DDB_G0289553.
ddi:DDB_G0289663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03281 Genomic DNA. Translation: CAA27031.1.
X03282 Genomic DNA. Translation: CAA27032.1.
M14146 Genomic DNA. Translation: AAA33145.1.
AAFI02000005 Genomic DNA. Translation: EAL71967.1.
AAFI02000008 Genomic DNA. Translation: EAL71184.1.
AAFI02000008 Genomic DNA. Translation: EAL71276.1.
AAFI02000012 Genomic DNA. Translation: EAL69957.1.
AAFI02000012 Genomic DNA. Translation: EAL69959.1.
AAFI02000012 Genomic DNA. Translation: EAL69960.1.
AAFI02000012 Genomic DNA. Translation: EAL69961.1.
AAFI02000012 Genomic DNA. Translation: EAL70035.1.
AAFI02000012 Genomic DNA. Translation: EAL70173.1.
AAFI02000012 Genomic DNA. Translation: EAL70192.1.
AAFI02000012 Genomic DNA. Translation: EAL70193.1.
AAFI02000012 Genomic DNA. Translation: EAL70256.1.
AAFI02000037 Genomic DNA. Translation: EAL67074.1.
AAFI02000126 Genomic DNA. Translation: EAL62963.1.
AAFI02000129 Genomic DNA. Translation: EAL62918.1.
AAFI02000142 Genomic DNA. Translation: EAL62666.1.
AAFI02000148 Genomic DNA. Translation: EAL62543.1.
U25660 Genomic DNA. Translation: AAA74186.1.
V00183 Genomic DNA. Translation: CAA23479.1.
V00186 Genomic DNA. Translation: CAA23482.1.
V00188 mRNA. Translation: CAA23484.1.
J01267 Genomic DNA. Translation: AAA33147.1.
J01273 Genomic DNA. Translation: AAA33151.1.
J01274 Genomic DNA. Translation: AAA33153.1.
J01276 Genomic DNA. Translation: AAA51618.1.
J01279 Genomic DNA. Translation: AAA33146.1.
J01265 mRNA. Translation: AAA33158.1.
J01270 mRNA. Translation: AAA33159.1.
J01272 Genomic DNA. Translation: AAA33160.1.
K02954 Genomic DNA. Translation: AAA33148.1.
K02958 Genomic DNA. Translation: AAA33152.1.
K02960 Genomic DNA. Translation: AAA51619.1.
J01278 mRNA. Translation: AAA33157.1.
PIRiA25084.
A39239.
A93223. ATDO.
B23412.
RefSeqiXP_636088.1. XM_630996.1.
XP_636169.1. XM_631077.1.
XP_636425.1. XM_631333.1.
XP_636507.1. XM_631415.1.
XP_641146.1. XM_636054.1.
XP_643986.1. XM_638894.1.
XP_643988.1. XM_638896.1.
XP_643989.1. XM_638897.1.
XP_643990.1. XM_638898.1.
XP_644132.1. XM_639040.1.
XP_644146.1. XM_639054.1.
XP_644157.1. XM_639065.1.
XP_644244.1. XM_639152.1.
XP_644246.1. XM_639154.1.
XP_645099.1. XM_640007.1.
XP_645262.1. XM_640170.1.
XP_646688.1. XM_641596.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C0FX-ray2.40A2-376[»]
1C0GX-ray2.00A2-376[»]
1DEJX-ray2.40A2-376[»]
1NLVX-ray1.80A2-376[»]
1NM1X-ray1.80A2-376[»]
1NMDX-ray1.90A2-376[»]
3A5LX-ray2.40C2-376[»]
3A5MX-ray2.40C2-376[»]
3A5NX-ray2.36C2-376[»]
3A5OX-ray2.40C2-376[»]
3CHWX-ray2.30A2-376[»]
3CI5X-ray1.70A2-376[»]
3CIPX-ray1.60A2-376[»]
ProteinModelPortaliP07830.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-40989N.
MINTiMINT-121645.
STRINGi44689.DDB0220456.

PTM databases

iPTMnetiP07830.

2D gel databases

SWISS-2DPAGEP07830.

Proteomic databases

PaxDbiP07830.
PRIDEiP07830.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0185015; DDB0185015; DDB_G0272520.
DDB0185124; DDB0185124; DDB_G0274133.
DDB0185126; DDB0185126; DDB_G0274135.
DDB0185127; DDB0185127; DDB_G0272248.
DDB0216213; DDB0216213; DDB_G0269234.
DDB0216214; DDB0216214; DDB_G0274129.
DDB0220444; DDB0220444; DDB_G0289553.
DDB0220445; DDB0220445; DDB_G0280545.
DDB0220446; DDB0220446; DDB_G0274727.
DDB0220447; DDB0220447; DDB_G0289663.
DDB0220448; DDB0220448; DDB_G0289005.
DDB0220449; DDB0220449; DDB_G0288879.
DDB0220450; DDB0220450; DDB_G0274285.
DDB0220451; DDB0220451; DDB_G0274561.
DDB0220454; DDB0220454; DDB_G0274599.
DDB0220455; DDB0220455; DDB_G0274137.
DDB0220456; DDB0220456; DDB_G0274601.
GeneIDi8617663.
8618428.
8618493.
8619412.
8619414.
8619415.
8619416.
8619562.
8619575.
8619586.
8619672.
8619674.
8622703.
8626890.
8626916.
8627198.
8627300.
KEGGiddi:DDB_G0269234.
ddi:DDB_G0272248.
ddi:DDB_G0272520.
ddi:DDB_G0274129.
ddi:DDB_G0274133.
ddi:DDB_G0274135.
ddi:DDB_G0274137.
ddi:DDB_G0274285.
ddi:DDB_G0274561.
ddi:DDB_G0274599.
ddi:DDB_G0274601.
ddi:DDB_G0274727.
ddi:DDB_G0280545.
ddi:DDB_G0288879.
ddi:DDB_G0289005.
ddi:DDB_G0289553.
ddi:DDB_G0289663.

Organism-specific databases

dictyBaseiDDB_G0289553. act1.
DDB_G0288879. act11.
DDB_G0274129. act12.
DDB_G0274599. act13.
DDB_G0274137. act14.
DDB_G0272520. act15.
DDB_G0272248. act16.
DDB_G0274727. act19.
DDB_G0274133. act2.
DDB_G0274285. act20.
DDB_G0274561. act21.
DDB_G0289005. act4.
DDB_G0289663. act5.
DDB_G0274135. act6.
DDB_G0280545. act7.
DDB_G0269234. act8.
DDB_G0274601. act9.

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
InParanoidiP07830.
KOiK10355.
OMAiMAENEDI.
PhylomeDBiP07830.

Miscellaneous databases

EvolutionaryTraceiP07830.
PROiP07830.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the actin multigene family of Dictyostelium discoideum and analysis of variability in the protein coding regions."
    Romans P., Firtel R.A.
    J. Mol. Biol. 186:321-335(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ACT8 AND ACT12).
  2. "Developmental regulation of Dictyostelium discoideum actin gene fusions carried on low-copy and high-copy transformation vectors."
    Knecht D.A., Cohen S.M., Loomis W.F., Lodish H.F.
    Mol. Cell. Biol. 6:3973-3983(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  4. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  5. "A new Dictyostelium discoideum actin gene."
    Zhou S.
    Prog. Inorg. Biochem. Biophys. 15:372-376(1988)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-260 (ACT15).
    Strain: 79A.
  6. "Unusual nucleotide sequences at the 5' end of actin genes in Dictyostelium discoideum."
    Firtel R.A., Timm R., Kimmel A.R., McKeown M.
    Proc. Natl. Acad. Sci. U.S.A. 76:6206-6210(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-68 (ACT2; ACT5; ACT7; ACT14 AND ACT16).
  7. "Differential expression and 5' end mapping of actin genes in Dictyostelium."
    McKeown M., Firtel R.A.
    Cell 24:799-807(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9 (ACT8).
  8. "Cell-type-specific actin mRNA populations in Dictyostelium discoideum."
    Tsang A.S., Mahbubani H.M., Williams J.G.
    Cell 31:375-382(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-9 (ACT4).
  9. "Actin multigene family of Dictyostelium."
    McKeown M., Firtel R.A.
    Cold Spring Harb. Symp. Quant. Biol. 46:495-505(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8 (ACT6 AND ACT8).
  10. "Vegetative Dictyostelium cells containing 17 actin genes express a single major actin."
    Vandekerckhove J., Weber K.
    Nature 284:475-477(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-376.
  11. "Expression of actin in Escherichia coli. Aggregation, solubilization, and functional analysis."
    Frankel S., Condeelis J., Leinwand L.
    J. Biol. Chem. 265:17980-17987(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 120-133.
  12. "Evidence for sub-families of actin genes in Dictyostelium as determined by comparisons of 3' end sequences."
    McKeown M., Firtel R.A.
    J. Mol. Biol. 151:593-606(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 289-376 (ACT2; ACT5; ACT8 AND ACT15).
    Strain: AX3.
  13. "Stress-induced tyrosine phosphorylation of actin in Dictyostelium cells and localization of the phosphorylation site to tyrosine-53 adjacent to the DNase I binding loop."
    Jungbluth A., Eckerskorn C., Gerisch G., Lottspeich F., Stocker S., Schweiger A.
    FEBS Lett. 375:87-90(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-54.
  14. "Structure of gelsolin segment 1-actin complex and the mechanism of filament severing."
    McLaughlin P.J., Gooch J.T., Mannherz H.-G., Weeds A.G.
    Nature 364:685-692(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH GELSOLIN AND ATP.
  15. "The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism."
    Vorobiev S., Strokopytov B., Drubin D.G., Frieden C., Ono S., Condeelis J., Rubenstein P.A., Almo S.C.
    Proc. Natl. Acad. Sci. U.S.A. 100:5760-5765(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH GELSOLIN AND ATP.

Entry informationi

Entry nameiACT1_DICDI
AccessioniPrimary (citable) accession number: P07830
Secondary accession number(s): P02577
, P07827, Q23856, Q23875, Q23877, Q23879, Q23880, Q54H30, Q7KWV6, Q94466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.