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Protein

Synaptophysin

Gene

Syp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).By similarity

GO - Molecular functioni

  • syntaxin-1 binding Source: MGI

GO - Biological processi

  • endocytosis Source: UniProtKB
  • regulation of neuronal synaptic plasticity Source: GO_Central
  • regulation of opioid receptor signaling pathway Source: UniProtKB
  • response to amyloid-beta Source: RGD

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin
Alternative name(s):
Major synaptic vesicle protein p38
Gene namesi
Name:Syp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi3802 Syp

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 43HelicalSequence analysisAdd BLAST24
Topological domaini44 – 101VesicularSequence analysisAdd BLAST58
Transmembranei102 – 125HelicalSequence analysisAdd BLAST24
Topological domaini126 – 132CytoplasmicSequence analysis7
Transmembranei133 – 156HelicalSequence analysisAdd BLAST24
Topological domaini157 – 194VesicularSequence analysisAdd BLAST38
Transmembranei195 – 218HelicalSequence analysisAdd BLAST24
Topological domaini219 – 307CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791631 – 307SynaptophysinAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei75PhosphotyrosineCombined sources1
Modified residuei221PhosphothreonineSequence analysis1
Modified residuei273PhosphotyrosineSequence analysis1
Modified residuei289PhosphotyrosineSequence analysis1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP07825
PRIDEiP07825

PTM databases

iPTMnetiP07825
PhosphoSitePlusiP07825

Expressioni

Tissue specificityi

Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

Interactioni

Subunit structurei

Homohexamer or homotetramer. Interacts with SRCIN1 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • syntaxin-1 binding Source: MGI

Protein-protein interaction databases

BioGridi246927, 6 interactors
IntActiP07825, 13 interactors
MINTiP07825
STRINGi10116.ENSRNOP00000013724

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 222MARVELPROSITE-ProRule annotationAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni249 – 298Repeats, Gly-richAdd BLAST50

Domaini

The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYC Eukaryota
ENOG4111J4N LUCA
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiP07825
PhylomeDBiP07825

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
IPR028714 SYP
PANTHERiPTHR10306 PTHR10306, 1 hit
PTHR10306:SF10 PTHR10306:SF10, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
PS00604 SYNAPTOP, 1 hit

Sequencei

Sequence statusi: Complete.

P07825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVVNQLVAG GQFRVVKEPL GFVKVLQWVF AIFAFATCGS YTGELRLSVE
60 70 80 90 100
CANKTESALN IEVEFEYPFR LHQVYFDAPS CVKGGTTKIF LVGDYSSSAE
110 120 130 140 150
FFVTVAVFAF LYSMGALATY IFLQNKYREN NKGPMMDFLA TAVFAFMWLV
160 170 180 190 200
SSSAWAKGLS DVKMATDPEN IIKEMPMCRQ TGNTCKELRD PVTSGLNTSV
210 220 230 240 250
VFGFLNLVLW VGNLWFVFKE TGWAAPFMRA PPGAPEKQPA PGDAYGDAGY
260 270 280 290 300
GQGPGGYGPQ DSYGPQGGYQ PDYGQPASGG GGYGPQGDYG QQGYGQQGAP

TSFSNQM
Length:307
Mass (Da):33,311
Last modified:August 1, 1988 - v1
Checksum:iA245E4F70BF0EAF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06177 mRNA Translation: CAA29543.1
X06388 mRNA Translation: CAA29685.1
M58396
, M58402, M58401, M58399 Genomic DNA Translation: AAA42196.1
BC099798 mRNA Translation: AAH99798.1
X06655 mRNA Translation: CAA29854.1
PIRiJU0464 B27287
RefSeqiNP_036796.1, NM_012664.3
UniGeneiRn.11067

Genome annotation databases

GeneIDi24804
KEGGirno:24804
UCSCiRGD:3802 rat

Similar proteinsi

Entry informationi

Entry nameiSYPH_RAT
AccessioniPrimary (citable) accession number: P07825
Secondary accession number(s): Q499R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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