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Reviewed, UniProtKB/Swiss-Prot P07821 (FHUC_ECOLI)

Last modified June 16, 2009. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Iron(3+)-hydroxamate import ATP-binding protein fhuC
    EC=3.6.3.34
Alternative name(s):
    Iron(III)-hydroxamate import ATP-binding protein fhuC
    Ferrichrome transport ATP-binding protein fhuC
    Ferric hydroxamate uptake protein C
Gene names
Name: fhuC
Ordered Locus Names: b0151, JW0147
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Part of the ABC transporter complex fhuCDB involved in iron3+-hydroxamate import. Responsible for energy coupling to the transport system. Ref.7

Catalytic activity

ATP + H2O + iron chelate(Out) = ADP + phosphate + iron chelate(In).

Subunit structure

The complex is composed of an ATP-binding protein (fhuC), two transmembrane proteins (fhuB) and a solute-binding protein (fhuD).

Subcellular location

Cell inner membrane; Peripheral membrane protein. Ref.7

Sequence similarities

Belongs to the ABC transporter family. Iron (Fe3+)-hydroxamate importer (TC 3.A.1.14.7) subfamily. [View classification]

Contains 1 ABC transporter domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

yjfPP392981EBI-1114151,EBI-1114160

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Iron(3+)-hydroxamate import ATP-binding protein fhuC
PRO_0000092327

Regions

Domain12 – 248237ABC transporter
Nucleotide binding44 – 518ATP Potential
Nucleotide binding168 – 17912ATP Potential

Experimental info

Sequence conflict311S → C in CAA29254. Ref.2
Sequence conflict226 – 24924MIAQG…YGIPM → SDCSGNACGNYARRNPRNDL WHPD Ref.1
Sequence conflict226 – 24924MIAQG…YGIPM → SDCSGNACGNYARRNPRNDL WHPD Ref.3

Sequences

Sequence LengthMass (Da)Tools
P07821-1 [UniParc].

Last modified November 1, 1997. Version 3.
Checksum: 2511770D6D9EE772

FASTA26528,886
        10         20         30         40         50         60 
MQEYTNHSDT TFALRNISFR VPGRTLLHPL SLTFPAGKVT GLIGHNGSGK STLLKMLGRH 

        70         80         90        100        110        120 
QPPSEGEILL DAQPLESWSS KAFARKVAYL PQQLPPAEGM TVRELVAIGR YPWHGALGRF 

       130        140        150        160        170        180 
GAADREKVEE AISLVGLKPL AHRLVDSLSG GERQRAWIAM LVAQDSRCLL LDEPTSALDI 

       190        200        210        220        230        240 
AHQVDVLSLV HRLSQERGLT VIAVLHDINM AARYCDYLVA LRGGEMIAQG TPAEIMRGET 

       250        260 
LEMIYGIPMG ILPHPAGAAP VSFVY 

« Hide

References

« Hide 'large scale' references
[1]"fhuC and fhuD genes for iron (III)-ferrichrome transport into Escherichia coli K-12."
Coulton J.W., Mason P., Allatt D.D.
J. Bacteriol. 169:3844-3849(1987) [PubMed: 3301821] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Nucleotide sequence of the fhuC and fhuD genes involved in iron (III) hydroxamate transport: domains in FhuC homologous to ATP-binding proteins."
Burkhardt R., Braun V.
Mol. Gen. Genet. 209:49-55(1987) [PubMed: 2823072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region."
Fujita N., Mori H., Yura T., Ishihama A.
Nucleic Acids Res. 22:1637-1639(1994) [PubMed: 8202364] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[5]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[6]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[7]"Iron(III) hydroxamate transport in Escherichia coli K-12: FhuB-mediated membrane association of the FhuC protein and negative complementation of fhuC mutants."
Schultz-Hauser G., Koester W., Schwarz H., Braun V.
J. Bacteriol. 174:2305-2311(1992) [PubMed: 1551849] [Abstract]
Cited for: FUNCTION IN IRON(3+)-HYDROXAMATE TRANSPORT, INTERACTION WITH FHUB, SUBCELLULAR LOCATION.
Strain: K12.

Cross-references

Sequence databases

X05810 Genomic DNA. Translation: CAA29254.1.
M12486 Genomic DNA. Translation: AAB61769.1.
U70214 Genomic DNA. Translation: AAB08581.1.
U00096 Genomic DNA. Translation: AAC73262.1.
AP009048 Genomic DNA. Translation: BAB96727.1.
PIRQRECFH. G64738.
RefSeqAP_000812.1.
NP_414693.1.

3D structure databases

HSSPHSSP built from PDB template 1L7V based on UniProtKB P06611.
ModBaseSearch...

Protein-protein interaction databases

IntActP07821. 3 interactions.

Protein family/group databases

TCDB3.A.1.14.3. ATP-binding cassette (ABC) superfamily.

Genome annotation databases

GeneID945250.
GenomeReviewsGene locus JW0147 in contig AP009048_GR.
Gene locus b0151 in contig U00096_GR.
KEGGecj:JW0147.
eco:b0151.

Organism-specific databases

EchoBASEEB0300.
EcoGeneEG10304. fhuC.
CMRSearch...

Phylogenomic databases

HOGENOMP07821.
OMAP07821. DTLEMIY.

Enzyme and pathway databases

BioCycEcoCyc:FHUC-MON.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
ProDomPD000006. ABC_transporter. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFHUC_ECOLI
AccessionPrimary (citable) accession number: P07821
Secondary accession number(s): P77548
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 1, 1997
Last modified: June 16, 2009
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents