P07821 (FHUC_ECOLI) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 113.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Iron(3+)-hydroxamate import ATP-binding protein FhuC EC=3.6.3.34 Alternative name(s): Ferric hydroxamate uptake protein C Ferrichrome transport ATP-binding protein FhuC Iron(III)-hydroxamate import ATP-binding protein FhuC | ||||
| Gene names |
| ||||
| Organism | Escherichia coli (strain K12) | ||||
| Taxonomic identifier | 83333 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 265 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Part of the ABC transporter complex FhuCDB involved in iron3+-hydroxamate import. Responsible for energy coupling to the transport system. Ref.7 |
| Catalytic activity | ATP + H2O + iron chelate(Out) = ADP + phosphate + iron chelate(In). |
| Subunit structure | The complex is composed of an ATP-binding protein (FhuC), two transmembrane proteins (FhuB) and a solute-binding protein (FhuD). |
| Subcellular location | |
| Sequence similarities | Belongs to the ABC transporter superfamily. Iron (Fe3+)-hydroxamate importer (TC 3.A.1.14.7) family. [View classification] Contains 1 ABC transporter domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Iron transport Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Ligand | ATP-binding Iron Nucleotide-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW iron-chelate-transporting ATPase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 265 | 265 | Iron(3+)-hydroxamate import ATP-binding protein FhuC | PRO_0000092327 | |||||
Regions | |||||||||
| Domain | 12 – 248 | 237 | ABC transporter | ||||||
| Nucleotide binding | 44 – 51 | 8 | ATP Potential | ||||||
| Nucleotide binding | 168 – 179 | 12 | ATP Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 31 | 1 | S → C in CAA29254. Ref.2 | ||||||
| Sequence conflict | 226 – 249 | 24 | MIAQG…YGIPM → SDCSGNACGNYARRNPRNDL WHPD in AAB61769. Ref.1 | ||||||
| Sequence conflict | 226 – 249 | 24 | MIAQG…YGIPM → SDCSGNACGNYARRNPRNDL WHPD no nucleotide entry Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "fhuC and fhuD genes for iron (III)-ferrichrome transport into Escherichia coli K-12." Coulton J.W., Mason P., Allatt D.D. J. Bacteriol. 169:3844-3849(1987) [PubMed: 3301821] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12. |
| [2] | "Nucleotide sequence of the fhuC and fhuD genes involved in iron (III) hydroxamate transport: domains in FhuC homologous to ATP-binding proteins." Burkhardt R., Braun V. Mol. Gen. Genet. 209:49-55(1987) [PubMed: 2823072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region." Fujita N., Mori H., Yura T., Ishihama A. Nucleic Acids Res. 22:1637-1639(1994) [PubMed: 8202364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [4] | "Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [5] | "The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [6] | "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [7] | "Iron(III) hydroxamate transport in Escherichia coli K-12: FhuB-mediated membrane association of the FhuC protein and negative complementation of fhuC mutants." Schultz-Hauser G., Koester W., Schwarz H., Braun V. J. Bacteriol. 174:2305-2311(1992) [PubMed: 1551849] [Abstract] Cited for: FUNCTION IN IRON(3+)-HYDROXAMATE TRANSPORT, INTERACTION WITH FHUB, SUBCELLULAR LOCATION. Strain: K12. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M12486 Genomic DNA. Translation: AAB61769.1. X05810 Genomic DNA. Translation: CAA29254.1. U70214 Genomic DNA. Translation: AAB08581.1. U00096 Genomic DNA. Translation: AAC73262.1. AP009048 Genomic DNA. Translation: BAB96727.1. |
| PIR | QRECFH. G64738. |
| RefSeq | NP_414693.1. NC_000913.2. |
3D structure databases | |
| ProteinModelPortal | P07821. |
| SMR | P07821. Positions 11-239. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P07821. 3 interactions. |
Protein family/group databases | |
| TCDB | 3.A.1.14.3. ATP-binding cassette (ABC) superfamily. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000003399; EBESCP00000003399; EBESCG00000002785. EBESCT00000016122; EBESCP00000015413; EBESCG00000015182. |
| GeneID | 945250. |
| GenomeReviews | Gene locus JW0147 in contig AP009048_GR. Gene locus b0151 in contig U00096_GR. |
| KEGG | ecj:JW0147. eco:b0151. |
| PATRIC | 32115411. VBIEscCol129921_0157. |
Organism-specific databases | |
| EchoBASE | EB0300. |
| EcoGene | EG10304. fhuC. |
Phylogenomic databases | |
| eggNOG | COG1120. |
| GeneTree | EBGT00050000008237. |
| HOGENOM | HBG758042. |
| OMA | NSKAFAR. |
| PhylomeDB | P07821. |
| ProtClustDB | PRK10575. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:FHUC-MONOMER. |
Gene expression databases | |
| Genevestigator | P07821. |
Family and domain databases | |
| InterPro | IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view] |
| KO | K02013. |
| Pfam | PF00005. ABC_tran. 1 hit. [Graphical view] |
| SMART | SM00382. AAA. 1 hit. [Graphical view] |
| PROSITE | PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FHUC_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P07821 Secondary accession number(s): P77548 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

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