Reviewed, UniProtKB/Swiss-Prot P07820 (CATA_CANTR)

Names and origin

Protein names

Recommended name:
    Peroxisomal catalase
    EC=1.11.1.6
Alternative name(s):
    PXP-9

Gene names

Name:

POX9

Organism

Candida tropicalis (Yeast)

Taxonomic identifier

5482 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group.
Subunit structure	Homotetramer.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Peroxisome
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 485	484	Peroxisomal catalase		PRO_0000084920
Sites
	Active site	53	1	By similarity
	Active site	126	1	By similarity
	Metal binding	336	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	166	1	T → S in AAA34327. Ref.2
	Sequence conflict	377	1	L → V in CAA29093. Ref.4
	Sequence conflict	390	1	I → V in AAA34327. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P07820-1 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 612629F910FF4E8D	FASTA	485	54,938
	10 20 30 40 50 60 MAPTFTNSNG QPIPEPFATQ RVGQHGPLLL QDFNLIDSLA HFDRERIPER VVHAKGSGAY 70 80 90 100 110 120 GVFEVTDDIT DVCAAKFLDT VGKKTRIFTR FSTVGGELGS ADTARDPRGF ATKFYTEEGN 130 140 150 160 170 180 LDLVYNNTPV FFIRDPSKFP HFIHTQKRNP ETHLKDANMF WDYLTTNEES VHQVMVLFSD 190 200 210 220 230 240 RGTPASYREM NGYSGHTYKW SNNKGEWFYV QVHFISDQGI KTLTNEEAGS LAGSNPDYAQ 250 260 270 280 290 300 EDLFKNIAAG NYPSWTCYIQ TMTEAQAKEA EFSVFDLTKV WPHGKYPMRR FGKFTLNENP 310 320 330 340 350 360 KNYFAEVEQA AFSPAHTVPH MEPSADPVLQ SRLFSYADTH RHRLGTNYTQ IPVNCPVTGA 370 380 390 400 410 420 VFNPHMRDGA MNVNGNLGNH PNYLASDKPI EFKQFSLQED QEVWHGAATP FHWKATPADF 430 440 450 460 470 480 KQATELWKVL KKYPNQQEHL AHNVAVHASA ADAPIQDRVI AYFTKVHPDL GDLIKKEILE LSPRK

References

[1]	"Catalase gene of the yeast Candida tropicalis. Sequence analysis and comparison with peroxisomal and cytosolic catalases from other sources." Okada H., Ueda M., Sugaya T., Atomi H., Mozaffar S., Hishida T., Teranishi Y., Okazaki K., Takechi T., Kamiryo T., Tanaka A. Eur. J. Biochem. 170:105-110(1987) [PubMed: 3691514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of complementary DNA and the deduced amino acid sequence of peroxisomal catalase of the yeast Candida tropicalis pK233." Murray W.W., Rachubinski R.A. Gene 61:401-413(1987) [PubMed: 3446581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 20336 / pK233 / NCYC 997.
[3]	"Nucleotide sequence of peroxisomal catalase from the yeast Candida tropicalis pK233: identification of an upstream BamHI site polymorphism." Murray W.W., Rachubinski R.A. Nucleic Acids Res. 17:3600-3600(1989) [PubMed: 2726500] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 20336 / pK233 / NCYC 997.
[4]	"Isolation of cDNA clones coding for peroxisomal proteins of Candida tropicalis: identification and sequence of a clone for catalase." Rachubinski R.A., Fujiki Y., Lazarow P.B. Biochim. Biophys. Acta 909:35-43(1987) [PubMed: 3580373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 377-385. Strain: ATCC 20336 / pK233 / NCYC 997.
[5]	"Isolation of several cDNAs encoding yeast peroxisomal enzymes." Ueda M., Okada H., Hishida T., Teranishi Y., Tanaka A. FEBS Lett. 220:31-35(1987) [PubMed: 2440725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 394-451, PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M18832 mRNA. Translation: AAA34327.1. X05886 mRNA. Translation: CAA29310.1. X05604 mRNA. Translation: CAA29093.1. X06660 Genomic DNA. Translation: CAA29859.1. X13978 Genomic DNA. Translation: CAA32159.1.
PIR	CSCKPT. A29629.
3D structure databases
HSSP	HSSP built from PDB template 1A4E based on UniProtKB P15202.
ModBase	Search...
Protein family/group databases
PeroxiBase	5256. CtKat01.
Enzyme and pathway databases
BRENDA	1.11.1.6. 1242.
Family and domain databases
InterPro	IPR002226. Catalase. IPR010582. Catalase-rel_immune_responsive. IPR011614. Catalase_N. IPR018028. Catalase_rel_subgroup. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
ProDom	PD000510. Catalase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_CANTR

Accession

Primary (citable) accession number: P07820

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 69 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)