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P07817

- PYRF_ASPNG

UniProt

P07817 - PYRF_ASPNG

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrG

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Aug 1988)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateBy similarity
    Active sitei95 – 951Proton donorPROSITE-ProRule annotation
    Binding sitei229 – 2291SubstrateBy similarity
    Binding sitei247 – 2471SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:pyrG
    Synonyms:pyrA
    OrganismiAspergillus niger
    Taxonomic identifieri5061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Orotidine 5'-phosphate decarboxylasePRO_0000134643Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00009614.

    Structurei

    3D structure databases

    ProteinModelPortaliP07817.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 643Substrate bindingBy similarity
    Regioni93 – 10210Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0284.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P07817-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSKSQLTYT ARASKHPNAL AKRLFEIAEA KKTNVTVSAD VTTTKELLDL    50
    ADRLGPYIAV IKTHIDILSD FSDETIEGLK ALAQKHNFLI FEDRKFIDIG 100
    NTVQKQYHRG TLRISEWAHI INCSILPGEG IVEALAQTAS APDFSYGPER 150
    GLLILAEMTS KGSLATGQYT TSSVDYARKY KNFVMGFVST RSLGEVQSEV 200
    SSPSDEEDFV VFTTGVNISS KGDKLGQQYQ TPASAIGRGA DFIIAGRGIY 250
    AAPDPVQAAQ QYQKEGWEAY LARVGGN 277
    Length:277
    Mass (Da):30,196
    Last modified:August 1, 1988 - v1
    Checksum:i02F30DAF5D9DA808
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti73 – 731D → N in strain: CBS 120.49 / N400.
    Natural varianti109 – 1091R → G in strain: CBS 120.49 / N400.
    Natural varianti145 – 1451S → A in strain: CBS 120.49 / N400.
    Natural varianti192 – 1921S → A in strain: CBS 120.49 / N400.
    Natural varianti233 – 2331A → G in strain: CBS 120.49 / N400.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06626 Genomic DNA. Translation: CAA29838.1.
    X96734 Genomic DNA. Translation: CAA65508.2.
    PIRiS03652. DCASON.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06626 Genomic DNA. Translation: CAA29838.1 .
    X96734 Genomic DNA. Translation: CAA65508.2 .
    PIRi S03652. DCASON.

    3D structure databases

    ProteinModelPortali P07817.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00009614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0284.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: L112.
    2. "The pyrA gene from Aspergillus niger: characterization of gene and mutants; targeting to homologous locus and use of disruption strains in locus-specific integration."
      van den Hombergh J.P.T.W., de Vries R.P., de Zwart P.J.I., van de Vondervoort L.H., de Graaff L.H., Visser J.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

    Entry informationi

    Entry nameiPYRF_ASPNG
    AccessioniPrimary (citable) accession number: P07817
    Secondary accession number(s): Q9HGS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3