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P07817 (PYRF_ASPNG) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:pyrG
Synonyms:pyrA
OrganismAspergillus niger
Taxonomic identifier5061 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Orotidine 5'-phosphate decarboxylase
PRO_0000134643

Regions

Region62 – 643Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site401Substrate By similarity
Binding site2291Substrate By similarity
Binding site2471Substrate By similarity

Natural variations

Natural variant731D → N in strain: CBS 120.49 / N400.
Natural variant1091R → G in strain: CBS 120.49 / N400.
Natural variant1451S → A in strain: CBS 120.49 / N400.
Natural variant1921S → A in strain: CBS 120.49 / N400.
Natural variant2331A → G in strain: CBS 120.49 / N400.

Sequences

Sequence LengthMass (Da)Tools
P07817 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 02F30DAF5D9DA808

FASTA27730,196
        10         20         30         40         50         60 
MSSKSQLTYT ARASKHPNAL AKRLFEIAEA KKTNVTVSAD VTTTKELLDL ADRLGPYIAV 

        70         80         90        100        110        120 
IKTHIDILSD FSDETIEGLK ALAQKHNFLI FEDRKFIDIG NTVQKQYHRG TLRISEWAHI 

       130        140        150        160        170        180 
INCSILPGEG IVEALAQTAS APDFSYGPER GLLILAEMTS KGSLATGQYT TSSVDYARKY 

       190        200        210        220        230        240 
KNFVMGFVST RSLGEVQSEV SSPSDEEDFV VFTTGVNISS KGDKLGQQYQ TPASAIGRGA 

       250        260        270 
DFIIAGRGIY AAPDPVQAAQ QYQKEGWEAY LARVGGN 

« Hide

References

[1]"Sequence of the Aspergillus niger pyrG gene."
Wilson L.J., Ward M., Carmona C.
Nucleic Acids Res. 16:2339-2339(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: L112.
[2]"The pyrA gene from Aspergillus niger: characterization of gene and mutants; targeting to homologous locus and use of disruption strains in locus-specific integration."
van den Hombergh J.P.T.W., de Vries R.P., de Zwart P.J.I., van de Vondervoort L.H., de Graaff L.H., Visser J.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06626 Genomic DNA. Translation: CAA29838.1.
X96734 Genomic DNA. Translation: CAA65508.2.
PIRDCASON. S03652.

3D structure databases

ProteinModelPortalP07817.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00009614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0284.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_ASPNG
AccessionPrimary (citable) accession number: P07817
Secondary accession number(s): Q9HGS5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 13, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways