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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrG

Organism
Aspergillus niger
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Orotidine 5'-phosphate decarboxylase (pyrG), Orotidine 5'-phosphate decarboxylase (ABL_07721)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40SubstrateBy similarity1
Active sitei95Proton donorPROSITE-ProRule annotation1
Binding sitei229SubstrateBy similarity1
Binding sitei247SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:pyrG
Synonyms:pyrA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346431 – 277Orotidine 5'-phosphate decarboxylaseAdd BLAST277

Proteomic databases

PaxDbiP07817.
PRIDEiP07817.

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00009614.

Chemistry databases

BindingDBiP07817.

Structurei

3D structure databases

ProteinModelPortaliP07817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 64Substrate bindingBy similarity3
Regioni93 – 102Substrate bindingBy similarity10

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKSQLTYT ARASKHPNAL AKRLFEIAEA KKTNVTVSAD VTTTKELLDL
60 70 80 90 100
ADRLGPYIAV IKTHIDILSD FSDETIEGLK ALAQKHNFLI FEDRKFIDIG
110 120 130 140 150
NTVQKQYHRG TLRISEWAHI INCSILPGEG IVEALAQTAS APDFSYGPER
160 170 180 190 200
GLLILAEMTS KGSLATGQYT TSSVDYARKY KNFVMGFVST RSLGEVQSEV
210 220 230 240 250
SSPSDEEDFV VFTTGVNISS KGDKLGQQYQ TPASAIGRGA DFIIAGRGIY
260 270
AAPDPVQAAQ QYQKEGWEAY LARVGGN
Length:277
Mass (Da):30,196
Last modified:August 1, 1988 - v1
Checksum:i02F30DAF5D9DA808
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti73D → N in strain: CBS 120.49 / N400. 1
Natural varianti109R → G in strain: CBS 120.49 / N400. 1
Natural varianti145S → A in strain: CBS 120.49 / N400. 1
Natural varianti192S → A in strain: CBS 120.49 / N400. 1
Natural varianti233A → G in strain: CBS 120.49 / N400. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06626 Genomic DNA. Translation: CAA29838.1.
X96734 Genomic DNA. Translation: CAA65508.2.
PIRiS03652. DCASON.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06626 Genomic DNA. Translation: CAA29838.1.
X96734 Genomic DNA. Translation: CAA65508.2.
PIRiS03652. DCASON.

3D structure databases

ProteinModelPortaliP07817.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00009614.

Chemistry databases

BindingDBiP07817.

Proteomic databases

PaxDbiP07817.
PRIDEiP07817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1377. Eukaryota.
COG0284. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRF_ASPNG
AccessioniPrimary (citable) accession number: P07817
Secondary accession number(s): Q9HGS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.