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P07817

- PYRF_ASPNG

UniProt

P07817 - PYRF_ASPNG

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrG, pyrA
Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Substrate By similarity
Active sitei95 – 951Proton donor By similarity
Binding sitei229 – 2291Substrate By similarity
Binding sitei247 – 2471Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:pyrG
Synonyms:pyrA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Orotidine 5'-phosphate decarboxylase
PRO_0000134643Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00009614.

Structurei

3D structure databases

ProteinModelPortaliP07817.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 643Substrate binding By similarity
Regioni93 – 10210Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Phylogenomic databases

eggNOGiCOG0284.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07817-1 [UniParc]FASTAAdd to Basket

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MSSKSQLTYT ARASKHPNAL AKRLFEIAEA KKTNVTVSAD VTTTKELLDL    50
ADRLGPYIAV IKTHIDILSD FSDETIEGLK ALAQKHNFLI FEDRKFIDIG 100
NTVQKQYHRG TLRISEWAHI INCSILPGEG IVEALAQTAS APDFSYGPER 150
GLLILAEMTS KGSLATGQYT TSSVDYARKY KNFVMGFVST RSLGEVQSEV 200
SSPSDEEDFV VFTTGVNISS KGDKLGQQYQ TPASAIGRGA DFIIAGRGIY 250
AAPDPVQAAQ QYQKEGWEAY LARVGGN 277
Length:277
Mass (Da):30,196
Last modified:August 1, 1988 - v1
Checksum:i02F30DAF5D9DA808
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731D → N in strain: CBS 120.49 / N400.
Natural varianti109 – 1091R → G in strain: CBS 120.49 / N400.
Natural varianti145 – 1451S → A in strain: CBS 120.49 / N400.
Natural varianti192 – 1921S → A in strain: CBS 120.49 / N400.
Natural varianti233 – 2331A → G in strain: CBS 120.49 / N400.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06626 Genomic DNA. Translation: CAA29838.1.
X96734 Genomic DNA. Translation: CAA65508.2.
PIRiS03652. DCASON.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06626 Genomic DNA. Translation: CAA29838.1 .
X96734 Genomic DNA. Translation: CAA65508.2 .
PIRi S03652. DCASON.

3D structure databases

ProteinModelPortali P07817.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00009614.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0284.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: L112.
  2. "The pyrA gene from Aspergillus niger: characterization of gene and mutants; targeting to homologous locus and use of disruption strains in locus-specific integration."
    van den Hombergh J.P.T.W., de Vries R.P., de Zwart P.J.I., van de Vondervoort L.H., de Graaff L.H., Visser J.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

Entry informationi

Entry nameiPYRF_ASPNG
AccessioniPrimary (citable) accession number: P07817
Secondary accession number(s): Q9HGS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 13, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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