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Protein

Pro-neuropeptide Y

Gene

Npy

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

GO - Molecular functioni

  • neuropeptide hormone activity Source: GO_Central
  • neuropeptide Y receptor binding Source: RGD

GO - Biological processi

  • adult feeding behavior Source: HGNC
  • aging Source: RGD
  • chemical synaptic transmission Source: RGD
  • digestion Source: GO_Central
  • monocyte activation Source: RGD
  • negative regulation of acute inflammatory response to antigenic stimulus Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of neuron death Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • positive regulation of appetite Source: HGNC
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cell-substrate adhesion Source: RGD
  • positive regulation of dopamine metabolic process Source: RGD
  • positive regulation of eating behavior Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of nitric oxide metabolic process Source: RGD
  • regulation of nerve growth factor production Source: RGD
  • sensory perception of taste Source: RGD
  • short-day photoperiodism Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:Npy
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3197. Npy.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: HGNC
  • neuron projection Source: RGD
  • perikaryon Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
PeptideiPRO_000002532930 – 65Neuropeptide Y1 PublicationAdd BLAST36
PeptideiPRO_000002533069 – 98C-flanking peptide of NPYAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65Tyrosine amide2 Publications1
Modified residuei84PhosphothreonineBy similarity1

Post-translational modificationi

The neuropeptide Y form is cleaved at Pro-31 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei31 – 32Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP07808.
PRIDEiP07808.

PTM databases

iPTMnetiP07808.
PhosphoSitePlusiP07808.

Miscellaneous databases

PMAP-CutDBP07808.

Expressioni

Tissue specificityi

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Gene expression databases

BgeeiENSRNOG00000009768.
ExpressionAtlasiP07808. baseline.
GenevisibleiP07808. RN.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: GO_Central
  • neuropeptide Y receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013146.

Chemistry databases

BindingDBiP07808.

Structurei

3D structure databases

ProteinModelPortaliP07808.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP07808.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG091G0ZRE.
PhylomeDBiP07808.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLGNKRMGL CGLTLALSLL VCLGILAEGY PSKPDNPGED APAEDMARYY
60 70 80 90
SALRHYINLI TRQRYGKRSS PETLISDLLM RESTENAPRT RLEDPSMW
Length:98
Mass (Da):11,033
Last modified:August 1, 1988 - v1
Checksum:iE77EACEF3A3914B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15880 mRNA. Translation: AAA41722.1.
M15793, M15792 Genomic DNA. Translation: AAA41723.1.
M20373 mRNA. Translation: AAA41724.1.
AF392056 Genomic DNA. Translation: AAL28016.1.
AF392057 Genomic DNA. Translation: AAL28017.1.
AF392058 Genomic DNA. Translation: AAL28018.1.
AF392059 Genomic DNA. Translation: AAL28019.1.
AF392060 Genomic DNA. Translation: AAL28020.1.
AF392061 Genomic DNA. Translation: AAL28021.1.
PIRiA27651. A25916.
RefSeqiNP_036746.1. NM_012614.2.
XP_003749793.1. XM_003749745.4.
UniGeneiRn.9714.

Genome annotation databases

EnsembliENSRNOT00000013145; ENSRNOP00000013146; ENSRNOG00000009768.
ENSRNOT00000074351; ENSRNOP00000066713; ENSRNOG00000046449.
GeneIDi100912228.
24604.
KEGGirno:100912228.
rno:24604.
UCSCiRGD:3197. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15880 mRNA. Translation: AAA41722.1.
M15793, M15792 Genomic DNA. Translation: AAA41723.1.
M20373 mRNA. Translation: AAA41724.1.
AF392056 Genomic DNA. Translation: AAL28016.1.
AF392057 Genomic DNA. Translation: AAL28017.1.
AF392058 Genomic DNA. Translation: AAL28018.1.
AF392059 Genomic DNA. Translation: AAL28019.1.
AF392060 Genomic DNA. Translation: AAL28020.1.
AF392061 Genomic DNA. Translation: AAL28021.1.
PIRiA27651. A25916.
RefSeqiNP_036746.1. NM_012614.2.
XP_003749793.1. XM_003749745.4.
UniGeneiRn.9714.

3D structure databases

ProteinModelPortaliP07808.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013146.

Chemistry databases

BindingDBiP07808.

PTM databases

iPTMnetiP07808.
PhosphoSitePlusiP07808.

Proteomic databases

PaxDbiP07808.
PRIDEiP07808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013145; ENSRNOP00000013146; ENSRNOG00000009768.
ENSRNOT00000074351; ENSRNOP00000066713; ENSRNOG00000046449.
GeneIDi100912228.
24604.
KEGGirno:100912228.
rno:24604.
UCSCiRGD:3197. rat.

Organism-specific databases

CTDi4852.
RGDi3197. Npy.

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP07808.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG091G0ZRE.
PhylomeDBiP07808.
TreeFamiTF332778.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PMAP-CutDBP07808.
PROiP07808.

Gene expression databases

BgeeiENSRNOG00000009768.
ExpressionAtlasiP07808. baseline.
GenevisibleiP07808. RN.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPY_RAT
AccessioniPrimary (citable) accession number: P07808
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.