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Protein

Pro-neuropeptide Y

Gene

Npy

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

GO - Molecular functioni

  • neuropeptide hormone activity Source: GO_Central
  • neuropeptide Y receptor binding Source: RGD

GO - Biological processi

  • adult feeding behavior Source: HGNC
  • aging Source: RGD
  • chemical synaptic transmission Source: RGD
  • monocyte activation Source: RGD
  • negative regulation of acute inflammatory response to antigenic stimulus Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of neuron death Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • positive regulation of appetite Source: HGNC
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cell-substrate adhesion Source: RGD
  • positive regulation of dopamine metabolic process Source: RGD
  • positive regulation of eating behavior Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of nitric oxide metabolic process Source: RGD
  • regulation of nerve growth factor production Source: RGD
  • sensory perception of taste Source: RGD
  • short-day photoperiodism Source: RGD

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:Npy
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3197 Npy

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
PeptideiPRO_000002532930 – 65Neuropeptide Y1 PublicationAdd BLAST36
PeptideiPRO_000002533069 – 98C-flanking peptide of NPYAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65Tyrosine amide2 Publications1
Modified residuei84PhosphothreonineBy similarity1

Post-translational modificationi

The neuropeptide Y form is cleaved at Pro-31 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei31 – 32Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP07808

PTM databases

iPTMnetiP07808
PhosphoSitePlusiP07808

Miscellaneous databases

PMAP-CutDBiP07808

Expressioni

Tissue specificityi

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Gene expression databases

BgeeiENSRNOG00000009768
ExpressionAtlasiP07808 differential
GenevisibleiP07808 RN

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: GO_Central
  • neuropeptide Y receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013146

Chemistry databases

BindingDBiP07808

Structurei

3D structure databases

ProteinModelPortaliP07808
SMRiP07808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KC Eukaryota
ENOG41128I2 LUCA
GeneTreeiENSGT00390000010775
HOGENOMiHOG000252942
HOVERGENiHBG006485
InParanoidiP07808
KOiK05232
OMAiFEDPSMW
OrthoDBiEOG091G0ZRE
PhylomeDBiP07808
TreeFamiTF332778

Family and domain databases

CDDicd00126 PAH, 1 hit
InterProiView protein in InterPro
IPR001955 Pancreatic_hormone-like
IPR020392 Pancreatic_hormone-like_CS
PANTHERiPTHR10533 PTHR10533, 1 hit
PfamiView protein in Pfam
PF00159 Hormone_3, 1 hit
PRINTSiPR00278 PANCHORMONE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267 Pancreatic_hormone-like, 1 hit
SMARTiView protein in SMART
SM00309 PAH, 1 hit
PROSITEiView protein in PROSITE
PS00265 PANCREATIC_HORMONE_1, 1 hit
PS50276 PANCREATIC_HORMONE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLGNKRMGL CGLTLALSLL VCLGILAEGY PSKPDNPGED APAEDMARYY
60 70 80 90
SALRHYINLI TRQRYGKRSS PETLISDLLM RESTENAPRT RLEDPSMW
Length:98
Mass (Da):11,033
Last modified:August 1, 1988 - v1
Checksum:iE77EACEF3A3914B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15880 mRNA Translation: AAA41722.1
M15793, M15792 Genomic DNA Translation: AAA41723.1
M20373 mRNA Translation: AAA41724.1
AF392056 Genomic DNA Translation: AAL28016.1
AF392057 Genomic DNA Translation: AAL28017.1
AF392058 Genomic DNA Translation: AAL28018.1
AF392059 Genomic DNA Translation: AAL28019.1
AF392060 Genomic DNA Translation: AAL28020.1
AF392061 Genomic DNA Translation: AAL28021.1
PIRiA27651 A25916
RefSeqiNP_036746.1, NM_012614.2
XP_003749793.1, XM_003749745.4
UniGeneiRn.9714

Genome annotation databases

EnsembliENSRNOT00000013145; ENSRNOP00000013146; ENSRNOG00000009768
ENSRNOT00000074351; ENSRNOP00000066713; ENSRNOG00000046449
GeneIDi100912228
24604
KEGGirno:100912228
rno:24604
UCSCiRGD:3197 rat

Similar proteinsi

Entry informationi

Entry nameiNPY_RAT
AccessioniPrimary (citable) accession number: P07808
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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