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Protein

Ornithine decarboxylase

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei358 – 3581Proton donor; shared with dimeric partner

GO - Molecular functioni

  • ornithine decarboxylase activity Source: GeneDB

GO - Biological processi

  • polyamine biosynthetic process Source: GeneDB
  • putrescine biosynthetic process from ornithine Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.17. 6519.
SABIO-RKP07805.
UniPathwayiUPA00535; UER00288.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase (EC:4.1.1.17)
Short name:
ODC
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Ornithine decarboxylasePRO_0000149903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671N6-(pyridoxal phosphate)lysine

Proteomic databases

PRIDEiP07805.

Structurei

Secondary structure

1
423
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 268Combined sources
Beta strandi38 – 425Combined sources
Helixi43 – 5614Combined sources
Beta strandi60 – 656Combined sources
Helixi66 – 683Combined sources
Helixi72 – 809Combined sources
Beta strandi84 – 874Combined sources
Helixi90 – 989Combined sources
Helixi103 – 1053Combined sources
Beta strandi106 – 1083Combined sources
Helixi115 – 1239Combined sources
Beta strandi128 – 1314Combined sources
Helixi134 – 14310Combined sources
Beta strandi148 – 1536Combined sources
Beta strandi166 – 1683Combined sources
Helixi172 – 18413Combined sources
Beta strandi188 – 1936Combined sources
Helixi204 – 22219Combined sources
Beta strandi229 – 2313Combined sources
Beta strandi239 – 2413Combined sources
Beta strandi242 – 2443Combined sources
Helixi246 – 26015Combined sources
Beta strandi268 – 2714Combined sources
Helixi275 – 2784Combined sources
Helixi279 – 2813Combined sources
Beta strandi282 – 29312Combined sources
Beta strandi312 – 3176Combined sources
Turni320 – 3223Combined sources
Helixi323 – 3253Combined sources
Helixi326 – 3294Combined sources
Beta strandi337 – 3404Combined sources
Beta strandi348 – 3547Combined sources
Beta strandi356 – 3583Combined sources
Beta strandi363 – 3719Combined sources
Beta strandi378 – 3814Combined sources
Beta strandi386 – 3883Combined sources
Helixi389 – 3913Combined sources
Helixi395 – 3973Combined sources
Beta strandi402 – 4065Combined sources
Helixi414 – 4185Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F3TX-ray2.00A/B/C/D1-423[»]
1QU4X-ray2.90A/B/C/D21-423[»]
1SZRX-ray2.15A/B/C/D1-423[»]
2TODX-ray2.00A/B/C/D21-423[»]
DisProtiDP00051.
ProteinModelPortaliP07805.
SMRiP07805. Positions 12-420.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07805.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIVVNDDLS CRFLEGFNTR DALCKKISMN TCDEGDPFFV ADLGDIVRKH
60 70 80 90 100
ETWKKCLPRV TPFYAVKCND DWRVLGTLAA LGTGFDCASN TEIQRVRGIG
110 120 130 140 150
VPPEKIIYAN PCKQISHIRY ARDSGVDVMT FDCVDELEKV AKTHPKAKMV
160 170 180 190 200
LRISTDDSLA RCRLSVKFGA KVEDCRFILE QAKKLNIDVT GVSFHVGSGS
210 220 230 240 250
TDASTFAQAI SDSRFVFDMG TELGFNMHIL DIGGGFPGTR DAPLKFEEIA
260 270 280 290 300
GVINNALEKH FPPDLKLTIV AEPGRYYVAS AFTLAVNVIA KKVTPGVQTD
310 320 330 340 350
VGAHAESNAQ SFMYYVNDGV YGSFNCILYD HAVVRPLPQR EPIPNEKLYP
360 370 380 390 400
SSVWGPTCDG LDQIVERYYL PEMQVGEWLL FEDMGAYTVV GTSSFNGFQS
410 420
PTIYYVVSGL PDHVVRELKS QKS
Length:423
Mass (Da):46,881
Last modified:May 30, 2000 - v2
Checksum:i924A5AA6C4CD2C36
GO

Sequence cautioni

The sequence AAA30218 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02771 Genomic DNA. Translation: AAA30218.1. Different initiation.
J02771 Genomic DNA. Translation: AAA30219.1.

Genome annotation databases

GeneDBiTb927.11.13730:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02771 Genomic DNA. Translation: AAA30218.1. Different initiation.
J02771 Genomic DNA. Translation: AAA30219.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F3TX-ray2.00A/B/C/D1-423[»]
1QU4X-ray2.90A/B/C/D21-423[»]
1SZRX-ray2.15A/B/C/D1-423[»]
2TODX-ray2.00A/B/C/D21-423[»]
DisProtiDP00051.
ProteinModelPortaliP07805.
SMRiP07805. Positions 12-420.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP07805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTb927.11.13730:pep.

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288.
BRENDAi4.1.1.17. 6519.
SABIO-RKP07805.

Miscellaneous databases

EvolutionaryTraceiP07805.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCOR_TRYBB
AccessioniPrimary (citable) accession number: P07805
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 30, 2000
Last modified: March 16, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.