##gff-version 3
P07799	UniProtKB	Chain	1	814	.	.	.	ID=PRO_0000145209;Note=DNA topoisomerase 1	
P07799	UniProtKB	Domain	411	814	.	.	.	Note=Topo IB-type catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01382	
P07799	UniProtKB	Region	1	180	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P07799	UniProtKB	Region	404	405	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Region	467	472	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Region	559	561	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Compositional bias	23	65	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P07799	UniProtKB	Compositional bias	94	113	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P07799	UniProtKB	Compositional bias	142	169	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P07799	UniProtKB	Active site	773	773	.	.	.	Note=O-(3'-phospho-DNA)-tyrosine intermediate;Ontology_term=ECO:0000255,ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01382,ECO:0000255|PROSITE-ProRule:PRU10130,ECO:0000269|PubMed:2547758;Dbxref=PMID:2547758	
P07799	UniProtKB	Site	343	343	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Site	391	391	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Site	422	422	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Site	479	479	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Site	505	505	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Site	548	548	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Site	605	605	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P07799	UniProtKB	Modified residue	52	52	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18257517;Dbxref=PMID:18257517	
P07799	UniProtKB	Modified residue	54	54	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18257517;Dbxref=PMID:18257517	
P07799	UniProtKB	Modified residue	136	136	.	.	.	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18257517;Dbxref=PMID:18257517	
P07799	UniProtKB	Modified residue	138	138	.	.	.	Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18257517;Dbxref=PMID:18257517	
P07799	UniProtKB	Sequence conflict	7	8	.	.	.	Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P07799	UniProtKB	Sequence conflict	308	308	.	.	.	Note=Q->E;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P07799	UniProtKB	Sequence conflict	446	446	.	.	.	Note=S->N;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P07799	UniProtKB	Sequence conflict	698	698	.	.	.	Note=V->M;Ontology_term=ECO:0000305;evidence=ECO:0000305