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P07798

- FRI2_LITCT

UniProt

P07798 - FRI2_LITCT

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Protein

Ferritin, middle subunit

Gene
N/A
Organism
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi24 – 241Iron 1
Metal bindingi59 – 591Iron 1
Metal bindingi59 – 591Iron 2
Metal bindingi62 – 621Iron 1
Metal bindingi104 – 1041Iron 2
Metal bindingi138 – 1381Iron 2
Metal bindingi141 – 1411Iron 2

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP07798.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, middle subunit (EC:1.16.3.1)
Short name:
Ferritin M
Alternative name(s):
Ferritin H'
Ferritin X
OrganismiLithobates catesbeiana (American bullfrog) (Rana catesbeiana)
Taxonomic identifieri8400 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeRanaAquarana

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 176175Ferritin, middle subunitPRO_0000201073Add
BLAST

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited.

Structurei

Secondary structure

1
176
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 3828Combined sources
Turni41 – 433Combined sources
Helixi46 – 7328Combined sources
Helixi93 – 12028Combined sources
Helixi124 – 13310Combined sources
Helixi135 – 15420Combined sources
Turni155 – 1595Combined sources
Helixi161 – 17010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MFRX-ray2.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-176[»]
3KA3X-ray1.40A1-176[»]
3KA4X-ray1.40A1-176[»]
3KA6X-ray1.40A1-176[»]
3KA8X-ray1.35A1-176[»]
3KA9X-ray1.45A1-176[»]
3RBCX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-176[»]
3RE7X-ray2.82A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-176[»]
3RGDX-ray2.89A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-176[»]
3SE1X-ray1.65A1-176[»]
3SH6X-ray1.40A1-176[»]
3SHXX-ray1.35A1-176[»]
4DASX-ray2.56A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-176[»]
4LPJX-ray1.27A1-176[»]
4LPMX-ray1.65A2-175[»]
4LPNX-ray1.66A1-176[»]
4LQHX-ray1.16A1-176[»]
4LQJX-ray1.20A1-176[»]
4LQNX-ray1.59A1-176[»]
4LQVX-ray1.54A1-176[»]
4LYUX-ray1.75A1-176[»]
4LYXX-ray1.23A1-176[»]
4MJYX-ray1.40A1-176[»]
4MKUX-ray1.30A1-176[»]
4ML5X-ray1.22A1-176[»]
4MN9X-ray1.15A1-176[»]
4MY7X-ray1.48A1-176[»]
4P18X-ray1.91A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X1-176[»]
ProteinModelPortaliP07798.
SMRiP07798. Positions 2-172.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07798.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 156150Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG000410.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07798-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSQVRQNYH SDCEAAVNRM LNLELYASYT YSSMYAFFDR DDVALHNVAE
60 70 80 90 100
FFKEHSHEER EHAEKFMKYQ NKRGGRVVLQ DIKKPERDEW GNTLEAMQAA
110 120 130 140 150
LQLEKTVNQA LLDLHKLATD KVDPHLCDFL ESEYLEEQVK DIKRIGDFIT
160 170
NLKRLGLPEN GMGEYLFDKH SVKESS
Length:176
Mass (Da):20,592
Last modified:January 23, 2007 - v3
Checksum:iA9F0F5BEB8584D46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02724 mRNA. Translation: AAA49525.1.
PIRiC27805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02724 mRNA. Translation: AAA49525.1 .
PIRi C27805.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MFR X-ray 2.80 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X 1-176 [» ]
3KA3 X-ray 1.40 A 1-176 [» ]
3KA4 X-ray 1.40 A 1-176 [» ]
3KA6 X-ray 1.40 A 1-176 [» ]
3KA8 X-ray 1.35 A 1-176 [» ]
3KA9 X-ray 1.45 A 1-176 [» ]
3RBC X-ray 2.70 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X 1-176 [» ]
3RE7 X-ray 2.82 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X 1-176 [» ]
3RGD X-ray 2.89 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X 1-176 [» ]
3SE1 X-ray 1.65 A 1-176 [» ]
3SH6 X-ray 1.40 A 1-176 [» ]
3SHX X-ray 1.35 A 1-176 [» ]
4DAS X-ray 2.56 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X 1-176 [» ]
4LPJ X-ray 1.27 A 1-176 [» ]
4LPM X-ray 1.65 A 2-175 [» ]
4LPN X-ray 1.66 A 1-176 [» ]
4LQH X-ray 1.16 A 1-176 [» ]
4LQJ X-ray 1.20 A 1-176 [» ]
4LQN X-ray 1.59 A 1-176 [» ]
4LQV X-ray 1.54 A 1-176 [» ]
4LYU X-ray 1.75 A 1-176 [» ]
4LYX X-ray 1.23 A 1-176 [» ]
4MJY X-ray 1.40 A 1-176 [» ]
4MKU X-ray 1.30 A 1-176 [» ]
4ML5 X-ray 1.22 A 1-176 [» ]
4MN9 X-ray 1.15 A 1-176 [» ]
4MY7 X-ray 1.48 A 1-176 [» ]
4P18 X-ray 1.91 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X 1-176 [» ]
ProteinModelPortali P07798.
SMRi P07798. Positions 2-172.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000410.

Enzyme and pathway databases

SABIO-RK P07798.

Miscellaneous databases

EvolutionaryTracei P07798.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differences in the regulation of messenger RNA for housekeeping and specialized-cell ferritin. A comparison of three distinct ferritin complementary DNAs, the corresponding subunits, and identification of the first processed in amphibia."
    Dickey L.F., Sreedharan S., Theil E.C., Didsbury J.R., Wang Y.-H., Kaufman R.E.
    J. Biol. Chem. 262:7901-7907(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Crystal structure of bullfrog M ferritin at 2.8 A resolution: analysis of subunit interactions and the binuclear metal center."
    Ha Y., Shi D., Small G.W., Theil E.C., Allewell N.M.
    J. Biol. Inorg. Chem. 4:243-256(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

Entry informationi

Entry nameiFRI2_LITCT
AccessioniPrimary (citable) accession number: P07798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are three types of ferritin subunits in amphibia: L, M and H chains. M and H chains are fast mineralizing; the L chain is very slow mineralizing.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3