ID   PQQC_ACICA              Reviewed;         252 AA.
AC   P07780;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   20-JAN-2009, entry version 45.
DE   RecName: Full=Pyrroloquinoline-quinone synthase;
DE            EC=1.3.3.11;
DE   AltName: Full=Coenzyme PQQ synthesis protein C;
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein C;
DE   AltName: Full=Coenzyme PQQ synthesis protein I;
GN   Name=pqqC; Synonyms=pqqI;
OS   Acinetobacter calcoaceticus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Acinetobacter.
OX   NCBI_TaxID=471;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LMD 79.41;
RX   MEDLINE=89123056; PubMed=2536663;
RA   Goosen N., Horsman H.P.A., Huinen R.G.M., van de Putte P.;
RT   "Acinetobacter calcoaceticus genes involved in biosynthesis of the
RT   coenzyme pyrrolo-quinoline-quinone: nucleotide sequence and expression
RT   in Escherichia coli K-12.";
RL   J. Bacteriol. 171:447-455(1989).
CC   -!- FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-
CC       amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-
CC       7,9-dicarboxylic-acid to PQQ (By similarity).
CC   -!- CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-
CC       1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 4,5-
CC       dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate
CC       + 2 H(2)O(2) + 2 H(2)O.
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the pqqC family.
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DR   EMBL; X06452; CAA29754.1; -; Genomic_DNA.
DR   PIR; D32252; D32252.
DR   BRENDA; 1.3.3.11; 412.
DR   GO; GO:0033732; F:pyrroloquinoline-quinone synthase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00654; -; 1.
DR   InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR   InterPro; IPR011845; PQQ_synth_PqqC.
DR   InterPro; IPR004305; TENA/THI4/PQQ_synth_PqqC.
DR   Gene3D; G3DSA:1.20.910.10; Haem_Oase-like_multi-hlx; 1.
DR   Pfam; PF03070; TENA_THI-4; 1.
DR   TIGRFAMs; TIGR02111; PQQ_syn_pqqC; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; PQQ biosynthesis.
FT   CHAIN         1    252       Pyrroloquinoline-quinone synthase.
FT                                /FTId=PRO_0000219976.
SQ   SEQUENCE   252 AA;  29706 MW;  CCD97341C0C2B815 CRC64;
     MTQTPEALTT EQFKQAIIDK GQYYHIYHPF HVMMYEGKAT QQQIQAWVAN RYYYQINIPL
     KDAAIMANCP DQRVRQEWIQ RMIDQDGEYP DGGGREAWLR LAEAVGLSRE QVISEELVLP
     GVRFAVDAYV NFRRRASWRE AASSSLTELF APQIHQSRLD SWPQHYPWID DKGYEYFRSR
     LSQARRDVEH GLTITLDSFT TFEQQERMLE ILQFKLDILW SILDALTLAY VHNEAPYHSV
     TSKRVWHKGL FK
//