Reviewed, UniProtKB/Swiss-Prot P07780 (PQQC_ACICA)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C
    Coenzyme PQQ synthesis protein I

Gene names

Name:	pqqC
Synonyms:	pqqI

Organism

Acinetobacter calcoaceticus

Taxonomic identifier

471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP MF_00654
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_0000219976

Sequences

	Sequence		Length	Mass (Da)
	P07780-1 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: CCD97341C0C2B815	FASTA	252	29,706
	10 20 30 40 50 60 MTQTPEALTT EQFKQAIIDK GQYYHIYHPF HVMMYEGKAT QQQIQAWVAN RYYYQINIPL 70 80 90 100 110 120 KDAAIMANCP DQRVRQEWIQ RMIDQDGEYP DGGGREAWLR LAEAVGLSRE QVISEELVLP 130 140 150 160 170 180 GVRFAVDAYV NFRRRASWRE AASSSLTELF APQIHQSRLD SWPQHYPWID DKGYEYFRSR 190 200 210 220 230 240 LSQARRDVEH GLTITLDSFT TFEQQERMLE ILQFKLDILW SILDALTLAY VHNEAPYHSV 250 TSKRVWHKGL FK

References

[1]

"Acinetobacter calcoaceticus genes involved in biosynthesis of the coenzyme pyrrolo-quinoline-quinone: nucleotide sequence and expression in Escherichia coli K-12." Goosen N., Horsman H.P.A., Huinen R.G.M., van de Putte P. J. Bacteriol. 171:447-455(1989) [PubMed: 2536663] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LMD 79.41.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X06452 Genomic DNA. Translation: CAA29754.1.
PIR	D32252.
3D structure databases
SMR	P07780. Positions 6-247.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.3.3.11. 412.
Family and domain databases
HAMAP	MF_00654. PQQ_syn_PqqC. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_ACICA

Accession

Primary (citable) accession number: P07780

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	February 9, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)