Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional regulator CatM

Gene

catM

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Positively regulates the expression of catA, catBCIJFD and benPK in response to cis,cis-muconate. It binds to the catB-catM intercistronic region, to a specific sequence upstream of catA and to the benPK promoter region. Can also repress pca genes.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99Cis,cis-muconate1 Publication1
Binding sitei128Cis,cis-muconate1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 37H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processAromatic hydrocarbons catabolism, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CatM
Alternative name(s):
Cat operon transcriptional regulator
Gene namesi
Name:catM
Synonyms:catR
Ordered Locus Names:ACIAD1445
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001055991 – 303HTH-type transcriptional regulator CatMAdd BLAST303

Expressioni

Inductioni

Negatively autoregulated.

Interactioni

Subunit structurei

Homotetramer in solution.2 Publications

Protein-protein interaction databases

STRINGi62977.ACIAD1445.

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi91 – 96Combined sources6
Helixi98 – 102Combined sources5
Helixi105 – 115Combined sources11
Beta strandi119 – 125Combined sources7
Helixi128 – 136Combined sources9
Beta strandi141 – 147Combined sources7
Beta strandi154 – 169Combined sources16
Helixi173 – 177Combined sources5
Turni178 – 180Combined sources3
Helixi184 – 187Combined sources4
Beta strandi192 – 194Combined sources3
Beta strandi198 – 202Combined sources5
Helixi203 – 213Combined sources11
Beta strandi221 – 223Combined sources3
Helixi227 – 235Combined sources9
Beta strandi240 – 244Combined sources5
Helixi245 – 249Combined sources5
Beta strandi255 – 260Combined sources6
Beta strandi266 – 274Combined sources9
Helixi281 – 295Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F7BX-ray1.90A81-303[»]
2F7CX-ray2.16A81-303[»]
2H98X-ray1.80A/B1-303[»]
3GLBX-ray2.80A/B/C/D89-303[»]
ProteinModelPortaliP07774.
SMRiP07774.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07774.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4108KB2. Bacteria.
ENOG410XSY7. LUCA.
HOGENOMiHOG000233514.
KOiK21756.
OMAiPNIMFEG.
OrthoDBiPOG091H09F3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50931. HTH_LYSR. 1 hit.

Sequencei

Sequence statusi: Complete.

P07774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRHLRYFV TVVEEQSISK AAEKLCIAQP PLSRQIQKLE EELGIQLFER
60 70 80 90 100
GFRPAKVTEA GMFFYQHAVQ ILTHTAQASS MAKRIATVSQ TLRIGYVSSL
110 120 130 140 150
LYGLLPEIIY LFRQQNPEIH IELIECGTKD QINALKQGKI DLGFGRLKIT
160 170 180 190 200
DPAIRRIVLH KEQLKLAIHK HHHLNQFAAT GVHLSQIIDE PMLLYPVSQK
210 220 230 240 250
PNFATFIQSL FTELGLVPSK LTEIREIQLA LGLVAAGEGV CIVPASAMDI
260 270 280 290 300
GVKNLLYIPI LDDDAYSPIS LAVRNMDHSN YIPKILACVQ EVFATHHIRP

LIE
Length:303
Mass (Da):34,084
Last modified:July 15, 1999 - v3
Checksum:i658BB1FF4682BB38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009224 Genomic DNA. Translation: AAC46429.1.
CR543861 Genomic DNA. Translation: CAG68308.1.
RefSeqiWP_004925462.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG68308; CAG68308; ACIAD1445.
KEGGiaci:ACIAD1445.

Similar proteinsi

Entry informationi

Entry nameiCATM_ACIAD
AccessioniPrimary (citable) accession number: P07774
Secondary accession number(s): Q43930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 15, 1999
Last modified: January 31, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally (PubMed:2793826) reported to be a transcriptional repressor of cat genes. However, further investigations have shown it to be a transcriptional activator.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references