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Protein

Catechol 1,2-dioxygenase

Gene

catA

Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Catechol + O2 = cis,cis-muconate.

Cofactori

Fe3+Note: Binds 1 Fe3+ ion per subunit.

Pathwayi: beta-ketoadipate pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-oxo-4,5-dihydro-2-furylacetate from catechol.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Catechol 1,2-dioxygenase (catA)
  2. Muconate cycloisomerase 1 (catB)
  3. Muconolactone Delta-isomerase (catC)
This subpathway is part of the pathway beta-ketoadipate pathway, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-oxo-4,5-dihydro-2-furylacetate from catechol, the pathway beta-ketoadipate pathway and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi164 – 1641Iron
Metal bindingi200 – 2001Iron
Metal bindingi224 – 2241Iron
Metal bindingi226 – 2261Iron

GO - Molecular functioni

  • catechol 1,2-dioxygenase activity Source: UniProtKB
  • ferric iron binding Source: UniProtKB

GO - Biological processi

  • beta-ketoadipate pathway Source: UniProtKB-UniPathway
  • catechol-containing compound catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciASP62977:GJVV-1369-MONOMER.
BRENDAi1.13.11.1. 107.
UniPathwayiUPA00157; UER00258.

Names & Taxonomyi

Protein namesi
Recommended name:
Catechol 1,2-dioxygenase (EC:1.13.11.1)
Alternative name(s):
1,2-CTD
Gene namesi
Name:catA
Ordered Locus Names:ACIAD1442
OrganismiAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Taxonomic identifieri62977 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000000430 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Catechol 1,2-dioxygenasePRO_0000085078Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi62977.ACIAD1442.

Structurei

Secondary structure

1
311
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 1810Combined sources
Turni19 – 224Combined sources
Beta strandi24 – 263Combined sources
Helixi28 – 4720Combined sources
Helixi52 – 6716Combined sources
Helixi71 – 777Combined sources
Helixi80 – 9415Combined sources
Beta strandi116 – 1227Combined sources
Beta strandi133 – 1419Combined sources
Beta strandi152 – 1565Combined sources
Beta strandi169 – 1713Combined sources
Turni175 – 1784Combined sources
Beta strandi179 – 1835Combined sources
Beta strandi188 – 1958Combined sources
Helixi207 – 2148Combined sources
Beta strandi223 – 2308Combined sources
Beta strandi237 – 2437Combined sources
Turni247 – 2504Combined sources
Beta strandi266 – 2683Combined sources
Helixi271 – 2766Combined sources
Beta strandi283 – 2875Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DLMX-ray2.00A/B1-311[»]
1DLQX-ray2.30A/B1-311[»]
1DLTX-ray1.90A/B1-311[»]
1DMHX-ray1.70A/B1-311[»]
ProteinModelPortaliP07773.
SMRiP07773. Positions 3-311.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07773.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410626B. Bacteria.
COG3485. LUCA.
HOGENOMiHOG000150199.
KOiK03381.
OMAiILGPFWR.
OrthoDBiPOG091H0FN4.

Family and domain databases

Gene3Di2.60.130.10. 1 hit.
InterProiIPR007535. Catechol_dOase_N.
IPR012801. Cchol_dOase_prob.
IPR000627. Intradiol_dOase_C.
IPR015889. Intradiol_dOase_core.
[Graphical view]
PfamiPF00775. Dioxygenase_C. 1 hit.
PF04444. Dioxygenase_N. 1 hit.
[Graphical view]
SUPFAMiSSF49482. SSF49482. 1 hit.
TIGRFAMsiTIGR02439. catechol_proteo. 1 hit.
PROSITEiPS00083. INTRADIOL_DIOXYGENAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKIFNTQD VQDFLRVASG LEQEGGNPRV KQIIHRVLSD LYKAIEDLNI
60 70 80 90 100
TSDEYWAGVA YLNQLGANQE AGLLSPGLGF DHYLDMRMDA EDAALGIENA
110 120 130 140 150
TPRTIEGPLY VAGAPESVGY ARMDDGSDPN GHTLILHGTI FDADGKPLPN
160 170 180 190 200
AKVEIWHANT KGFYSHFDPT GEQQAFNMRR SIITDENGQY RVRTILPAGY
210 220 230 240 250
GCPPEGPTQQ LLNQLGRHGN RPAHIHYFVS ADGHRKLTTQ INVAGDPYTY
260 270 280 290 300
DDFAYATREG LVVDAVEHTD PEAIKANDVE GPFAEMVFDL KLTRLVDGVD
310
NQVVDRPRLA V
Length:311
Mass (Da):34,347
Last modified:January 1, 1990 - v1
Checksum:i8999FDD3F783B4DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009224 Genomic DNA. Translation: AAC46426.1.
CR543861 Genomic DNA. Translation: CAG68305.1.
RefSeqiWP_004925474.1. NC_005966.1.

Genome annotation databases

EnsemblBacteriaiCAG68305; CAG68305; ACIAD1442.
GeneIDi25683999.
KEGGiaci:ACIAD1442.
PATRICi20740694. VBIAciSp98416_1299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009224 Genomic DNA. Translation: AAC46426.1.
CR543861 Genomic DNA. Translation: CAG68305.1.
RefSeqiWP_004925474.1. NC_005966.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DLMX-ray2.00A/B1-311[»]
1DLQX-ray2.30A/B1-311[»]
1DLTX-ray1.90A/B1-311[»]
1DMHX-ray1.70A/B1-311[»]
ProteinModelPortaliP07773.
SMRiP07773. Positions 3-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi62977.ACIAD1442.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG68305; CAG68305; ACIAD1442.
GeneIDi25683999.
KEGGiaci:ACIAD1442.
PATRICi20740694. VBIAciSp98416_1299.

Phylogenomic databases

eggNOGiENOG410626B. Bacteria.
COG3485. LUCA.
HOGENOMiHOG000150199.
KOiK03381.
OMAiILGPFWR.
OrthoDBiPOG091H0FN4.

Enzyme and pathway databases

UniPathwayiUPA00157; UER00258.
BioCyciASP62977:GJVV-1369-MONOMER.
BRENDAi1.13.11.1. 107.

Miscellaneous databases

EvolutionaryTraceiP07773.

Family and domain databases

Gene3Di2.60.130.10. 1 hit.
InterProiIPR007535. Catechol_dOase_N.
IPR012801. Cchol_dOase_prob.
IPR000627. Intradiol_dOase_C.
IPR015889. Intradiol_dOase_core.
[Graphical view]
PfamiPF00775. Dioxygenase_C. 1 hit.
PF04444. Dioxygenase_N. 1 hit.
[Graphical view]
SUPFAMiSSF49482. SSF49482. 1 hit.
TIGRFAMsiTIGR02439. catechol_proteo. 1 hit.
PROSITEiPS00083. INTRADIOL_DIOXYGENAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_ACIAD
AccessioniPrimary (citable) accession number: P07773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.