Reviewed,
UniProtKB/Swiss-Prot P07772 (BEND_ACIAD)
Last modified
June 16, 2009.
Version 69.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase EC=1.3.1.25 Alternative name(s): Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase Cis-1,2-dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase 2-hydro-1,2-dihydroxybenzoate dehydrogenase Short name=DHB dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Acinetobacter sp. (strain ADP1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 62977 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter |
Protein attributes
| Sequence length | 261 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Degradation of 2-hydro-1,2-dihydroxy benzoate (DHB) to catechol. |
| Catalytic activity | (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH. |
| Pathway | |
| Subunit structure | Homodimer. |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Aromatic hydrocarbons catabolism |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity Inferred from electronic annotation. Source: EC bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 261 | 261 | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | PRO_0000054529 | |||||
Regions | |||||||||
| Nucleotide binding | 13 – 37 | 25 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 156 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 145 | 1 | Substrate By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 159 | 1 | S → C in AAC46439. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily." Neidle E.L., Hartnett C., Ornston L.N., Bairoch A., Rekik M., Harayama S. Eur. J. Biochem. 204:113-120(1992) [PubMed: 1740120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium." Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L., Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N., Weissenbach J., Marliere P., Cohen G.N., Medigue C. Nucleic Acids Res. 32:5766-5779(2004) [PubMed: 15514110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AF009224 Genomic DNA. Translation: AAC46439.1. CR543861 Genomic DNA. Translation: CAG68303.1. | |
| PIR | S23480. |
| RefSeq | YP_046125.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GZ6 based on UniProtKB P97852. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2880309. |
| GenomeReviews | Gene locus ACIAD1439 in contig CR543861_GR. |
| KEGG | aci:ACIAD1439. |
| NMPDR | fig|62977.3.peg.797. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P07772. |
| OMA | P07772. MQQVVDQ. |
Enzyme and pathway databases | |
| BioCyc | ASP62977:ACIAD1439-MON. |
Family and domain databases | |
| InterPro | IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR19410. ADH_short_C2. 1 hit. |
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] |
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. |
| PROSITE | PS00061. ADH_SHORT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BEND_ACIAD | ||||||||
| Accession | Primary (citable) accession number: P07772 Secondary accession number(s): Q6FCA8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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