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P07766

- CD3E_HUMAN

UniProt

P07766 - CD3E_HUMAN

Protein

T-cell surface glycoprotein CD3 epsilon chain

Gene

CD3E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 164 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    The CD3 complex mediates signal transduction.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein heterodimerization activity Source: UniProtKB
    3. protein kinase binding Source: UniProtKB
    4. receptor signaling complex scaffold activity Source: UniProtKB
    5. receptor signaling protein activity Source: ProtInc
    6. SH3 domain binding Source: UniProtKB
    7. T cell receptor binding Source: UniProtKB
    8. transmembrane signaling receptor activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic signaling pathway Source: Ensembl
    2. cell surface receptor signaling pathway Source: UniProtKB
    3. G-protein coupled receptor signaling pathway Source: ProtInc
    4. intracellular signal transduction Source: GOC
    5. negative regulation of smoothened signaling pathway Source: Ensembl
    6. negative thymic T cell selection Source: Ensembl
    7. positive regulation of alpha-beta T cell proliferation Source: Ensembl
    8. positive regulation of calcium-mediated signaling Source: Ensembl
    9. positive regulation of interferon-gamma production Source: Ensembl
    10. positive regulation of interleukin-2 biosynthetic process Source: Ensembl
    11. positive regulation of interleukin-4 production Source: Ensembl
    12. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    13. positive regulation of T cell anergy Source: Ensembl
    14. positive regulation of T cell proliferation Source: UniProtKB
    15. protein complex assembly Source: UniProtKB
    16. regulation of apoptotic process Source: UniProtKB
    17. regulation of immune response Source: Reactome
    18. response to nutrient Source: Ensembl
    19. signal complex assembly Source: ProtInc
    20. T cell activation Source: UniProtKB
    21. T cell costimulation Source: Reactome
    22. T cell receptor signaling pathway Source: Reactome
    23. transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    SignaLinkiP07766.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell surface glycoprotein CD3 epsilon chain
    Alternative name(s):
    T-cell surface antigen T3/Leu-4 epsilon chain
    CD_antigen: CD3e
    Gene namesi
    Name:CD3E
    Synonyms:T3E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1674. CD3E.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-beta T cell receptor complex Source: Ensembl
    2. external side of plasma membrane Source: MGI
    3. immunological synapse Source: Ensembl
    4. integral component of plasma membrane Source: UniProtKB
    5. plasma membrane Source: MGI
    6. T cell receptor complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Immunodeficiency 18 (IMD18) [MIM:615615]: An autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. The severity is variable, encompassing both a mild immunodeficiency and severe combined immunodeficiency (SCID), resulting in early death without bone marrow transplantation in some patients. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell-positive, natural killer (NK) cell-positive phenotype, whereas T-cell development is not impaired in the mild form of IMD18.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi615615. phenotype.
    Orphaneti169160. T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta.
    PharmGKBiPA26216.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Add
    BLAST
    Chaini23 – 207185T-cell surface glycoprotein CD3 epsilon chainPRO_0000014607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 982 Publications
    Modified residuei188 – 1881Phosphotyrosine3 PublicationsPROSITE-ProRule annotation
    Modified residuei199 – 1991Phosphotyrosine1 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiP07766.
    PaxDbiP07766.
    PeptideAtlasiP07766.
    PRIDEiP07766.

    PTM databases

    PhosphoSiteiP07766.

    Expressioni

    Gene expression databases

    ArrayExpressiP07766.
    BgeeiP07766.
    CleanExiHS_CD3E.
    GenevestigatoriP07766.

    Organism-specific databases

    HPAiCAB000010.

    Interactioni

    Subunit structurei

    The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EPS8L1Q8TE686EBI-1211297,EBI-7487998
    NCK1P163336EBI-1211297,EBI-389883
    SYKP434056EBI-1211297,EBI-78302
    ZAP70P434033EBI-1211297,EBI-1211276

    Protein-protein interaction databases

    BioGridi107354. 19 interactions.
    IntActiP07766. 15 interactions.
    MINTiMINT-7213890.
    STRINGi9606.ENSP00000354566.

    Structurei

    Secondary structure

    1
    207
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi37 – 415
    Beta strandi44 – 485
    Beta strandi57 – 615
    Beta strandi64 – 696
    Beta strandi75 – 784
    Beta strandi81 – 844
    Helixi89 – 924
    Beta strandi94 – 1007
    Helixi105 – 1073
    Beta strandi110 – 1167
    Helixi193 – 1953

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A81X-ray3.00B/D/F/H/J/L186-203[»]
    1SY6X-ray2.10A21-118[»]
    1XIWX-ray1.90A/E23-126[»]
    2ROLNMR-B181-192[»]
    DisProtiDP00506.
    ProteinModelPortaliP07766.
    SMRiP07766. Positions 33-123, 152-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07766.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 126104ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 20755CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei127 – 15226HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 11281Ig-likeAdd
    BLAST
    Domaini178 – 20528ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG78872.
    HOGENOMiHOG000290664.
    HOVERGENiHBG102121.
    InParanoidiP07766.
    KOiK06451.
    OMAiYLRARVC.
    OrthoDBiEOG7N0C6H.
    PhylomeDBiP07766.
    TreeFamiTF335892.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR015484. CD3_esu/gsu/dsu.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view]
    PANTHERiPTHR10570. PTHR10570. 1 hit.
    PfamiPF02189. ITAM. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view]
    PROSITEiPS51055. ITAM_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07766-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP    50
    QYPGSEILWQ HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP 100
    RGSKPEDANF YLYLRARVCE NCMEMDVMSV ATIVIVDICI TGGLLLLVYY 150
    WSKNRKAKAK PVTRGAGAGG RQRGQNKERP PPVPNPDYEP IRKGQRDLYS 200
    GLNQRRI 207
    Length:207
    Mass (Da):23,147
    Last modified:February 1, 1996 - v2
    Checksum:iA1603D01CE9957D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03884 mRNA. Translation: CAA27516.1.
    M23323
    , M23317, M23318, M23319, M23320, M23321, L34846, M23322 Genomic DNA. Translation: AAA52295.1.
    AK292612 mRNA. Translation: BAF85301.1.
    CH471065 Genomic DNA. Translation: EAW67364.1.
    BC049847 mRNA. Translation: AAH49847.1.
    CCDSiCCDS31685.1.
    PIRiA32069.
    RefSeqiNP_000724.1. NM_000733.3.
    UniGeneiHs.3003.

    Genome annotation databases

    EnsembliENST00000361763; ENSP00000354566; ENSG00000198851.
    GeneIDi916.
    KEGGihsa:916.
    UCSCiuc001psq.4. human.

    Polymorphism databases

    DMDMi1345708.

    Cross-referencesi

    Web resourcesi

    CD3Ebase

    CD3E mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03884 mRNA. Translation: CAA27516.1 .
    M23323
    , M23317 , M23318 , M23319 , M23320 , M23321 , L34846 , M23322 Genomic DNA. Translation: AAA52295.1 .
    AK292612 mRNA. Translation: BAF85301.1 .
    CH471065 Genomic DNA. Translation: EAW67364.1 .
    BC049847 mRNA. Translation: AAH49847.1 .
    CCDSi CCDS31685.1.
    PIRi A32069.
    RefSeqi NP_000724.1. NM_000733.3.
    UniGenei Hs.3003.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A81 X-ray 3.00 B/D/F/H/J/L 186-203 [» ]
    1SY6 X-ray 2.10 A 21-118 [» ]
    1XIW X-ray 1.90 A/E 23-126 [» ]
    2ROL NMR - B 181-192 [» ]
    DisProti DP00506.
    ProteinModelPortali P07766.
    SMRi P07766. Positions 33-123, 152-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107354. 19 interactions.
    IntActi P07766. 15 interactions.
    MINTi MINT-7213890.
    STRINGi 9606.ENSP00000354566.

    Chemistry

    ChEMBLi CHEMBL2364168.
    DrugBanki DB00075. Muromonab.
    GuidetoPHARMACOLOGYi 2742.

    PTM databases

    PhosphoSitei P07766.

    Polymorphism databases

    DMDMi 1345708.

    Proteomic databases

    MaxQBi P07766.
    PaxDbi P07766.
    PeptideAtlasi P07766.
    PRIDEi P07766.

    Protocols and materials databases

    DNASUi 916.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361763 ; ENSP00000354566 ; ENSG00000198851 .
    GeneIDi 916.
    KEGGi hsa:916.
    UCSCi uc001psq.4. human.

    Organism-specific databases

    CTDi 916.
    GeneCardsi GC11P118209.
    HGNCi HGNC:1674. CD3E.
    HPAi CAB000010.
    MIMi 186830. gene.
    615615. phenotype.
    neXtProti NX_P07766.
    Orphaneti 169160. T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta.
    PharmGKBi PA26216.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78872.
    HOGENOMi HOG000290664.
    HOVERGENi HBG102121.
    InParanoidi P07766.
    KOi K06451.
    OMAi YLRARVC.
    OrthoDBi EOG7N0C6H.
    PhylomeDBi P07766.
    TreeFami TF335892.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    SignaLinki P07766.

    Miscellaneous databases

    ChiTaRSi CD3E. human.
    EvolutionaryTracei P07766.
    GeneWikii T-cell_surface_glycoprotein_CD3_epsilon_chain.
    GenomeRNAii 916.
    NextBioi 3790.
    PROi P07766.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07766.
    Bgeei P07766.
    CleanExi HS_CD3E.
    Genevestigatori P07766.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR015484. CD3_esu/gsu/dsu.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR003110. Phos_immunorcpt_sig_ITAM.
    [Graphical view ]
    PANTHERi PTHR10570. PTHR10570. 1 hit.
    Pfami PF02189. ITAM. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 1 hit.
    SM00077. ITAM. 1 hit.
    [Graphical view ]
    PROSITEi PS51055. ITAM_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex."
      Gold D.P., Puck J.M., Pettey C.L., Cho M., Coligan J., Woody J.N., Terhorst C.
      Nature 321:431-434(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Terhorst C.
      Submitted (JAN-1987) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter."
      Clevers H.C., Dunlap S., Wileman T.E., Terhorst C.
      Proc. Natl. Acad. Sci. U.S.A. 85:8156-8160(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    7. "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency."
      Soudais C., de Villartay J.P., Le Deist F., Fischer A., Lisowska-Grospierre B.
      Nat. Genet. 3:77-81(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN IMD18.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3."
      de Saint Basile G., Geissmann F., Flori E., Uring-Lambert B., Soudais C., Cavazzana-Calvo M., Durandy A., Jabado N., Fischer A., Le Deist F.
      J. Clin. Invest. 114:1512-1517(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN IMD18.
    11. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide."
      Fuetterer K., Wong J., Grucza R.A., Chan A.C., Waksman G.
      J. Mol. Biol. 281:523-537(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 186-203 IN COMPLEX WITH SYK, PHOSPHORYLATION AT TYR-188 AND TYR-199.
    14. "Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3."
      Kjer-Nielsen L., Dunstone M.A., Kostenko L., Ely L.K., Beddoe T., Mifsud N.A., Purcell A.W., Brooks A.G., McCluskey J., Rossjohn J.
      Proc. Natl. Acad. Sci. U.S.A. 101:7675-7680(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-118 IN COMPLEX WITH CD3G AND ANTIBODY, SUBUNIT, DISULFIDE BOND.
    15. "Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment."
      Arnett K.L., Harrison S.C., Wiley D.C.
      Proc. Natl. Acad. Sci. U.S.A. 101:16268-16273(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-126 IN COMPLEX WITH CD3D AND ANTIBODY FRAGMENT, SUBUNIT, DISULFIDE BOND.

    Entry informationi

    Entry nameiCD3E_HUMAN
    AccessioniPrimary (citable) accession number: P07766
    Secondary accession number(s): A8K997
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 164 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3