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P07758

- A1AT1_MOUSE

UniProt

P07758 - A1AT1_MOUSE

Protein

Alpha-1-antitrypsin 1-1

Gene

Serpina1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 4 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei377 – 3782Reactive bondBy similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. protein N-linked glycosylation Source: MGI
    4. regulation of proteolysis Source: RefGenome
    5. response to cytokine Source: MGI
    6. response to peptide hormone Source: MGI

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Acute phase

    Protein family/group databases

    MEROPSiI04.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-1-antitrypsin 1-1
    Short name:
    AAT
    Alternative name(s):
    Alpha-1 protease inhibitor 1
    Alpha-1-antiproteinase
    Serine protease inhibitor 1-1
    Serine protease inhibitor A1a
    Short name:
    Serpin A1a
    Gene namesi
    Name:Serpina1a
    Synonyms:Dom1, Spi1-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:891971. Serpina1a.

    Subcellular locationi

    Secreted 2 Publications

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 413389Alpha-1-antitrypsin 1-1PRO_0000032388Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)1 Publication
    Glycosylationi101 – 1011N-linked (GlcNAc...)1 Publication
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP07758.
    PRIDEiP07758.

    PTM databases

    PhosphoSiteiP07758.

    Expressioni

    Gene expression databases

    ArrayExpressiP07758.
    BgeeiP07758.
    GenevestigatoriP07758.

    Interactioni

    Protein-protein interaction databases

    BioGridi203427. 3 interactions.
    IntActiP07758. 5 interactions.
    MINTiMINT-4086354.

    Structurei

    3D structure databases

    ProteinModelPortaliP07758.
    SMRiP07758. Positions 42-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni368 – 38720RCLAdd
    BLAST

    Domaini

    The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable By similarity. Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity.By similarity

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00750000117448.
    HOGENOMiHOG000238521.
    HOVERGENiHBG005957.
    InParanoidiP07758.
    KOiK03984.
    OMAiTHEDEIH.
    OrthoDBiEOG7QC7W9.
    PhylomeDBiP07758.
    TreeFamiTF343201.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07758-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPSISWGLL LLAGLCCLVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD    50
    FAISLYRELV HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF 100
    NLTQTSEADI HKSFQHLLQT LNRPDSELQL STGNGLFVNN DLKLVEKFLE 150
    EAKNHYQAEV FSVNFAESEE AKKVINDFVE KGTQGKIAEA VKKLDQDTVF 200
    ALANYILFKG KWKKPFDPEN TEEAEFHVDE STTVKVPMMT LSGMLHVHHC 250
    STLSSWVLLM DYAGNATAVF LLPDDGKMQH LEQTLSKELI SKFLLNRRRR 300
    LAQIHFPRLS ISGEYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSQ 350
    AVHKAVLTID ETGTEAAAVT VLQMVPMSMP PILRFDHPFL FIIFEEHTQS 400
    PIFLGKVVDP THK 413
    Length:413
    Mass (Da):46,003
    Last modified:October 1, 1996 - v4
    Checksum:i1124B2CC356232F4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti246 – 2461H → D in AAM47488. (PubMed:12408969)Curated
    Sequence conflicti246 – 2461H → D in AAH11040. (PubMed:15489334)Curated
    Sequence conflicti246 – 2461H → D in AAH37007. (PubMed:15489334)Curated
    Sequence conflicti246 – 2461H → D in AAH49970. (PubMed:15489334)Curated
    Sequence conflicti246 – 2461H → D in AAH57982. (PubMed:15489334)Curated
    Sequence conflicti246 – 2461H → D in AAH57984. (PubMed:15489334)Curated
    Sequence conflicti246 – 2461H → D in AAH57989. (PubMed:15489334)Curated
    Sequence conflicti246 – 2461H → D in AAA51624. (PubMed:3007061)Curated
    Sequence conflicti323 – 3231P → L in AAA51624. (PubMed:3007061)Curated
    Sequence conflicti404 – 4041L → V in AAM47488. (PubMed:12408969)Curated
    Sequence conflicti404 – 4041L → V in AAH11040. (PubMed:15489334)Curated
    Sequence conflicti404 – 4041L → V in AAH37007. (PubMed:15489334)Curated
    Sequence conflicti404 – 4041L → V in AAH49970. (PubMed:15489334)Curated
    Sequence conflicti404 – 4041L → V in AAH57982. (PubMed:15489334)Curated
    Sequence conflicti404 – 4041L → V in AAH57984. (PubMed:15489334)Curated
    Sequence conflicti404 – 4041L → V in AAH57989. (PubMed:15489334)Curated
    Sequence conflicti404 – 4041L → V in AAA51624. (PubMed:3007061)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75721 mRNA. Translation: AAC28869.1.
    AF481949 Genomic DNA. Translation: AAM47488.1.
    AK146619 mRNA. Translation: BAE27308.1.
    BC011040 mRNA. Translation: AAH11040.1.
    BC037007 mRNA. Translation: AAH37007.2.
    BC049970 mRNA. Translation: AAH49970.2.
    BC057982 mRNA. Translation: AAH57982.1.
    BC057984 mRNA. Translation: AAH57984.1.
    BC057989 mRNA. Translation: AAH57989.1.
    AH002568 mRNA. Translation: AAA51624.1.
    CCDSiCCDS26140.1.
    PIRiI49470.
    RefSeqiNP_033269.1. NM_009243.4.
    UniGeneiMm.439692.

    Genome annotation databases

    EnsembliENSMUST00000072876; ENSMUSP00000072652; ENSMUSG00000066366.
    ENSMUST00000085056; ENSMUSP00000082132; ENSMUSG00000066366.
    GeneIDi20700.
    KEGGimmu:20700.
    UCSCiuc007owh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75721 mRNA. Translation: AAC28869.1 .
    AF481949 Genomic DNA. Translation: AAM47488.1 .
    AK146619 mRNA. Translation: BAE27308.1 .
    BC011040 mRNA. Translation: AAH11040.1 .
    BC037007 mRNA. Translation: AAH37007.2 .
    BC049970 mRNA. Translation: AAH49970.2 .
    BC057982 mRNA. Translation: AAH57982.1 .
    BC057984 mRNA. Translation: AAH57984.1 .
    BC057989 mRNA. Translation: AAH57989.1 .
    AH002568 mRNA. Translation: AAA51624.1 .
    CCDSi CCDS26140.1.
    PIRi I49470.
    RefSeqi NP_033269.1. NM_009243.4.
    UniGenei Mm.439692.

    3D structure databases

    ProteinModelPortali P07758.
    SMRi P07758. Positions 42-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203427. 3 interactions.
    IntActi P07758. 5 interactions.
    MINTi MINT-4086354.

    Protein family/group databases

    MEROPSi I04.001.

    PTM databases

    PhosphoSitei P07758.

    Proteomic databases

    PaxDbi P07758.
    PRIDEi P07758.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072876 ; ENSMUSP00000072652 ; ENSMUSG00000066366 .
    ENSMUST00000085056 ; ENSMUSP00000082132 ; ENSMUSG00000066366 .
    GeneIDi 20700.
    KEGGi mmu:20700.
    UCSCi uc007owh.1. mouse.

    Organism-specific databases

    CTDi 20700.
    MGIi MGI:891971. Serpina1a.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00750000117448.
    HOGENOMi HOG000238521.
    HOVERGENi HBG005957.
    InParanoidi P07758.
    KOi K03984.
    OMAi THEDEIH.
    OrthoDBi EOG7QC7W9.
    PhylomeDBi P07758.
    TreeFami TF343201.

    Miscellaneous databases

    NextBioi 299247.
    PROi P07758.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07758.
    Bgeei P07758.
    Genevestigatori P07758.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence."
      Borriello F., Krauter K.S.
      Proc. Natl. Acad. Sci. U.S.A. 88:9417-9421(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Liver.
    2. "The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure."
      Barbour K.W., Wei F., Brannan C., Flotte T.R., Baumann H., Berger F.G.
      Genomics 80:515-522(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    5. "Isolation and characterization of the alpha 1-antitrypsin gene of mice."
      Krauter K.S., Citron B.A., Hsu M.T., Powell D., Darnell J.E. Jr.
      DNA 5:29-36(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-413.
    6. "The expression and characterization of five recombinant murine alpha 1-protease inhibitor proteins."
      Paterson T., Moore S.
      Biochem. Biophys. Res. Commun. 219:64-69(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop."
      Barbour K.W., Goodwin R.L., Guillonneau F., Wang Y., Baumann H., Berger F.G.
      Mol. Biol. Evol. 19:718-727(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION RCL.
    8. "A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins."
      Forsyth S., Horvath A., Coughlin P.
      Genomics 81:336-345(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    9. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64 AND ASN-101.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiA1AT1_MOUSE
    AccessioniPrimary (citable) accession number: P07758
    Secondary accession number(s): Q3UJ47
    , Q80YB8, Q8JZV6, Q91XB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 132 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3