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Protein

Alpha-1-antitrypsin 1-1

Gene

Serpina1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.2 Publications

Miscellaneous

Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei377 – 378Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • protein N-linked glycosylation Source: MGI
  • response to cytokine Source: MGI
  • response to peptide hormone Source: MGI

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processAcute phase

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6798695 Neutrophil degranulation
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI04.001

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-antitrypsin 1-1
Short name:
AAT
Alternative name(s):
Alpha-1 protease inhibitor 1
Alpha-1-antiproteinase
Serine protease inhibitor 1-1
Serine protease inhibitor A1a
Short name:
Serpin A1a
Gene namesi
Name:Serpina1a
Synonyms:Dom1, Spi1-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:891971 Serpina1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000003238825 – 413Alpha-1-antitrypsin 1-1Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi101N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP07758
PaxDbiP07758
PeptideAtlasiP07758
PRIDEiP07758

PTM databases

iPTMnetiP07758
PhosphoSitePlusiP07758

Expressioni

Gene expression databases

BgeeiENSMUSG00000066366
ExpressionAtlasiP07758 baseline and differential
GenevisibleiP07758 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203427, 4 interactors
IntActiP07758, 5 interactors
MINTiP07758
STRINGi10090.ENSMUSP00000072652

Structurei

3D structure databases

ProteinModelPortaliP07758
SMRiP07758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni368 – 387RCLAdd BLAST20

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiP07758
KOiK03984
PhylomeDBiP07758
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPSISWGLL LLAGLCCLVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD
60 70 80 90 100
FAISLYRELV HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF
110 120 130 140 150
NLTQTSEADI HKSFQHLLQT LNRPDSELQL STGNGLFVNN DLKLVEKFLE
160 170 180 190 200
EAKNHYQAEV FSVNFAESEE AKKVINDFVE KGTQGKIAEA VKKLDQDTVF
210 220 230 240 250
ALANYILFKG KWKKPFDPEN TEEAEFHVDE STTVKVPMMT LSGMLHVHHC
260 270 280 290 300
STLSSWVLLM DYAGNATAVF LLPDDGKMQH LEQTLSKELI SKFLLNRRRR
310 320 330 340 350
LAQIHFPRLS ISGEYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSQ
360 370 380 390 400
AVHKAVLTID ETGTEAAAVT VLQMVPMSMP PILRFDHPFL FIIFEEHTQS
410
PIFLGKVVDP THK
Length:413
Mass (Da):46,003
Last modified:October 1, 1996 - v4
Checksum:i1124B2CC356232F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246H → D in AAM47488 (PubMed:12408969).Curated1
Sequence conflicti246H → D in AAH11040 (PubMed:15489334).Curated1
Sequence conflicti246H → D in AAH37007 (PubMed:15489334).Curated1
Sequence conflicti246H → D in AAH49970 (PubMed:15489334).Curated1
Sequence conflicti246H → D in AAH57982 (PubMed:15489334).Curated1
Sequence conflicti246H → D in AAH57984 (PubMed:15489334).Curated1
Sequence conflicti246H → D in AAH57989 (PubMed:15489334).Curated1
Sequence conflicti246H → D in AAA51624 (PubMed:3007061).Curated1
Sequence conflicti323P → L in AAA51624 (PubMed:3007061).Curated1
Sequence conflicti404L → V in AAM47488 (PubMed:12408969).Curated1
Sequence conflicti404L → V in AAH11040 (PubMed:15489334).Curated1
Sequence conflicti404L → V in AAH37007 (PubMed:15489334).Curated1
Sequence conflicti404L → V in AAH49970 (PubMed:15489334).Curated1
Sequence conflicti404L → V in AAH57982 (PubMed:15489334).Curated1
Sequence conflicti404L → V in AAH57984 (PubMed:15489334).Curated1
Sequence conflicti404L → V in AAH57989 (PubMed:15489334).Curated1
Sequence conflicti404L → V in AAA51624 (PubMed:3007061).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75721 mRNA Translation: AAC28869.1
AF481949 Genomic DNA Translation: AAM47488.1
AK146619 mRNA Translation: BAE27308.1
BC011040 mRNA Translation: AAH11040.1
BC037007 mRNA Translation: AAH37007.2
BC049970 mRNA Translation: AAH49970.2
BC057982 mRNA Translation: AAH57982.1
BC057984 mRNA Translation: AAH57984.1
BC057989 mRNA Translation: AAH57989.1
AH002568 mRNA Translation: AAA51624.1
CCDSiCCDS26140.1
PIRiI49470
RefSeqiNP_033269.1, NM_009243.4
XP_017174431.1, XM_017318942.1
UniGeneiMm.439692
Mm.439695

Genome annotation databases

EnsembliENSMUST00000085056; ENSMUSP00000082132; ENSMUSG00000066366
GeneIDi20700
20703
KEGGimmu:20700
UCSCiuc007owh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiA1AT1_MOUSE
AccessioniPrimary (citable) accession number: P07758
Secondary accession number(s): Q3UJ47
, Q80YB8, Q8JZV6, Q91XB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 161 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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