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Protein

Alcohol dehydrogenase 3

Gene

alcC

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi156Zinc 1; catalyticBy similarity1
Binding sitei204NADBy similarity1
Binding sitei209NADBy similarity1
Binding sitei345NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 186NADBy similarity7
Nucleotide bindingi273 – 275NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 3 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase III
Short name:
ADH III
Gene namesi
Name:alcC
Synonyms:adh3
ORF Names:AN2286
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607211 – 352Alcohol dehydrogenase 3Add BLAST352

Proteomic databases

PRIDEiP07754

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi162425.CADANIAP00008978

Structurei

3D structure databases

ProteinModelPortaliP07754
SMRiP07754
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685
InParanoidiP07754
KOiK13953
OMAiARIPKEC
OrthoDBiEOG092C2Q8E

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P07754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPEVQWAQ VVEKAGTPPV YKQVPVPKPG PDEILVKMRY SGVCHTDLHA
60 70 80 90 100
MKGDWPLPSK MPLIGGHEGA GVVVAKGELV KDEDFKIGDR AGIKWLNGSC
110 120 130 140 150
LSCEMCMQAD EPLCPHASLS GYTVDGTFQQ YTIGKAALAS KIPDNVPLDA
160 170 180 190 200
AAPILCAGIT VYKGLKESGA RPGQTVAIVG AGGGLGSLAQ QYAKAMGLRT
210 220 230 240 250
IAIDSGDEKK AMCEQLGAEV FIDFSKSADV VADVKAATPG GLGAHAVILL
260 270 280 290 300
AVAEKPFQQA TEYVRSHGSV VAIGLPANAF LKAPVFTTVV RMINIKGSYV
310 320 330 340 350
GNRQDGVEAL DFFARGLIKA PFKKAPLQDL PQIFELMGQG KIAGRYVLEI

PE
Length:352
Mass (Da):37,126
Last modified:August 1, 1988 - v1
Checksum:iAFDE78FE442E3144
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02764 Genomic DNA Translation: CAA26541.1
AACD01000038 Genomic DNA Translation: EAA64397.1
BN001307 Genomic DNA Translation: CBF86535.1
PIRiA24648
RefSeqiXP_659890.1, XM_654798.1

Genome annotation databases

EnsemblFungiiCADANIAT00008978; CADANIAP00008978; CADANIAG00008978
EAA64397; EAA64397; AN2286.2
GeneIDi2874791
KEGGiani:AN2286.2

Similar proteinsi

Entry informationi

Entry nameiADH3_EMENI
AccessioniPrimary (citable) accession number: P07754
Secondary accession number(s): C8VN33, Q5BAZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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