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Protein

Alcohol dehydrogenase 3

Gene

alcC

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi156Zinc 1; catalyticBy similarity1
Binding sitei204NADBy similarity1
Binding sitei209NADBy similarity1
Binding sitei345NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 186NADBy similarity7
Nucleotide bindingi273 – 275NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 3 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase III
Short name:
ADH III
Gene namesi
Name:alcC
Synonyms:adh3
ORF Names:AN2286
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607211 – 352Alcohol dehydrogenase 3Add BLAST352

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP07754.
SMRiP07754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685.
InParanoidiP07754.
KOiK13953.
OMAiAWFYDAC.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P07754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPEVQWAQ VVEKAGTPPV YKQVPVPKPG PDEILVKMRY SGVCHTDLHA
60 70 80 90 100
MKGDWPLPSK MPLIGGHEGA GVVVAKGELV KDEDFKIGDR AGIKWLNGSC
110 120 130 140 150
LSCEMCMQAD EPLCPHASLS GYTVDGTFQQ YTIGKAALAS KIPDNVPLDA
160 170 180 190 200
AAPILCAGIT VYKGLKESGA RPGQTVAIVG AGGGLGSLAQ QYAKAMGLRT
210 220 230 240 250
IAIDSGDEKK AMCEQLGAEV FIDFSKSADV VADVKAATPG GLGAHAVILL
260 270 280 290 300
AVAEKPFQQA TEYVRSHGSV VAIGLPANAF LKAPVFTTVV RMINIKGSYV
310 320 330 340 350
GNRQDGVEAL DFFARGLIKA PFKKAPLQDL PQIFELMGQG KIAGRYVLEI

PE
Length:352
Mass (Da):37,126
Last modified:August 1, 1988 - v1
Checksum:iAFDE78FE442E3144
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02764 Genomic DNA. Translation: CAA26541.1.
AACD01000038 Genomic DNA. Translation: EAA64397.1.
BN001307 Genomic DNA. Translation: CBF86535.1.
PIRiA24648.
RefSeqiXP_659890.1. XM_654798.1.

Genome annotation databases

EnsemblFungiiCADANIAT00008978; CADANIAP00008978; CADANIAG00008978.
EAA64397; EAA64397; AN2286.2.
GeneIDi2874791.
KEGGiani:AN2286.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02764 Genomic DNA. Translation: CAA26541.1.
AACD01000038 Genomic DNA. Translation: EAA64397.1.
BN001307 Genomic DNA. Translation: CBF86535.1.
PIRiA24648.
RefSeqiXP_659890.1. XM_654798.1.

3D structure databases

ProteinModelPortaliP07754.
SMRiP07754.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00008978; CADANIAP00008978; CADANIAG00008978.
EAA64397; EAA64397; AN2286.2.
GeneIDi2874791.
KEGGiani:AN2286.2.

Phylogenomic databases

HOGENOMiHOG000294685.
InParanoidiP07754.
KOiK13953.
OMAiAWFYDAC.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH3_EMENI
AccessioniPrimary (citable) accession number: P07754
Secondary accession number(s): C8VN33, Q5BAZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 12, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.