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P07750

- IL4_MOUSE

UniProt

P07750 - IL4_MOUSE

Protein

Interleukin-4

Gene

Il4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. B cell activation Source: MGI
    2. B cell costimulation Source: MGI
    3. cellular response to mercury ion Source: Ensembl
    4. cholesterol metabolic process Source: UniProtKB
    5. defense response to protozoan Source: MGI
    6. dendritic cell differentiation Source: Ensembl
    7. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    8. female pregnancy Source: Ensembl
    9. innate immune response in mucosa Source: BHF-UCL
    10. negative regulation of acute inflammatory response Source: Ensembl
    11. negative regulation of chronic inflammatory response Source: Ensembl
    12. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
    13. negative regulation of macrophage activation Source: Ensembl
    14. negative regulation of nitric oxide biosynthetic process Source: Ensembl
    15. negative regulation of osteoclast differentiation Source: MGI
    16. negative regulation of T cell activation Source: MGI
    17. negative regulation of T-helper 17 cell differentiation Source: MGI
    18. negative regulation of transcription, DNA-templated Source: Ensembl
    19. positive regulation of activated T cell proliferation Source: MGI
    20. positive regulation of B cell activation Source: MGI
    21. positive regulation of B cell proliferation Source: MGI
    22. positive regulation of chemokine biosynthetic process Source: BHF-UCL
    23. positive regulation of interleukin-10 production Source: Ensembl
    24. positive regulation of interleukin-13 production Source: Ensembl
    25. positive regulation of isotype switching to IgE isotypes Source: MGI
    26. positive regulation of isotype switching to IgG isotypes Source: MGI
    27. positive regulation of MHC class II biosynthetic process Source: MGI
    28. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
    29. positive regulation of protein phosphorylation Source: MGI
    30. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    31. positive regulation of T cell differentiation Source: Ensembl
    32. positive regulation of T cell proliferation Source: MGI
    33. positive regulation of transcription, DNA-templated Source: UniProtKB
    34. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    35. positive regulation of tyrosine phosphorylation of Stat5 protein Source: MGI
    36. regulation of immune response Source: MGI
    37. regulation of proton transport Source: Ensembl
    38. response to cytokine Source: Ensembl
    39. response to drug Source: Ensembl
    40. response to ethanol Source: Ensembl
    41. response to nutrient Source: Ensembl
    42. response to organic cyclic compound Source: Ensembl
    43. T-helper 1 cell lineage commitment Source: MGI
    44. T-helper 2 cell cytokine production Source: Ensembl
    45. T-helper 2 cell differentiation Source: MGI

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Keywords - Biological processi

    B-cell activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-4
    Short name:
    IL-4
    Alternative name(s):
    B-cell IgG differentiation factor
    B-cell growth factor 1
    B-cell stimulatory factor 1
    Short name:
    BSF-1
    IGG1 induction factor
    Lymphocyte stimulatory factor 1
    Gene namesi
    Name:Il4
    Synonyms:Il-4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96556. Il4.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 140120Interleukin-4PRO_0000015538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 1071 Publication
    Disulfide bondi47 ↔ 871 Publication
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi69 ↔ 1141 Publication
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP07750.

    Expressioni

    Gene expression databases

    BgeeiP07750.
    CleanExiMM_IL4.
    GenevestigatoriP07750.

    Interactioni

    Protein-protein interaction databases

    IntActiP07750. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP07750.
    SMRiP07750. Positions 23-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-4/IL-13 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG266404.
    GeneTreeiENSGT00390000013108.
    HOGENOMiHOG000254781.
    HOVERGENiHBG000290.
    InParanoidiP07750.
    KOiK05430.
    OMAiTESELVC.
    OrthoDBiEOG7SJD75.
    PhylomeDBiP07750.
    TreeFamiTF336383.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002354. IL-4.
    IPR001325. IL-4/IL-13.
    IPR018096. IL-4/IL-13_CS.
    [Graphical view]
    PANTHERiPTHR11456. PTHR11456. 1 hit.
    PfamiPF00727. IL4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001941. Interleukin_4. 1 hit.
    PRINTSiPR00431. INTERLEUKIN4.
    SMARTiSM00190. IL4_13. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07750-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLNPQLVVI LLFFLECTRS HIHGCDKNHL REIIGILNEV TGEGTPCTEM    50
    DVPNVLTATK NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR 100
    LFRAFRCLDS SISCTMNESK STSLKDFLES LKSIMQMDYS 140
    Length:140
    Mass (Da):15,834
    Last modified:August 1, 1988 - v1
    Checksum:iE43CE16195DE051F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03532 mRNA. Translation: CAA27233.1.
    X05064 Genomic DNA. Translation: CAA28731.1.
    X05252 Genomic DNA. Translation: CAA28873.1. Sequence problems.
    X05253 Genomic DNA. Translation: CAA28874.1. Sequence problems.
    M13238 mRNA. Translation: AAA39307.1.
    M25892 mRNA. Translation: AAA39298.1.
    BC027514 mRNA. Translation: AAH27514.1.
    CCDSiCCDS24682.1.
    PIRiA25870. IIMSG1.
    RefSeqiNP_067258.1. NM_021283.2.
    UniGeneiMm.276360.

    Genome annotation databases

    EnsembliENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869.
    GeneIDi16189.
    KEGGimmu:16189.
    UCSCiuc007iwq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03532 mRNA. Translation: CAA27233.1 .
    X05064 Genomic DNA. Translation: CAA28731.1 .
    X05252 Genomic DNA. Translation: CAA28873.1 . Sequence problems.
    X05253 Genomic DNA. Translation: CAA28874.1 . Sequence problems.
    M13238 mRNA. Translation: AAA39307.1 .
    M25892 mRNA. Translation: AAA39298.1 .
    BC027514 mRNA. Translation: AAH27514.1 .
    CCDSi CCDS24682.1.
    PIRi A25870. IIMSG1.
    RefSeqi NP_067258.1. NM_021283.2.
    UniGenei Mm.276360.

    3D structure databases

    ProteinModelPortali P07750.
    SMRi P07750. Positions 23-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P07750. 1 interaction.

    Proteomic databases

    PRIDEi P07750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000889 ; ENSMUSP00000000889 ; ENSMUSG00000000869 .
    GeneIDi 16189.
    KEGGi mmu:16189.
    UCSCi uc007iwq.2. mouse.

    Organism-specific databases

    CTDi 3565.
    MGIi MGI:96556. Il4.

    Phylogenomic databases

    eggNOGi NOG266404.
    GeneTreei ENSGT00390000013108.
    HOGENOMi HOG000254781.
    HOVERGENi HBG000290.
    InParanoidi P07750.
    KOi K05430.
    OMAi TESELVC.
    OrthoDBi EOG7SJD75.
    PhylomeDBi P07750.
    TreeFami TF336383.

    Miscellaneous databases

    NextBioi 289093.
    PROi P07750.
    SOURCEi Search...

    Gene expression databases

    Bgeei P07750.
    CleanExi MM_IL4.
    Genevestigatori P07750.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR002354. IL-4.
    IPR001325. IL-4/IL-13.
    IPR018096. IL-4/IL-13_CS.
    [Graphical view ]
    PANTHERi PTHR11456. PTHR11456. 1 hit.
    Pfami PF00727. IL4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001941. Interleukin_4. 1 hit.
    PRINTSi PR00431. INTERLEUKIN4.
    SMARTi SM00190. IL4_13. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00838. INTERLEUKIN_4_13. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter."
      Noma Y., Sideras P., Naito T., Bergstedt-Lindqvist S., Azuma C., Severinson E., Tanabe T., Kinashi T., Matsuda F., Yaoita Y., Honjo T.
      Nature 319:640-646(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities."
      Otsuka T., Villaret D., Yokota T., Takebe Y., Lee F., Arai N., Arai K.
      Nucleic Acids Res. 15:333-344(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    3. "Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities."
      Lee F., Yokota T., Otsuka T., Meyerson P., Villaret D., Coffman R., Mosmann T., Rennick D., Roehm N., Smith C., Zlotnik A., Arai K.
      Proc. Natl. Acad. Sci. U.S.A. 83:2061-2065(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "IgG1 induction factor: a single molecular entity with multiple biological functions."
      Sideras P., Bergstedt-Lindqvist S., Severinson E., Noma Y., Naito T., Azuma C., Tanabe T., Kinashi T., Matsude F., Yaoita Y., Honjo T.
      Adv. Exp. Med. Biol. 213:227-236(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    6. "Disulfide assignments in recombinant mouse and human interleukin 4."
      Carr C., Aykent S., Kimack N.M., Levine A.D.
      Biochemistry 30:1515-1523(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.

    Entry informationi

    Entry nameiIL4_MOUSE
    AccessioniPrimary (citable) accession number: P07750
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1988
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3