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Protein

Interleukin-4

Gene

Il4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241).3 Publications

GO - Molecular functioni

GO - Biological processi

  • B cell activation Source: MGI
  • B cell costimulation Source: MGI
  • cholesterol metabolic process Source: UniProtKB
  • defense response to protozoan Source: MGI
  • dendritic cell differentiation Source: MGI
  • extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • innate immune response in mucosa Source: BHF-UCL
  • myeloid dendritic cell differentiation Source: MGI
  • negative regulation of complement-dependent cytotoxicity Source: MGI
  • negative regulation of endothelial cell apoptotic process Source: MGI
  • negative regulation of epithelial cell migration Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  • negative regulation of osteoclast differentiation Source: MGI
  • negative regulation of T cell activation Source: MGI
  • negative regulation of T-helper 17 cell differentiation Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of white fat cell proliferation Source: CACAO
  • positive regulation of activated T cell proliferation Source: MGI
  • positive regulation of B cell activation Source: MGI
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of chemokine biosynthetic process Source: BHF-UCL
  • positive regulation of DNA binding transcription factor activity Source: BHF-UCL
  • positive regulation of immunoglobulin production Source: MGI
  • positive regulation of interleukin-13 production Source: MGI
  • positive regulation of isotype switching to IgE isotypes Source: MGI
  • positive regulation of isotype switching to IgG isotypes Source: MGI
  • positive regulation of mast cell degranulation Source: MGI
  • positive regulation of MHC class II biosynthetic process Source: MGI
  • positive regulation of myoblast fusion Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of T cell differentiation Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
  • regulation of immune response Source: MGI
  • T cell activation Source: MGI
  • T-helper 1 cell lineage commitment Source: MGI
  • T-helper 2 cell cytokine production Source: MGI
  • T-helper 2 cell differentiation Source: MGI

Keywordsi

Molecular functionCytokine, Growth factor
Biological processB-cell activation

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and 13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell IgG differentiation factor
B-cell growth factor 1
B-cell stimulatory factor 1
Short name:
BSF-1
IGG1 induction factor
Lymphocyte stimulatory factor 1
Gene namesi
Name:Il4
Synonyms:Il-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96556 Il4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001553821 – 140Interleukin-4Add BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 1071 Publication
Disulfide bondi47 ↔ 871 Publication
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi69 ↔ 1141 Publication
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07750
PRIDEiP07750

PTM databases

PhosphoSitePlusiP07750

Expressioni

Gene expression databases

BgeeiENSMUSG00000000869
CleanExiMM_IL4
ExpressionAtlasiP07750 baseline and differential
GenevisibleiP07750 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP07750, 1 interactor
STRINGi10090.ENSMUSP00000000889

Structurei

3D structure databases

ProteinModelPortaliP07750
SMRiP07750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3886 Eukaryota
ENOG410XQ0R LUCA
GeneTreeiENSGT00390000013108
HOGENOMiHOG000254781
HOVERGENiHBG000290
InParanoidiP07750
KOiK05430
OrthoDBiEOG091G0WDE
PhylomeDBiP07750
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002354 IL-4
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PfamiView protein in Pfam
PF00727 IL4, 1 hit
PIRSFiPIRSF001941 Interleukin_4, 1 hit
PRINTSiPR00431 INTERLEUKIN4
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLNPQLVVI LLFFLECTRS HIHGCDKNHL REIIGILNEV TGEGTPCTEM
60 70 80 90 100
DVPNVLTATK NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR
110 120 130 140
LFRAFRCLDS SISCTMNESK STSLKDFLES LKSIMQMDYS
Length:140
Mass (Da):15,834
Last modified:August 1, 1988 - v1
Checksum:iE43CE16195DE051F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03532 mRNA Translation: CAA27233.1
X05064 Genomic DNA Translation: CAA28731.1
X05252 Genomic DNA Translation: CAA28873.1 Sequence problems.
X05253 Genomic DNA Translation: CAA28874.1 Sequence problems.
M13238 mRNA Translation: AAA39307.1
M25892 mRNA Translation: AAA39298.1
BC027514 mRNA Translation: AAH27514.1
CCDSiCCDS24682.1
PIRiA25870 IIMSG1
RefSeqiNP_067258.1, NM_021283.2
UniGeneiMm.276360

Genome annotation databases

EnsembliENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869
GeneIDi16189
KEGGimmu:16189
UCSCiuc007iwq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIL4_MOUSE
AccessioniPrimary (citable) accession number: P07750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: March 28, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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