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P07750

- IL4_MOUSE

UniProt

P07750 - IL4_MOUSE

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Protein

Interleukin-4

Gene

Il4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. B cell activation Source: MGI
  2. B cell costimulation Source: MGI
  3. cellular response to mercury ion Source: Ensembl
  4. cholesterol metabolic process Source: UniProtKB
  5. defense response to protozoan Source: MGI
  6. dendritic cell differentiation Source: Ensembl
  7. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  8. female pregnancy Source: Ensembl
  9. innate immune response in mucosa Source: BHF-UCL
  10. negative regulation of acute inflammatory response Source: Ensembl
  11. negative regulation of chronic inflammatory response Source: Ensembl
  12. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  13. negative regulation of macrophage activation Source: Ensembl
  14. negative regulation of nitric oxide biosynthetic process Source: Ensembl
  15. negative regulation of osteoclast differentiation Source: MGI
  16. negative regulation of T cell activation Source: MGI
  17. negative regulation of T-helper 17 cell differentiation Source: MGI
  18. negative regulation of transcription, DNA-templated Source: Ensembl
  19. positive regulation of activated T cell proliferation Source: MGI
  20. positive regulation of B cell activation Source: MGI
  21. positive regulation of B cell proliferation Source: MGI
  22. positive regulation of chemokine biosynthetic process Source: BHF-UCL
  23. positive regulation of interleukin-10 production Source: Ensembl
  24. positive regulation of interleukin-13 production Source: Ensembl
  25. positive regulation of isotype switching to IgE isotypes Source: MGI
  26. positive regulation of isotype switching to IgG isotypes Source: MGI
  27. positive regulation of MHC class II biosynthetic process Source: MGI
  28. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  29. positive regulation of protein phosphorylation Source: MGI
  30. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  31. positive regulation of T cell differentiation Source: Ensembl
  32. positive regulation of T cell proliferation Source: MGI
  33. positive regulation of transcription, DNA-templated Source: UniProtKB
  34. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  35. positive regulation of tyrosine phosphorylation of Stat5 protein Source: MGI
  36. regulation of immune response Source: MGI
  37. regulation of proton transport Source: Ensembl
  38. response to cytokine Source: Ensembl
  39. response to drug Source: Ensembl
  40. response to ethanol Source: Ensembl
  41. response to nutrient Source: Ensembl
  42. response to organic cyclic compound Source: Ensembl
  43. T-helper 1 cell lineage commitment Source: MGI
  44. T-helper 2 cell cytokine production Source: Ensembl
  45. T-helper 2 cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell IgG differentiation factor
B-cell growth factor 1
B-cell stimulatory factor 1
Short name:
BSF-1
IGG1 induction factor
Lymphocyte stimulatory factor 1
Gene namesi
Name:Il4
Synonyms:Il-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96556. Il4.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 140120Interleukin-4PRO_0000015538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 1071 Publication
Disulfide bondi47 ↔ 871 Publication
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi69 ↔ 1141 Publication
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP07750.

Expressioni

Gene expression databases

BgeeiP07750.
CleanExiMM_IL4.
ExpressionAtlasiP07750. baseline and differential.
GenevestigatoriP07750.

Interactioni

Protein-protein interaction databases

IntActiP07750. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP07750.
SMRiP07750. Positions 23-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG266404.
GeneTreeiENSGT00390000013108.
HOGENOMiHOG000254781.
HOVERGENiHBG000290.
InParanoidiP07750.
KOiK05430.
OMAiTESELVC.
OrthoDBiEOG7SJD75.
PhylomeDBiP07750.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002354. IL-4.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11456. PTHR11456. 1 hit.
PfamiPF00727. IL4. 1 hit.
[Graphical view]
PIRSFiPIRSF001941. Interleukin_4. 1 hit.
PRINTSiPR00431. INTERLEUKIN4.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07750-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLNPQLVVI LLFFLECTRS HIHGCDKNHL REIIGILNEV TGEGTPCTEM
60 70 80 90 100
DVPNVLTATK NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR
110 120 130 140
LFRAFRCLDS SISCTMNESK STSLKDFLES LKSIMQMDYS
Length:140
Mass (Da):15,834
Last modified:August 1, 1988 - v1
Checksum:iE43CE16195DE051F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03532 mRNA. Translation: CAA27233.1.
X05064 Genomic DNA. Translation: CAA28731.1.
X05252 Genomic DNA. Translation: CAA28873.1. Sequence problems.
X05253 Genomic DNA. Translation: CAA28874.1. Sequence problems.
M13238 mRNA. Translation: AAA39307.1.
M25892 mRNA. Translation: AAA39298.1.
BC027514 mRNA. Translation: AAH27514.1.
CCDSiCCDS24682.1.
PIRiA25870. IIMSG1.
RefSeqiNP_067258.1. NM_021283.2.
UniGeneiMm.276360.

Genome annotation databases

EnsembliENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869.
GeneIDi16189.
KEGGimmu:16189.
UCSCiuc007iwq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03532 mRNA. Translation: CAA27233.1 .
X05064 Genomic DNA. Translation: CAA28731.1 .
X05252 Genomic DNA. Translation: CAA28873.1 . Sequence problems.
X05253 Genomic DNA. Translation: CAA28874.1 . Sequence problems.
M13238 mRNA. Translation: AAA39307.1 .
M25892 mRNA. Translation: AAA39298.1 .
BC027514 mRNA. Translation: AAH27514.1 .
CCDSi CCDS24682.1.
PIRi A25870. IIMSG1.
RefSeqi NP_067258.1. NM_021283.2.
UniGenei Mm.276360.

3D structure databases

ProteinModelPortali P07750.
SMRi P07750. Positions 23-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P07750. 1 interaction.

Proteomic databases

PRIDEi P07750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000889 ; ENSMUSP00000000889 ; ENSMUSG00000000869 .
GeneIDi 16189.
KEGGi mmu:16189.
UCSCi uc007iwq.2. mouse.

Organism-specific databases

CTDi 3565.
MGIi MGI:96556. Il4.

Phylogenomic databases

eggNOGi NOG266404.
GeneTreei ENSGT00390000013108.
HOGENOMi HOG000254781.
HOVERGENi HBG000290.
InParanoidi P07750.
KOi K05430.
OMAi TESELVC.
OrthoDBi EOG7SJD75.
PhylomeDBi P07750.
TreeFami TF336383.

Miscellaneous databases

NextBioi 289093.
PROi P07750.
SOURCEi Search...

Gene expression databases

Bgeei P07750.
CleanExi MM_IL4.
ExpressionAtlasi P07750. baseline and differential.
Genevestigatori P07750.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002354. IL-4.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view ]
PANTHERi PTHR11456. PTHR11456. 1 hit.
Pfami PF00727. IL4. 1 hit.
[Graphical view ]
PIRSFi PIRSF001941. Interleukin_4. 1 hit.
PRINTSi PR00431. INTERLEUKIN4.
SMARTi SM00190. IL4_13. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter."
    Noma Y., Sideras P., Naito T., Bergstedt-Lindqvist S., Azuma C., Severinson E., Tanabe T., Kinashi T., Matsuda F., Yaoita Y., Honjo T.
    Nature 319:640-646(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities."
    Otsuka T., Villaret D., Yokota T., Takebe Y., Lee F., Arai N., Arai K.
    Nucleic Acids Res. 15:333-344(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities."
    Lee F., Yokota T., Otsuka T., Meyerson P., Villaret D., Coffman R., Mosmann T., Rennick D., Roehm N., Smith C., Zlotnik A., Arai K.
    Proc. Natl. Acad. Sci. U.S.A. 83:2061-2065(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "IgG1 induction factor: a single molecular entity with multiple biological functions."
    Sideras P., Bergstedt-Lindqvist S., Severinson E., Noma Y., Naito T., Azuma C., Tanabe T., Kinashi T., Matsude F., Yaoita Y., Honjo T.
    Adv. Exp. Med. Biol. 213:227-236(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  6. "Disulfide assignments in recombinant mouse and human interleukin 4."
    Carr C., Aykent S., Kimack N.M., Levine A.D.
    Biochemistry 30:1515-1523(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.

Entry informationi

Entry nameiIL4_MOUSE
AccessioniPrimary (citable) accession number: P07750
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 29, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3