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Protein

Interleukin-4

Gene

Il4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

GO - Molecular functioni

  • cytokine activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell IgG differentiation factor
B-cell growth factor 1
B-cell stimulatory factor 1
Short name:
BSF-1
IGG1 induction factor
Lymphocyte stimulatory factor 1
Gene namesi
Name:Il4
Synonyms:Il-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96556. Il4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 140120Interleukin-4PRO_0000015538Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 1071 Publication
Disulfide bondi47 ↔ 871 Publication
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi69 ↔ 1141 Publication
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP07750.

Expressioni

Gene expression databases

BgeeiP07750.
CleanExiMM_IL4.
ExpressionAtlasiP07750. baseline and differential.
GenevisibleiP07750. MM.

Interactioni

Protein-protein interaction databases

IntActiP07750. 1 interaction.
STRINGi10090.ENSMUSP00000000889.

Structurei

3D structure databases

ProteinModelPortaliP07750.
SMRiP07750. Positions 23-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG266404.
GeneTreeiENSGT00390000013108.
HOGENOMiHOG000254781.
HOVERGENiHBG000290.
InParanoidiP07750.
KOiK05430.
OrthoDBiEOG7SJD75.
PhylomeDBiP07750.
TreeFamiTF336383.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002354. IL-4.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11456. PTHR11456. 1 hit.
PfamiPF00727. IL4. 1 hit.
[Graphical view]
PIRSFiPIRSF001941. Interleukin_4. 1 hit.
PRINTSiPR00431. INTERLEUKIN4.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLNPQLVVI LLFFLECTRS HIHGCDKNHL REIIGILNEV TGEGTPCTEM
60 70 80 90 100
DVPNVLTATK NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR
110 120 130 140
LFRAFRCLDS SISCTMNESK STSLKDFLES LKSIMQMDYS
Length:140
Mass (Da):15,834
Last modified:August 1, 1988 - v1
Checksum:iE43CE16195DE051F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03532 mRNA. Translation: CAA27233.1.
X05064 Genomic DNA. Translation: CAA28731.1.
X05252 Genomic DNA. Translation: CAA28873.1. Sequence problems.
X05253 Genomic DNA. Translation: CAA28874.1. Sequence problems.
M13238 mRNA. Translation: AAA39307.1.
M25892 mRNA. Translation: AAA39298.1.
BC027514 mRNA. Translation: AAH27514.1.
CCDSiCCDS24682.1.
PIRiA25870. IIMSG1.
RefSeqiNP_067258.1. NM_021283.2.
UniGeneiMm.276360.

Genome annotation databases

EnsembliENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869.
GeneIDi16189.
KEGGimmu:16189.
UCSCiuc007iwq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03532 mRNA. Translation: CAA27233.1.
X05064 Genomic DNA. Translation: CAA28731.1.
X05252 Genomic DNA. Translation: CAA28873.1. Sequence problems.
X05253 Genomic DNA. Translation: CAA28874.1. Sequence problems.
M13238 mRNA. Translation: AAA39307.1.
M25892 mRNA. Translation: AAA39298.1.
BC027514 mRNA. Translation: AAH27514.1.
CCDSiCCDS24682.1.
PIRiA25870. IIMSG1.
RefSeqiNP_067258.1. NM_021283.2.
UniGeneiMm.276360.

3D structure databases

ProteinModelPortaliP07750.
SMRiP07750. Positions 23-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP07750. 1 interaction.
STRINGi10090.ENSMUSP00000000889.

Proteomic databases

PRIDEiP07750.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869.
GeneIDi16189.
KEGGimmu:16189.
UCSCiuc007iwq.2. mouse.

Organism-specific databases

CTDi3565.
MGIiMGI:96556. Il4.

Phylogenomic databases

eggNOGiNOG266404.
GeneTreeiENSGT00390000013108.
HOGENOMiHOG000254781.
HOVERGENiHBG000290.
InParanoidiP07750.
KOiK05430.
OrthoDBiEOG7SJD75.
PhylomeDBiP07750.
TreeFamiTF336383.

Miscellaneous databases

NextBioi289093.
PROiP07750.
SOURCEiSearch...

Gene expression databases

BgeeiP07750.
CleanExiMM_IL4.
ExpressionAtlasiP07750. baseline and differential.
GenevisibleiP07750. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002354. IL-4.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
[Graphical view]
PANTHERiPTHR11456. PTHR11456. 1 hit.
PfamiPF00727. IL4. 1 hit.
[Graphical view]
PIRSFiPIRSF001941. Interleukin_4. 1 hit.
PRINTSiPR00431. INTERLEUKIN4.
SMARTiSM00190. IL4_13. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00838. INTERLEUKIN_4_13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter."
    Noma Y., Sideras P., Naito T., Bergstedt-Lindqvist S., Azuma C., Severinson E., Tanabe T., Kinashi T., Matsuda F., Yaoita Y., Honjo T.
    Nature 319:640-646(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities."
    Otsuka T., Villaret D., Yokota T., Takebe Y., Lee F., Arai N., Arai K.
    Nucleic Acids Res. 15:333-344(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities."
    Lee F., Yokota T., Otsuka T., Meyerson P., Villaret D., Coffman R., Mosmann T., Rennick D., Roehm N., Smith C., Zlotnik A., Arai K.
    Proc. Natl. Acad. Sci. U.S.A. 83:2061-2065(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "IgG1 induction factor: a single molecular entity with multiple biological functions."
    Sideras P., Bergstedt-Lindqvist S., Severinson E., Noma Y., Naito T., Azuma C., Tanabe T., Kinashi T., Matsude F., Yaoita Y., Honjo T.
    Adv. Exp. Med. Biol. 213:227-236(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  6. "Disulfide assignments in recombinant mouse and human interleukin 4."
    Carr C., Aykent S., Kimack N.M., Levine A.D.
    Biochemistry 30:1515-1523(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.

Entry informationi

Entry nameiIL4_MOUSE
AccessioniPrimary (citable) accession number: P07750
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: June 24, 2015
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.