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Protein

High mobility group-T protein

Gene
N/A
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds preferentially single-stranded DNA and unwinds double-stranded DNA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi8 – 7871HMG box 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi94 – 16269HMG box 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group-T protein
Short name:
HMG-T
Alternative name(s):
HMG-T1
Short name:
HMG-1
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204High mobility group-T proteinPRO_0000048544Add
BLAST

Structurei

3D structure databases

DisProtiDP00041.
ProteinModelPortaliP07746.
SMRiP07746. Positions 4-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 20424Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the HMGB family.Curated
Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG009000.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
IPR017967. HMG_boxA_CS.
IPR031076. HMGB1.
[Graphical view]
PANTHERiPTHR13711:SF157. PTHR13711:SF157. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKDPRKPRG KMSSYAYFVQ TRREEHKKKH PEASVNFSEF SKKCSERWKT
60 70 80 90 100
MSAKEKGKFE DLAKLDKVRY EREMRSYIPP KGEKKKRFKD PNAPKRPSSA
110 120 130 140 150
FFIFCADFRP QVKGETPGLS IGDVAKKLGE KWNNLTAEDK VPYEKKASRL
160 170 180 190 200
KEKYEKDITA YRNKGKVPVS MPAKAAAPAK DDDDDDDDDD DDEDDDDDDD

EDDE
Length:204
Mass (Da):23,572
Last modified:July 1, 1989 - v2
Checksum:i6A858A144AD669A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221R → C in AAA58771 (PubMed:7957172).Curated
Sequence conflicti149 – 1491R → K in AAA58771 (PubMed:7957172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02666 mRNA. Translation: CAA26500.1.
L32859 Genomic DNA. Translation: AAA58771.1.
PIRiA24019.
T01071.
RefSeqiNP_001118186.1. NM_001124714.1.
UniGeneiOmy.18840.

Genome annotation databases

GeneIDi100136765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02666 mRNA. Translation: CAA26500.1.
L32859 Genomic DNA. Translation: AAA58771.1.
PIRiA24019.
T01071.
RefSeqiNP_001118186.1. NM_001124714.1.
UniGeneiOmy.18840.

3D structure databases

DisProtiDP00041.
ProteinModelPortaliP07746.
SMRiP07746. Positions 4-165.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100136765.

Phylogenomic databases

HOVERGENiHBG009000.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
IPR017967. HMG_boxA_CS.
IPR031076. HMGB1.
[Graphical view]
PANTHERiPTHR13711:SF157. PTHR13711:SF157. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGT_ONCMY
AccessioniPrimary (citable) accession number: P07746
Secondary accession number(s): Q91200
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 1, 1989
Last modified: October 14, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.