Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BPI fold-containing family A member 2

Gene

Bpifa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has strong antibacterial activity against P. aeruginosa.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Enzyme and pathway databases

ReactomeiR-MMU-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family A member 2
Alternative name(s):
Parotid secretory protein
Short name:
PSP
Gene namesi
Name:Bpifa2
Synonyms:Psp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97787 Bpifa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001718521 – 235BPI fold-containing family A member 2Add BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi161 ↔ 204By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP07743
PaxDbiP07743
PeptideAtlasiP07743
PRIDEiP07743

Expressioni

Tissue specificityi

Predominates in the parotid glands, present in smaller amounts (1/10) in the submaxillary glands and in the sublingual glands, and at lower amount in the pancreas but undetectable in the liver. Found also in lacrimal gland.1 Publication

Developmental stagei

Expressed at low levels at day 3 after birth but increased gradually with age from this time.

Gene expression databases

BgeeiENSMUSG00000042459
CleanExiMM_PSP
ExpressionAtlasiP07743 baseline and differential
GenevisibleiP07743 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046080

Structurei

3D structure databases

ProteinModelPortaliP07743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQB Eukaryota
ENOG4111BIC LUCA
GeneTreeiENSGT00390000014788
HOGENOMiHOG000231511
HOVERGENiHBG004495
InParanoidiP07743
OMAiMLQLWKL
OrthoDBiEOG091G0RXE
PhylomeDBiP07743
TreeFamiTF337052

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
SUPFAMiSSF55394 SSF55394, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQLGSLVVL CGLLIGNSES LLGELGSAVN NLKILNPPSE AVPQNLNLDV
60 70 80 90 100
ELLQQATSWP LAKNSILETL NTADLGNLKS FTSLNGLLLK INNLKVLDFQ
110 120 130 140 150
AKLSSNGNGI DLTVPLAGEA SLVLPFIGKT VDISVSLDLI NSLSIKTNAQ
160 170 180 190 200
TGLPEVTIGK CSSNTDKISI SLLGRRLPII NSILDGVSTL LTSTLSTVLQ
210 220 230
NFLCPLLQYV LSTLNPSVLQ GLLSNLLAGQ VQLAL
Length:235
Mass (Da):24,753
Last modified:August 1, 1988 - v1
Checksum:i23311BAE1E6E2EF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → P in BAB26418 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01697 mRNA Translation: CAA25846.1
M26807, M26806 Genomic DNA Translation: AAA40009.1
AK009032 mRNA Translation: BAB26037.1
AK009654 mRNA Translation: BAB26418.1
AK010181 mRNA Translation: BAB26753.1
AL732466 Genomic DNA Translation: CAM15382.1
BC010288 mRNA Translation: AAH10288.1
BC053336 mRNA Translation: AAH53336.1
CCDSiCCDS16923.1
PIRiA23031 SQMS
RefSeqiNP_032979.1, NM_008953.2
UniGeneiMm.29197

Genome annotation databases

EnsembliENSMUST00000048103; ENSMUSP00000046080; ENSMUSG00000042459
GeneIDi19194
KEGGimmu:19194
UCSCiuc008nis.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBPIA2_MOUSE
AccessioniPrimary (citable) accession number: P07743
Secondary accession number(s): A2AIF8, Q9D734
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 25, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health