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Protein

BPI fold-containing family A member 2

Gene

Bpifa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has strong antibacterial activity against P. aeruginosa.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Enzyme and pathway databases

ReactomeiR-MMU-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family A member 2
Alternative name(s):
Parotid secretory protein
Short name:
PSP
Gene namesi
Name:Bpifa2
Synonyms:Psp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97787. Bpifa2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001718521 – 235BPI fold-containing family A member 2Add BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi161 ↔ 204By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP07743.
PaxDbiP07743.
PeptideAtlasiP07743.
PRIDEiP07743.

Expressioni

Tissue specificityi

Predominates in the parotid glands, present in smaller amounts (1/10) in the submaxillary glands and in the sublingual glands, and at lower amount in the pancreas but undetectable in the liver. Found also in lacrimal gland.1 Publication

Developmental stagei

Expressed at low levels at day 3 after birth but increased gradually with age from this time.

Gene expression databases

BgeeiENSMUSG00000042459.
CleanExiMM_PSP.
ExpressionAtlasiP07743. baseline and differential.
GenevisibleiP07743. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046080.

Structurei

3D structure databases

ProteinModelPortaliP07743.
SMRiP07743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQB. Eukaryota.
ENOG4111BIC. LUCA.
GeneTreeiENSGT00390000014788.
HOGENOMiHOG000231511.
HOVERGENiHBG004495.
InParanoidiP07743.
OMAiMLQLWKL.
OrthoDBiEOG091G0RXE.
PhylomeDBiP07743.
TreeFamiTF337052.

Family and domain databases

InterProiView protein in InterPro
IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR017942. Lipid-bd_serum_glycop_N.
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiView protein in Pfam
PF01273. LBP_BPI_CETP. 1 hit.
SUPFAMiSSF55394. SSF55394. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQLGSLVVL CGLLIGNSES LLGELGSAVN NLKILNPPSE AVPQNLNLDV
60 70 80 90 100
ELLQQATSWP LAKNSILETL NTADLGNLKS FTSLNGLLLK INNLKVLDFQ
110 120 130 140 150
AKLSSNGNGI DLTVPLAGEA SLVLPFIGKT VDISVSLDLI NSLSIKTNAQ
160 170 180 190 200
TGLPEVTIGK CSSNTDKISI SLLGRRLPII NSILDGVSTL LTSTLSTVLQ
210 220 230
NFLCPLLQYV LSTLNPSVLQ GLLSNLLAGQ VQLAL
Length:235
Mass (Da):24,753
Last modified:August 1, 1988 - v1
Checksum:i23311BAE1E6E2EF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → P in BAB26418 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01697 mRNA. Translation: CAA25846.1.
M26807, M26806 Genomic DNA. Translation: AAA40009.1.
AK009032 mRNA. Translation: BAB26037.1.
AK009654 mRNA. Translation: BAB26418.1.
AK010181 mRNA. Translation: BAB26753.1.
AL732466 Genomic DNA. Translation: CAM15382.1.
BC010288 mRNA. Translation: AAH10288.1.
BC053336 mRNA. Translation: AAH53336.1.
CCDSiCCDS16923.1.
PIRiA23031. SQMS.
RefSeqiNP_032979.1. NM_008953.2.
UniGeneiMm.29197.

Genome annotation databases

EnsembliENSMUST00000048103; ENSMUSP00000046080; ENSMUSG00000042459.
GeneIDi19194.
KEGGimmu:19194.
UCSCiuc008nis.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01697 mRNA. Translation: CAA25846.1.
M26807, M26806 Genomic DNA. Translation: AAA40009.1.
AK009032 mRNA. Translation: BAB26037.1.
AK009654 mRNA. Translation: BAB26418.1.
AK010181 mRNA. Translation: BAB26753.1.
AL732466 Genomic DNA. Translation: CAM15382.1.
BC010288 mRNA. Translation: AAH10288.1.
BC053336 mRNA. Translation: AAH53336.1.
CCDSiCCDS16923.1.
PIRiA23031. SQMS.
RefSeqiNP_032979.1. NM_008953.2.
UniGeneiMm.29197.

3D structure databases

ProteinModelPortaliP07743.
SMRiP07743.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046080.

Proteomic databases

MaxQBiP07743.
PaxDbiP07743.
PeptideAtlasiP07743.
PRIDEiP07743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048103; ENSMUSP00000046080; ENSMUSG00000042459.
GeneIDi19194.
KEGGimmu:19194.
UCSCiuc008nis.1. mouse.

Organism-specific databases

CTDi140683.
MGIiMGI:97787. Bpifa2.

Phylogenomic databases

eggNOGiENOG410IXQB. Eukaryota.
ENOG4111BIC. LUCA.
GeneTreeiENSGT00390000014788.
HOGENOMiHOG000231511.
HOVERGENiHBG004495.
InParanoidiP07743.
OMAiMLQLWKL.
OrthoDBiEOG091G0RXE.
PhylomeDBiP07743.
TreeFamiTF337052.

Enzyme and pathway databases

ReactomeiR-MMU-6803157. Antimicrobial peptides.

Miscellaneous databases

ChiTaRSiBpifa2. mouse.
PROiPR:P07743.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042459.
CleanExiMM_PSP.
ExpressionAtlasiP07743. baseline and differential.
GenevisibleiP07743. MM.

Family and domain databases

InterProiView protein in InterPro
IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR017942. Lipid-bd_serum_glycop_N.
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiView protein in Pfam
PF01273. LBP_BPI_CETP. 1 hit.
SUPFAMiSSF55394. SSF55394. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBPIA2_MOUSE
AccessioniPrimary (citable) accession number: P07743
Secondary accession number(s): A2AIF8, Q9D734
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: June 7, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.