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Protein

BPI fold-containing family A member 2

Gene

Bpifa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has strong antibacterial activity against P. aeruginosa.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family A member 2
Alternative name(s):
Parotid secretory protein
Short name:
PSP
Gene namesi
Name:Bpifa2
Synonyms:Psp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97787. Bpifa2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 235215BPI fold-containing family A member 2PRO_0000017185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi161 ↔ 204By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP07743.
PaxDbiP07743.
PeptideAtlasiP07743.
PRIDEiP07743.

Expressioni

Tissue specificityi

Predominates in the parotid glands, present in smaller amounts (1/10) in the submaxillary glands and in the sublingual glands, and at lower amount in the pancreas but undetectable in the liver. Found also in lacrimal gland.1 Publication

Developmental stagei

Expressed at low levels at day 3 after birth but increased gradually with age from this time.

Gene expression databases

BgeeiENSMUSG00000042459.
CleanExiMM_PSP.
ExpressionAtlasiP07743. baseline and differential.
GenevisibleiP07743. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046080.

Structurei

3D structure databases

ProteinModelPortaliP07743.
SMRiP07743. Positions 83-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQB. Eukaryota.
ENOG4111BIC. LUCA.
GeneTreeiENSGT00390000014788.
HOGENOMiHOG000231511.
HOVERGENiHBG004495.
InParanoidiP07743.
OMAiLCPRIRE.
OrthoDBiEOG091G0RXE.
PhylomeDBiP07743.
TreeFamiTF337052.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQLGSLVVL CGLLIGNSES LLGELGSAVN NLKILNPPSE AVPQNLNLDV
60 70 80 90 100
ELLQQATSWP LAKNSILETL NTADLGNLKS FTSLNGLLLK INNLKVLDFQ
110 120 130 140 150
AKLSSNGNGI DLTVPLAGEA SLVLPFIGKT VDISVSLDLI NSLSIKTNAQ
160 170 180 190 200
TGLPEVTIGK CSSNTDKISI SLLGRRLPII NSILDGVSTL LTSTLSTVLQ
210 220 230
NFLCPLLQYV LSTLNPSVLQ GLLSNLLAGQ VQLAL
Length:235
Mass (Da):24,753
Last modified:August 1, 1988 - v1
Checksum:i23311BAE1E6E2EF3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41L → P in BAB26418 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01697 mRNA. Translation: CAA25846.1.
M26807, M26806 Genomic DNA. Translation: AAA40009.1.
AK009032 mRNA. Translation: BAB26037.1.
AK009654 mRNA. Translation: BAB26418.1.
AK010181 mRNA. Translation: BAB26753.1.
AL732466 Genomic DNA. Translation: CAM15382.1.
BC010288 mRNA. Translation: AAH10288.1.
BC053336 mRNA. Translation: AAH53336.1.
CCDSiCCDS16923.1.
PIRiA23031. SQMS.
RefSeqiNP_032979.1. NM_008953.2.
UniGeneiMm.29197.

Genome annotation databases

EnsembliENSMUST00000048103; ENSMUSP00000046080; ENSMUSG00000042459.
GeneIDi19194.
KEGGimmu:19194.
UCSCiuc008nis.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01697 mRNA. Translation: CAA25846.1.
M26807, M26806 Genomic DNA. Translation: AAA40009.1.
AK009032 mRNA. Translation: BAB26037.1.
AK009654 mRNA. Translation: BAB26418.1.
AK010181 mRNA. Translation: BAB26753.1.
AL732466 Genomic DNA. Translation: CAM15382.1.
BC010288 mRNA. Translation: AAH10288.1.
BC053336 mRNA. Translation: AAH53336.1.
CCDSiCCDS16923.1.
PIRiA23031. SQMS.
RefSeqiNP_032979.1. NM_008953.2.
UniGeneiMm.29197.

3D structure databases

ProteinModelPortaliP07743.
SMRiP07743. Positions 83-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046080.

Proteomic databases

MaxQBiP07743.
PaxDbiP07743.
PeptideAtlasiP07743.
PRIDEiP07743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048103; ENSMUSP00000046080; ENSMUSG00000042459.
GeneIDi19194.
KEGGimmu:19194.
UCSCiuc008nis.1. mouse.

Organism-specific databases

CTDi140683.
MGIiMGI:97787. Bpifa2.

Phylogenomic databases

eggNOGiENOG410IXQB. Eukaryota.
ENOG4111BIC. LUCA.
GeneTreeiENSGT00390000014788.
HOGENOMiHOG000231511.
HOVERGENiHBG004495.
InParanoidiP07743.
OMAiLCPRIRE.
OrthoDBiEOG091G0RXE.
PhylomeDBiP07743.
TreeFamiTF337052.

Miscellaneous databases

ChiTaRSiBpifa2. mouse.
PROiP07743.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042459.
CleanExiMM_PSP.
ExpressionAtlasiP07743. baseline and differential.
GenevisibleiP07743. MM.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBPIA2_MOUSE
AccessioniPrimary (citable) accession number: P07743
Secondary accession number(s): A2AIF8, Q9D734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.