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Protein

Alkanal monooxygenase alpha chain

Gene

luxA

Organism
Vibrio harveyi (Beneckea harveyi)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Light-emitting reaction in luminous bacteria.By similarity

Miscellaneous

The synthesis of this protein is regulated by a complex control mechanism that has been termed autoinduction. In fully induced cells luciferase comprises up to 5% of the soluble protein.

Catalytic activityi

A long-chain aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + H2O + light.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase, Photoprotein
Biological processLuminescence
LigandFlavoprotein, FMN

Enzyme and pathway databases

BRENDAi1.14.14.3 6632

Names & Taxonomyi

Protein namesi
Recommended name:
Alkanal monooxygenase alpha chain (EC:1.14.14.3By similarity)
Alternative name(s):
Bacterial luciferase alpha chain
Gene namesi
Name:luxA
OrganismiVibrio harveyi (Beneckea harveyi)
Taxonomic identifieri669 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002201721 – 355Alkanal monooxygenase alpha chainAdd BLAST355

Proteomic databases

PRIDEiP07740

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.2 Publications

Protein-protein interaction databases

MINTiP07740

Chemistry databases

BindingDBiP07740

Structurei

Secondary structure

1355
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi17 – 30Combined sources14
Helixi32 – 34Combined sources3
Beta strandi37 – 41Combined sources5
Helixi55 – 65Combined sources11
Beta strandi70 – 77Combined sources8
Helixi78 – 80Combined sources3
Helixi83 – 97Combined sources15
Beta strandi101 – 106Combined sources6
Helixi111 – 117Combined sources7
Helixi121 – 123Combined sources3
Helixi124 – 141Combined sources18
Beta strandi142 – 150Combined sources9
Beta strandi152 – 157Combined sources6
Beta strandi170 – 172Combined sources3
Helixi177 – 185Combined sources9
Beta strandi190 – 192Combined sources3
Beta strandi194 – 196Combined sources3
Helixi198 – 214Combined sources17
Helixi219 – 221Combined sources3
Beta strandi225 – 229Combined sources5
Helixi236 – 259Combined sources24
Turni260 – 263Combined sources4
Helixi274 – 276Combined sources3
Helixi294 – 298Combined sources5
Beta strandi299 – 303Combined sources5
Helixi304 – 318Combined sources15
Beta strandi322 – 326Combined sources5
Helixi328 – 330Combined sources3
Helixi333 – 346Combined sources14
Helixi348 – 350Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BRLX-ray2.40A/C1-355[»]
1LUCX-ray1.50A1-355[»]
3FGCX-ray2.30A/C1-355[»]
ProteinModelPortaliP07740
SMRiP07740
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07740

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108M8W Bacteria
COG2141 LUCA

Family and domain databases

CDDicd01096 Alkanal_monooxygenase, 1 hit
Gene3Di3.20.20.30, 1 hit
InterProiView protein in InterPro
IPR033924 Alkanal_monooxygenase
IPR018235 Bacterial_luciferase_CS
IPR011251 Luciferase-like_dom
IPR036661 Luciferase-like_sf
IPR002103 Luciferase_bac/NFP
PfamiView protein in Pfam
PF00296 Bac_luciferase, 1 hit
PRINTSiPR00089 LUCIFERASE
SUPFAMiSSF51679 SSF51679, 1 hit
PROSITEiView protein in PROSITE
PS00494 BACTERIAL_LUCIFERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P07740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGNFLLTY QPPELSQTEV MKRLVNLGKA SEGCGFDTVW LLEHHFTEFG
60 70 80 90 100
LLGNPYVAAA HLLGATETLN VGTAAIVLPT AHPVRQAEDV NLLDQMSKGR
110 120 130 140 150
FRFGICRGLY DKDFRVFGTD MDNSRALMDC WYDLMKEGFN EGYIAADNEH
160 170 180 190 200
IKFPKIQLNP SAYTQGGAPV YVVAESASTT EWAAERGLPM ILSWIINTHE
210 220 230 240 250
KKAQLDLYNE VATEHGYDVT KIDHCLSYIT SVDHDSNRAK DICRNFLGHW
260 270 280 290 300
YDSYVNATKI FDDSDQTKGY DFNKGQWRDF VLKGHKDTNR RIDYSYEINP
310 320 330 340 350
VGTPEECIAI IQQDIDATGI DNICCGFEAN GSEEEIIASM KLFQSDVMPY

LKEKQ
Length:355
Mass (Da):40,153
Last modified:August 1, 1988 - v1
Checksum:iF915E6BBE41ACEEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17Q → E AA sequence (PubMed:3997817).Curated1
Sequence conflicti68T → K in CAA41597 (PubMed:1685011).Curated1
Sequence conflicti169P → A AA sequence (PubMed:3997817).Curated1
Sequence conflicti174A → P AA sequence (PubMed:3997817).Curated1
Sequence conflicti204 – 205QL → HV in CAA41597 (PubMed:1685011).Curated2
Sequence conflicti238R → K in CAA41597 (PubMed:1685011).Curated1
Sequence conflicti321D → N in CAA41597 (PubMed:1685011).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10961 Genomic DNA Translation: AAA88685.1
X58791 Genomic DNA Translation: CAA41597.1
V01422 Genomic DNA Translation: CAA24692.1
V01423 Genomic DNA Translation: CAA24693.1
PIRiA22613
RefSeqiWP_010991819.1, NZ_LOSK02000001.1

Similar proteinsi

Entry informationi

Entry nameiLUXA_VIBHA
AccessioniPrimary (citable) accession number: P07740
Secondary accession number(s): Q56698, Q6LBZ4, Q6LBZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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