P07732 (GTHB2_ONCTS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gonadotropin subunit beta-2

Alternative name(s):
GTH-II-beta
Gonadotropin beta-II chain

Gene names

Name:

cgbb

Organism

Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha)

Taxonomic identifier

74940 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonoidei › Salmonidae › Salmoninae › Oncorhynchus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in gametogenesis and steroidogenesis.
Subunit structure	Heterodimer of an alpha and a beta chain.
Subcellular location	Secreted.
Sequence similarities	Belongs to the glycoprotein hormones subunit beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23
	Chain	24 – 142	119	Gonadotropin subunit beta-2		PRO_0000011703
Amino acid modifications
	Glycosylation	33	1	N-linked (GlcNAc...) Probable
	Disulfide bond	29 ↔ 77		By similarity
	Disulfide bond	43 ↔ 92		By similarity
	Disulfide bond	46 ↔ 130		By similarity
	Disulfide bond	54 ↔ 108		By similarity
	Disulfide bond	58 ↔ 110		By similarity
	Disulfide bond	113 ↔ 120		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P07732 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: BEAEBEBFFD1292F8	FASTA	142	15,903
	10 20 30 40 50 60 MLGLHVGTLI SLFLCILLEP IEGSLMQPCQ PINQTVSLEK EGCPTCLVIR APICSGHCVT 70 80 90 100 110 120 KEPVFKSPFS TVYQHVCTYR DVRYEMIRLP DCPPWSDPHV TYPVALSCDC SLCNMDTSDC 130 140 TIESLQPDFC ITQRVLTDGD MW

References

[1]	"Molecular cloning and sequencing of salmon gonadotropin beta subunit." Trinh K.-Y., Wang N.C., Hew C.-L., Crim L.W. Eur. J. Biochem. 159:619-624(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X04404 mRNA. Translation: CAA27992.1.
PIR	A25800.
3D structure databases
ProteinModelPortal	P07732.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006698.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR001545. Gonadotropin_bsu. IPR018245. Gonadotropin_bsu_CS. IPR015564. LH_beta-like. [Graphical view]
PANTHER	PTHR11515. PTHR11515. 1 hit. PTHR11515:SF7. PTHR11515:SF7. 1 hit.
Pfam	PF00007. Cys_knot. 1 hit. [Graphical view]
SMART	SM00068. GHB. 1 hit. [Graphical view]
PROSITE	PS00261. GLYCO_HORMONE_BETA_1. 1 hit. PS00689. GLYCO_HORMONE_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GTHB2_ONCTS

Accession

Primary (citable) accession number: P07732

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program