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P07732 (GTHB2_ONCTS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gonadotropin subunit beta-2
Alternative name(s):
GTH-II-beta
Gonadotropin beta-II chain
Gene names
Name:cgbb
OrganismOncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha)
Taxonomic identifier74940 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in gametogenesis and steroidogenesis.

Subunit structure

Heterodimer of an alpha and a beta chain.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glycoprotein hormones subunit beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 142119Gonadotropin subunit beta-2
PRO_0000011703

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Probable
Disulfide bond29 ↔ 77 By similarity
Disulfide bond43 ↔ 92 By similarity
Disulfide bond46 ↔ 130 By similarity
Disulfide bond54 ↔ 108 By similarity
Disulfide bond58 ↔ 110 By similarity
Disulfide bond113 ↔ 120 By similarity

Sequences

Sequence LengthMass (Da)Tools
P07732 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: BEAEBEBFFD1292F8

FASTA14215,903
        10         20         30         40         50         60 
MLGLHVGTLI SLFLCILLEP IEGSLMQPCQ PINQTVSLEK EGCPTCLVIR APICSGHCVT 

        70         80         90        100        110        120 
KEPVFKSPFS TVYQHVCTYR DVRYEMIRLP DCPPWSDPHV TYPVALSCDC SLCNMDTSDC 

       130        140 
TIESLQPDFC ITQRVLTDGD MW 

« Hide

References

[1]"Molecular cloning and sequencing of salmon gonadotropin beta subunit."
Trinh K.-Y., Wang N.C., Hew C.-L., Crim L.W.
Eur. J. Biochem. 159:619-624(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X04404 mRNA. Translation: CAA27992.1.
PIRA25800.

3D structure databases

ProteinModelPortalP07732.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006698.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERPTHR11515. PTHR11515. 1 hit.
PfamPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGTHB2_ONCTS
AccessionPrimary (citable) accession number: P07732
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families