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P07732

- GTHB2_ONCTS

UniProt

P07732 - GTHB2_ONCTS

Protein

Gonadotropin subunit beta-2

Gene

cgbb

Organism
Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Involved in gametogenesis and steroidogenesis.

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gonadotropin subunit beta-2
    Alternative name(s):
    GTH-II-beta
    Gonadotropin beta-II chain
    Gene namesi
    Name:cgbb
    OrganismiOncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha)
    Taxonomic identifieri74940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 142119Gonadotropin subunit beta-2PRO_0000011703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 77By similarity
    Glycosylationi33 – 331N-linked (GlcNAc...)Curated
    Disulfide bondi43 ↔ 92By similarity
    Disulfide bondi46 ↔ 130By similarity
    Disulfide bondi54 ↔ 108By similarity
    Disulfide bondi58 ↔ 110By similarity
    Disulfide bondi113 ↔ 120By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Structurei

    3D structure databases

    ProteinModelPortaliP07732.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006698.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view]
    PANTHERiPTHR11515. PTHR11515. 1 hit.
    PfamiPF00007. Cys_knot. 1 hit.
    [Graphical view]
    SMARTiSM00068. GHB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07732-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGLHVGTLI SLFLCILLEP IEGSLMQPCQ PINQTVSLEK EGCPTCLVIR    50
    APICSGHCVT KEPVFKSPFS TVYQHVCTYR DVRYEMIRLP DCPPWSDPHV 100
    TYPVALSCDC SLCNMDTSDC TIESLQPDFC ITQRVLTDGD MW 142
    Length:142
    Mass (Da):15,903
    Last modified:April 1, 1988 - v1
    Checksum:iBEAEBEBFFD1292F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04404 mRNA. Translation: CAA27992.1.
    PIRiA25800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04404 mRNA. Translation: CAA27992.1 .
    PIRi A25800.

    3D structure databases

    ProteinModelPortali P07732.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006698.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view ]
    PANTHERi PTHR11515. PTHR11515. 1 hit.
    Pfami PF00007. Cys_knot. 1 hit.
    [Graphical view ]
    SMARTi SM00068. GHB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of salmon gonadotropin beta subunit."
      Trinh K.-Y., Wang N.C., Hew C.-L., Crim L.W.
      Eur. J. Biochem. 159:619-624(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGTHB2_ONCTS
    AccessioniPrimary (citable) accession number: P07732
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3