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Protein

T-cell surface glycoprotein CD8 alpha chain

Gene

Cd8a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

GO - Molecular functioni

  • protein kinase binding Source: RGD

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • cytotoxic T cell differentiation Source: GO_Central
  • defense response to virus Source: Ensembl
  • inflammatory response Source: RGD
  • positive regulation of calcium-mediated signaling Source: Ensembl
  • T cell activation Source: RGD
  • T cell mediated immunity Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD8 alpha chain
Alternative name(s):
CD8 antigen 32 kDa chain
OX-8 membrane antigen
CD_antigen: CD8a
Gene namesi
Name:Cd8a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2316. Cd8a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 189ExtracellularSequence analysisAdd BLAST163
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 236CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001464127 – 236T-cell surface glycoprotein CD8 alpha chainAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 119PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...)1 Publication1
Glycosylationi144O-linked (GalNAc...); partial1 Publication1
Glycosylationi148O-linked (GalNAc...)1 Publication1
Glycosylationi152O-linked (GalNAc...)1 Publication1
Glycosylationi158O-linked (GalNAc...)1 Publication1
Glycosylationi160O-linked (GalNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07725.
PRIDEiP07725.

PTM databases

PhosphoSitePlusiP07725.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007178.
GenevisibleiP07725. RN.

Interactioni

Subunit structurei

In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers.

GO - Molecular functioni

  • protein kinase binding Source: RGD

Protein-protein interaction databases

DIPiDIP-60779N.
STRINGi10116.ENSRNOP00000009516.

Structurei

3D structure databases

ProteinModelPortaliP07725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 130Ig-like V-typeAdd BLAST104

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWN3. Eukaryota.
ENOG410Z6EI. LUCA.
GeneTreeiENSGT00510000048935.
HOGENOMiHOG000004794.
HOVERGENiHBG008488.
InParanoidiP07725.
KOiK06458.
OMAiRVCKCPR.
OrthoDBiEOG091G0YIT.
PhylomeDBiP07725.
TreeFamiTF336070.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015468. CD8_asu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR10441. PTHR10441. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRVICFLS LNLLLLDVIT RLQVSGQLQL SPKKVDAEIG QEVKLTCEVL
60 70 80 90 100
RDTSQGCSWL FRNSSSELLQ PTFIIYVSSS RSKLNDILDP NLFSARKENN
110 120 130 140 150
KYILTLSKFS TKNQGYYFCS ITSNSVMYFS PLVPVFQKVN SIITKPVTRA
160 170 180 190 200
PTPVPPPTGT PRPLRPEACR PGASGSVEGM GLGFACDIYI WAPLAGICAV
210 220 230
LLLSLVITLI CCHRNRRRVC KCPRPLVKPR PSEKFV
Length:236
Mass (Da):26,196
Last modified:April 1, 1988 - v1
Checksum:iADFAC54E4C99C1BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03015 mRNA. Translation: CAA26798.1.
BC088126 mRNA. Translation: AAH88126.1.
PIRiA24637.
RefSeqiNP_113726.1. NM_031538.2.
XP_006236692.1. XM_006236630.3.
XP_008761198.1. XM_008762976.2.
UniGeneiRn.10306.

Genome annotation databases

EnsembliENSRNOT00000009515; ENSRNOP00000009516; ENSRNOG00000007178.
GeneIDi24930.
KEGGirno:24930.
UCSCiRGD:2316. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03015 mRNA. Translation: CAA26798.1.
BC088126 mRNA. Translation: AAH88126.1.
PIRiA24637.
RefSeqiNP_113726.1. NM_031538.2.
XP_006236692.1. XM_006236630.3.
XP_008761198.1. XM_008762976.2.
UniGeneiRn.10306.

3D structure databases

ProteinModelPortaliP07725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60779N.
STRINGi10116.ENSRNOP00000009516.

PTM databases

PhosphoSitePlusiP07725.

Proteomic databases

PaxDbiP07725.
PRIDEiP07725.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009515; ENSRNOP00000009516; ENSRNOG00000007178.
GeneIDi24930.
KEGGirno:24930.
UCSCiRGD:2316. rat.

Organism-specific databases

CTDi925.
RGDi2316. Cd8a.

Phylogenomic databases

eggNOGiENOG410IWN3. Eukaryota.
ENOG410Z6EI. LUCA.
GeneTreeiENSGT00510000048935.
HOGENOMiHOG000004794.
HOVERGENiHBG008488.
InParanoidiP07725.
KOiK06458.
OMAiRVCKCPR.
OrthoDBiEOG091G0YIT.
PhylomeDBiP07725.
TreeFamiTF336070.

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

PROiP07725.

Gene expression databases

BgeeiENSRNOG00000007178.
GenevisibleiP07725. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015468. CD8_asu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PANTHERiPTHR10441. PTHR10441. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD8A_RAT
AccessioniPrimary (citable) accession number: P07725
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.