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P07724

- ALBU_MOUSE

UniProt

P07724 - ALBU_MOUSE

Protein

Serum albumin

Gene

Alb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 3 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271Copper
    Metal bindingi91 – 911ZincBy similarity
    Metal bindingi123 – 1231ZincBy similarity
    Metal bindingi271 – 2711ZincBy similarity
    Metal bindingi273 – 2731ZincBy similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. drug binding Source: UniProtKB
    3. fatty acid binding Source: Ensembl
    4. oxygen binding Source: Ensembl
    5. pyridoxal phosphate binding Source: UniProtKB
    6. toxic substance binding Source: UniProtKB
    7. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. cellular response to starvation Source: UniProtKB
    2. hemolysis by symbiont of host erythrocytes Source: UniProtKB
    3. maintenance of mitochondrion location Source: UniProtKB
    4. negative regulation of apoptotic process Source: UniProtKB
    5. positive regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
    6. response to mercury ion Source: Ensembl
    7. response to nutrient Source: Ensembl
    8. response to organic substance Source: Ensembl
    9. response to platinum ion Source: Ensembl
    10. transport Source: InterPro

    Keywords - Ligandi

    Copper, Lipid-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_196575. Scavenging of heme from plasma.
    REACT_210189. Transport of organic anions.
    REACT_213857. HDL-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serum albumin
    Gene namesi
    Name:Alb
    Synonyms:Alb-1, Alb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:87991. Alb.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: Ensembl
    2. cytoplasm Source: MGI
    3. extracellular region Source: MGI
    4. extracellular space Source: MGI
    5. extracellular vesicular exosome Source: Ensembl
    6. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Protein family/group databases

    Allergomei755. Mus m 4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Propeptidei19 – 224PRO_0000001073
    Chaini25 – 608584Serum albuminPRO_0000001074Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
    Modified residuei82 – 821PhosphoserineBy similarity
    Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
    Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
    Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
    Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
    Modified residuei229 – 2291N6-succinyllysine1 Publication
    Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
    Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
    Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
    Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
    Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
    Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
    Modified residuei443 – 4431PhosphoserineBy similarity
    Modified residuei444 – 4441PhosphothreonineBy similarity
    Modified residuei446 – 4461PhosphothreonineBy similarity
    Modified residuei460 – 4601N6-succinyllysine1 Publication
    Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
    Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
    Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
    Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
    Modified residuei543 – 5431N6-succinyllysine1 Publication
    Disulfide bondi582 ↔ 591PROSITE-ProRule annotation
    Modified residuei588 – 5881N6-succinyllysine1 Publication

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiP07724.
    PaxDbiP07724.
    PRIDEiP07724.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00131695.
    P07724.
    Q8CG74.
    SWISS-2DPAGEP07724.
    UCD-2DPAGEP07724.

    PTM databases

    PhosphoSiteiP07724.

    Expressioni

    Tissue specificityi

    Plasma.

    Gene expression databases

    BgeeiP07724.
    CleanExiMM_ALB.
    GenevestigatoriP07724.

    Interactioni

    Protein-protein interaction databases

    BioGridi198060. 5 interactions.
    IntActiP07724. 9 interactions.
    MINTiMINT-1854591.

    Structurei

    3D structure databases

    ProteinModelPortaliP07724.
    SMRiP07724. Positions 29-585.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 211193Albumin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini212 – 403192Albumin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini404 – 601198Albumin 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
    Contains 3 albumin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG45992.
    HOGENOMiHOG000293137.
    HOVERGENiHBG004207.
    InParanoidiP07724.
    KOiK16141.
    OMAiNCDKSLH.
    OrthoDBiEOG7S4X5C.
    PhylomeDBiP07724.
    TreeFamiTF335561.

    Family and domain databases

    InterProiIPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view]
    PfamiPF00273. Serum_albumin. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSiPR00802. SERUMALBUMIN.
    SMARTiSM00103. ALBUMIN. 3 hits.
    [Graphical view]
    SUPFAMiSSF48552. SSF48552. 3 hits.
    PROSITEiPS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07724-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWVTFLLLL FVSGSAFSRG VFRREAHKSE IAHRYNDLGE QHFKGLVLIA    50
    FSQYLQKCSY DEHAKLVQEV TDFAKTCVAD ESAANCDKSL HTLFGDKLCA 100
    IPNLRENYGE LADCCTKQEP ERNECFLQHK DDNPSLPPFE RPEAEAMCTS 150
    FKENPTTFMG HYLHEVARRH PYFYAPELLY YAEQYNEILT QCCAEADKES 200
    CLTPKLDGVK EKALVSSVRQ RMKCSSMQKF GERAFKAWAV ARLSQTFPNA 250
    DFAEITKLAT DLTKVNKECC HGDLLECADD RAELAKYMCE NQATISSKLQ 300
    TCCDKPLLKK AHCLSEVEHD TMPADLPAIA ADFVEDQEVC KNYAEAKDVF 350
    LGTFLYEYSR RHPDYSVSLL LRLAKKYEAT LEKCCAEANP PACYGTVLAE 400
    FQPLVEEPKN LVKTNCDLYE KLGEYGFQNA ILVRYTQKAP QVSTPTLVEA 450
    ARNLGRVGTK CCTLPEDQRL PCVEDYLSAI LNRVCLLHEK TPVSEHVTKC 500
    CSGSLVERRP CFSALTVDET YVPKEFKAET FTFHSDICTL PEKEKQIKKQ 550
    TALAELVKHK PKATAEQLKT VMDDFAQFLD TCCKAADKDT CFSTEGPNLV 600
    TRCKDALA 608
    Length:608
    Mass (Da):68,693
    Last modified:July 15, 1999 - v3
    Checksum:i292F7C7EED3A61B4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271H → D AA sequence (PubMed:1286668)Curated
    Sequence conflicti33 – 331H → D AA sequence (PubMed:1286668)Curated
    Sequence conflicti33 – 331H → N in BAC34360. (PubMed:16141072)Curated
    Sequence conflicti41 – 411Q → I AA sequence (PubMed:1286668)Curated
    Sequence conflicti561 – 5611P → H in BAE35818. (PubMed:16141072)Curated
    Sequence conflicti606 – 6061A → T in BAC34145. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011413 mRNA. Translation: CAA09617.1.
    AJ277794 Genomic DNA. Translation: CAC81903.1.
    AK010025 mRNA. Translation: BAB26650.1.
    AK050248 mRNA. Translation: BAC34145.1.
    AK050644 mRNA. Translation: BAC34360.1.
    AK160487 mRNA. Translation: BAE35818.1.
    BC024643 mRNA. Translation: AAH24643.1.
    BC049971 mRNA. Translation: AAH49971.1.
    M16111 mRNA. Translation: AAA37190.1.
    X13060 Genomic DNA. Translation: CAA31458.1.
    CCDSiCCDS19412.1.
    PIRiA05139.
    RefSeqiNP_033784.2. NM_009654.3.
    UniGeneiMm.16773.

    Genome annotation databases

    EnsembliENSMUST00000031314; ENSMUSP00000031314; ENSMUSG00000029368.
    GeneIDi11657.
    KEGGimmu:11657.
    UCSCiuc008yaz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011413 mRNA. Translation: CAA09617.1 .
    AJ277794 Genomic DNA. Translation: CAC81903.1 .
    AK010025 mRNA. Translation: BAB26650.1 .
    AK050248 mRNA. Translation: BAC34145.1 .
    AK050644 mRNA. Translation: BAC34360.1 .
    AK160487 mRNA. Translation: BAE35818.1 .
    BC024643 mRNA. Translation: AAH24643.1 .
    BC049971 mRNA. Translation: AAH49971.1 .
    M16111 mRNA. Translation: AAA37190.1 .
    X13060 Genomic DNA. Translation: CAA31458.1 .
    CCDSi CCDS19412.1.
    PIRi A05139.
    RefSeqi NP_033784.2. NM_009654.3.
    UniGenei Mm.16773.

    3D structure databases

    ProteinModelPortali P07724.
    SMRi P07724. Positions 29-585.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198060. 5 interactions.
    IntActi P07724. 9 interactions.
    MINTi MINT-1854591.

    Chemistry

    ChEMBLi CHEMBL1075271.

    Protein family/group databases

    Allergomei 755. Mus m 4.

    PTM databases

    PhosphoSitei P07724.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00131695.
    P07724.
    Q8CG74.
    SWISS-2DPAGE P07724.
    UCD-2DPAGE P07724.

    Proteomic databases

    MaxQBi P07724.
    PaxDbi P07724.
    PRIDEi P07724.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031314 ; ENSMUSP00000031314 ; ENSMUSG00000029368 .
    GeneIDi 11657.
    KEGGi mmu:11657.
    UCSCi uc008yaz.2. mouse.

    Organism-specific databases

    CTDi 213.
    MGIi MGI:87991. Alb.

    Phylogenomic databases

    eggNOGi NOG45992.
    HOGENOMi HOG000293137.
    HOVERGENi HBG004207.
    InParanoidi P07724.
    KOi K16141.
    OMAi NCDKSLH.
    OrthoDBi EOG7S4X5C.
    PhylomeDBi P07724.
    TreeFami TF335561.

    Enzyme and pathway databases

    Reactomei REACT_196575. Scavenging of heme from plasma.
    REACT_210189. Transport of organic anions.
    REACT_213857. HDL-mediated lipid transport.

    Miscellaneous databases

    ChiTaRSi ALB. mouse.
    NextBioi 279275.
    PROi P07724.
    SOURCEi Search...

    Gene expression databases

    Bgeei P07724.
    CleanExi MM_ALB.
    Genevestigatori P07724.

    Family and domain databases

    InterProi IPR000264. ALB/AFP/VDB.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view ]
    Pfami PF00273. Serum_albumin. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSi PR00802. SERUMALBUMIN.
    SMARTi SM00103. ALBUMIN. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48552. SSF48552. 3 hits.
    PROSITEi PS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Van Reeth T., Dreze P.L., Gabant P., Szpirer C., Szpirer J.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-205.
      Strain: 129/SvEvTacfBr.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver, Stomach, Thymus and Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney and Liver.
    4. "Mouse liver protein database: a catalog of proteins detected by two-dimensional gel electrophoresis."
      Giometti C.S., Taylor J., Tollaksen S.L.
      Electrophoresis 13:970-991(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-44.
      Tissue: Liver.
    5. Lubec G., Klug S., Yang J.W., Zigmond M., Kang S.U., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 35-57; 66-75; 89-105; 243-257; 299-309; 348-372; 422-434; 439-452; 470-483; 509-524; 550-558 AND 570-602, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.
    6. "The rate of molecular evolution of alpha-fetoprotein approaches that of pseudogenes."
      Minghetti P.P., Law S.W., Dugaiczyk A.
      Mol. Biol. Evol. 2:347-358(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-516.
    7. "Empty and occupied insertion site of the truncated LINE-1 repeat located in the mouse serum albumin-encoding gene."
      Boccaccio C., Deschatrette J., Meunier-Rotival M.
      Gene 88:181-186(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 477-551.
      Strain: BALB/c.
    8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-229; LYS-460; LYS-543 AND LYS-588, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiALBU_MOUSE
    AccessioniPrimary (citable) accession number: P07724
    Secondary accession number(s): Q3TV03
    , Q61802, Q8C7C7, Q8C7H3, Q8CG74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 152 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3