P07724 (ALBU_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serum albumin

Gene names

Name:	Alb
Synonyms:	Alb-1, Alb1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	608 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Subcellular location	Secreted.
Tissue specificity	Plasma.
Post-translational modification	Phosphorylation sites are present in the extracellular medium By similarity.
Sequence similarities	Belongs to the ALB/AFP/VDB family. Contains 3 albumin domains.

Ontologies

Keywords
Cellular component	Secreted
Domain	Repeat Signal
Ligand	Copper Lipid-binding Metal-binding Zinc
PTM	Cleavage on pair of basic residues Disulfide bond Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to starvation Inferred from sequence or structural similarity. Source: UniProtKB hemolysis by symbiont of host erythrocytes Inferred from sequence or structural similarity. Source: UniProtKB maintenance of mitochondrion location Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of circadian sleep/wake cycle, non-REM sleep Inferred from electronic annotation. Source: Compara response to mercury ion Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara response to organic substance Inferred from electronic annotation. Source: Compara response to platinum ion Inferred from electronic annotation. Source: Compara transport Inferred from electronic annotation. Source: InterPro
Cellular_component	basement membrane Inferred from electronic annotation. Source: Compara cytoplasm Inferred from direct assay PubMed 11197537PubMed 15576401PubMed 16880525PubMed 8607965. Source: MGI extracellular space Inferred from direct assay PubMed 7798939. Source: MGI protein complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB cell surface binding Inferred from electronic annotation. Source: Compara drug binding Inferred from sequence or structural similarity. Source: UniProtKB fatty acid binding Inferred from electronic annotation. Source: Compara oxygen binding Inferred from electronic annotation. Source: Compara pyridoxal phosphate binding Inferred from sequence or structural similarity. Source: UniProtKB toxin binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	By similarity
	Propeptide	19 – 22	4			PRO_0000001073
	Chain	25 – 608	584	Serum albumin		PRO_0000001074
Regions
	Domain	19 – 211	193	Albumin 1
	Domain	212 – 403	192	Albumin 2
	Domain	404 – 601	198	Albumin 3
Sites
	Metal binding	27	1	Copper
	Metal binding	91	1	Zinc By similarity
	Metal binding	123	1	Zinc By similarity
	Metal binding	271	1	Zinc By similarity
	Metal binding	273	1	Zinc By similarity
Amino acid modifications
	Modified residue	82	1	Phosphoserine By similarity
	Modified residue	443	1	Phosphoserine By similarity
	Modified residue	444	1	Phosphothreonine By similarity
	Modified residue	446	1	Phosphothreonine By similarity
	Disulfide bond	77 ↔ 86		By similarity
	Disulfide bond	99 ↔ 115		By similarity
	Disulfide bond	114 ↔ 125		By similarity
	Disulfide bond	148 ↔ 193		By similarity
	Disulfide bond	192 ↔ 201		By similarity
	Disulfide bond	224 ↔ 270		By similarity
	Disulfide bond	269 ↔ 277		By similarity
	Disulfide bond	289 ↔ 303		By similarity
	Disulfide bond	302 ↔ 313		By similarity
	Disulfide bond	340 ↔ 385		By similarity
	Disulfide bond	384 ↔ 393		By similarity
	Disulfide bond	416 ↔ 462		By similarity
	Disulfide bond	461 ↔ 472		By similarity
	Disulfide bond	485 ↔ 501		By similarity
	Disulfide bond	500 ↔ 511		By similarity
	Disulfide bond	538 ↔ 583		By similarity
	Disulfide bond	582 ↔ 591		By similarity
Experimental info
	Sequence conflict	27	1	H → D AA sequence Ref.4
	Sequence conflict	33	1	H → D AA sequence Ref.4
	Sequence conflict	33	1	H → N in BAC34360. Ref.2
	Sequence conflict	41	1	Q → I AA sequence Ref.4
	Sequence conflict	561	1	P → H in BAE35818. Ref.2
	Sequence conflict	606	1	A → T in BAC34145. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P07724 [UniParc]. Last modified July 15, 1999. Version 3. Checksum: 292F7C7EED3A61B4	FASTA	608	68,693
	10 20 30 40 50 60 MKWVTFLLLL FVSGSAFSRG VFRREAHKSE IAHRYNDLGE QHFKGLVLIA FSQYLQKCSY 70 80 90 100 110 120 DEHAKLVQEV TDFAKTCVAD ESAANCDKSL HTLFGDKLCA IPNLRENYGE LADCCTKQEP 130 140 150 160 170 180 ERNECFLQHK DDNPSLPPFE RPEAEAMCTS FKENPTTFMG HYLHEVARRH PYFYAPELLY 190 200 210 220 230 240 YAEQYNEILT QCCAEADKES CLTPKLDGVK EKALVSSVRQ RMKCSSMQKF GERAFKAWAV 250 260 270 280 290 300 ARLSQTFPNA DFAEITKLAT DLTKVNKECC HGDLLECADD RAELAKYMCE NQATISSKLQ 310 320 330 340 350 360 TCCDKPLLKK AHCLSEVEHD TMPADLPAIA ADFVEDQEVC KNYAEAKDVF LGTFLYEYSR 370 380 390 400 410 420 RHPDYSVSLL LRLAKKYEAT LEKCCAEANP PACYGTVLAE FQPLVEEPKN LVKTNCDLYE 430 440 450 460 470 480 KLGEYGFQNA ILVRYTQKAP QVSTPTLVEA ARNLGRVGTK CCTLPEDQRL PCVEDYLSAI 490 500 510 520 530 540 LNRVCLLHEK TPVSEHVTKC CSGSLVERRP CFSALTVDET YVPKEFKAET FTFHSDICTL 550 560 570 580 590 600 PEKEKQIKKQ TALAELVKHK PKATAEQLKT VMDDFAQFLD TCCKAADKDT CFSTEGPNLV TRCKDALA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Van Reeth T., Dreze P.L., Gabant P., Szpirer C., Szpirer J. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-205. Strain: 129/SvEvTacfBr. Tissue: Liver.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Liver, Stomach, Thymus and Tongue.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney and Liver.
[4]	"Mouse liver protein database: a catalog of proteins detected by two-dimensional gel electrophoresis." Giometti C.S., Taylor J., Tollaksen S.L. Electrophoresis 13:970-991(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-44. Tissue: Liver.
[5]	Lubec G., Klug S., Yang J.W., Zigmond M., Kang S.U., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 35-57; 66-75; 89-105; 243-257; 299-309; 348-372; 422-434; 439-452; 470-483; 509-524; 550-558 AND 570-602, MASS SPECTROMETRY. Strain: C57BL/6 and OF1. Tissue: Brain and Hippocampus.
[6]	"The rate of molecular evolution of alpha-fetoprotein approaches that of pseudogenes." Minghetti P.P., Law S.W., Dugaiczyk A. Mol. Biol. Evol. 2:347-358(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-516.
[7]	"Empty and occupied insertion site of the truncated LINE-1 repeat located in the mouse serum albumin-encoding gene." Boccaccio C., Deschatrette J., Meunier-Rotival M. Gene 88:181-186(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 477-551. Strain: BALB/c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011413 mRNA. Translation: CAA09617.1. AJ277794 Genomic DNA. Translation: CAC81903.1. AK010025 mRNA. Translation: BAB26650.1. AK050248 mRNA. Translation: BAC34145.1. AK050644 mRNA. Translation: BAC34360.1. AK160487 mRNA. Translation: BAE35818.1. BC024643 mRNA. Translation: AAH24643.1. BC049971 mRNA. Translation: AAH49971.1. M16111 mRNA. Translation: AAA37190.1. X13060 Genomic DNA. Translation: CAA31458.1.
IPI	IPI00131695.
PIR	A05139.
RefSeq	NP_033784.2. NM_009654.3.
UniGene	Mm.16773.
3D structure databases
ProteinModelPortal	P07724.
SMR	P07724. Positions 29-585.
ModBase	Search...
Protein-protein interaction databases
IntAct	P07724. 4 interactions.
Protein family/group databases
Allergome	755. Mus m 4.
PTM databases
PhosphoSite	P07724.
2D gel databases
REPRODUCTION-2DPAGE	IPI00131695. P07724. Q8CG74.
SWISS-2DPAGE	P07724.
UCD-2DPAGE	P07724.
Proteomic databases
PaxDb	P07724.
PRIDE	P07724.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031314; ENSMUSP00000031314; ENSMUSG00000029368.
GeneID	11657.
KEGG	mmu:11657.
Organism-specific databases
CTD	213.
MGI	MGI:87991. Alb.
Phylogenomic databases
eggNOG	NOG45992.
HOGENOM	HOG000293137.
HOVERGEN	HBG004207.
InParanoid	P07724.
KO	K16141.
OMA	NCDKSLH.
OrthoDB	EOG4Z0B55.
Gene expression databases
ArrayExpress	P07724.
Bgee	P07724.
CleanEx	MM_ALB.
Genevestigator	P07724.
GermOnline	ENSMUSG00000029368. Mus musculus.
Family and domain databases
InterPro	IPR000264. ALB/AFP/VDB. IPR020858. Serum_albumin-like. IPR021177. Serum_albumin/AFP. IPR020857. Serum_albumin_CS. IPR014760. Serum_albumin_N. [Graphical view]
Pfam	PF00273. Serum_albumin. 3 hits. [Graphical view]
PIRSF	PIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTS	PR00802. SERUMALBUMIN.
SMART	SM00103. ALBUMIN. 3 hits. [Graphical view]
SUPFAM	SSF48552. Serum_albumin. 3 hits.
PROSITE	PS00212. ALBUMIN_1. 3 hits. PS51438. ALBUMIN_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1075271.
ChiTaRS	ALB. mouse.
NextBio	279275.
SOURCE	Search...

Entry information

Entry name

ALBU_MOUSE

Accession

Primary (citable) accession number: P07724
Secondary accession number(s): Q3TV03 , Q61802, Q8C7C7, Q8C7H3, Q8CG74

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	July 15, 1999
Last modified:	May 1, 2013
This is version 137 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program