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P07724

- ALBU_MOUSE

UniProt

P07724 - ALBU_MOUSE

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Protein
Serum albumin
Gene
Alb, Alb-1, Alb1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Copper
Metal bindingi91 – 911Zinc By similarity
Metal bindingi123 – 1231Zinc By similarity
Metal bindingi271 – 2711Zinc By similarity
Metal bindingi273 – 2731Zinc By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. drug binding Source: UniProtKB
  3. fatty acid binding Source: Ensembl
  4. oxygen binding Source: Ensembl
  5. pyridoxal phosphate binding Source: UniProtKB
  6. toxic substance binding Source: UniProtKB
  7. zinc ion binding Source: Ensembl

GO - Biological processi

  1. cellular response to starvation Source: UniProtKB
  2. hemolysis by symbiont of host erythrocytes Source: UniProtKB
  3. maintenance of mitochondrion location Source: UniProtKB
  4. negative regulation of apoptotic process Source: UniProtKB
  5. positive regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  6. response to mercury ion Source: Ensembl
  7. response to nutrient Source: Ensembl
  8. response to organic substance Source: Ensembl
  9. response to platinum ion Source: Ensembl
  10. transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_196575. Scavenging of heme from plasma.
REACT_210189. Transport of organic anions.
REACT_213857. HDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:Alb
Synonyms:Alb-1, Alb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:87991. Alb.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. cytoplasm Source: MGI
  3. extracellular region Source: MGI
  4. extracellular space Source: MGI
  5. extracellular vesicular exosome Source: Ensembl
  6. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei755. Mus m 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarity
Add
BLAST
Propeptidei19 – 224
PRO_0000001073
Chaini25 – 608584Serum albumin
PRO_0000001074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi77 ↔ 86 By similarity
Modified residuei82 – 821Phosphoserine By similarity
Disulfide bondi99 ↔ 115 By similarity
Disulfide bondi114 ↔ 125 By similarity
Disulfide bondi148 ↔ 193 By similarity
Disulfide bondi192 ↔ 201 By similarity
Disulfide bondi224 ↔ 270 By similarity
Modified residuei229 – 2291N6-succinyllysine1 Publication
Disulfide bondi269 ↔ 277 By similarity
Disulfide bondi289 ↔ 303 By similarity
Disulfide bondi302 ↔ 313 By similarity
Disulfide bondi340 ↔ 385 By similarity
Disulfide bondi384 ↔ 393 By similarity
Disulfide bondi416 ↔ 462 By similarity
Modified residuei443 – 4431Phosphoserine By similarity
Modified residuei444 – 4441Phosphothreonine By similarity
Modified residuei446 – 4461Phosphothreonine By similarity
Modified residuei460 – 4601N6-succinyllysine1 Publication
Disulfide bondi461 ↔ 472 By similarity
Disulfide bondi485 ↔ 501 By similarity
Disulfide bondi500 ↔ 511 By similarity
Disulfide bondi538 ↔ 583 By similarity
Modified residuei543 – 5431N6-succinyllysine1 Publication
Disulfide bondi582 ↔ 591 By similarity
Modified residuei588 – 5881N6-succinyllysine1 Publication

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP07724.
PaxDbiP07724.
PRIDEiP07724.

2D gel databases

REPRODUCTION-2DPAGEIPI00131695.
P07724.
Q8CG74.
SWISS-2DPAGEP07724.
UCD-2DPAGEP07724.

PTM databases

PhosphoSiteiP07724.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiP07724.
CleanExiMM_ALB.
GenevestigatoriP07724.

Interactioni

Protein-protein interaction databases

BioGridi198060. 5 interactions.
IntActiP07724. 9 interactions.
MINTiMINT-1854591.

Structurei

3D structure databases

ProteinModelPortaliP07724.
SMRiP07724. Positions 29-585.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 211193Albumin 1
Add
BLAST
Domaini212 – 403192Albumin 2
Add
BLAST
Domaini404 – 601198Albumin 3
Add
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG45992.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP07724.
KOiK16141.
OMAiNCDKSLH.
OrthoDBiEOG7S4X5C.
PhylomeDBiP07724.
TreeFamiTF335561.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07724-1 [UniParc]FASTAAdd to Basket

« Hide

MKWVTFLLLL FVSGSAFSRG VFRREAHKSE IAHRYNDLGE QHFKGLVLIA    50
FSQYLQKCSY DEHAKLVQEV TDFAKTCVAD ESAANCDKSL HTLFGDKLCA 100
IPNLRENYGE LADCCTKQEP ERNECFLQHK DDNPSLPPFE RPEAEAMCTS 150
FKENPTTFMG HYLHEVARRH PYFYAPELLY YAEQYNEILT QCCAEADKES 200
CLTPKLDGVK EKALVSSVRQ RMKCSSMQKF GERAFKAWAV ARLSQTFPNA 250
DFAEITKLAT DLTKVNKECC HGDLLECADD RAELAKYMCE NQATISSKLQ 300
TCCDKPLLKK AHCLSEVEHD TMPADLPAIA ADFVEDQEVC KNYAEAKDVF 350
LGTFLYEYSR RHPDYSVSLL LRLAKKYEAT LEKCCAEANP PACYGTVLAE 400
FQPLVEEPKN LVKTNCDLYE KLGEYGFQNA ILVRYTQKAP QVSTPTLVEA 450
ARNLGRVGTK CCTLPEDQRL PCVEDYLSAI LNRVCLLHEK TPVSEHVTKC 500
CSGSLVERRP CFSALTVDET YVPKEFKAET FTFHSDICTL PEKEKQIKKQ 550
TALAELVKHK PKATAEQLKT VMDDFAQFLD TCCKAADKDT CFSTEGPNLV 600
TRCKDALA 608
Length:608
Mass (Da):68,693
Last modified:July 15, 1999 - v3
Checksum:i292F7C7EED3A61B4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271H → D AA sequence 1 Publication
Sequence conflicti33 – 331H → D AA sequence 1 Publication
Sequence conflicti33 – 331H → N in BAC34360. 1 Publication
Sequence conflicti41 – 411Q → I AA sequence 1 Publication
Sequence conflicti561 – 5611P → H in BAE35818. 1 Publication
Sequence conflicti606 – 6061A → T in BAC34145. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011413 mRNA. Translation: CAA09617.1.
AJ277794 Genomic DNA. Translation: CAC81903.1.
AK010025 mRNA. Translation: BAB26650.1.
AK050248 mRNA. Translation: BAC34145.1.
AK050644 mRNA. Translation: BAC34360.1.
AK160487 mRNA. Translation: BAE35818.1.
BC024643 mRNA. Translation: AAH24643.1.
BC049971 mRNA. Translation: AAH49971.1.
M16111 mRNA. Translation: AAA37190.1.
X13060 Genomic DNA. Translation: CAA31458.1.
CCDSiCCDS19412.1.
PIRiA05139.
RefSeqiNP_033784.2. NM_009654.3.
UniGeneiMm.16773.

Genome annotation databases

EnsembliENSMUST00000031314; ENSMUSP00000031314; ENSMUSG00000029368.
GeneIDi11657.
KEGGimmu:11657.
UCSCiuc008yaz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011413 mRNA. Translation: CAA09617.1 .
AJ277794 Genomic DNA. Translation: CAC81903.1 .
AK010025 mRNA. Translation: BAB26650.1 .
AK050248 mRNA. Translation: BAC34145.1 .
AK050644 mRNA. Translation: BAC34360.1 .
AK160487 mRNA. Translation: BAE35818.1 .
BC024643 mRNA. Translation: AAH24643.1 .
BC049971 mRNA. Translation: AAH49971.1 .
M16111 mRNA. Translation: AAA37190.1 .
X13060 Genomic DNA. Translation: CAA31458.1 .
CCDSi CCDS19412.1.
PIRi A05139.
RefSeqi NP_033784.2. NM_009654.3.
UniGenei Mm.16773.

3D structure databases

ProteinModelPortali P07724.
SMRi P07724. Positions 29-585.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198060. 5 interactions.
IntActi P07724. 9 interactions.
MINTi MINT-1854591.

Chemistry

ChEMBLi CHEMBL1075271.

Protein family/group databases

Allergomei 755. Mus m 4.

PTM databases

PhosphoSitei P07724.

2D gel databases

REPRODUCTION-2DPAGE IPI00131695.
P07724.
Q8CG74.
SWISS-2DPAGE P07724.
UCD-2DPAGE P07724.

Proteomic databases

MaxQBi P07724.
PaxDbi P07724.
PRIDEi P07724.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031314 ; ENSMUSP00000031314 ; ENSMUSG00000029368 .
GeneIDi 11657.
KEGGi mmu:11657.
UCSCi uc008yaz.2. mouse.

Organism-specific databases

CTDi 213.
MGIi MGI:87991. Alb.

Phylogenomic databases

eggNOGi NOG45992.
HOGENOMi HOG000293137.
HOVERGENi HBG004207.
InParanoidi P07724.
KOi K16141.
OMAi NCDKSLH.
OrthoDBi EOG7S4X5C.
PhylomeDBi P07724.
TreeFami TF335561.

Enzyme and pathway databases

Reactomei REACT_196575. Scavenging of heme from plasma.
REACT_210189. Transport of organic anions.
REACT_213857. HDL-mediated lipid transport.

Miscellaneous databases

ChiTaRSi ALB. mouse.
NextBioi 279275.
PROi P07724.
SOURCEi Search...

Gene expression databases

Bgeei P07724.
CleanExi MM_ALB.
Genevestigatori P07724.

Family and domain databases

InterProi IPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view ]
Pfami PF00273. Serum_albumin. 3 hits.
[Graphical view ]
PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSi PR00802. SERUMALBUMIN.
SMARTi SM00103. ALBUMIN. 3 hits.
[Graphical view ]
SUPFAMi SSF48552. SSF48552. 3 hits.
PROSITEi PS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Van Reeth T., Dreze P.L., Gabant P., Szpirer C., Szpirer J.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-205.
    Strain: 129/SvEvTacfBr.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver, Stomach, Thymus and Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney and Liver.
  4. "Mouse liver protein database: a catalog of proteins detected by two-dimensional gel electrophoresis."
    Giometti C.S., Taylor J., Tollaksen S.L.
    Electrophoresis 13:970-991(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-44.
    Tissue: Liver.
  5. Lubec G., Klug S., Yang J.W., Zigmond M., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 35-57; 66-75; 89-105; 243-257; 299-309; 348-372; 422-434; 439-452; 470-483; 509-524; 550-558 AND 570-602, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  6. "The rate of molecular evolution of alpha-fetoprotein approaches that of pseudogenes."
    Minghetti P.P., Law S.W., Dugaiczyk A.
    Mol. Biol. Evol. 2:347-358(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-516.
  7. "Empty and occupied insertion site of the truncated LINE-1 repeat located in the mouse serum albumin-encoding gene."
    Boccaccio C., Deschatrette J., Meunier-Rotival M.
    Gene 88:181-186(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 477-551.
    Strain: BALB/c.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-229; LYS-460; LYS-543 AND LYS-588, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiALBU_MOUSE
AccessioniPrimary (citable) accession number: P07724
Secondary accession number(s): Q3TV03
, Q61802, Q8C7C7, Q8C7H3, Q8CG74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: July 15, 1999
Last modified: September 3, 2014
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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