Reviewed, UniProtKB/Swiss-Prot P07720 (POLG_TBEVS)

Names and origin

Protein names	Recommended name:     Genome polyprotein Cleaved into the following 10 chains:     1- Recommended name:             Protein C         Alternative name(s):             Core protein             Capsid protein     2- Recommended name:             Small envelope protein M         Alternative name(s):             Matrix protein     3- Recommended name:             Envelope protein E     4- Recommended name:             Non-structural protein 1                 Short name=NS1     5- Recommended name:             Non-structural protein 2A                 Short name=NS2A     6- Recommended name:             Flavivirin protease NS2B regulatory subunit     7- Recommended name:             Flavivirin protease NS3 catalytic subunit               EC=3.4.21.91     8- Recommended name:             Non-structural protein 4A                 Short name=NS4A     9- Recommended name:             Non-structural protein 4B                 Short name=NS4B     10- Recommended name:             RNA-directed RNA polymerase               EC=2.7.7.48         Alternative name(s):             NS5
Organism	Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus) [Complete proteome]
Taxonomic identifier	11087 [NCBI]
Taxonomic lineage	Viruses › ssRNA positive-strand viruses, no DNA stage › Flaviviridae › Flavivirus › tick-borne encephalitis virus group
Virus host	Ixodes ricinus (Sheep tick) [TaxID: 34613] Ixodes persulcatus (Taiga tick) [TaxID: 34615]

Protein attributes

Sequence length	3412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The small proteins NS2A, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function. NS5 may play a role in the viral RNA replication. The NS2B/NS3 protease complex processes the viral polyprotein.
Catalytic activity	Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala. Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Subunit structure	NS3 and NS2B form a heterodimer. NS3 is the catalytic subunit, whereas NS2B strongly stimulates the latter By similarity.
Subcellular location	Protein C: Virion Potential. Host membrane; Single-pass membrane protein Potential. Small envelope protein M: Virion Potential. Host membrane; Single-pass membrane protein Potential. Envelope protein E: Virion Potential. Host membrane; Multi-pass membrane protein Potential. Non-structural protein 4A: Host membrane; Single-pass membrane protein Potential. Non-structural protein 4B: Host membrane; Multi-pass membrane protein Potential.
Post-translational modification	Specific enzymatic cleavages in vivo yield mature proteins By similarity.
Miscellaneous	The virion of this virus is a nucleocapsid covered by a lipoprotein envelope. The envelope contains two proteins: the protein M and glycoprotein E. The nucleocapsid is a complex of protein C and mRNA. In immature particles, there are 60 icosaedrally organized trimeric spikes on the surface. Each spike consists of three heterodimers of envelope protein M precursor (prM) and envelope protein E By similarity. The nonstructural protein NS1 presents 2 alternative cleavage sites for its C-terminus (either at position 1128 or at 1190), which may define a soluble or a membrane-bound form of NS1.
Sequence similarities	Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 peptidase S7 domain. Contains 1 RdRp catalytic domain.

Ontologies

Keywords
Biological process	RNA replication
Cellular component	Capsid protein Core protein Envelope protein Membrane Virion
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase Nucleotidyltransferase RNA-directed RNA polymerase Transferase
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	RNA metabolic process Inferred from electronic annotation. Source: InterPro methylation Inferred from electronic annotation. Source: InterPro transcription, RNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: UniProtKB-KW viral nucleocapsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro RNA helicase activity Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW double-stranded RNA binding Inferred from electronic annotation. Source: InterPro methyltransferase activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed; by host

Chain

2 – 112

111

Protein C

PRO_0000037804

Propeptide

113 – 205

93

PRO_0000037805

Chain

206 – 280

75

Small envelope protein M

PRO_0000037806

Chain

281 – 776

496

Envelope protein E

PRO_0000037807

Chain

777 – ?1128

352

Non-structural protein 1

PRO_0000037808

Chain

?1129 – 1358

230

Non-structural protein 2A

PRO_0000037809

Chain

1359 – 1489

131

Flavivirin protease NS2B regulatory subunit

PRO_0000037810

Chain

1490 – 2110

621

Flavivirin protease NS3 catalytic subunit

PRO_0000037811

Chain

2111 – 2259

149

Non-structural protein 4A

PRO_0000037812

Chain

2260 – 2510

251

Non-structural protein 4B

PRO_0000037813

Chain

2511 – 3412

902

RNA-directed RNA polymerase

PRO_0000037814

Regions

Transmembrane

101 – 112

12

Hydrophobic signal sequence Potential

Transmembrane

247 – 259

13

Potential

Transmembrane

266 – 280

15

Potential

Transmembrane

738 – 751

14

Potential

Domain

1675 – 1831

157

Helicase ATP-binding

Domain

1841 – 2000

160

Helicase C-terminal

Domain

3038 – 3187

150

RdRp catalytic

Nucleotide binding

1688 – 1695

8

ATP Potential

Motif

1779 – 1782

4

DEAH box

Sites

Active site

1543

1

Charge relay system By similarity

Active site

1567

1

Charge relay system By similarity

Active site

1627

1

Charge relay system By similarity

Amino acid modifications

Glycosylation

144

1

N-linked (GlcNAc...); by host Potential

Glycosylation

434

1

N-linked (GlcNAc...); by host

Glycosylation

861

1

N-linked (GlcNAc...); by host Potential

Glycosylation

983

1

N-linked (GlcNAc...); by host Potential

Glycosylation

999

1

N-linked (GlcNAc...); by host Potential

Glycosylation

1228

1

N-linked (GlcNAc...); by host Potential

Glycosylation

2447

1

N-linked (GlcNAc...); by host Potential

Glycosylation

2466

1

N-linked (GlcNAc...); by host Potential

Disulfide bond

283 ↔ 310

By similarity

Disulfide bond

340 ↔ 396

By similarity

Disulfide bond

354 ↔ 385

By similarity

Disulfide bond

372 ↔ 401

By similarity

Disulfide bond

466 ↔ 570

By similarity

Disulfide bond

587 ↔ 618

By similarity

Experimental info

Sequence conflict

381

1

W → S Ref.3

Sequence conflict

850

1

E → D Ref.3

Secondary structure

1

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3412

Helix Strand Turn

Details...

Helix

282 – 285

4

Beta strand

290 – 294

5

Beta strand

300 – 306

7

Beta strand

311 – 315

5

Beta strand

318 – 332

15

Beta strand

334 – 352

19

Helix

363 – 366

4

Beta strand

370 – 380

11

Helix

381 – 383

3

Beta strand

389 – 401

13

Beta strand

406 – 411

6

Turn

414 – 416

3

Beta strand

418 – 425

8

Beta strand

441 – 446

6

Beta strand

451 – 455

5

Helix

457 – 459

3

Beta strand

460 – 467

8

Helix

468 – 470

3

Beta strand

477 – 482

6

Beta strand

491 – 496

6

Helix

497 – 501

5

Helix

518 – 521

4

Beta strand

522 – 524

3

Beta strand

534 – 536

3

Helix

541 – 547

7

Turn

548 – 550

3

Beta strand

553 – 557

5

Beta strand

560 – 562

3

Beta strand

567 – 573

7

Beta strand

591 – 600

10

Beta strand

602 – 604

3

Beta strand

606 – 612

7

Beta strand

616 – 619

4

Beta strand

622 – 626

5

Beta strand

636 – 641

6

Beta strand

643 – 645

3

Beta strand

651 – 655

5

Beta strand

658 – 665

8

Beta strand

668 – 674

7

Sequences

	Sequence		Length	Mass (Da)
	P07720-1 [UniParc]. Last modified May 1, 1991. Version 3. Checksum: 0F61CE6DCCDC5965	FASTA	3,412	377,981
	10 20 30 40 50 60 MAGKAILKGK GGGPPRRVSK ETAKKTRQSR VQMPNGLVLM RMMGILWHAV AGTARSPVLK 70 80 90 100 110 120 SFWKSVPLKQ ATAALRKIKK AVSTLMVGLQ RRGKRRSAVD WTGWLLVVVL LGVTLAATVR 130 140 150 160 170 180 KERDGTTVIR AEGKDAATQV RVENGTCVIL ATDMGSWCDD SLTYECVTID QGEEPVDVDC 190 200 210 220 230 240 SCRNVDGVYL EYGRCGKQEG SRTRRSVLIP SHAQGDLTGR GHKWLEGDSL RTHLTRVEGW 250 260 270 280 290 300 VWKNKVLTLA VIAVVWLTVE SVVTRVAVVV VLLCLAPVYA SRCTHLENRD FVTGTQGTTR 310 320 330 340 350 360 VTLVLELGGC VTITAEGKPS MDVWLDSIYQ ENPAKTREYC LHAKLSDTKV AARCPTMGPA 370 380 390 400 410 420 TLAEEHQSGT VCKRDQSDRG WGNHCGLFGK GSIVTCVKAS CEAKKKATGH VYDANKIVYT 430 440 450 460 470 480 VKVEPHTGDY VAANETHSGR KTASFTVSSE RTILTMGDYG DVSLLCRVAS GVDLAQTVIL 490 500 510 520 530 540 ELDKTSEHLP TAWQVHRDWF NDLALPWKHE GAQNWNNAER LVEFGAPHAV KMDVYNLGDQ 550 560 570 580 590 600 TGVLLKSLAG VPVAHIDGTK YHLKSGHVTC EVGLEKLKMK GLTYTMCDKT KFTWKRIPTD 610 620 630 640 650 660 SGHDTVVMEV AFSGTKPCRI PVRAVAHGSP DVNVAMLMTP NPTIENNGGG FIEMQLPPGD 670 680 690 700 710 720 NIIYVGELSH QWFQKGSSIG RVFQKTRKGI ERLTVIGEHA WDFGSTGGFL TSVGKALHTV 730 740 750 760 770 780 LGGAFNSLFG GVGFLPKILV GVVLAWLGLN MRNPTMSMSF LLAGGLVLAM TLGVGADVGC 790 800 810 820 830 840 AVDTERMELR CGEGLVVWRE VSEWYDNYAY YPETLGALAS AIKETFEEGT CGIVPQNRLE 850 860 870 880 890 900 MAMWRSSATE LNLALVEGDA NLTVVVDKLD PTDYRGGIPS LLKKGKDIKV SWKSWGHSMI 910 920 930 940 950 960 WSVPEAPRLF MVGTEGSSEC PLERRKTGVF TVAEFGVGLR TKVFLDFRQE STHECDTGVM 970 980 990 1000 1010 1020 GAAVKNGMAV HTDQSLWMKS VRNDTGTYIV ELLVTDLRNC SWPASHTIDN AEVVDSELFL 1030 1040 1050 1060 1070 1080 PASLAGPRSW YNRIPGYSEQ VKGPWKYSPI RVTREECPGT RVTINADCDK RGASVRSTTE 1090 1100 1110 1120 1130 1140 SGKVIPEWCC RTCTLPPVTF RTGTDCWYAM EIRPVHDQGG LVRSMVVADN GELLSEGGIP 1150 1160 1170 1180 1190 1200 GIVALFVVLE YVIRRRPATG TTAMWGGIVV LALLVTGLVK IESLVRYVVA VGITFHLELG 1210 1220 1230 1240 1250 1260 PEIVALTLLQ AVFELRVGLL SAFALRSNLT VREMVTIYFL LLVLELGLPS EGLGALWKWG 1270 1280 1290 1300 1310 1320 DALAMGALIF RACTAEEKTG VGLLLMALMT QQDLATVHYG LMLFLGVASC CSIWKLIRGH 1330 1340 1350 1360 1370 1380 REQKGLTWIV PLAGLLGGEG SGVRLVAFWE LTVHGRRRSF SEPLTVVGVM LTLASGMIRH 1390 1400 1410 1420 1430 1440 TSQEALCALA VASFLLLMLV LGTRKMQLVA EWSGCVEWHP ELMNEGGEVS LRVRQDSMGN 1450 1460 1470 1480 1490 1500 FHLTELEKEE RVMAFWLLAG LAASAFHWSG ILGVMGLWTL SEMLRTARRS GLVFSGQGGR 1510 1520 1530 1540 1550 1560 ERGDRPFEVK DGVYRIFSPG LLWGQRQVGV GYGSKGVLHT MWHVTRGAAL SIDDAVAGPY 1570 1580 1590 1600 1610 1620 WADVKEDVVC YGGAWSLEEK WKGETVQVHA FPPGRAHEVH QCQPGELLLD TGRRIGAVPI 1630 1640 1650 1660 1670 1680 DLAKGTSGSP ILNSQGVVVG LYGNGLKTNE TYVSSIAQGE AEKSRPNLPP AVTGTGWTAK 1690 1700 1710 1720 1730 1740 GQITVLDMHP GSGKTHRVLP ELIRQCIDRR LRTLVLAPTR VVLKEMERAL NGKRVRFHSP 1750 1760 1770 1780 1790 1800 AVGDQQVGGS IVDVMCHATY VNRRLLPQGR QNWEVAIMDE AHWTDPHSIA ARGHLYTLAK 1810 1820 1830 1840 1850 1860 ENKCALVLMT ATPPGKSEPF PESNGAISSE EKQIPDGEWR DGFDWITEYE GRTAWFVPSS 1870 1880 1890 1900 1910 1920 AKGGIIARTL IQKGKSVICL NSKTFEKDYS RVRDEKPDFV VTTDISEMGA NLDVSRVIDG 1930 1940 1950 1960 1970 1980 RTNIKPEEVD GRVELTGTRR VTTASAAQRR GRVGRQEGRT DEYIYSGQCD DDDSGLVQWK 1990 2000 2010 2020 2030 2040 EAQILLDNIT TLRGPVATFY GPEQDKMPEV AGHFRLTEEK RKHFRHLLTH CDFTPWLAWH 2050 2060 2070 2080 2090 2100 VAANVSSVTS RNWTWEGPEE NTVDEANGDL VTFRSPNGAE RTLRPVWRDA RMFREGRDIR 2110 2120 2130 2140 2150 2160 EFVAYASGRR SFGDVLSGMS GVPELLRHRC VSAMDVFYTL MHEEPGSRAM KMAERDAPEA 2170 2180 2190 2200 2210 2220 FLTVVEMMVL GLATLGVVWC FVVRTSISRM MLGTLVLLAS LALLWAGGVS YGNMAGVALI 2230 2240 2250 2260 2270 2280 FYTLLTVLQP EAGKQRSSDD NKLAYFLLTL CSLAGLVAAN EMGFLEKTKA DLSTVLWSEH 2290 2300 2310 2320 2330 2340 EELRSWEEWT NIDIQPARSW GTYVLVVSLF TPYIIHQLQT KIQQLVNSAV ATGAQAMRDL 2350 2360 2370 2380 2390 2400 GGGAPFFGVA GHVMALGVVS LVGATPTSLV VGVGLAAFHL AIVVSGLEAE LTQRAHKVFF 2410 2420 2430 2440 2450 2460 SAMVRNPMVD GDVINPFGEG EAKPALYERK MSLVLAIVLC LMSVVMNRTV PSTPRLLLWD 2470 2480 2490 2500 2510 2520 WRQRDNCSNQ RRTPFGRCQA CGLSGVVRGS LWGFCPLGHR LWLRASGSRR GGSEGDTLGD 2530 2540 2550 2560 2570 2580 LWKRKLNGCT KEEFFAYRRT GILETERDKA RELLKRGETN MGLAVSRGTA KLAWLEERGY 2590 2600 2610 2620 2630 2640 ATLKGEVVDL GCGRGGWSYY AASRPAVMSV KACAIAGKGH ETPKMVTSLG WNLIKFRAGM 2650 2660 2670 2680 2690 2700 DVFSMQPHRA DTIMCDIGES NPDAVVEGER TRKVILLMEQ WKNRNPTATC VFKALAPYRP 2710 2720 2730 2740 2750 2760 EVTEALHRFQ LQWGGGLVRT PFSRNSTHEM YYSTAITGNI VNSVNIQSRK LLARFGDQRG 2770 2780 2790 2800 2810 2820 PTRVPELDLG VGTRCVVLAE DKVKEKDVQE RISALREQYG ETWHMDREHP YRTWQYWAAT 2830 2840 2850 2860 2870 2880 ACANRVGGAL INGVVKLLSW PWNAREDVVR MAMTDTTAFG QQRVFKEKVD TKAQEPQPGT 2890 2900 2910 2920 2930 2940 KVIMRAVNDW ILERLARKSK PRMCSREEFI AKVKSNAALG AWSDEQNRWS SAKEAVEDPA 2950 2960 2970 2980 2990 3000 FWQLVDEERE RHLAGRCAHC VYNMMGKREK KLGEFGVAKG SRAIWYMWLG SRFLEFEALG 3010 3020 3030 3040 3050 3060 FLNEDHWASR GSSGSGVEGI SLNYLGWHLK GLSTLEGGLF YADDTAGWDT KVTNADLEDE 3070 3080 3090 3100 3110 3120 EQLLRYMEGE HKQLAATIMQ KAYHAKVVKV ARPSRDGGCI MDVITRRDQR GSGQVVTYAL 3130 3140 3150 3160 3170 3180 NTLTNIKVQL IRMMEGEGVI EASDAHNPRL LRVERWLRDH GEERLGRMLV SGDDCVVRPV 3190 3200 3210 3220 3230 3240 DDRFSGALYF LNDMAKTRKD IGEWDHSVGF SNWEEVPFCS HHFHELVMKD GRTLIVPCRD 3250 3260 3270 3280 3290 3300 QDELVGRARV SPGCGRSVRE TACLSKAYGQ MWLLSYFHRR DLRTLGLAIC SAVPVDWVPA 3310 3320 3330 3340 3350 3360 GRTTWSIHAS GAWMTTEDML DVWNRVWILD NPFMHSKEKI AEWRDVPYLP KSHDMLCSSL 3370 3380 3390 3400 3410 VGRKERAEWA KNIWGAVEKV RKMIGQEKFK DYLSCMDRHD LHWESKLESS II

References

[1]	"Nucleotide sequence of the genome and complete amino acid sequence of the polyprotein of tick-borne encephalitis virus." Pletnev A.G., Yamshchikov V.F., Blinov V.M. Virology 174:250-263(1990) [PubMed: 2136778] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Nucleotide sequence of the genome region encoding the structural proteins and the NS1 protein of the tick borne encephalitis virus." Yamshchikov V.F., Pletnev A.G. Nucleic Acids Res. 16:7750-7750(1988) [PubMed: 2970626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-1190.
[3]	"Tick-borne encephalitis virus genome. The nucleotide sequence coding for virion structural proteins." Pletnev A.G., Yamshchikov V.F., Blinov V.M. FEBS Lett. 200:317-321(1986) [PubMed: 3709796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-683 AND 777-1002.
+	Additional computationally mapped references.

Web resources

Virus Particle ExploreR db

Icosahedral capsid structure

Cross-references

Sequence databases

EMBLGenBankDDBJ

X07755 Genomic RNA. Translation: CAA30581.1.
X03870 Genomic RNA. Translation: CAA27500.1.
X03870 Genomic RNA. Translation: CAA27501.1. Sequence problems.
X03870 Genomic RNA. Translation: CAA27502.1. Sequence problems.
X03870 Genomic RNA. Translation: CAA27503.1. Sequence problems.
X03871 Genomic RNA. Translation: CAA27505.1.

PIR

GNWVTB. A33776.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1K4R	electron microscopy	24.00	A/B/C	281-675	[»]

SMR

P07720. Positions 281-675.

ModBase

Search...

Family and domain databases

InterPro

IPR014001. DEAD-like_N.
IPR011492. DEAD_Flavivir.
IPR001650. DNA/RNA_helicase_C.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR000069. Env_glycoprot_M_flavivir.
IPR011999. Flav_glyE_cen_dm.
IPR013754. Flav_glyE_dim.
IPR001122. Flavi_capsidC.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flv_glyE_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR014021. Helicase_SF1/SF2_ATP-bd.
IPR001850. Peptidase_S7.
IPR000208. RNA_pol_flaviviral.
IPR007094. RNA_pol_PSvir.
IPR002877. rRNA_MeTrfase_RrmJ/FtsJ.
[Graphical view]

Gene3D

G3DSA:2.60.98.10. Flav_glyE_dim. 1 hit.
G3DSA:2.60.40.350. Flv_glyE_Ig-like. 1 hit.

Pfam

PF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]

PIRSF

PIRSF003817. Gen_Poly_FLV. 1 hit.

ProDom

PD001496. Flavi_NS1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]

PROSITE

PS00690. DEAH_ATP_HELICASE. False negative.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

POLG_TBEVS

Accession

Primary (citable) accession number: P07720
Secondary accession number(s): P07721 , Q88475, Q88476, Q88477, Q88478, Q88479, Q88877, Q88878, Q88879

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	May 1, 1991
Last modified:	June 16, 2009
This is version 100 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)