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Protein

Protein decapentaplegic

Gene

dpp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.15 Publications

GO - Molecular functioni

  • collagen binding Source: FlyBase
  • cytokine activity Source: GO_Central
  • heparin binding Source: FlyBase
  • morphogen activity Source: FlyBase
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  • amnioserosa formation Source: FlyBase
  • anterior/posterior axis specification Source: FlyBase
  • anterior/posterior pattern specification, imaginal disc Source: FlyBase
  • anterior Malpighian tubule development Source: FlyBase
  • BMP signaling pathway Source: FlyBase
  • BMP signaling pathway involved in Malpighian tubule cell chemotaxis Source: FlyBase
  • branched duct epithelial cell fate determination, open tracheal system Source: FlyBase
  • branch fusion, open tracheal system Source: FlyBase
  • cardioblast differentiation Source: FlyBase
  • cell fate determination Source: FlyBase
  • cell fate specification Source: FlyBase
  • chorion-containing eggshell formation Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • developmental pigmentation Source: FlyBase
  • dorsal/ventral axis specification Source: UniProtKB
  • dorsal/ventral pattern formation, imaginal disc Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • dorsal closure Source: FlyBase
  • dorsal closure, leading edge cell fate determination Source: FlyBase
  • ectodermal cell fate specification Source: FlyBase
  • ectoderm development Source: FlyBase
  • embryonic hindgut morphogenesis Source: UniProtKB
  • epithelial cell fate determination, open tracheal system Source: FlyBase
  • epithelial cell migration, open tracheal system Source: UniProtKB
  • eye-antennal disc development Source: FlyBase
  • eye-antennal disc morphogenesis Source: FlyBase
  • female germ-line stem cell population maintenance Source: FlyBase
  • foregut morphogenesis Source: FlyBase
  • fusion cell fate specification Source: UniProtKB
  • genital disc anterior/posterior pattern formation Source: FlyBase
  • genital disc development Source: FlyBase
  • genital disc sexually dimorphic development Source: FlyBase
  • germ cell development Source: FlyBase
  • germ cell migration Source: FlyBase
  • germ-line stem cell division Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • head morphogenesis Source: FlyBase
  • heart development Source: UniProtKB
  • hemocyte development Source: FlyBase
  • hindgut morphogenesis Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein specification Source: FlyBase
  • imaginal disc development Source: FlyBase
  • imaginal disc growth Source: FlyBase
  • imaginal disc pattern formation Source: FlyBase
  • labial disc development Source: FlyBase
  • larval lymph gland hemocyte differentiation Source: FlyBase
  • leg disc proximal/distal pattern formation Source: FlyBase
  • lymph gland development Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • maternal specification of dorsal/ventral axis, oocyte, soma encoded Source: FlyBase
  • mesoderm development Source: UniProtKB
  • negative regulation of cell proliferation Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • negative regulation of salivary gland boundary specification Source: FlyBase
  • nurse cell apoptotic process Source: FlyBase
  • oogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • pericardial nephrocyte differentiation Source: FlyBase
  • positive regulation of muscle organ development Source: FlyBase
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  • progression of morphogenetic furrow involved in compound eye morphogenesis Source: UniProtKB
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell differentiation Source: FlyBase
  • regulation of cell proliferation Source: FlyBase
  • regulation of cell shape Source: UniProtKB
  • regulation of imaginal disc growth Source: FlyBase
  • regulation of MAPK cascade Source: GO_Central
  • regulation of organ growth Source: FlyBase
  • regulation of tube diameter, open tracheal system Source: FlyBase
  • sensory organ development Source: FlyBase
  • SMAD protein signal transduction Source: GO_Central
  • spectrosome organization Source: FlyBase
  • stem cell division Source: FlyBase
  • stem cell population maintenance Source: FlyBase
  • transforming growth factor beta receptor signaling pathway Source: FlyBase
  • wing and notum subfield formation Source: UniProtKB
  • wing disc anterior/posterior pattern formation Source: FlyBase
  • wing disc pattern formation Source: UniProtKB
  • wing disc proximal/distal pattern formation Source: FlyBase
  • zygotic determination of anterior/posterior axis, embryo Source: FlyBase
  • zygotic specification of dorsal/ventral axis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiR-DME-201451. Signaling by BMP.
R-DME-2129379. Molecules associated with elastic fibres.
SignaLinkiP07713.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein decapentaplegic
Short name:
Protein DPP-C
Gene namesi
Name:dpp
ORF Names:CG9885
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000490. dpp.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: FlyBase
  • intracellular Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 4564331 PublicationPRO_0000033664Add
BLAST
Chaini457 – 588132Protein decapentaplegicPRO_0000033665Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi487 ↔ 553By similarity
Disulfide bondi516 ↔ 585By similarity
Disulfide bondi520 ↔ 587By similarity
Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi552 – 552InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07713.

Expressioni

Tissue specificityi

Expressed in the dorsal region of the embryo, and becomes enriched in a dorsal midline stripe just prior to gastrulation. Expressed in midgut mesoderm and in two overlapping regions of the embryonic large intestine. Expressed in a long-range concentration gradient in the wing imaginal disk.4 Publications

Developmental stagei

Expressed both maternally and zygotically. First detected during stages 8 to 10 of oogenesis.1 Publication

Gene expression databases

BgeeiFBgn0000490.
GenevisibleiP07713. DM.

Interactioni

Subunit structurei

Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern. Component of a complex composed of dpp, sog and tsg.1 Publication

GO - Molecular functioni

  • collagen binding Source: FlyBase
  • cytokine activity Source: GO_Central
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi59659. 55 interactions.
DIPiDIP-19N.
MINTiMINT-1025264.
STRINGi7227.FBpp0077451.

Structurei

3D structure databases

ProteinModelPortaliP07713.
SMRiP07713. Positions 486-588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
InParanoidiP07713.
KOiK04662.
OMAiFTHKDSK.
OrthoDBiEOG091G0K7Z.
PhylomeDBiP07713.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAWLLLLAV LATFQTIVRV ASTEDISQRF IAAIAPVAAH IPLASASGSG
60 70 80 90 100
SGRSGSRSVG ASTSTALAKA FNPFSEPASF SDSDKSHRSK TNKKPSKSDA
110 120 130 140 150
NRQFNEVHKP RTDQLENSKN KSKQLVNKPN HNKMAVKEQR SHHKKSHHHR
160 170 180 190 200
SHQPKQASAS TESHQSSSIE SIFVEEPTLV LDREVASINV PANAKAIIAE
210 220 230 240 250
QGPSTYSKEA LIKDKLKPDP STLVEIEKSL LSLFNMKRPP KIDRSKIIIP
260 270 280 290 300
EPMKKLYAEI MGHELDSVNI PKPGLLTKSA NTVRSFTHKD SKIDDRFPHH
310 320 330 340 350
HRFRLHFDVK SIPADEKLKA AELQLTRDAL SQQVVASRSS ANRTRYQVLV
360 370 380 390 400
YDITRVGVRG QREPSYLLLD TKTVRLNSTD TVSLDVQPAV DRWLASPQRN
410 420 430 440 450
YGLLVEVRTV RSLKPAPHHH VRLRRSADEA HERWQHKQPL LFTYTDDGRH
460 470 480 490 500
KARSIRDVSG GEGGGKGGRN KRQPRRPTRR KNHDDTCRRH SLYVDFSDVG
510 520 530 540 550
WDDWIVAPLG YDAYYCHGKC PFPLADHFNS TNHAVVQTLV NNMNPGKVPK
560 570 580
ACCVPTQLDS VAMLYLNDQS TVVLKNYQEM TVVGCGCR
Length:588
Mass (Da):65,868
Last modified:September 13, 2005 - v2
Checksum:i2C8166C1BD2F666B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4742QP → HA in AAA28482 (PubMed:3467201).Curated
Sequence conflicti556 – 5561T → K in AAT94456 (Ref. 5) Curated
Sequence conflicti568 – 5681D → G in AAT94456 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591V → G in strain: dp cn bw. 1 Publication
Natural varianti121 – 1211K → M in strain: dp cn bw. 1 Publication
Natural varianti439 – 4391P → A.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30116 mRNA. Translation: AAA28482.1.
U63857 Genomic DNA. Translation: AAC47552.1.
AE014134 Genomic DNA. Translation: AAF51250.1.
AE014134 Genomic DNA. Translation: AAN10431.1.
AE014134 Genomic DNA. Translation: AAN10432.1.
AE014134 Genomic DNA. Translation: AAN10434.1.
BT015227 mRNA. Translation: AAT94456.1.
AF459545 Genomic DNA. Translation: AAN61361.1.
AF459546 Genomic DNA. Translation: AAN61362.1.
AF459547 Genomic DNA. Translation: AAN61363.1.
AF459548 Genomic DNA. Translation: AAN61364.1.
AF459549 Genomic DNA. Translation: AAN61365.1.
AF459550 Genomic DNA. Translation: AAN61366.1.
AF459551 Genomic DNA. Translation: AAN61367.1.
AF459552 Genomic DNA. Translation: AAN61368.1.
AF459553 Genomic DNA. Translation: AAN61369.1.
AF459554 Genomic DNA. Translation: AAN61370.1.
AF459555 Genomic DNA. Translation: AAN61371.1.
AF459556 Genomic DNA. Translation: AAN61372.1.
AF459557 Genomic DNA. Translation: AAN61373.1.
AF459558 Genomic DNA. Translation: AAN61374.1.
AF459559 Genomic DNA. Translation: AAN61375.1.
AF459560 Genomic DNA. Translation: AAN61376.1.
AF459561 Genomic DNA. Translation: AAN61377.1.
AF459562 Genomic DNA. Translation: AAN61378.1.
AF459563 Genomic DNA. Translation: AAN61379.1.
AF459564 Genomic DNA. Translation: AAN61380.1.
PIRiA26158.
RefSeqiNP_477311.1. NM_057963.5.
NP_722810.1. NM_164485.2.
NP_722811.1. NM_164486.2.
NP_722813.1. NM_164488.2.
UniGeneiDm.4767.

Genome annotation databases

EnsemblMetazoaiFBtr0077771; FBpp0077451; FBgn0000490.
FBtr0077772; FBpp0077452; FBgn0000490.
FBtr0077773; FBpp0077453; FBgn0000490.
FBtr0077775; FBpp0077455; FBgn0000490.
GeneIDi33432.
KEGGidme:Dmel_CG9885.
UCSCiCG9885-RB. d. melanogaster.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30116 mRNA. Translation: AAA28482.1.
U63857 Genomic DNA. Translation: AAC47552.1.
AE014134 Genomic DNA. Translation: AAF51250.1.
AE014134 Genomic DNA. Translation: AAN10431.1.
AE014134 Genomic DNA. Translation: AAN10432.1.
AE014134 Genomic DNA. Translation: AAN10434.1.
BT015227 mRNA. Translation: AAT94456.1.
AF459545 Genomic DNA. Translation: AAN61361.1.
AF459546 Genomic DNA. Translation: AAN61362.1.
AF459547 Genomic DNA. Translation: AAN61363.1.
AF459548 Genomic DNA. Translation: AAN61364.1.
AF459549 Genomic DNA. Translation: AAN61365.1.
AF459550 Genomic DNA. Translation: AAN61366.1.
AF459551 Genomic DNA. Translation: AAN61367.1.
AF459552 Genomic DNA. Translation: AAN61368.1.
AF459553 Genomic DNA. Translation: AAN61369.1.
AF459554 Genomic DNA. Translation: AAN61370.1.
AF459555 Genomic DNA. Translation: AAN61371.1.
AF459556 Genomic DNA. Translation: AAN61372.1.
AF459557 Genomic DNA. Translation: AAN61373.1.
AF459558 Genomic DNA. Translation: AAN61374.1.
AF459559 Genomic DNA. Translation: AAN61375.1.
AF459560 Genomic DNA. Translation: AAN61376.1.
AF459561 Genomic DNA. Translation: AAN61377.1.
AF459562 Genomic DNA. Translation: AAN61378.1.
AF459563 Genomic DNA. Translation: AAN61379.1.
AF459564 Genomic DNA. Translation: AAN61380.1.
PIRiA26158.
RefSeqiNP_477311.1. NM_057963.5.
NP_722810.1. NM_164485.2.
NP_722811.1. NM_164486.2.
NP_722813.1. NM_164488.2.
UniGeneiDm.4767.

3D structure databases

ProteinModelPortaliP07713.
SMRiP07713. Positions 486-588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59659. 55 interactions.
DIPiDIP-19N.
MINTiMINT-1025264.
STRINGi7227.FBpp0077451.

Proteomic databases

PaxDbiP07713.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077771; FBpp0077451; FBgn0000490.
FBtr0077772; FBpp0077452; FBgn0000490.
FBtr0077773; FBpp0077453; FBgn0000490.
FBtr0077775; FBpp0077455; FBgn0000490.
GeneIDi33432.
KEGGidme:Dmel_CG9885.
UCSCiCG9885-RB. d. melanogaster.

Organism-specific databases

CTDi33432.
FlyBaseiFBgn0000490. dpp.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
InParanoidiP07713.
KOiK04662.
OMAiFTHKDSK.
OrthoDBiEOG091G0K7Z.
PhylomeDBiP07713.

Enzyme and pathway databases

ReactomeiR-DME-201451. Signaling by BMP.
R-DME-2129379. Molecules associated with elastic fibres.
SignaLinkiP07713.

Miscellaneous databases

GenomeRNAii33432.
PROiP07713.

Gene expression databases

BgeeiFBgn0000490.
GenevisibleiP07713. DM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDECA_DROME
AccessioniPrimary (citable) accession number: P07713
Secondary accession number(s): A4V009
, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.