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P07700

- ADRB1_MELGA

UniProt

P07700 - ADRB1_MELGA

Protein

Beta-1 adrenergic receptor

Gene

ADRB1

Organism
Meleagris gallopavo (Common turkey)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei121 – 1211Agonist or antagonist
    Binding sitei126 – 1261Agonist or antagonistBy similarity

    GO - Molecular functioni

    1. beta1-adrenergic receptor activity Source: InterPro
    2. Ras guanyl-nucleotide exchange factor activity Source: UniProtKB
    3. receptor signaling protein activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating adrenergic receptor signaling pathway Source: UniProtKB
    2. intracellular signal transduction Source: GOC
    3. positive regulation of cAMP biosynthetic process Source: UniProtKB
    4. positive regulation of cAMP-mediated signaling Source: UniProtKB
    5. positive regulation of heart contraction Source: InterPro
    6. positive regulation of Ras GTPase activity Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-1 adrenergic receptor
    Alternative name(s):
    Beta-1 adrenoreceptor
    Short name:
    Beta-1 adrenoceptor
    Short name:
    Beta-T
    Gene namesi
    Name:ADRB1
    OrganismiMeleagris gallopavo (Common turkey)
    Taxonomic identifieri9103 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaeMeleagridinaeMeleagris
    ProteomesiUP000001645: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Beta-1 adrenergic receptorPRO_0000069120Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Curated
    Disulfide bondi114 ↔ 1991 PublicationPROSITE-ProRule annotation
    Disulfide bondi192 ↔ 1981 PublicationPROSITE-ProRule annotation
    Lipidationi358 – 3581S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60236N.

    Structurei

    Secondary structure

    1
    483
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi37 – 6832
    Helixi70 – 723
    Helixi75 – 9218
    Helixi94 – 10411
    Helixi110 – 14435
    Helixi146 – 1527
    Helixi155 – 17824
    Turni179 – 1824
    Helixi187 – 1948
    Helixi205 – 21511
    Helixi217 – 23923
    Helixi248 – 2514
    Helixi279 – 31537
    Helixi317 – 3193
    Helixi322 – 34322
    Helixi347 – 35610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DEPNMR-A345-359[»]
    2VT4X-ray2.70A/B/C/D33-367[»]
    2Y00X-ray2.50A/B33-368[»]
    2Y01X-ray2.60A/B33-368[»]
    2Y02X-ray2.60A/B33-368[»]
    2Y03X-ray2.85A/B33-368[»]
    2Y04X-ray3.05A/B33-368[»]
    2YCWX-ray3.00A/B33-367[»]
    2YCXX-ray3.25A/B33-367[»]
    2YCYX-ray3.15A/B33-367[»]
    2YCZX-ray3.65A/B33-367[»]
    3ZPQX-ray2.80A/B33-368[»]
    3ZPRX-ray2.70A/B33-368[»]
    4AMIX-ray3.20A/B33-368[»]
    4AMJX-ray2.30A/B33-368[»]
    4BVNX-ray2.10A33-368[»]
    4GPOX-ray3.50A/B33-368[»]
    ProteinModelPortaliP07700.
    SMRiP07700. Positions 39-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07700.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838Extracellular1 PublicationAdd
    BLAST
    Topological domaini68 – 769Cytoplasmic1 Publication
    Topological domaini104 – 11512Extracellular1 PublicationAdd
    BLAST
    Topological domaini138 – 15518Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini180 – 20526Extracellular1 PublicationAdd
    BLAST
    Topological domaini232 – 28554Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini316 – 3205Extracellular1 Publication
    Topological domaini344 – 483140Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6729Helical; Name=1Add
    BLAST
    Transmembranei77 – 10327Helical; Name=2Add
    BLAST
    Transmembranei116 – 13722Helical; Name=3Add
    BLAST
    Transmembranei156 – 17924Helical; Name=4Add
    BLAST
    Transmembranei206 – 23126Helical; Name=5Add
    BLAST
    Transmembranei286 – 31530Helical; Name=6Add
    BLAST
    Transmembranei321 – 34323Helical; Name=7Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni201 – 21515Agonist and antagonist bindingAdd
    BLAST
    Regioni303 – 3108Agonist and antagonist binding
    Regioni329 – 3335Agonist and antagonist binding

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG106962.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002233. ADR_fam.
    IPR000507. ADRB1_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00561. ADRENRGCB1AR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P07700-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDGWLPPDC GPHNRSGGGG ATAAPTGSRQ VSAELLSQQW EAGMSLLMAL    50
    VVLLIVAGNV LVIAAIGRTQ RLQTLTNLFI TSLACADLVM GLLVVPFGAT 100
    LVVRGTWLWG SFLCECWTSL DVLCVTASIE TLCVIAIDRY LAITSPFRYQ 150
    SLMTRARAKV IICTVWAISA LVSFLPIMMH WWRDEDPQAL KCYQDPGCCD 200
    FVTNRAYAIA SSIISFYIPL LIMIFVYLRV YREAKEQIRK IDRCEGRFYG 250
    SQEQPQPPPL PQHQPILGNG RASKRKTSRV MAMREHKALK TLGIIMGVFT 300
    LCWLPFFLVN IVNVFNRDLV PDWLFVFFNW LGYANSAFNP IIYCRSPDFR 350
    KAFKRLLCFP RKADRRLHAG GQPAPLPGGF ISTLGSPEHS PGGTWSDCNG 400
    GTRGGSESSL EERHSKTSRS ESKMEREKNI LATTRFYCTF LGNGDKAVFC 450
    TVLRIVKLFE DATCTCPHTH KLKMKWRFKQ HQA 483
    Length:483
    Mass (Da):54,078
    Last modified:April 1, 1988 - v1
    Checksum:iB11A7E71F6CCE3E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14379 mRNA. Translation: AAA49627.1.
    PIRiA25896.
    UniGeneiMga.4462.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14379 mRNA. Translation: AAA49627.1 .
    PIRi A25896.
    UniGenei Mga.4462.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DEP NMR - A 345-359 [» ]
    2VT4 X-ray 2.70 A/B/C/D 33-367 [» ]
    2Y00 X-ray 2.50 A/B 33-368 [» ]
    2Y01 X-ray 2.60 A/B 33-368 [» ]
    2Y02 X-ray 2.60 A/B 33-368 [» ]
    2Y03 X-ray 2.85 A/B 33-368 [» ]
    2Y04 X-ray 3.05 A/B 33-368 [» ]
    2YCW X-ray 3.00 A/B 33-367 [» ]
    2YCX X-ray 3.25 A/B 33-367 [» ]
    2YCY X-ray 3.15 A/B 33-367 [» ]
    2YCZ X-ray 3.65 A/B 33-367 [» ]
    3ZPQ X-ray 2.80 A/B 33-368 [» ]
    3ZPR X-ray 2.70 A/B 33-368 [» ]
    4AMI X-ray 3.20 A/B 33-368 [» ]
    4AMJ X-ray 2.30 A/B 33-368 [» ]
    4BVN X-ray 2.10 A 33-368 [» ]
    4GPO X-ray 3.50 A/B 33-368 [» ]
    ProteinModelPortali P07700.
    SMRi P07700. Positions 39-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60236N.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106962.

    Miscellaneous databases

    EvolutionaryTracei P07700.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002233. ADR_fam.
    IPR000507. ADRB1_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00561. ADRENRGCB1AR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "NMR and circular dichroism studies of synthetic peptides derived from the third intracellular loop of the beta-adrenoceptor."
      Jung H., Windhaber R., Palm D., Schnackerz K.D.
      FEBS Lett. 358:133-136(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 345-359.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 33-367 IN COMPLEX WITH THE ANTAGONIST CYANOPINDOLOL, DISULFIDE BONDS, FUNCTION, TOPOLOGY.

    Entry informationi

    Entry nameiADRB1_MELGA
    AccessioniPrimary (citable) accession number: P07700
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3