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Protein

Beta-1 adrenergic receptor

Gene

ADRB1

Organism
Meleagris gallopavo (Common turkey)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121Agonist or antagonist1
Binding sitei126Agonist or antagonistBy similarity1

GO - Molecular functioni

  • beta1-adrenergic receptor activity Source: AgBase
  • drug binding Source: AgBase
  • Ras guanyl-nucleotide exchange factor activity Source: UniProtKB
  • signal transducer activity, downstream of receptor Source: UniProtKB
  • sodium ion binding Source: AgBase
  • water binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1 adrenergic receptor
Alternative name(s):
Beta-1 adrenoreceptor
Short name:
Beta-1 adrenoceptor
Short name:
Beta-T
Gene namesi
Name:ADRB1
OrganismiMeleagris gallopavo (Common turkey)
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
Proteomesi
  • UP000001645 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38Extracellular1 PublicationAdd BLAST38
Transmembranei39 – 67Helical; Name=1Add BLAST29
Topological domaini68 – 76Cytoplasmic1 Publication9
Transmembranei77 – 103Helical; Name=2Add BLAST27
Topological domaini104 – 115Extracellular1 PublicationAdd BLAST12
Transmembranei116 – 137Helical; Name=3Add BLAST22
Topological domaini138 – 155Cytoplasmic1 PublicationAdd BLAST18
Transmembranei156 – 179Helical; Name=4Add BLAST24
Topological domaini180 – 205Extracellular1 PublicationAdd BLAST26
Transmembranei206 – 231Helical; Name=5Add BLAST26
Topological domaini232 – 285Cytoplasmic1 PublicationAdd BLAST54
Transmembranei286 – 315Helical; Name=6Add BLAST30
Topological domaini316 – 320Extracellular1 Publication5
Transmembranei321 – 343Helical; Name=7Add BLAST23
Topological domaini344 – 483Cytoplasmic1 PublicationAdd BLAST140

GO - Cellular componenti

  • early endosome Source: UniProtKB
  • integral component of plasma membrane Source: AgBase
  • membrane Source: AgBase
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691201 – 483Beta-1 adrenergic receptorAdd BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...)Curated1
Disulfide bondi114 ↔ 199PROSITE-ProRule annotation1 Publication
Disulfide bondi192 ↔ 198PROSITE-ProRule annotation1 Publication
Lipidationi358S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Protein-protein interaction databases

DIPiDIP-60236N.
STRINGi9103.ENSMGAP00000011521.

Structurei

Secondary structure

1483
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi37 – 68Combined sources32
Helixi70 – 72Combined sources3
Helixi75 – 92Combined sources18
Helixi94 – 104Combined sources11
Helixi110 – 144Combined sources35
Helixi146 – 152Combined sources7
Helixi155 – 178Combined sources24
Turni179 – 182Combined sources4
Helixi187 – 194Combined sources8
Helixi205 – 215Combined sources11
Helixi217 – 239Combined sources23
Turni240 – 242Combined sources3
Helixi248 – 251Combined sources4
Helixi272 – 274Combined sources3
Turni275 – 277Combined sources3
Helixi279 – 315Combined sources37
Helixi317 – 319Combined sources3
Helixi322 – 343Combined sources22
Helixi347 – 356Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEPNMR-A345-359[»]
2VT4X-ray2.70A/B/C/D33-367[»]
2Y00X-ray2.50A/B33-368[»]
2Y01X-ray2.60A/B33-368[»]
2Y02X-ray2.60A/B33-368[»]
2Y03X-ray2.85A/B33-368[»]
2Y04X-ray3.05A/B33-368[»]
2YCWX-ray3.00A/B33-367[»]
2YCXX-ray3.25A/B33-367[»]
2YCYX-ray3.15A/B33-367[»]
2YCZX-ray3.65A/B33-367[»]
3ZPQX-ray2.80A/B33-368[»]
3ZPRX-ray2.70A/B33-368[»]
4AMIX-ray3.20A/B33-368[»]
4AMJX-ray2.30A/B33-368[»]
4BVNX-ray2.10A33-368[»]
4GPOX-ray3.50A/B33-368[»]
5A8EX-ray2.40A33-368[»]
5F8UX-ray3.35A/B33-368[»]
ProteinModelPortaliP07700.
SMRiP07700.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07700.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 215Agonist and antagonist bindingAdd BLAST15
Regioni303 – 310Agonist and antagonist binding8
Regioni329 – 333Agonist and antagonist binding5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiP07700.
KOiK04141.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000507. ADRB1_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00561. ADRENRGCB1AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDGWLPPDC GPHNRSGGGG ATAAPTGSRQ VSAELLSQQW EAGMSLLMAL
60 70 80 90 100
VVLLIVAGNV LVIAAIGRTQ RLQTLTNLFI TSLACADLVM GLLVVPFGAT
110 120 130 140 150
LVVRGTWLWG SFLCECWTSL DVLCVTASIE TLCVIAIDRY LAITSPFRYQ
160 170 180 190 200
SLMTRARAKV IICTVWAISA LVSFLPIMMH WWRDEDPQAL KCYQDPGCCD
210 220 230 240 250
FVTNRAYAIA SSIISFYIPL LIMIFVYLRV YREAKEQIRK IDRCEGRFYG
260 270 280 290 300
SQEQPQPPPL PQHQPILGNG RASKRKTSRV MAMREHKALK TLGIIMGVFT
310 320 330 340 350
LCWLPFFLVN IVNVFNRDLV PDWLFVFFNW LGYANSAFNP IIYCRSPDFR
360 370 380 390 400
KAFKRLLCFP RKADRRLHAG GQPAPLPGGF ISTLGSPEHS PGGTWSDCNG
410 420 430 440 450
GTRGGSESSL EERHSKTSRS ESKMEREKNI LATTRFYCTF LGNGDKAVFC
460 470 480
TVLRIVKLFE DATCTCPHTH KLKMKWRFKQ HQA
Length:483
Mass (Da):54,078
Last modified:April 1, 1988 - v1
Checksum:iB11A7E71F6CCE3E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14379 mRNA. Translation: AAA49627.1.
PIRiA25896.
RefSeqiNP_001290104.1. NM_001303175.1.
UniGeneiMga.4462.

Genome annotation databases

GeneIDi100303680.
KEGGimgp:100303680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14379 mRNA. Translation: AAA49627.1.
PIRiA25896.
RefSeqiNP_001290104.1. NM_001303175.1.
UniGeneiMga.4462.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DEPNMR-A345-359[»]
2VT4X-ray2.70A/B/C/D33-367[»]
2Y00X-ray2.50A/B33-368[»]
2Y01X-ray2.60A/B33-368[»]
2Y02X-ray2.60A/B33-368[»]
2Y03X-ray2.85A/B33-368[»]
2Y04X-ray3.05A/B33-368[»]
2YCWX-ray3.00A/B33-367[»]
2YCXX-ray3.25A/B33-367[»]
2YCYX-ray3.15A/B33-367[»]
2YCZX-ray3.65A/B33-367[»]
3ZPQX-ray2.80A/B33-368[»]
3ZPRX-ray2.70A/B33-368[»]
4AMIX-ray3.20A/B33-368[»]
4AMJX-ray2.30A/B33-368[»]
4BVNX-ray2.10A33-368[»]
4GPOX-ray3.50A/B33-368[»]
5A8EX-ray2.40A33-368[»]
5F8UX-ray3.35A/B33-368[»]
ProteinModelPortaliP07700.
SMRiP07700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60236N.
STRINGi9103.ENSMGAP00000011521.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100303680.
KEGGimgp:100303680.

Organism-specific databases

CTDi153.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiP07700.
KOiK04141.

Miscellaneous databases

EvolutionaryTraceiP07700.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000507. ADRB1_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00561. ADRENRGCB1AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADRB1_MELGA
AccessioniPrimary (citable) accession number: P07700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.