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P07687

- HYEP_RAT

UniProt

P07687 - HYEP_RAT

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Protein
Epoxide hydrolase 1
Gene
Ephx1, Eph-1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.

Catalytic activityi

Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

GO - Molecular functioni

  1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC
  2. enzyme binding Source: RGD
  3. epoxide hydrolase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
  2. cellular response to glucocorticoid stimulus Source: RGD
  3. cellular response to organic substance Source: RGD
  4. liver development Source: RGD
  5. response to toxic substance Source: UniProtKB-KW
  6. xenobiotic metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism, Detoxification

Enzyme and pathway databases

SABIO-RKP07687.

Protein family/group databases

MEROPSiS33.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 1 (EC:3.3.2.9)
Alternative name(s):
Epoxide hydratase
Microsomal epoxide hydrolase
Gene namesi
Name:Ephx1
Synonyms:Eph-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi2557. Ephx1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2019Helical; Signal-anchor; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Epoxide hydrolase 1
PRO_0000080859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei295 – 2951Omega-N-methylated arginine1 Publication
Modified residuei439 – 4391N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiP07687.
PRIDEiP07687.

PTM databases

PhosphoSiteiP07687.

Expressioni

Gene expression databases

GenevestigatoriP07687.

Interactioni

Protein-protein interaction databases

IntActiP07687. 1 interaction.
MINTiMINT-4579972.
STRINGi10116.ENSRNOP00000004780.

Structurei

3D structure databases

ProteinModelPortaliP07687.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00390000002210.
HOGENOMiHOG000132894.
HOVERGENiHBG002366.
InParanoidiP07687.
KOiK01253.
OMAiHLNMALV.
OrthoDBiEOG7B5WZH.
PhylomeDBiP07687.
TreeFamiTF313813.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

P07687-1 [UniParc]FASTAAdd to Basket

« Hide

MWLELVLASL LGFVIYWFVS RDKEETLPLG DGWWGPGSKP SAKEDESIRP    50
FKVETSDEEI KDLHQRIDRF RASPPLEGSR FHYGFNSNYM KKVVSYWRNE 100
FDWRKQVEIL NQYPHFKTKI EGLDIHFIHV KPPQLPSGRT PKPLLMVHGW 150
PGSFYEFYKI IPLLTDPKSH GLSDEHVFEV ICPSIPGYGY SEASSKKGLN 200
SVATARIFYK LMTRLGFQKF YIQGGDWGSL ICTNMAQMVP NHVKGLHLNM 250
AFISRSFYTM TPLLGQRFGR FLGYTEKDIE LLYPYKEKVF YSIMRESGYL 300
HIQATKPDTV GCALNDSPVG LAAYILEKFS TWTKSEYREL EDGGLERKFS 350
LDDLLVNIMI YWTTGTIVSS QRYYKENLGQ GIMVHKHEGM KVFVPTGFSA 400
FPSELLHAPE KWVKVKYPKL ISYSYMERGG HFAAFEEPKL LAQDIRKFVS 450
LAELQ 455
Length:455
Mass (Da):52,582
Last modified:April 1, 1988 - v1
Checksum:i437A15BBCD6861FA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti348 – 38942Missing in AAA41585. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15345
, M15339, M15340, M15341, M15342, M15343, M15344 Genomic DNA. Translation: AAA41585.1.
M26125 mRNA. Translation: AAA42350.1.
BC061568 mRNA. Translation: AAH61568.1.
PIRiA26732. A26081.
RefSeqiNP_001029262.1. NM_001034090.3.
NP_036976.2. NM_012844.3.
UniGeneiRn.3603.

Genome annotation databases

EnsembliENSRNOT00000004780; ENSRNOP00000004780; ENSRNOG00000003515.
GeneIDi25315.
KEGGirno:25315.
UCSCiRGD:2557. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15345
, M15339 , M15340 , M15341 , M15342 , M15343 , M15344 Genomic DNA. Translation: AAA41585.1 .
M26125 mRNA. Translation: AAA42350.1 .
BC061568 mRNA. Translation: AAH61568.1 .
PIRi A26732. A26081.
RefSeqi NP_001029262.1. NM_001034090.3.
NP_036976.2. NM_012844.3.
UniGenei Rn.3603.

3D structure databases

ProteinModelPortali P07687.
ModBasei Search...

Protein-protein interaction databases

IntActi P07687. 1 interaction.
MINTi MINT-4579972.
STRINGi 10116.ENSRNOP00000004780.

Chemistry

ChEMBLi CHEMBL2299.

Protein family/group databases

MEROPSi S33.971.

PTM databases

PhosphoSitei P07687.

Proteomic databases

PaxDbi P07687.
PRIDEi P07687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004780 ; ENSRNOP00000004780 ; ENSRNOG00000003515 .
GeneIDi 25315.
KEGGi rno:25315.
UCSCi RGD:2557. rat.

Organism-specific databases

CTDi 2052.
RGDi 2557. Ephx1.

Phylogenomic databases

eggNOGi COG0596.
GeneTreei ENSGT00390000002210.
HOGENOMi HOG000132894.
HOVERGENi HBG002366.
InParanoidi P07687.
KOi K01253.
OMAi HLNMALV.
OrthoDBi EOG7B5WZH.
PhylomeDBi P07687.
TreeFami TF313813.

Enzyme and pathway databases

SABIO-RK P07687.

Miscellaneous databases

NextBioi 606139.
PROi P07687.

Gene expression databases

Genevestigatori P07687.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view ]
Pfami PF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSi PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and organization of the microsomal xenobiotic epoxide hydrolase gene."
    Falany C.N., McQuiddy P., Kasper C.B.
    J. Biol. Chem. 262:5924-5930(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complementary DNA and amino acid sequence of rat liver microsomal, xenobiotic epoxide hydrolase."
    Porter T.D., Beck T.W., Kasper C.B.
    Arch. Biochem. Biophys. 248:121-129(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  4. Cited for: METHYLATION AT ARG-295, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiHYEP_RAT
AccessioniPrimary (citable) accession number: P07687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 11, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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