P07666 (SRYA_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serendipity locus protein alpha

Gene names

Name:	Sry-alpha
Synonyms:	Sry-a
ORF Names:	CG17957

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. Ref.5
Subcellular location	Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Inner membrane-associated and cytoplasmic. Colocalizes with the structural transitions in the microfilament network during cellularization. Ref.5
Tissue specificity	Transient expression in blastoderm from nuclear cycle 11 to the onset of gastrulation. Ref.5
Developmental stage	Transcript levels rise steadily during synctial stages to reach a peak in early cycle 14 and then decline rapidly during cellularization. Ref.5

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	actin filament organization Inferred from mutant phenotype Ref.5. Source: FlyBase cellularization Traceable author statement. Source: FlyBase cytokinesis, actomyosin contractile ring assembly Non-traceable author statement. Source: FlyBase
Cellular component	cytosol Inferred from direct assay Ref.5. Source: FlyBase plasma membrane Inferred from direct assay Ref.5. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Serendipity locus protein alpha		PRO_0000072197

Sequences

	Sequence		Length	Mass (Da)
	P07666 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: EC576378256193FB	FASTA	530	59,385
	10 20 30 40 50 60 MEQLLAQLHT CSELIAEGYS STGNIGWLNE FCATFLDFAS DLKARLPEVA PSGANLDVET 70 80 90 100 110 120 IFLCLTQVVT CITHLERTIS MEAPHMTRQH FLDRLDWCLR RLLVSLTQLE GNVTPVKNLE 130 140 150 160 170 180 DHSFVELMDL ALDHLDDYME KLAQQRNNSL HILEESFTED TYQLASIVNH IVRHALAFAN 190 200 210 220 230 240 VAIHSDKKAL TALCETLLAE CATFHEEAGE PNSGHRKLEA LSLERALYAL ESFLNEALLH 250 260 270 280 290 300 LLFVSLIDLE NASVEKLKDA LQRDPAGAQE LISAFDTNMD RIQQIGVLAI AFSQDIKTKT 310 320 330 340 350 360 IVRSCLASLE SLDACIVPAL QLPESTSSAH HAEVLQEHFN QELLIFRNVI HEIIDSCSLI 370 380 390 400 410 420 NNYLDMLGER IHVQDKSHLK LIVQRGGVVV DHFRLPVNYS GLSEDGKRVH KDLILILREC 430 440 450 460 470 480 QAVVNLDVPV DPKRIVKRLK ILYSVLAKLR DLICRDNLEP DSSVASEAQV PSSATRTFVR 490 500 510 520 530 SSRSFGKRHR SFVKQTGNCS VFGPQDSLAE SGHSESDLIS FQITEILRLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene." Vincent A., Colot H.V., Rosbash M. J. Mol. Biol. 186:149-166(1985) [PubMed: 3935797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Oregon-R.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[5]	"The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo." Schweisguth F., Lepesant J.-A., Vincent A. Genes Dev. 4:922-931(1990) [PubMed: 2166703] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X03121 Genomic DNA. Translation: CAA26897.1. AE014297 Genomic DNA. Translation: AAF56999.1. AY071374 mRNA. Translation: AAL48996.1.
PIR	B23351.
RefSeq	NP_524580.1. NM_079841.2.
UniGene	Dm.1915.
3D structure databases
ProteinModelPortal	P07666.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-19017N.
IntAct	P07666. 2 interactions.
MINT	MINT-282509.
STRING	P07666.
Proteomic databases
PRIDE	P07666.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0085557; FBpp0084923; FBgn0003510.
GeneID	43571.
KEGG	dme:Dmel_CG17957.
NMPDR	fig|7227.3.peg.15372.
Organism-specific databases
CTD	43571.
FlyBase	FBgn0003510. Sry-alpha.
Phylogenomic databases
eggNOG	inNOG09476.
GeneTree	EMGT00050000018123.
InParanoid	P07666.
OMA	DRIQQIG.
OrthoDB	EOG473N6T.
PhylomeDB	P07666.
Gene expression databases
Bgee	P07666.
GermOnline	CG17957. Drosophila melanogaster.
Family and domain databases
InterPro	IPR008837. Serendipity_A. [Graphical view]
PANTHER	PTHR10187. Serendipity_A. 1 hit.
Pfam	PF05482. Serendipity_A. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	834617.

Entry information

Entry name

SRYA_DROME

Accession

Primary (citable) accession number: P07666
Secondary accession number(s): Q9VAB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	January 25, 2012
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project