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Protein

Serendipity locus protein beta

Gene

Sry-beta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the consensus DNA sequence 5'-YCAGAGATGCGCA-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serendipity locus protein beta
Gene namesi
Name:Sry-beta
Synonyms:Sry-b
ORF Names:CG7938
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0003511. Sry-beta.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470491 – 356Serendipity locus protein betaAdd BLAST356

Proteomic databases

PaxDbiP07665.
PRIDEiP07665.

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Abundant in early embryos and present in very low amounts at every stage of the life-cycle.2 Publications

Gene expression databases

BgeeiFBgn0003511.
GenevisibleiP07665. DM.

Interactioni

Subunit structurei

Binds chromatin; requires N-terminal regions to form protein-protein contacts, in addition to DNA specific recognition by the zinc fingers.

Protein-protein interaction databases

BioGridi68426. 9 interactors.
IntActiP07665. 4 interactors.
MINTiMINT-303581.
STRINGi7227.FBpp0084922.

Structurei

3D structure databases

ProteinModelPortaliP07665.
SMRiP07665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00870000136554.
InParanoidiP07665.
OMAiECEEFMK.
OrthoDBiEOG091G0CLO.
PhylomeDBiP07665.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 6 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.

Sequencei

Sequence statusi: Complete.

P07665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTRPFCFV CGKEKSVGVF QLIEGCIVPG TFKPIKDILK YFEKIINQRL
60 70 80 90 100
ELLPNSAACR DCLEYLFNYD RLVRNLSQVQ RQIADALLGC RQVEGKAETK
110 120 130 140 150
QQAAKRARVQ VPAFKIVQAT ALKEPERQPG EEDECEEFMK EEMLDEEFQF
160 170 180 190 200
SEPDDSMPSS EEEFFTETTE IPCHICGEMF SSQEVLERHI KADTCQKSEQ
210 220 230 240 250
ATCNVCGLKV KDDEVLDLHM NLHEGKTELE CRYCDKKFSH KRNVLRHMEV
260 270 280 290 300
HWDKKKYQCD KCGERFSLSW LMYNHLMRHD AEENALICEV CHQQFKTKRT
310 320 330 340 350
YKHHLRTHQT DRPRYPCPDC EKSFVDKYTL KVHKRVHQPV EKPESAEAKE

ATVTFF
Length:356
Mass (Da):41,709
Last modified:August 16, 2005 - v2
Checksum:i6B5F2206A20CE8D4
GO

Sequence cautioni

The sequence CAA26896 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03121 Genomic DNA. Translation: CAA26896.1. Sequence problems.
AE014297 Genomic DNA. Translation: AAF56998.1.
AY118322 mRNA. Translation: AAM48351.1.
PIRiA23351.
RefSeqiNP_001303451.1. NM_001316522.1.
NP_524579.1. NM_079840.3.
UniGeneiDm.1378.

Genome annotation databases

EnsemblMetazoaiFBtr0085556; FBpp0084922; FBgn0003511.
FBtr0346861; FBpp0312401; FBgn0003511.
GeneIDi43570.
KEGGidme:Dmel_CG7938.

Similar proteinsi

Entry informationi

Entry nameiSRYB_DROME
AccessioniPrimary (citable) accession number: P07665
Secondary accession number(s): Q9VAB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: August 16, 2005
Last modified: October 25, 2017
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase