P07665 (SRYB_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serendipity locus protein beta

Gene names

Name:	Sry-beta
Synonyms:	Sry-b
ORF Names:	CG7938

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the consensus DNA sequence 5'-YCAGAGATGCGCA-3'.
Subunit structure	Binds chromatin; requires N-terminal regions to form protein-protein contacts, in addition to DNA specific recognition by the zinc fingers.
Subcellular location	Nucleus Ref.5.
Developmental stage	Expressed both maternally and zygotically. Abundant in early embryos and present in very low amounts at every stage of the life-cycle. Ref.1 Ref.5
Sequence similarities	Contains 6 C2H2-type zinc fingers.
Sequence caution	The sequence CAA26896.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay Ref.5. Source: UniProtKB polytene chromosome interband Inferred from direct assay Ref.5. Source: UniProtKB
Molecular function	DNA binding Inferred from direct assay Ref.7Ref.6Ref.5. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Serendipity locus protein beta		PRO_0000047049
Regions
	Zinc finger	171 – 193	23	C2H2-type 1; degenerate
	Zinc finger	201 – 223	23	C2H2-type 2
	Zinc finger	229 – 251	23	C2H2-type 3
	Zinc finger	257 – 279	23	C2H2-type 4
	Zinc finger	286 – 308	23	C2H2-type 5
	Zinc finger	315 – 337	23	C2H2-type 6

Sequences

	Sequence		Length	Mass (Da)
	P07665 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: 6B5F2206A20CE8D4	FASTA	356	41,709
	10 20 30 40 50 60 MSSTRPFCFV CGKEKSVGVF QLIEGCIVPG TFKPIKDILK YFEKIINQRL ELLPNSAACR 70 80 90 100 110 120 DCLEYLFNYD RLVRNLSQVQ RQIADALLGC RQVEGKAETK QQAAKRARVQ VPAFKIVQAT 130 140 150 160 170 180 ALKEPERQPG EEDECEEFMK EEMLDEEFQF SEPDDSMPSS EEEFFTETTE IPCHICGEMF 190 200 210 220 230 240 SSQEVLERHI KADTCQKSEQ ATCNVCGLKV KDDEVLDLHM NLHEGKTELE CRYCDKKFSH 250 260 270 280 290 300 KRNVLRHMEV HWDKKKYQCD KCGERFSLSW LMYNHLMRHD AEENALICEV CHQQFKTKRT 310 320 330 340 350 YKHHLRTHQT DRPRYPCPDC EKSFVDKYTL KVHKRVHQPV EKPESAEAKE ATVTFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene." Vincent A., Colot H.V., Rosbash M. J. Mol. Biol. 186:149-166(1985) [PubMed: 3935797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE. Strain: Oregon-R.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[5]	"The closely related Drosophila sry beta and sry delta zinc finger proteins show differential embryonic expression and distinct patterns of binding sites on polytene chromosomes." Payre F., Noselli S., Lefrere V., Vincent A. Development 110:141-149(1990) [PubMed: 2081456] [Abstract] Cited for: DNA-BINDING, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[6]	"Genomic targets of the serendipity beta and delta zinc finger proteins and their respective DNA recognition sites." Payre F., Vincent A. EMBO J. 10:2533-2541(1991) [PubMed: 1868833] [Abstract] Cited for: DNA-BINDING SPECIFICITY.
[7]	"Zinc fingers and other domains cooperate in binding of Drosophila sry beta and delta proteins at specific chromosomal sites." Noselli S., Payre F., Vincent A. Mol. Cell. Biol. 12:724-733(1992) [PubMed: 1732741] [Abstract] Cited for: DNA-BINDING SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X03121 Genomic DNA. Translation: CAA26896.1. Sequence problems. AE014297 Genomic DNA. Translation: AAF56998.1. AY118322 mRNA. Translation: AAM48351.1.
PIR	A23351.
RefSeq	NP_524579.1. NM_079840.2.
UniGene	Dm.1378.
3D structure databases
ProteinModelPortal	P07665.
SMR	P07665. Positions 2-79, 180-341.
ModBase	Search...
Protein-protein interaction databases
IntAct	P07665. 4 interactions.
MINT	MINT-303581.
STRING	P07665.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0085556; FBpp0084922; FBgn0003511.
GeneID	43570.
KEGG	dme:Dmel_CG7938.
NMPDR	fig|7227.3.peg.15371.
Organism-specific databases
CTD	43570.
FlyBase	FBgn0003511. Sry-beta.
Phylogenomic databases
eggNOG	KOG1721.
GeneTree	EMGT00050000001803.
InParanoid	P07665.
OMA	KTELECR.
OrthoDB	EOG47M0DG.
PhylomeDB	P07665.
Gene expression databases
ArrayExpress	P07665.
Bgee	P07665.
GermOnline	CG7938. Drosophila melanogaster.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
Pfam	PF00096. zf-C2H2. 5 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 6 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	834612.

Entry information

Entry name

SRYB_DROME

Accession

Primary (citable) accession number: P07665
Secondary accession number(s): Q9VAB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	August 16, 2005
Last modified:	January 25, 2012
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project