P07663 (PER_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Period circadian protein

Alternative name(s):
Protein clock-6
Short name=CLK-6

Gene names

Name:	per
ORF Names:	CG2647

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1224 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.
Subunit structure	Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer. Ref.14
Subcellular location	Nucleus. Cytoplasm › perinuclear region. Note: Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization.
Tissue specificity	Expressed in neural tissues and in several nonneural tissues of the abdomen. Malpighian tubules contain a circadian pacemaker that functions independently of the brain. Expression oscillates in all tissues studied except for the ovary. PER-A isoforms are mainly expressed in adult's head.
Induction	Expression is sensitive to temperature but not to light.
Domain	Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least three types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), and two major variants (Gly-Thr)17 and (Gly-Thr)20. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior. Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).
Post-translational modification	Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim. Ref.13
Sequence similarities	Contains 2 PAS (PER-ARNT-SIM) domains.
Sequence caution	The sequence CAA27285.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Biological rhythms
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	age-dependent response to oxidative stress Inferred from mutant phenotype PubMed 20157575. Source: FlyBase behavioral response to cocaine Non-traceable author statement PubMed 11715043. Source: FlyBase circadian temperature homeostasis Inferred from mutant phenotype PubMed 22981774. Source: FlyBase copulation Inferred from mutant phenotype PubMed 15324667. Source: FlyBase determination of adult lifespan Inferred from mutant phenotype PubMed 20157575. Source: FlyBase eclosion rhythm Inferred from mutant phenotype PubMed 11264660. Source: FlyBase entrainment of circadian clock by photoperiod Inferred from mutant phenotype PubMed 16361445. Source: FlyBase locomotor rhythm Inferred from mutant phenotype PubMed 11264660PubMed 18044989. Source: FlyBase long-term memory Inferred from mutant phenotype PubMed 15522971PubMed 22323813. Source: FlyBase male courtship behavior, veined wing generated song production Non-traceable author statement PubMed 11092827. Source: FlyBase negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 10409723PubMed 17578907PubMed 17578908. Source: FlyBase negative regulation of transcription regulatory region DNA binding Inferred from direct assay PubMed 10409723. Source: FlyBase regulation of circadian sleep/wake cycle, sleep Inferred from mutant phenotype PubMed 12015603. Source: FlyBase response to temperature stimulus Traceable author statement PubMed 12626480. Source: FlyBase
Cellular_component	cytoplasm Inferred from direct assay PubMed 12944510PubMed 15356209PubMed 16410523PubMed 17369364PubMed 19223210. Source: FlyBase nucleus Inferred from direct assay PubMed 12944510PubMed 15356209PubMed 15930393PubMed 16410523PubMed 17369364. Source: FlyBase perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein heterodimerization activity Non-traceable author statement PubMed 11178250. Source: FlyBase signal transducer activity Inferred from electronic annotation. Source: InterPro transcription corepressor activity Traceable author statement PubMed 12486701. Source: FlyBase
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform PER-A-long (identifier: P07663-1)

Also known as: perA;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform PER-A-short (identifier: P07663-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Isoform PER-B (identifier: P07663-3)

The sequence of this isoform differs from the canonical sequence as follows:
     868-963: Missing.

Isoform PER-C (identifier: P07663-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1224: TTPASMTKKV...EEDQTQHGDG → VSQWPVVPHR...SRQQQGMLYE

Isoform PER-D (identifier: P07663-5)

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.

Isoform PER-E (identifier: P07663-6)

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.
     1155-1224: KYTDSNGNSD...EEDQTQHGDG → VCYTNEVHW

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1224

1224

Period circadian protein

PRO_0000162596

Regions

Domain

238 – 373

136

PAS 1

Domain

391 – 497

107

PAS 2

Repeat

694 – 695

2

1

Repeat

697 – 698

2

2

Repeat

699 – 700

2

3

Repeat

701 – 702

2

4

Repeat

703 – 704

2

5

Repeat

705 – 706

2

6

Repeat

707 – 708

2

7

Repeat

709 – 710

2

8

Repeat

711 – 712

2

9

Repeat

713 – 714

2

10

Repeat

715 – 716

2

11

Repeat

717 – 718

2

12

Repeat

719 – 720

2

13

Repeat

721 – 722

2

14

Repeat

723 – 724

2

15

Repeat

725 – 726

2

16

Repeat

727 – 728

2

17

Repeat

729 – 730

2

18

Repeat

731 – 732

2

19

Repeat

733 – 734

2

20

Repeat

735 – 736

2

21

Repeat

737 – 738

2

22

Repeat

739 – 740

2

23

Repeat

741 – 742

2

24

Repeat

743 – 744

2

25

Repeat

745 – 746

2

26

Repeat

747 – 748

2

27; approximate

Repeat

749 – 750

2

28

Repeat

751 – 752

2

29

Repeat

753 – 754

2

30

Region

694 – 754

61

30 X 2 AA approximate tandem repeats of G-[TN]

Region

749 – 868

120

Regulates the rhythm of species-specific courtship song

Motif

66 – 79

14

Nuclear localization signal Potential

Compositional bias

74 – 79

6

Poly-Lys

Compositional bias

143 – 146

4

Poly-Glu

Compositional bias

223 – 226

4

Poly-Ala

Compositional bias

872 – 879

8

Poly-Gly

Compositional bias

898 – 905

8

Poly-Gly

Compositional bias

906 – 914

9

Poly-Ala

Compositional bias

1006 – 1013

8

Poly-Ala

Compositional bias

1035 – 1041

7

Poly-Ala

Natural variations

Alternative sequence

1 – 62

62

Missing in isoform PER-A-short.

VSP_004657

Alternative sequence

863 – 958

96

Missing in isoform PER-D and isoform PER-E.

VSP_004659

Alternative sequence

868 – 963

96

Missing in isoform PER-B.

VSP_004658

Alternative sequence

1076 – 1224

149

TTPAS…QHGDG → VSQWPVVPHRTVLTPTPTPY SSIDHAGVHDEEGAGCIPLG HHSCPGAASLLAERIRQDGA GLQCSGIRSLQEGGAGLLAH SLRDGRLQLRPALQQQQSRQ QQGMLYE in isoform PER-C.

VSP_004660

Alternative sequence

1155 – 1224

70

KYTDS…QHGDG → VCYTNEVHW in isoform PER-E.

VSP_004661

Natural variant

697 – 708

12

Missing in (Gly-Thr)17.

Natural variant

697 – 702

6

Missing in (Gly-Thr)20.

Natural variant

748

1

S → F in strain: U79.

Natural variant

762

1

T → S in strain: Berkeley, L18, Oregon-R, SP1 and U79.

Natural variant

846

1

A → T in strain: U79.

Natural variant

858

1

V → A in strain: L18 and U79.

Natural variant

1176

1

S → P in strain: L18.

Experimental info

Sequence conflict

211

1

G → V in AAA28777. Ref.8

Sequence conflict

498 – 499

2

GP → A in AAA28777. Ref.8

Sequence conflict

637

1

E → A Ref.10

Sequence conflict

733 – 767

35

Missing Ref.3

Sequence conflict

762 – 764

3

TAA → RR Ref.3

Sequence conflict

762 – 764

3

TAA → RR Ref.10

Sequence conflict

1029

1

L → V Ref.10

Sequence conflict

1038

1

A → P Ref.10

Sequence conflict

1075

1

T → TVSQWPV in CAA19677. Ref.6

Sequence conflict

1114

1

S → F Ref.1

Sequence conflict

1215

1

E → D Ref.1

Secondary structure

1

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1224

Helix Strand Turn

Details...

Beta strand

240 – 245

6

Turn

246 – 248

3

Beta strand

250 – 254

5

Helix

258 – 262

5

Helix

274 – 277

4

Helix

280 – 282

3

Helix

283 – 291

9

Beta strand

310 – 316

7

Beta strand

326 – 328

3

Beta strand

335 – 346

12

Beta strand

364 – 372

9

Beta strand

390 – 396

7

Beta strand

400 – 404

5

Helix

408 – 412

5

Helix

416 – 419

4

Helix

424 – 427

4

Helix

430 – 432

3

Helix

433 – 446

14

Beta strand

459 – 462

4

Beta strand

468 – 479

12

Turn

481 – 483

3

Beta strand

485 – 497

13

Beta strand

500 – 502

3

Beta strand

504 – 507

4

Helix

516 – 535

20

Turn

544 – 550

7

Helix

554 – 573

20

Sequences

	Sequence		Length	Mass (Da)
	Isoform PER-A-long (perA) [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 71FA54ECF3E90F4A	FASTA	1,224	127,852
	10 20 30 40 50 60 MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY GGKPSTQASS 70 80 90 100 110 120 SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG RDEEKPRPSG TGCVEQQICR 130 140 150 160 170 180 ELQDQQHGED HSEPQAIEQL QQEEEEDQSG SESEADRVEG VAKSEAAQSF PIPSPLSVTI 190 200 210 220 230 240 VPPSMGGCGG VGHAAGLDSG LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF 250 260 270 280 290 300 CCVISMHDGI VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 310 320 330 340 350 360 GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE ARPDNYMVSN 370 380 390 400 410 420 GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI ISHVDSAAVS ALGYLPQDLI 430 440 450 460 470 480 GRSIMDFYHH EDLSVMKETY ETVMKKGQTA GASFCSKPYR FLIQNGCYVL LETEWTSFVN 490 500 510 520 530 540 PWSRKLEFVV GHHRVFQGPK QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR 550 560 570 580 590 600 PSDTVKQEVS RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 610 620 630 640 650 660 YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG TCVSGASGPM 670 680 690 700 710 720 SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT GTGTGTGTGT GTGTGTGTGT 730 740 750 760 770 780 GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT GTGTASSSKG GTAAIPPVTL TESLLNKHND 790 800 810 820 830 840 EMEKFMLKKH RESRGRTGEK SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL 850 860 870 880 890 900 TLGTDAIKGA AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA 910 920 930 940 950 960 GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH STHTAMAQSS 970 980 990 1000 1010 1020 FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP TTSQQAAAAA AQAMPLQYMA 1030 1040 1050 1060 1070 1080 GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP GMANALQIPE RPLGSQSAYN KSVYTTTPAS 1090 1100 1110 1120 1130 1140 MTKKVPGAFH SVTTPAQVQR PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN 1150 1160 1170 1180 1190 1200 SDPPCSSSNP ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL 1210 1220 KSMSTSESKI MEHPEEDQTQ HGDG
	Isoform PER-A-short [UniParc]. Checksum: 7EF93EDE76EC5A5B	FASTA	1,162	121,661
	10 20 30 40 50 60 MIIKRNKDKS RKKKKNKGAG QGAGQAQTLI SASTSLEGRD EEKPRPSGTG CVEQQICREL 70 80 90 100 110 120 QDQQHGEDHS EPQAIEQLQQ EEEEDQSGSE SEADRVEGVA KSEAAQSFPI PSPLSVTIVP 130 140 150 160 170 180 PSMGGCGGVG HAAGLDSGLA KFDKTWEAGP GKLESMTGVG AAAAGTGQRG ERVKEDSFCC 190 200 210 220 230 240 VISMHDGIVL YTTPSITDVL GYPRDMWLGR SFIDFVHLKD RATFASQITT GIPIAESRGS 250 260 270 280 290 300 VPKDAKSTFC VMLRRYRGLK SGGFGVIGRP VSYEPFRLGL TFREAPEEAR PDNYMVSNGT 310 320 330 340 350 360 NMLLVICATP IKSSYKVPDE ILSQKSPKFA IRHTATGIIS HVDSAAVSAL GYLPQDLIGR 370 380 390 400 410 420 SIMDFYHHED LSVMKETYET VMKKGQTAGA SFCSKPYRFL IQNGCYVLLE TEWTSFVNPW 430 440 450 460 470 480 SRKLEFVVGH HRVFQGPKQC NVFEAAPTCK LKISEEAQSR NTRIKEDIVK RLAETVSRPS 490 500 510 520 530 540 DTVKQEVSRR CQALASFMET LMDEVSRADL KLELPHENEL TVSERDSVML GEISPHHDYY 550 560 570 580 590 600 DSKSSTETPP SYNQLNYNEN LLRFFNSKPV TAPAELDPPK TEPPEPRGTC VSGASGPMSP 610 620 630 640 650 660 VHEGSGGSGS SGNFTTASNI HMSSVTNTSI AGTGGTGTGT GTGTGTGTGT GTGTGTGTGT 670 680 690 700 710 720 GTGTGTGTGT GTGTGTGTGT GNGTNSGTGT GTASSSKGGT AAIPPVTLTE SLLNKHNDEM 730 740 750 760 770 780 EKFMLKKHRE SRGRTGEKSK KSANDTLKML EYSGPGHGIK RGGSHSWEGE ANKPKQQLTL 790 800 810 820 830 840 GTDAIKGAAG SAGGAVGTGG VGSGGAGVAG GGGSGTGVAG TPEGRATTTS GTGTPGGAGG 850 860 870 880 890 900 GGGAGAAAAA GASSSVGSST PGPSSYPTCT QNINLWPPFS VGITPPVHST HTAMAQSSFS 910 920 930 940 950 960 SAGLFPTFYY IPASLTPTSP TRSPRMHKHP HKGGTDMPTT SQQAAAAAAQ AMPLQYMAGV 970 980 990 1000 1010 1020 MYPHPSLFYT HPAAAAATAM MYQPMPFPGM ANALQIPERP LGSQSAYNKS VYTTTPASMT 1030 1040 1050 1060 1070 1080 KKVPGAFHSV TTPAQVQRPS SQSASVKTEP GSSAAVSDPC KKEVPDSSPI PSVMGDYNSD 1090 1100 1110 1120 1130 1140 PPCSSSNPAN NKKYTDSNGN SDDMDGSSFS SFYSSFIKTT DGSESPPDTE KDPKHRKLKS 1150 1160 MSTSESKIME HPEEDQTQHG DG
	Isoform PER-B [UniParc]. Checksum: AE924CCDF4C5ADD9	FASTA	1,128	119,293
	10 20 30 40 50 60 MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY GGKPSTQASS 70 80 90 100 110 120 SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG RDEEKPRPSG TGCVEQQICR 130 140 150 160 170 180 ELQDQQHGED HSEPQAIEQL QQEEEEDQSG SESEADRVEG VAKSEAAQSF PIPSPLSVTI 190 200 210 220 230 240 VPPSMGGCGG VGHAAGLDSG LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF 250 260 270 280 290 300 CCVISMHDGI VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 310 320 330 340 350 360 GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE ARPDNYMVSN 370 380 390 400 410 420 GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI ISHVDSAAVS ALGYLPQDLI 430 440 450 460 470 480 GRSIMDFYHH EDLSVMKETY ETVMKKGQTA GASFCSKPYR FLIQNGCYVL LETEWTSFVN 490 500 510 520 530 540 PWSRKLEFVV GHHRVFQGPK QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR 550 560 570 580 590 600 PSDTVKQEVS RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 610 620 630 640 650 660 YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG TCVSGASGPM 670 680 690 700 710 720 SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT GTGTGTGTGT GTGTGTGTGT 730 740 750 760 770 780 GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT GTGTASSSKG GTAAIPPVTL TESLLNKHND 790 800 810 820 830 840 EMEKFMLKKH RESRGRTGEK SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL 850 860 870 880 890 900 TLGTDAIKGA AGSAGGAVGT GGVGSGGAGL FPTFYYIPAS LTPTSPTRSP RMHKHPHKGG 910 920 930 940 950 960 TDMPTTSQQA AAAAAQAMPL QYMAGVMYPH PSLFYTHPAA AAATAMMYQP MPFPGMANAL 970 980 990 1000 1010 1020 QIPERPLGSQ SAYNKSVYTT TPASMTKKVP GAFHSVTTPA QVQRPSSQSA SVKTEPGSSA 1030 1040 1050 1060 1070 1080 AVSDPCKKEV PDSSPIPSVM GDYNSDPPCS SSNPANNKKY TDSNGNSDDM DGSSFSSFYS 1090 1100 1110 1120 SFIKTTDGSE SPPDTEKDPK HRKLKSMSTS ESKIMEHPEE DQTQHGDG
	Isoform PER-C [UniParc]. Checksum: 434AC9036463909E	FASTA	1,182	123,485
	10 20 30 40 50 60 MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY GGKPSTQASS 70 80 90 100 110 120 SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG RDEEKPRPSG TGCVEQQICR 130 140 150 160 170 180 ELQDQQHGED HSEPQAIEQL QQEEEEDQSG SESEADRVEG VAKSEAAQSF PIPSPLSVTI 190 200 210 220 230 240 VPPSMGGCGG VGHAAGLDSG LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF 250 260 270 280 290 300 CCVISMHDGI VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 310 320 330 340 350 360 GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE ARPDNYMVSN 370 380 390 400 410 420 GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI ISHVDSAAVS ALGYLPQDLI 430 440 450 460 470 480 GRSIMDFYHH EDLSVMKETY ETVMKKGQTA GASFCSKPYR FLIQNGCYVL LETEWTSFVN 490 500 510 520 530 540 PWSRKLEFVV GHHRVFQGPK QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR 550 560 570 580 590 600 PSDTVKQEVS RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 610 620 630 640 650 660 YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG TCVSGASGPM 670 680 690 700 710 720 SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT GTGTGTGTGT GTGTGTGTGT 730 740 750 760 770 780 GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT GTGTASSSKG GTAAIPPVTL TESLLNKHND 790 800 810 820 830 840 EMEKFMLKKH RESRGRTGEK SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL 850 860 870 880 890 900 TLGTDAIKGA AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA 910 920 930 940 950 960 GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH STHTAMAQSS 970 980 990 1000 1010 1020 FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP TTSQQAAAAA AQAMPLQYMA 1030 1040 1050 1060 1070 1080 GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP GMANALQIPE RPLGSQSAYN KSVYTVSQWP 1090 1100 1110 1120 1130 1140 VVPHRTVLTP TPTPYSSIDH AGVHDEEGAG CIPLGHHSCP GAASLLAERI RQDGAGLQCS 1150 1160 1170 1180 GIRSLQEGGA GLLAHSLRDG RLQLRPALQQ QQSRQQQGML YE
	Isoform PER-D [UniParc]. Checksum: 5ED88CCD3FEE97B4	FASTA	1,128	119,431
	10 20 30 40 50 60 MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY GGKPSTQASS 70 80 90 100 110 120 SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG RDEEKPRPSG TGCVEQQICR 130 140 150 160 170 180 ELQDQQHGED HSEPQAIEQL QQEEEEDQSG SESEADRVEG VAKSEAAQSF PIPSPLSVTI 190 200 210 220 230 240 VPPSMGGCGG VGHAAGLDSG LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF 250 260 270 280 290 300 CCVISMHDGI VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 310 320 330 340 350 360 GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE ARPDNYMVSN 370 380 390 400 410 420 GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI ISHVDSAAVS ALGYLPQDLI 430 440 450 460 470 480 GRSIMDFYHH EDLSVMKETY ETVMKKGQTA GASFCSKPYR FLIQNGCYVL LETEWTSFVN 490 500 510 520 530 540 PWSRKLEFVV GHHRVFQGPK QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR 550 560 570 580 590 600 PSDTVKQEVS RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 610 620 630 640 650 660 YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG TCVSGASGPM 670 680 690 700 710 720 SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT GTGTGTGTGT GTGTGTGTGT 730 740 750 760 770 780 GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT GTGTASSSKG GTAAIPPVTL TESLLNKHND 790 800 810 820 830 840 EMEKFMLKKH RESRGRTGEK SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL 850 860 870 880 890 900 TLGTDAIKGA AGSAGGAVGT GGSSFSSAGL FPTFYYIPAS LTPTSPTRSP RMHKHPHKGG 910 920 930 940 950 960 TDMPTTSQQA AAAAAQAMPL QYMAGVMYPH PSLFYTHPAA AAATAMMYQP MPFPGMANAL 970 980 990 1000 1010 1020 QIPERPLGSQ SAYNKSVYTT TPASMTKKVP GAFHSVTTPA QVQRPSSQSA SVKTEPGSSA 1030 1040 1050 1060 1070 1080 AVSDPCKKEV PDSSPIPSVM GDYNSDPPCS SSNPANNKKY TDSNGNSDDM DGSSFSSFYS 1090 1100 1110 1120 SFIKTTDGSE SPPDTEKDPK HRKLKSMSTS ESKIMEHPEE DQTQHGDG
	Isoform PER-E [UniParc]. Checksum: BD72A8EC731BFD31	FASTA	1,067	112,804
	10 20 30 40 50 60 MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY GGKPSTQASS 70 80 90 100 110 120 SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG RDEEKPRPSG TGCVEQQICR 130 140 150 160 170 180 ELQDQQHGED HSEPQAIEQL QQEEEEDQSG SESEADRVEG VAKSEAAQSF PIPSPLSVTI 190 200 210 220 230 240 VPPSMGGCGG VGHAAGLDSG LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF 250 260 270 280 290 300 CCVISMHDGI VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 310 320 330 340 350 360 GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE ARPDNYMVSN 370 380 390 400 410 420 GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI ISHVDSAAVS ALGYLPQDLI 430 440 450 460 470 480 GRSIMDFYHH EDLSVMKETY ETVMKKGQTA GASFCSKPYR FLIQNGCYVL LETEWTSFVN 490 500 510 520 530 540 PWSRKLEFVV GHHRVFQGPK QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR 550 560 570 580 590 600 PSDTVKQEVS RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 610 620 630 640 650 660 YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG TCVSGASGPM 670 680 690 700 710 720 SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT GTGTGTGTGT GTGTGTGTGT 730 740 750 760 770 780 GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT GTGTASSSKG GTAAIPPVTL TESLLNKHND 790 800 810 820 830 840 EMEKFMLKKH RESRGRTGEK SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL 850 860 870 880 890 900 TLGTDAIKGA AGSAGGAVGT GGSSFSSAGL FPTFYYIPAS LTPTSPTRSP RMHKHPHKGG 910 920 930 940 950 960 TDMPTTSQQA AAAAAQAMPL QYMAGVMYPH PSLFYTHPAA AAATAMMYQP MPFPGMANAL 970 980 990 1000 1010 1020 QIPERPLGSQ SAYNKSVYTT TPASMTKKVP GAFHSVTTPA QVQRPSSQSA SVKTEPGSSA 1030 1040 1050 1060 AVSDPCKKEV PDSSPIPSVM GDYNSDPPCS SSNPANNKVC YTNEVHW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene." Citri Y., Colot H.V., Jacquier A.C., Yu Q., Hall J.C., Baltimore D., Rosbash M. Nature 326:42-47(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Oregon-R.
[2]	"Genetic, molecular and cellular studies of the period locus and its products in Drosophila melanogaster." Baylies M.K., Weiner L., Vosshall L.B., Saez L., Young M.W. (In) Young M.W. (eds.); Molecular genetics of biological rhythms, pp.123-153, Marcel Dekker, New York (1993) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PER-A-LONG). Strain: Canton-S.
[3]	"Product of per locus of Drosophila shares homology with proteoglycans." Jackson F.R., Bargiello T.A., Yun S.-H., Young M.W. Nature 320:185-188(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Canton-S.
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT (GLY-THR)20. Strain: Berkeley.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[6]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Oregon-R.
[7]	"Linking phylogenetics with population genetics to reconstruct the geographic origin of a species." Dean M.D., Ballard J.W.O. Mol. Phylogenet. Evol. 32:998-1009(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-609. Strain: Oregon-R.
[8]	"DNA sequence variation at the period locus within and among species of the Drosophila melanogaster complex." Kliman R.M., Hey J. Genetics 133:375-387(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-573.
[9]	"Population structure and founder effect in the colonization of D.simulans based on DNA sequence variation in the Drosophila clock gene period." Horio A.T., Date A., Noda R., Tajima F., Chigusa S.I., Kondo R. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 243-400; 744-926 AND 1076-1218. Strain: L18, SP1 and U79.
[10]	"The period clock locus of D. melanogaster codes for a proteoglycan." Reddy P., Jacquier A.C., Abovich N., Petersen G., Rosbash M. Cell 46:53-61(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 499-1075, VARIANT (GLY-THR)20. Strain: Oregon-R.
[11]	"Evolutionary novelties in islands: Drosophila santomea, a new melanogaster sister species from Sao Tome." Lachaise D., Harry M., Solignac M., Lemeunier F., Benassi V., Cariou M.L. Proc. R. Soc. B 267:1487-1495(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 683-932, VARIANT (GLY-THR)20.
[12]	"Hitchhiking mapping: a population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster." Harr B., Kauer M., Schloetterer C. Proc. Natl. Acad. Sci. U.S.A. 99:12949-12954(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1155-1224. Strain: AF1, AF2, AF3, AF4, K1, K11, K13, K14, K16, K17, K2, K20, K21, K3, K5, K7, K9, Wi1, Wi10, Wi12, Wi13, Wi14, Wi15, Wi16, Wi17, Wi18, Wi19, Wi2, Wi21, Wi22, Wi23, Wi24, Wi25, Wi27, Wi28, Wi29, Wi3, Wi30, Wi31, Wi32, Wi33, Wi4, Wi5, Wi6, Wi7, Wi8, Wi9, ZH1, ZH13, ZH16, ZH18, ZH19, ZH2, ZH20, ZH21, ZH23, ZH25, ZH29, ZH31, ZH33, ZH35 and ZH36.
[13]	"Temporal phosphorylation of the Drosophila period protein." Edery I., Zwiebel L.J., Dembinska M.E., Rosbash M. Proc. Natl. Acad. Sci. U.S.A. 91:2260-2264(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION.
[14]	"Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD." Yildiz O., Doi M., Yujnovsky I., Cardone L., Berndt A., Hennig S., Schulze S., Urbanke C., Sassone-Corsi P., Wolf E. Mol. Cell 17:69-82(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 232-599, SUBUNIT.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

The tale of a love song - Issue 6 of January 2001

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M30114 Genomic DNA. Translation: AAA28752.1.
M30114 Genomic DNA. Translation: AAA28753.1.
M30114 Genomic DNA. Translation: AAA28754.1.
AF033029 mRNA. Translation: AAB87476.1.
X03636 Genomic DNA. Translation: CAA27285.1. Sequence problems.
AE014298 Genomic DNA. Translation: AAF45804.1.
AL024485 Genomic DNA. Translation: CAA19677.1.
AL024485 Genomic DNA. Translation: CAA19678.1.
AL024485 Genomic DNA. Translation: CAA19679.1.
AL024485 Genomic DNA. Translation: CAA19680.1.
AY575847 Genomic DNA. Translation: AAS89667.1.
L07817 Genomic DNA. Translation: AAA28777.1.
L07818 Genomic DNA. Translation: AAA28776.1.
L07819 Genomic DNA. Translation: AAA28775.1.
L07821 Genomic DNA. Translation: AAA28773.1.
L07823 Genomic DNA. Translation: AAA28771.1.
L07825 Genomic DNA. Translation: AAA28769.1.
AB029194 Genomic DNA. Translation: BAB15868.1.
AB029195 Genomic DNA. Translation: BAB15869.1.
AB029196 Genomic DNA. Translation: BAB15870.1.
AB029222 Genomic DNA. Translation: BAB15896.1.
AB029223 Genomic DNA. Translation: BAB15897.1.
AB029224 Genomic DNA. Translation: BAB15898.1.
AB029250 Genomic DNA. Translation: BAB15924.1.
AB029251 Genomic DNA. Translation: BAB15925.1.
AB029252 Genomic DNA. Translation: BAB15926.1.
D00009 Genomic DNA. Translation: BAA00007.1.
AF251241 Genomic DNA. Translation: AAG44573.1.
AY047980 Genomic DNA. Translation: AAN02289.1.
AY047981 Genomic DNA. Translation: AAN02291.1.
AY047982 Genomic DNA. Translation: AAN02293.1.
AY047983 Genomic DNA. Translation: AAN02295.1.
AY047984 Genomic DNA. Translation: AAN02297.1.
AY047985 Genomic DNA. Translation: AAN02299.1.
AY047986 Genomic DNA. Translation: AAN02301.1.
AY047987 Genomic DNA. Translation: AAN02303.1.
AY047988 Genomic DNA. Translation: AAN02305.1.
AY047989 Genomic DNA. Translation: AAN02307.1.
AY047990 Genomic DNA. Translation: AAN02309.1.
AY047991 Genomic DNA. Translation: AAN02311.1.
AY047992 Genomic DNA. Translation: AAN02313.1.
AY047993 Genomic DNA. Translation: AAN02315.1.
AY047994 Genomic DNA. Translation: AAN02317.1.
AY047995 Genomic DNA. Translation: AAN02319.1.
AY047996 Genomic DNA. Translation: AAN02321.1.
AY047997 Genomic DNA. Translation: AAN02323.1.
AY047998 Genomic DNA. Translation: AAN02325.1.
AY047999 Genomic DNA. Translation: AAN02327.1.
AY048000 Genomic DNA. Translation: AAN02329.1.
AY048001 Genomic DNA. Translation: AAN02331.1.
AY048002 Genomic DNA. Translation: AAN02333.1.
AY048003 Genomic DNA. Translation: AAN02335.1.
AY048004 Genomic DNA. Translation: AAN02337.1.
AY048005 Genomic DNA. Translation: AAN02339.1.
AY048006 Genomic DNA. Translation: AAN02341.1.
AY048007 Genomic DNA. Translation: AAN02343.1.
AY048008 Genomic DNA. Translation: AAN02345.1.
AY048009 Genomic DNA. Translation: AAN02347.1.
AY048010 Genomic DNA. Translation: AAN02349.1.
AY048011 Genomic DNA. Translation: AAN02351.1.
AY048012 Genomic DNA. Translation: AAN02353.1.
AY048013 Genomic DNA. Translation: AAN02355.1.
AY048014 Genomic DNA. Translation: AAN02357.1.
AY048015 Genomic DNA. Translation: AAN02359.1.
AY048016 Genomic DNA. Translation: AAN02361.1.
AY048017 Genomic DNA. Translation: AAN02363.1.
AY048018 Genomic DNA. Translation: AAN02365.1.
AY048019 Genomic DNA. Translation: AAN02367.1.
AY048020 Genomic DNA. Translation: AAN02369.1.
AY048021 Genomic DNA. Translation: AAN02371.1.
AY048022 Genomic DNA. Translation: AAN02373.1.
AY048023 Genomic DNA. Translation: AAN02375.1.
AY048024 Genomic DNA. Translation: AAN02377.1.
AY048025 Genomic DNA. Translation: AAN02379.1.
AY048026 Genomic DNA. Translation: AAN02381.1.
AY048027 Genomic DNA. Translation: AAN02383.1.
AY048028 Genomic DNA. Translation: AAN02385.1.
AY048029 Genomic DNA. Translation: AAN02387.1.
AY048030 Genomic DNA. Translation: AAN02389.1.
AY048031 Genomic DNA. Translation: AAN02391.1.
AY048032 Genomic DNA. Translation: AAN02393.1.
AY048033 Genomic DNA. Translation: AAN02395.1.
AY048034 Genomic DNA. Translation: AAN02397.1.
AY048035 Genomic DNA. Translation: AAN02399.1.
AY048036 Genomic DNA. Translation: AAN02401.1.
AY048037 Genomic DNA. Translation: AAN02403.1.
AY048038 Genomic DNA. Translation: AAN02405.1.
AY048040 Genomic DNA. Translation: AAN02407.1.
AY048041 Genomic DNA. Translation: AAN02409.1.
AY048042 Genomic DNA. Translation: AAN02411.1.

PIR

UMFF. A23932.
A26427.
A26588.
B26427.
C26427.
S52943.

RefSeq

NP_001259194.1. NM_001272265.1.
NP_525056.2. NM_080317.2.

UniGene

Dm.65.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WA9	X-ray	3.15	A/B	232-599	[»]
3GEC	X-ray	4.00	A	232-538	[»]
3RTY	X-ray	2.85	A/B/C/D/E/F/G/H	236-574	[»]

ProteinModelPortal

P07663.

SMR

P07663. Positions 237-571.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29426N.

MINT

MINT-1327740.

Proteomic databases

PaxDb

P07663.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

31251.

KEGG

dme:Dmel_CG2647.

Organism-specific databases

CTD

31251.

FlyBase

FBgn0003068. per.

Phylogenomic databases

eggNOG

NOG253593.

InParanoid

P07663.

KO

K02633.

OrthoDB

EOG4V41PZ.

Gene expression databases

Bgee

P07663.

GermOnline

CG2647. Drosophila melanogaster.

Family and domain databases

InterPro

IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]

Pfam

PF00989. PAS. 2 hits.
[Graphical view]

SMART

SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]

PROSITE

PS50112. PAS. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P07663.

GenomeRNAi

31251.

NextBio

772671.

Entry information

Entry name

PER_DROME

Accession

Primary (citable) accession number: P07663
Secondary accession number(s): O17483 , O76882, O76883, O76884, O76885, Q24446, Q24447, Q24448, Q24449, Q6PVA3, Q8MLY0, Q9GN20, Q9GN51, Q9GQH9, Q9GV48, Q9GV53, Q9GV54, Q9GV55, Q9W4X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	December 15, 1998
Last modified:	April 3, 2013
This is version 142 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project