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P07663

- PER_DROME

UniProt

P07663 - PER_DROME

Protein

Period circadian protein

Gene

per

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein heterodimerization activity Source: FlyBase
    3. protein homodimerization activity Source: FlyBase
    4. signal transducer activity Source: InterPro
    5. transcription cofactor activity Source: FlyBase
    6. transcription corepressor activity Source: FlyBase
    7. transcription factor binding Source: FlyBase

    GO - Biological processi

    1. age-dependent response to oxidative stress Source: FlyBase
    2. behavioral response to cocaine Source: FlyBase
    3. circadian behavior Source: FlyBase
    4. circadian rhythm Source: FlyBase
    5. circadian sleep/wake cycle Source: FlyBase
    6. circadian temperature homeostasis Source: FlyBase
    7. copulation Source: FlyBase
    8. courtship behavior Source: FlyBase
    9. determination of adult lifespan Source: FlyBase
    10. eclosion rhythm Source: FlyBase
    11. entrainment of circadian clock Source: FlyBase
    12. entrainment of circadian clock by photoperiod Source: FlyBase
    13. locomotor rhythm Source: FlyBase
    14. long-term memory Source: FlyBase
    15. male courtship behavior, veined wing generated song production Source: FlyBase
    16. mating behavior Source: FlyBase
    17. negative regulation of transcription, DNA-templated Source: FlyBase
    18. negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
    19. negative regulation of transcription regulatory region DNA binding Source: FlyBase
    20. regulation of circadian rhythm Source: FlyBase
    21. regulation of circadian sleep/wake cycle, sleep Source: FlyBase
    22. response to light stimulus Source: FlyBase
    23. response to oxidative stress Source: FlyBase
    24. response to temperature stimulus Source: FlyBase
    25. rhythmic behavior Source: FlyBase

    Keywords - Biological processi

    Biological rhythms

    Enzyme and pathway databases

    ReactomeiREACT_180268. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Period circadian protein
    Alternative name(s):
    Protein clock-6
    Short name:
    CLK-6
    Gene namesi
    Name:per
    ORF Names:CG2647
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0003068. per.

    Subcellular locationi

    Nucleus. Cytoplasmperinuclear region
    Note: Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization.

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. nucleus Source: FlyBase
    3. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12241224Period circadian proteinPRO_0000162596Add
    BLAST

    Post-translational modificationi

    Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP07663.

    Expressioni

    Tissue specificityi

    Expressed in neural tissues and in several nonneural tissues of the abdomen. Malpighian tubules contain a circadian pacemaker that functions independently of the brain. Expression oscillates in all tissues studied except for the ovary. PER-A isoforms are mainly expressed in adult's head.

    Inductioni

    Expression is sensitive to temperature but not to light.

    Gene expression databases

    BgeeiP07663.

    Interactioni

    Subunit structurei

    Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi57782. 14 interactions.
    DIPiDIP-29426N.
    MINTiMINT-1327740.

    Structurei

    Secondary structure

    1
    1224
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi240 – 2456
    Turni246 – 2483
    Beta strandi250 – 2545
    Helixi258 – 2625
    Helixi274 – 2774
    Helixi280 – 2823
    Helixi283 – 2919
    Beta strandi310 – 3167
    Beta strandi326 – 3283
    Beta strandi335 – 34612
    Beta strandi364 – 3729
    Beta strandi390 – 3967
    Beta strandi400 – 4045
    Helixi408 – 4125
    Helixi416 – 4194
    Helixi424 – 4274
    Helixi430 – 4323
    Helixi433 – 44614
    Beta strandi459 – 4624
    Beta strandi468 – 47912
    Turni481 – 4833
    Beta strandi485 – 49713
    Beta strandi500 – 5023
    Beta strandi504 – 5074
    Helixi516 – 53520
    Turni544 – 5507
    Helixi554 – 57320

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WA9X-ray3.15A/B232-599[»]
    3GECX-ray4.00A232-538[»]
    3RTYX-ray2.85A/B/C/D/E/F/G/H236-574[»]
    ProteinModelPortaliP07663.
    SMRiP07663. Positions 237-571.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP07663.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini238 – 373136PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini391 – 497107PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati694 – 69521
    Repeati697 – 69822
    Repeati699 – 70023
    Repeati701 – 70224
    Repeati703 – 70425
    Repeati705 – 70626
    Repeati707 – 70827
    Repeati709 – 71028
    Repeati711 – 71229
    Repeati713 – 714210
    Repeati715 – 716211
    Repeati717 – 718212
    Repeati719 – 720213
    Repeati721 – 722214
    Repeati723 – 724215
    Repeati725 – 726216
    Repeati727 – 728217
    Repeati729 – 730218
    Repeati731 – 732219
    Repeati733 – 734220
    Repeati735 – 736221
    Repeati737 – 738222
    Repeati739 – 740223
    Repeati741 – 742224
    Repeati743 – 744225
    Repeati745 – 746226
    Repeati747 – 748227; approximate
    Repeati749 – 750228
    Repeati751 – 752229
    Repeati753 – 754230

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni694 – 7546130 X 2 AA approximate tandem repeats of G-[TN]Add
    BLAST
    Regioni749 – 868120Regulates the rhythm of species-specific courtship songAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi66 – 7914Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi74 – 796Poly-Lys
    Compositional biasi143 – 1464Poly-Glu
    Compositional biasi223 – 2264Poly-Ala
    Compositional biasi872 – 8798Poly-Gly
    Compositional biasi898 – 9058Poly-Gly
    Compositional biasi906 – 9149Poly-Ala
    Compositional biasi1006 – 10138Poly-Ala
    Compositional biasi1035 – 10417Poly-Ala

    Domaini

    Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least three types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), and two major variants (Gly-Thr)17 and (Gly-Thr)20. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior.
    Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).

    Sequence similaritiesi

    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG253593.
    InParanoidiP07663.
    KOiK02633.
    OrthoDBiEOG7TMZRC.

    Family and domain databases

    InterProiIPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view]
    PfamiPF00989. PAS. 1 hit.
    [Graphical view]
    SMARTiSM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 3 hits.
    PROSITEiPS50112. PAS. 2 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform PER-A-long (identifier: P07663-1) [UniParc]FASTAAdd to Basket

    Also known as: perA

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY     50
    GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG 100
    RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG 150
    SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG 200
    LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI 250
    VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 300
    GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE 350
    ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI 400
    ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA 450
    GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK 500
    QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS 550
    RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 600
    YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG 650
    TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT 700
    GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT 750
    GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK 800
    SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA 850
    AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA 900
    GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH 950
    STHTAMAQSS FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP 1000
    TTSQQAAAAA AQAMPLQYMA GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP 1050
    GMANALQIPE RPLGSQSAYN KSVYTTTPAS MTKKVPGAFH SVTTPAQVQR 1100
    PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN SDPPCSSSNP 1150
    ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL 1200
    KSMSTSESKI MEHPEEDQTQ HGDG 1224
    Length:1,224
    Mass (Da):127,852
    Last modified:December 15, 1998 - v2
    Checksum:i71FA54ECF3E90F4A
    GO
    Isoform PER-A-short (identifier: P07663-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-62: Missing.

    Show »
    Length:1,162
    Mass (Da):121,661
    Checksum:i7EF93EDE76EC5A5B
    GO
    Isoform PER-B (identifier: P07663-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         868-963: Missing.

    Show »
    Length:1,128
    Mass (Da):119,293
    Checksum:iAE924CCDF4C5ADD9
    GO
    Isoform PER-C (identifier: P07663-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1076-1224: TTPASMTKKV...EEDQTQHGDG → VSQWPVVPHR...SRQQQGMLYE

    Show »
    Length:1,182
    Mass (Da):123,485
    Checksum:i434AC9036463909E
    GO
    Isoform PER-D (identifier: P07663-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         863-958: Missing.

    Show »
    Length:1,128
    Mass (Da):119,431
    Checksum:i5ED88CCD3FEE97B4
    GO
    Isoform PER-E (identifier: P07663-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         863-958: Missing.
         1155-1224: KYTDSNGNSD...EEDQTQHGDG → VCYTNEVHW

    Show »
    Length:1,067
    Mass (Da):112,804
    Checksum:iBD72A8EC731BFD31
    GO

    Sequence cautioni

    The sequence CAA27285.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti211 – 2111G → V in AAA28777. (PubMed:8436278)Curated
    Sequence conflicti498 – 4992GP → A in AAA28777. (PubMed:8436278)Curated
    Sequence conflicti637 – 6371E → A(PubMed:3087625)Curated
    Sequence conflicti733 – 76735Missing(PubMed:3081818)CuratedAdd
    BLAST
    Sequence conflicti762 – 7643TAA → RR(PubMed:3081818)Curated
    Sequence conflicti762 – 7643TAA → RR(PubMed:3087625)Curated
    Sequence conflicti1029 – 10291L → V(PubMed:3087625)Curated
    Sequence conflicti1038 – 10381A → P(PubMed:3087625)Curated
    Sequence conflicti1075 – 10751T → TVSQWPV in CAA19677. (PubMed:10731137)Curated
    Sequence conflicti1114 – 11141S → F(PubMed:3102970)Curated
    Sequence conflicti1215 – 12151E → D(PubMed:3102970)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti697 – 70812Missing in (Gly-Thr)17.
    Add
    BLAST
    Natural varianti697 – 7026Missing in (Gly-Thr)20.
    Natural varianti748 – 7481S → F in strain: U79.
    Natural varianti762 – 7621T → S in strain: Berkeley, L18, Oregon-R, SP1 and U79.
    Natural varianti846 – 8461A → T in strain: U79.
    Natural varianti858 – 8581V → A in strain: L18 and U79.
    Natural varianti1176 – 11761S → P in strain: L18.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6262Missing in isoform PER-A-short. CuratedVSP_004657Add
    BLAST
    Alternative sequencei863 – 95896Missing in isoform PER-D and isoform PER-E. CuratedVSP_004659Add
    BLAST
    Alternative sequencei868 – 96396Missing in isoform PER-B. CuratedVSP_004658Add
    BLAST
    Alternative sequencei1076 – 1224149TTPAS…QHGDG → VSQWPVVPHRTVLTPTPTPY SSIDHAGVHDEEGAGCIPLG HHSCPGAASLLAERIRQDGA GLQCSGIRSLQEGGAGLLAH SLRDGRLQLRPALQQQQSRQ QQGMLYE in isoform PER-C. CuratedVSP_004660Add
    BLAST
    Alternative sequencei1155 – 122470KYTDS…QHGDG → VCYTNEVHW in isoform PER-E. CuratedVSP_004661Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30114 Genomic DNA. Translation: AAA28752.1.
    M30114 Genomic DNA. Translation: AAA28753.1.
    M30114 Genomic DNA. Translation: AAA28754.1.
    AF033029 mRNA. Translation: AAB87476.1.
    X03636 Genomic DNA. Translation: CAA27285.1. Sequence problems.
    AE014298 Genomic DNA. Translation: AAF45804.1.
    AL024485 Genomic DNA. Translation: CAA19677.1.
    AL024485 Genomic DNA. Translation: CAA19678.1.
    AL024485 Genomic DNA. Translation: CAA19679.1.
    AL024485 Genomic DNA. Translation: CAA19680.1.
    AY575847 Genomic DNA. Translation: AAS89667.1.
    L07817 Genomic DNA. Translation: AAA28777.1.
    L07818 Genomic DNA. Translation: AAA28776.1.
    L07819 Genomic DNA. Translation: AAA28775.1.
    L07821 Genomic DNA. Translation: AAA28773.1.
    L07823 Genomic DNA. Translation: AAA28771.1.
    L07825 Genomic DNA. Translation: AAA28769.1.
    AB029194 Genomic DNA. Translation: BAB15868.1.
    AB029195 Genomic DNA. Translation: BAB15869.1.
    AB029196 Genomic DNA. Translation: BAB15870.1.
    AB029222 Genomic DNA. Translation: BAB15896.1.
    AB029223 Genomic DNA. Translation: BAB15897.1.
    AB029224 Genomic DNA. Translation: BAB15898.1.
    AB029250 Genomic DNA. Translation: BAB15924.1.
    AB029251 Genomic DNA. Translation: BAB15925.1.
    AB029252 Genomic DNA. Translation: BAB15926.1.
    D00009 Genomic DNA. Translation: BAA00007.1.
    AF251241 Genomic DNA. Translation: AAG44573.1.
    AY047980 Genomic DNA. Translation: AAN02289.1.
    AY047981 Genomic DNA. Translation: AAN02291.1.
    AY047982 Genomic DNA. Translation: AAN02293.1.
    AY047983 Genomic DNA. Translation: AAN02295.1.
    AY047984 Genomic DNA. Translation: AAN02297.1.
    AY047985 Genomic DNA. Translation: AAN02299.1.
    AY047986 Genomic DNA. Translation: AAN02301.1.
    AY047987 Genomic DNA. Translation: AAN02303.1.
    AY047988 Genomic DNA. Translation: AAN02305.1.
    AY047989 Genomic DNA. Translation: AAN02307.1.
    AY047990 Genomic DNA. Translation: AAN02309.1.
    AY047991 Genomic DNA. Translation: AAN02311.1.
    AY047992 Genomic DNA. Translation: AAN02313.1.
    AY047993 Genomic DNA. Translation: AAN02315.1.
    AY047994 Genomic DNA. Translation: AAN02317.1.
    AY047995 Genomic DNA. Translation: AAN02319.1.
    AY047996 Genomic DNA. Translation: AAN02321.1.
    AY047997 Genomic DNA. Translation: AAN02323.1.
    AY047998 Genomic DNA. Translation: AAN02325.1.
    AY047999 Genomic DNA. Translation: AAN02327.1.
    AY048000 Genomic DNA. Translation: AAN02329.1.
    AY048001 Genomic DNA. Translation: AAN02331.1.
    AY048002 Genomic DNA. Translation: AAN02333.1.
    AY048003 Genomic DNA. Translation: AAN02335.1.
    AY048004 Genomic DNA. Translation: AAN02337.1.
    AY048005 Genomic DNA. Translation: AAN02339.1.
    AY048006 Genomic DNA. Translation: AAN02341.1.
    AY048007 Genomic DNA. Translation: AAN02343.1.
    AY048008 Genomic DNA. Translation: AAN02345.1.
    AY048009 Genomic DNA. Translation: AAN02347.1.
    AY048010 Genomic DNA. Translation: AAN02349.1.
    AY048011 Genomic DNA. Translation: AAN02351.1.
    AY048012 Genomic DNA. Translation: AAN02353.1.
    AY048013 Genomic DNA. Translation: AAN02355.1.
    AY048014 Genomic DNA. Translation: AAN02357.1.
    AY048015 Genomic DNA. Translation: AAN02359.1.
    AY048016 Genomic DNA. Translation: AAN02361.1.
    AY048017 Genomic DNA. Translation: AAN02363.1.
    AY048018 Genomic DNA. Translation: AAN02365.1.
    AY048019 Genomic DNA. Translation: AAN02367.1.
    AY048020 Genomic DNA. Translation: AAN02369.1.
    AY048021 Genomic DNA. Translation: AAN02371.1.
    AY048022 Genomic DNA. Translation: AAN02373.1.
    AY048023 Genomic DNA. Translation: AAN02375.1.
    AY048024 Genomic DNA. Translation: AAN02377.1.
    AY048025 Genomic DNA. Translation: AAN02379.1.
    AY048026 Genomic DNA. Translation: AAN02381.1.
    AY048027 Genomic DNA. Translation: AAN02383.1.
    AY048028 Genomic DNA. Translation: AAN02385.1.
    AY048029 Genomic DNA. Translation: AAN02387.1.
    AY048030 Genomic DNA. Translation: AAN02389.1.
    AY048031 Genomic DNA. Translation: AAN02391.1.
    AY048032 Genomic DNA. Translation: AAN02393.1.
    AY048033 Genomic DNA. Translation: AAN02395.1.
    AY048034 Genomic DNA. Translation: AAN02397.1.
    AY048035 Genomic DNA. Translation: AAN02399.1.
    AY048036 Genomic DNA. Translation: AAN02401.1.
    AY048037 Genomic DNA. Translation: AAN02403.1.
    AY048038 Genomic DNA. Translation: AAN02405.1.
    AY048040 Genomic DNA. Translation: AAN02407.1.
    AY048041 Genomic DNA. Translation: AAN02409.1.
    AY048042 Genomic DNA. Translation: AAN02411.1.
    PIRiA23932. UMFF.
    A26427.
    A26588.
    B26427.
    C26427.
    S52943.
    RefSeqiNP_001259194.1. NM_001272265.1.
    NP_525056.2. NM_080317.2.
    UniGeneiDm.65.

    Genome annotation databases

    GeneIDi31251.
    KEGGidme:Dmel_CG2647.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The tale of a love song - Issue 6 of January 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30114 Genomic DNA. Translation: AAA28752.1 .
    M30114 Genomic DNA. Translation: AAA28753.1 .
    M30114 Genomic DNA. Translation: AAA28754.1 .
    AF033029 mRNA. Translation: AAB87476.1 .
    X03636 Genomic DNA. Translation: CAA27285.1 . Sequence problems.
    AE014298 Genomic DNA. Translation: AAF45804.1 .
    AL024485 Genomic DNA. Translation: CAA19677.1 .
    AL024485 Genomic DNA. Translation: CAA19678.1 .
    AL024485 Genomic DNA. Translation: CAA19679.1 .
    AL024485 Genomic DNA. Translation: CAA19680.1 .
    AY575847 Genomic DNA. Translation: AAS89667.1 .
    L07817 Genomic DNA. Translation: AAA28777.1 .
    L07818 Genomic DNA. Translation: AAA28776.1 .
    L07819 Genomic DNA. Translation: AAA28775.1 .
    L07821 Genomic DNA. Translation: AAA28773.1 .
    L07823 Genomic DNA. Translation: AAA28771.1 .
    L07825 Genomic DNA. Translation: AAA28769.1 .
    AB029194 Genomic DNA. Translation: BAB15868.1 .
    AB029195 Genomic DNA. Translation: BAB15869.1 .
    AB029196 Genomic DNA. Translation: BAB15870.1 .
    AB029222 Genomic DNA. Translation: BAB15896.1 .
    AB029223 Genomic DNA. Translation: BAB15897.1 .
    AB029224 Genomic DNA. Translation: BAB15898.1 .
    AB029250 Genomic DNA. Translation: BAB15924.1 .
    AB029251 Genomic DNA. Translation: BAB15925.1 .
    AB029252 Genomic DNA. Translation: BAB15926.1 .
    D00009 Genomic DNA. Translation: BAA00007.1 .
    AF251241 Genomic DNA. Translation: AAG44573.1 .
    AY047980 Genomic DNA. Translation: AAN02289.1 .
    AY047981 Genomic DNA. Translation: AAN02291.1 .
    AY047982 Genomic DNA. Translation: AAN02293.1 .
    AY047983 Genomic DNA. Translation: AAN02295.1 .
    AY047984 Genomic DNA. Translation: AAN02297.1 .
    AY047985 Genomic DNA. Translation: AAN02299.1 .
    AY047986 Genomic DNA. Translation: AAN02301.1 .
    AY047987 Genomic DNA. Translation: AAN02303.1 .
    AY047988 Genomic DNA. Translation: AAN02305.1 .
    AY047989 Genomic DNA. Translation: AAN02307.1 .
    AY047990 Genomic DNA. Translation: AAN02309.1 .
    AY047991 Genomic DNA. Translation: AAN02311.1 .
    AY047992 Genomic DNA. Translation: AAN02313.1 .
    AY047993 Genomic DNA. Translation: AAN02315.1 .
    AY047994 Genomic DNA. Translation: AAN02317.1 .
    AY047995 Genomic DNA. Translation: AAN02319.1 .
    AY047996 Genomic DNA. Translation: AAN02321.1 .
    AY047997 Genomic DNA. Translation: AAN02323.1 .
    AY047998 Genomic DNA. Translation: AAN02325.1 .
    AY047999 Genomic DNA. Translation: AAN02327.1 .
    AY048000 Genomic DNA. Translation: AAN02329.1 .
    AY048001 Genomic DNA. Translation: AAN02331.1 .
    AY048002 Genomic DNA. Translation: AAN02333.1 .
    AY048003 Genomic DNA. Translation: AAN02335.1 .
    AY048004 Genomic DNA. Translation: AAN02337.1 .
    AY048005 Genomic DNA. Translation: AAN02339.1 .
    AY048006 Genomic DNA. Translation: AAN02341.1 .
    AY048007 Genomic DNA. Translation: AAN02343.1 .
    AY048008 Genomic DNA. Translation: AAN02345.1 .
    AY048009 Genomic DNA. Translation: AAN02347.1 .
    AY048010 Genomic DNA. Translation: AAN02349.1 .
    AY048011 Genomic DNA. Translation: AAN02351.1 .
    AY048012 Genomic DNA. Translation: AAN02353.1 .
    AY048013 Genomic DNA. Translation: AAN02355.1 .
    AY048014 Genomic DNA. Translation: AAN02357.1 .
    AY048015 Genomic DNA. Translation: AAN02359.1 .
    AY048016 Genomic DNA. Translation: AAN02361.1 .
    AY048017 Genomic DNA. Translation: AAN02363.1 .
    AY048018 Genomic DNA. Translation: AAN02365.1 .
    AY048019 Genomic DNA. Translation: AAN02367.1 .
    AY048020 Genomic DNA. Translation: AAN02369.1 .
    AY048021 Genomic DNA. Translation: AAN02371.1 .
    AY048022 Genomic DNA. Translation: AAN02373.1 .
    AY048023 Genomic DNA. Translation: AAN02375.1 .
    AY048024 Genomic DNA. Translation: AAN02377.1 .
    AY048025 Genomic DNA. Translation: AAN02379.1 .
    AY048026 Genomic DNA. Translation: AAN02381.1 .
    AY048027 Genomic DNA. Translation: AAN02383.1 .
    AY048028 Genomic DNA. Translation: AAN02385.1 .
    AY048029 Genomic DNA. Translation: AAN02387.1 .
    AY048030 Genomic DNA. Translation: AAN02389.1 .
    AY048031 Genomic DNA. Translation: AAN02391.1 .
    AY048032 Genomic DNA. Translation: AAN02393.1 .
    AY048033 Genomic DNA. Translation: AAN02395.1 .
    AY048034 Genomic DNA. Translation: AAN02397.1 .
    AY048035 Genomic DNA. Translation: AAN02399.1 .
    AY048036 Genomic DNA. Translation: AAN02401.1 .
    AY048037 Genomic DNA. Translation: AAN02403.1 .
    AY048038 Genomic DNA. Translation: AAN02405.1 .
    AY048040 Genomic DNA. Translation: AAN02407.1 .
    AY048041 Genomic DNA. Translation: AAN02409.1 .
    AY048042 Genomic DNA. Translation: AAN02411.1 .
    PIRi A23932. UMFF.
    A26427.
    A26588.
    B26427.
    C26427.
    S52943.
    RefSeqi NP_001259194.1. NM_001272265.1.
    NP_525056.2. NM_080317.2.
    UniGenei Dm.65.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WA9 X-ray 3.15 A/B 232-599 [» ]
    3GEC X-ray 4.00 A 232-538 [» ]
    3RTY X-ray 2.85 A/B/C/D/E/F/G/H 236-574 [» ]
    ProteinModelPortali P07663.
    SMRi P07663. Positions 237-571.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 57782. 14 interactions.
    DIPi DIP-29426N.
    MINTi MINT-1327740.

    Proteomic databases

    PaxDbi P07663.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 31251.
    KEGGi dme:Dmel_CG2647.

    Organism-specific databases

    CTDi 31251.
    FlyBasei FBgn0003068. per.

    Phylogenomic databases

    eggNOGi NOG253593.
    InParanoidi P07663.
    KOi K02633.
    OrthoDBi EOG7TMZRC.

    Enzyme and pathway databases

    Reactomei REACT_180268. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

    Miscellaneous databases

    EvolutionaryTracei P07663.
    GenomeRNAii 31251.
    NextBioi 772671.

    Gene expression databases

    Bgeei P07663.

    Family and domain databases

    InterProi IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view ]
    Pfami PF00989. PAS. 1 hit.
    [Graphical view ]
    SMARTi SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 3 hits.
    PROSITEi PS50112. PAS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene."
      Citri Y., Colot H.V., Jacquier A.C., Yu Q., Hall J.C., Baltimore D., Rosbash M.
      Nature 326:42-47(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Oregon-R.
    2. "Genetic, molecular and cellular studies of the period locus and its products in Drosophila melanogaster."
      Baylies M.K., Weiner L., Vosshall L.B., Saez L., Young M.W.
      (In) Young M.W. (eds.); Molecular genetics of biological rhythms, pp.123-153, Marcel Dekker, New York (1993)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PER-A-LONG).
      Strain: Canton-S.
    3. "Product of per locus of Drosophila shares homology with proteoglycans."
      Jackson F.R., Bargiello T.A., Yun S.-H., Young M.W.
      Nature 320:185-188(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Canton-S.
    4. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT (GLY-THR)20.
      Strain: Berkeley.
    5. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Oregon-R.
    7. "Linking phylogenetics with population genetics to reconstruct the geographic origin of a species."
      Dean M.D., Ballard J.W.O.
      Mol. Phylogenet. Evol. 32:998-1009(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-609.
      Strain: Oregon-R.
    8. "DNA sequence variation at the period locus within and among species of the Drosophila melanogaster complex."
      Kliman R.M., Hey J.
      Genetics 133:375-387(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-573.
    9. "Population structure and founder effect in the colonization of D.simulans based on DNA sequence variation in the Drosophila clock gene period."
      Horio A.T., Date A., Noda R., Tajima F., Chigusa S.I., Kondo R.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 243-400; 744-926 AND 1076-1218.
      Strain: L18, SP1 and U79.
    10. "The period clock locus of D. melanogaster codes for a proteoglycan."
      Reddy P., Jacquier A.C., Abovich N., Petersen G., Rosbash M.
      Cell 46:53-61(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 499-1075, VARIANT (GLY-THR)20.
      Strain: Oregon-R.
    11. "Evolutionary novelties in islands: Drosophila santomea, a new melanogaster sister species from Sao Tome."
      Lachaise D., Harry M., Solignac M., Lemeunier F., Benassi V., Cariou M.L.
      Proc. R. Soc. B 267:1487-1495(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 683-932, VARIANT (GLY-THR)20.
    12. "Hitchhiking mapping: a population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster."
      Harr B., Kauer M., Schloetterer C.
      Proc. Natl. Acad. Sci. U.S.A. 99:12949-12954(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1155-1224.
      Strain: AF1, AF2, AF3, AF4, K1, K11, K13, K14, K16, K17, K2, K20, K21, K3, K5, K7, K9, Wi1, Wi10, Wi12, Wi13, Wi14, Wi15, Wi16, Wi17, Wi18, Wi19, Wi2, Wi21, Wi22, Wi23, Wi24, Wi25, Wi27, Wi28, Wi29, Wi3, Wi30, Wi31, Wi32, Wi33, Wi4, Wi5, Wi6, Wi7, Wi8, Wi9, ZH1, ZH13, ZH16, ZH18, ZH19, ZH2, ZH20, ZH21, ZH23, ZH25, ZH29, ZH31, ZH33, ZH35 and ZH36.
    13. Cited for: PHOSPHORYLATION.
    14. "Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD."
      Yildiz O., Doi M., Yujnovsky I., Cardone L., Berndt A., Hennig S., Schulze S., Urbanke C., Sassone-Corsi P., Wolf E.
      Mol. Cell 17:69-82(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 232-599, SUBUNIT.

    Entry informationi

    Entry nameiPER_DROME
    AccessioniPrimary (citable) accession number: P07663
    Secondary accession number(s): O17483
    , O76882, O76883, O76884, O76885, Q24446, Q24447, Q24448, Q24449, Q6PVA3, Q8MLY0, Q9GN20, Q9GN51, Q9GQH9, Q9GV48, Q9GV53, Q9GV54, Q9GV55, Q9W4X0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 153 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3