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P07663 (PER_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 149. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Period circadian protein
Alternative name(s):
Protein clock-6
Short name=CLK-6
Gene names
Name:per
ORF Names:CG2647
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1224 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.

Subunit structure

Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer. Ref.14

Subcellular location

Nucleus. Cytoplasmperinuclear region. Note: Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization.

Tissue specificity

Expressed in neural tissues and in several nonneural tissues of the abdomen. Malpighian tubules contain a circadian pacemaker that functions independently of the brain. Expression oscillates in all tissues studied except for the ovary. PER-A isoforms are mainly expressed in adult's head.

Induction

Expression is sensitive to temperature but not to light.

Domain

Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least three types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), and two major variants (Gly-Thr)17 and (Gly-Thr)20. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior.

Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).

Post-translational modification

Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim. Ref.13

Sequence similarities

Contains 2 PAS (PER-ARNT-SIM) domains.

Sequence caution

The sequence CAA27285.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processBiological rhythms
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processage-dependent response to oxidative stress

Inferred from mutant phenotype PubMed 20157575. Source: FlyBase

behavioral response to cocaine

Non-traceable author statement PubMed 11715043. Source: FlyBase

circadian behavior

Inferred from mutant phenotype PubMed 10677013. Source: FlyBase

circadian rhythm

Inferred from mutant phenotype PubMed 12417656PubMed 12944510PubMed 16319317PubMed 18666831. Source: FlyBase

circadian sleep/wake cycle

Traceable author statement PubMed 12111533. Source: FlyBase

circadian temperature homeostasis

Inferred from mutant phenotype PubMed 22981774. Source: FlyBase

copulation

Inferred from mutant phenotype PubMed 15324667. Source: FlyBase

courtship behavior

Non-traceable author statement PubMed 11715043. Source: FlyBase

determination of adult lifespan

Inferred from mutant phenotype PubMed 20157575. Source: FlyBase

eclosion rhythm

Inferred from mutant phenotype PubMed 11264660. Source: FlyBase

entrainment of circadian clock

Inferred from mutant phenotype PubMed 16085487. Source: FlyBase

entrainment of circadian clock by photoperiod

Inferred from mutant phenotype PubMed 16361445. Source: FlyBase

locomotor rhythm

Inferred from mutant phenotype PubMed 11264660PubMed 17452449PubMed 18044989PubMed 19402744. Source: FlyBase

long-term memory

Inferred from mutant phenotype PubMed 15522971PubMed 22323813. Source: FlyBase

male courtship behavior, veined wing generated song production

Non-traceable author statement PubMed 11092827. Source: FlyBase

mating behavior

Inferred from mutant phenotype PubMed 11470898. Source: FlyBase

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10409723PubMed 17578907PubMed 17578908. Source: FlyBase

negative regulation of transcription regulatory region DNA binding

Inferred from direct assay PubMed 10409723. Source: FlyBase

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 17452449PubMed 19402744. Source: FlyBase

regulation of circadian rhythm

Inferred from mutant phenotype PubMed 17452449PubMed 19139270PubMed 19402744. Source: FlyBase

regulation of circadian sleep/wake cycle, sleep

Inferred from mutant phenotype PubMed 12015603. Source: FlyBase

response to light stimulus

Traceable author statement PubMed 12626480. Source: FlyBase

response to oxidative stress

Inferred from mutant phenotype PubMed 18627767. Source: FlyBase

response to temperature stimulus

Traceable author statement PubMed 12626480. Source: FlyBase

rhythmic behavior

Traceable author statement PubMed 12486701. Source: FlyBase

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 12944510PubMed 15356209PubMed 16410523PubMed 17369364PubMed 19223210PubMed 19402744. Source: FlyBase

nucleus

Inferred from direct assay PubMed 12944510PubMed 15356209PubMed 15930393PubMed 16410523PubMed 17369364PubMed 19402744. Source: FlyBase

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein heterodimerization activity

Inferred from physical interaction PubMed 10409723. Source: FlyBase

protein homodimerization activity

Inferred from physical interaction PubMed 19402744. Source: FlyBase

signal transducer activity

Inferred from electronic annotation. Source: InterPro

transcription cofactor activity

Non-traceable author statement PubMed 11715043. Source: FlyBase

transcription corepressor activity

Traceable author statement PubMed 12486701. Source: FlyBase

transcription factor binding

Inferred from physical interaction PubMed 10409723. Source: FlyBase

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform PER-A-long (identifier: P07663-1)

Also known as: perA;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PER-A-short (identifier: P07663-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
Isoform PER-B (identifier: P07663-3)

The sequence of this isoform differs from the canonical sequence as follows:
     868-963: Missing.
Isoform PER-C (identifier: P07663-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1224: TTPASMTKKV...EEDQTQHGDG → VSQWPVVPHR...SRQQQGMLYE
Isoform PER-D (identifier: P07663-5)

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.
Isoform PER-E (identifier: P07663-6)

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.
     1155-1224: KYTDSNGNSD...EEDQTQHGDG → VCYTNEVHW

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12241224Period circadian protein
PRO_0000162596

Regions

Domain238 – 373136PAS 1
Domain391 – 497107PAS 2
Repeat694 – 69521
Repeat697 – 69822
Repeat699 – 70023
Repeat701 – 70224
Repeat703 – 70425
Repeat705 – 70626
Repeat707 – 70827
Repeat709 – 71028
Repeat711 – 71229
Repeat713 – 714210
Repeat715 – 716211
Repeat717 – 718212
Repeat719 – 720213
Repeat721 – 722214
Repeat723 – 724215
Repeat725 – 726216
Repeat727 – 728217
Repeat729 – 730218
Repeat731 – 732219
Repeat733 – 734220
Repeat735 – 736221
Repeat737 – 738222
Repeat739 – 740223
Repeat741 – 742224
Repeat743 – 744225
Repeat745 – 746226
Repeat747 – 748227; approximate
Repeat749 – 750228
Repeat751 – 752229
Repeat753 – 754230
Region694 – 7546130 X 2 AA approximate tandem repeats of G-[TN]
Region749 – 868120Regulates the rhythm of species-specific courtship song
Motif66 – 7914Nuclear localization signal Potential
Compositional bias74 – 796Poly-Lys
Compositional bias143 – 1464Poly-Glu
Compositional bias223 – 2264Poly-Ala
Compositional bias872 – 8798Poly-Gly
Compositional bias898 – 9058Poly-Gly
Compositional bias906 – 9149Poly-Ala
Compositional bias1006 – 10138Poly-Ala
Compositional bias1035 – 10417Poly-Ala

Natural variations

Alternative sequence1 – 6262Missing in isoform PER-A-short.
VSP_004657
Alternative sequence863 – 95896Missing in isoform PER-D and isoform PER-E.
VSP_004659
Alternative sequence868 – 96396Missing in isoform PER-B.
VSP_004658
Alternative sequence1076 – 1224149TTPAS…QHGDG → VSQWPVVPHRTVLTPTPTPY SSIDHAGVHDEEGAGCIPLG HHSCPGAASLLAERIRQDGA GLQCSGIRSLQEGGAGLLAH SLRDGRLQLRPALQQQQSRQ QQGMLYE in isoform PER-C.
VSP_004660
Alternative sequence1155 – 122470KYTDS…QHGDG → VCYTNEVHW in isoform PER-E.
VSP_004661
Natural variant697 – 70812Missing in (Gly-Thr)17.
Natural variant697 – 7026Missing in (Gly-Thr)20.
Natural variant7481S → F in strain: U79.
Natural variant7621T → S in strain: Berkeley, L18, Oregon-R, SP1 and U79.
Natural variant8461A → T in strain: U79.
Natural variant8581V → A in strain: L18 and U79.
Natural variant11761S → P in strain: L18.

Experimental info

Sequence conflict2111G → V in AAA28777. Ref.8
Sequence conflict498 – 4992GP → A in AAA28777. Ref.8
Sequence conflict6371E → A Ref.10
Sequence conflict733 – 76735Missing Ref.3
Sequence conflict762 – 7643TAA → RR Ref.3
Sequence conflict762 – 7643TAA → RR Ref.10
Sequence conflict10291L → V Ref.10
Sequence conflict10381A → P Ref.10
Sequence conflict10751T → TVSQWPV in CAA19677. Ref.6
Sequence conflict11141S → F Ref.1
Sequence conflict12151E → D Ref.1

Secondary structure

.................................................... 1224
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform PER-A-long (perA) [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 71FA54ECF3E90F4A

FASTA1,224127,852
        10         20         30         40         50         60 
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY GGKPSTQASS 

        70         80         90        100        110        120 
SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG RDEEKPRPSG TGCVEQQICR 

       130        140        150        160        170        180 
ELQDQQHGED HSEPQAIEQL QQEEEEDQSG SESEADRVEG VAKSEAAQSF PIPSPLSVTI 

       190        200        210        220        230        240 
VPPSMGGCGG VGHAAGLDSG LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF 

       250        260        270        280        290        300 
CCVISMHDGI VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 

       310        320        330        340        350        360 
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE ARPDNYMVSN 

       370        380        390        400        410        420 
GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI ISHVDSAAVS ALGYLPQDLI 

       430        440        450        460        470        480 
GRSIMDFYHH EDLSVMKETY ETVMKKGQTA GASFCSKPYR FLIQNGCYVL LETEWTSFVN 

       490        500        510        520        530        540 
PWSRKLEFVV GHHRVFQGPK QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR 

       550        560        570        580        590        600 
PSDTVKQEVS RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 

       610        620        630        640        650        660 
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG TCVSGASGPM 

       670        680        690        700        710        720 
SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT GTGTGTGTGT GTGTGTGTGT 

       730        740        750        760        770        780 
GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT GTGTASSSKG GTAAIPPVTL TESLLNKHND 

       790        800        810        820        830        840 
EMEKFMLKKH RESRGRTGEK SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL 

       850        860        870        880        890        900 
TLGTDAIKGA AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA 

       910        920        930        940        950        960 
GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH STHTAMAQSS 

       970        980        990       1000       1010       1020 
FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP TTSQQAAAAA AQAMPLQYMA 

      1030       1040       1050       1060       1070       1080 
GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP GMANALQIPE RPLGSQSAYN KSVYTTTPAS 

      1090       1100       1110       1120       1130       1140 
MTKKVPGAFH SVTTPAQVQR PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN 

      1150       1160       1170       1180       1190       1200 
SDPPCSSSNP ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL 

      1210       1220 
KSMSTSESKI MEHPEEDQTQ HGDG 

« Hide

Isoform PER-A-short [UniParc].

Checksum: 7EF93EDE76EC5A5B
Show »

FASTA1,162121,661
Isoform PER-B [UniParc].

Checksum: AE924CCDF4C5ADD9
Show »

FASTA1,128119,293
Isoform PER-C [UniParc].

Checksum: 434AC9036463909E
Show »

FASTA1,182123,485
Isoform PER-D [UniParc].

Checksum: 5ED88CCD3FEE97B4
Show »

FASTA1,128119,431
Isoform PER-E [UniParc].

Checksum: BD72A8EC731BFD31
Show »

FASTA1,067112,804

References

« Hide 'large scale' references
[1]"A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene."
Citri Y., Colot H.V., Jacquier A.C., Yu Q., Hall J.C., Baltimore D., Rosbash M.
Nature 326:42-47(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Oregon-R.
[2]"Genetic, molecular and cellular studies of the period locus and its products in Drosophila melanogaster."
Baylies M.K., Weiner L., Vosshall L.B., Saez L., Young M.W.
(In) Young M.W. (eds.); Molecular genetics of biological rhythms, pp.123-153, Marcel Dekker, New York (1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PER-A-LONG).
Strain: Canton-S.
[3]"Product of per locus of Drosophila shares homology with proteoglycans."
Jackson F.R., Bargiello T.A., Yun S.-H., Young M.W.
Nature 320:185-188(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Canton-S.
[4]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT (GLY-THR)20.
Strain: Berkeley.
[5]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[6]"From sequence to chromosome: the tip of the X chromosome of D. melanogaster."
Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. expand/collapse author list , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M.
Science 287:2220-2222(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Oregon-R.
[7]"Linking phylogenetics with population genetics to reconstruct the geographic origin of a species."
Dean M.D., Ballard J.W.O.
Mol. Phylogenet. Evol. 32:998-1009(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-609.
Strain: Oregon-R.
[8]"DNA sequence variation at the period locus within and among species of the Drosophila melanogaster complex."
Kliman R.M., Hey J.
Genetics 133:375-387(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-573.
[9]"Population structure and founder effect in the colonization of D.simulans based on DNA sequence variation in the Drosophila clock gene period."
Horio A.T., Date A., Noda R., Tajima F., Chigusa S.I., Kondo R.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 243-400; 744-926 AND 1076-1218.
Strain: L18, SP1 and U79.
[10]"The period clock locus of D. melanogaster codes for a proteoglycan."
Reddy P., Jacquier A.C., Abovich N., Petersen G., Rosbash M.
Cell 46:53-61(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 499-1075, VARIANT (GLY-THR)20.
Strain: Oregon-R.
[11]"Evolutionary novelties in islands: Drosophila santomea, a new melanogaster sister species from Sao Tome."
Lachaise D., Harry M., Solignac M., Lemeunier F., Benassi V., Cariou M.L.
Proc. R. Soc. B 267:1487-1495(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 683-932, VARIANT (GLY-THR)20.
[12]"Hitchhiking mapping: a population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster."
Harr B., Kauer M., Schloetterer C.
Proc. Natl. Acad. Sci. U.S.A. 99:12949-12954(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1155-1224.
Strain: AF1, AF2, AF3, AF4, K1, K11, K13, K14, K16, K17, K2, K20, K21, K3, K5, K7, K9, Wi1, Wi10, Wi12, Wi13, Wi14, Wi15, Wi16, Wi17, Wi18, Wi19, Wi2, Wi21, Wi22, Wi23, Wi24, Wi25, Wi27, Wi28, Wi29, Wi3, Wi30, Wi31, Wi32, Wi33, Wi4, Wi5, Wi6, Wi7, Wi8, Wi9, ZH1, ZH13, ZH16, ZH18, ZH19, ZH2, ZH20, ZH21, ZH23, ZH25, ZH29, ZH31, ZH33, ZH35 and ZH36.
[13]"Temporal phosphorylation of the Drosophila period protein."
Edery I., Zwiebel L.J., Dembinska M.E., Rosbash M.
Proc. Natl. Acad. Sci. U.S.A. 91:2260-2264(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION.
[14]"Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD."
Yildiz O., Doi M., Yujnovsky I., Cardone L., Berndt A., Hennig S., Schulze S., Urbanke C., Sassone-Corsi P., Wolf E.
Mol. Cell 17:69-82(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 232-599, SUBUNIT.
+Additional computationally mapped references.

Web resources

Protein Spotlight

The tale of a love song - Issue 6 of January 2001

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M30114 Genomic DNA. Translation: AAA28752.1.
M30114 Genomic DNA. Translation: AAA28753.1.
M30114 Genomic DNA. Translation: AAA28754.1.
AF033029 mRNA. Translation: AAB87476.1.
X03636 Genomic DNA. Translation: CAA27285.1. Sequence problems.
AE014298 Genomic DNA. Translation: AAF45804.1.
AL024485 Genomic DNA. Translation: CAA19677.1.
AL024485 Genomic DNA. Translation: CAA19678.1.
AL024485 Genomic DNA. Translation: CAA19679.1.
AL024485 Genomic DNA. Translation: CAA19680.1.
AY575847 Genomic DNA. Translation: AAS89667.1.
L07817 Genomic DNA. Translation: AAA28777.1.
L07818 Genomic DNA. Translation: AAA28776.1.
L07819 Genomic DNA. Translation: AAA28775.1.
L07821 Genomic DNA. Translation: AAA28773.1.
L07823 Genomic DNA. Translation: AAA28771.1.
L07825 Genomic DNA. Translation: AAA28769.1.
AB029194 Genomic DNA. Translation: BAB15868.1.
AB029195 Genomic DNA. Translation: BAB15869.1.
AB029196 Genomic DNA. Translation: BAB15870.1.
AB029222 Genomic DNA. Translation: BAB15896.1.
AB029223 Genomic DNA. Translation: BAB15897.1.
AB029224 Genomic DNA. Translation: BAB15898.1.
AB029250 Genomic DNA. Translation: BAB15924.1.
AB029251 Genomic DNA. Translation: BAB15925.1.
AB029252 Genomic DNA. Translation: BAB15926.1.
D00009 Genomic DNA. Translation: BAA00007.1.
AF251241 Genomic DNA. Translation: AAG44573.1.
AY047980 Genomic DNA. Translation: AAN02289.1.
AY047981 Genomic DNA. Translation: AAN02291.1.
AY047982 Genomic DNA. Translation: AAN02293.1.
AY047983 Genomic DNA. Translation: AAN02295.1.
AY047984 Genomic DNA. Translation: AAN02297.1.
AY047985 Genomic DNA. Translation: AAN02299.1.
AY047986 Genomic DNA. Translation: AAN02301.1.
AY047987 Genomic DNA. Translation: AAN02303.1.
AY047988 Genomic DNA. Translation: AAN02305.1.
AY047989 Genomic DNA. Translation: AAN02307.1.
AY047990 Genomic DNA. Translation: AAN02309.1.
AY047991 Genomic DNA. Translation: AAN02311.1.
AY047992 Genomic DNA. Translation: AAN02313.1.
AY047993 Genomic DNA. Translation: AAN02315.1.
AY047994 Genomic DNA. Translation: AAN02317.1.
AY047995 Genomic DNA. Translation: AAN02319.1.
AY047996 Genomic DNA. Translation: AAN02321.1.
AY047997 Genomic DNA. Translation: AAN02323.1.
AY047998 Genomic DNA. Translation: AAN02325.1.
AY047999 Genomic DNA. Translation: AAN02327.1.
AY048000 Genomic DNA. Translation: AAN02329.1.
AY048001 Genomic DNA. Translation: AAN02331.1.
AY048002 Genomic DNA. Translation: AAN02333.1.
AY048003 Genomic DNA. Translation: AAN02335.1.
AY048004 Genomic DNA. Translation: AAN02337.1.
AY048005 Genomic DNA. Translation: AAN02339.1.
AY048006 Genomic DNA. Translation: AAN02341.1.
AY048007 Genomic DNA. Translation: AAN02343.1.
AY048008 Genomic DNA. Translation: AAN02345.1.
AY048009 Genomic DNA. Translation: AAN02347.1.
AY048010 Genomic DNA. Translation: AAN02349.1.
AY048011 Genomic DNA. Translation: AAN02351.1.
AY048012 Genomic DNA. Translation: AAN02353.1.
AY048013 Genomic DNA. Translation: AAN02355.1.
AY048014 Genomic DNA. Translation: AAN02357.1.
AY048015 Genomic DNA. Translation: AAN02359.1.
AY048016 Genomic DNA. Translation: AAN02361.1.
AY048017 Genomic DNA. Translation: AAN02363.1.
AY048018 Genomic DNA. Translation: AAN02365.1.
AY048019 Genomic DNA. Translation: AAN02367.1.
AY048020 Genomic DNA. Translation: AAN02369.1.
AY048021 Genomic DNA. Translation: AAN02371.1.
AY048022 Genomic DNA. Translation: AAN02373.1.
AY048023 Genomic DNA. Translation: AAN02375.1.
AY048024 Genomic DNA. Translation: AAN02377.1.
AY048025 Genomic DNA. Translation: AAN02379.1.
AY048026 Genomic DNA. Translation: AAN02381.1.
AY048027 Genomic DNA. Translation: AAN02383.1.
AY048028 Genomic DNA. Translation: AAN02385.1.
AY048029 Genomic DNA. Translation: AAN02387.1.
AY048030 Genomic DNA. Translation: AAN02389.1.
AY048031 Genomic DNA. Translation: AAN02391.1.
AY048032 Genomic DNA. Translation: AAN02393.1.
AY048033 Genomic DNA. Translation: AAN02395.1.
AY048034 Genomic DNA. Translation: AAN02397.1.
AY048035 Genomic DNA. Translation: AAN02399.1.
AY048036 Genomic DNA. Translation: AAN02401.1.
AY048037 Genomic DNA. Translation: AAN02403.1.
AY048038 Genomic DNA. Translation: AAN02405.1.
AY048040 Genomic DNA. Translation: AAN02407.1.
AY048041 Genomic DNA. Translation: AAN02409.1.
AY048042 Genomic DNA. Translation: AAN02411.1.
PIRUMFF. A23932.
A26427.
A26588.
B26427.
C26427.
S52943.
RefSeqNP_001259194.1. NM_001272265.1.
NP_525056.2. NM_080317.2.
UniGeneDm.65.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WA9X-ray3.15A/B232-599[»]
3GECX-ray4.00A232-538[»]
3RTYX-ray2.85A/B/C/D/E/F/G/H236-574[»]
ProteinModelPortalP07663.
SMRP07663. Positions 237-571.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid57782. 14 interactions.
DIPDIP-29426N.
MINTMINT-1327740.

Proteomic databases

PaxDbP07663.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID31251.
KEGGdme:Dmel_CG2647.

Organism-specific databases

CTD31251.
FlyBaseFBgn0003068. per.

Phylogenomic databases

eggNOGNOG253593.
InParanoidP07663.
KOK02633.
OrthoDBEOG7TMZRC.

Gene expression databases

BgeeP07663.

Family and domain databases

InterProIPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamPF00989. PAS. 1 hit.
[Graphical view]
SMARTSM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMSSF55785. SSF55785. 3 hits.
PROSITEPS50112. PAS. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP07663.
GenomeRNAi31251.
NextBio772671.

Entry information

Entry namePER_DROME
AccessionPrimary (citable) accession number: P07663
Secondary accession number(s): O17483 expand/collapse secondary AC list , O76882, O76883, O76884, O76885, Q24446, Q24447, Q24448, Q24449, Q6PVA3, Q8MLY0, Q9GN20, Q9GN51, Q9GQH9, Q9GV48, Q9GV53, Q9GV54, Q9GV55, Q9W4X0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: April 16, 2014
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase