Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Period circadian protein

Gene

per

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • transcription cofactor activity Source: FlyBase
  • transcription corepressor activity Source: FlyBase
  • transcription factor binding Source: FlyBase

GO - Biological processi

  • age-dependent response to oxidative stress Source: FlyBase
  • behavioral response to cocaine Source: FlyBase
  • circadian behavior Source: CACAO
  • circadian rhythm Source: FlyBase
  • circadian sleep/wake cycle Source: FlyBase
  • circadian temperature homeostasis Source: FlyBase
  • copulation Source: FlyBase
  • courtship behavior Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • eclosion rhythm Source: FlyBase
  • entrainment of circadian clock Source: FlyBase
  • entrainment of circadian clock by photoperiod Source: FlyBase
  • locomotor rhythm Source: FlyBase
  • long-term memory Source: FlyBase
  • male courtship behavior, veined wing generated song production Source: FlyBase
  • mating behavior Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • negative regulation of transcription regulatory region DNA binding Source: FlyBase
  • regulation of circadian rhythm Source: FlyBase
  • regulation of circadian sleep/wake cycle, sleep Source: FlyBase
  • regulation of locomotor rhythm Source: FlyBase
  • regulation of protein phosphorylation Source: FlyBase
  • response to light stimulus Source: FlyBase
  • response to oxidative stress Source: FlyBase
  • response to temperature stimulus Source: FlyBase
  • rhythmic behavior Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Period circadian protein
Alternative name(s):
Protein clock-6
Short name:
CLK-6
Gene namesi
Name:per
ORF Names:CG2647
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003068. per.

Subcellular locationi

  • Nucleus
  • Cytoplasmperinuclear region

  • Note: Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization.

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • nucleus Source: FlyBase
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625961 – 1224Period circadian proteinAdd BLAST1224

Post-translational modificationi

Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP07663.
PRIDEiP07663.

PTM databases

iPTMnetiP07663.

Expressioni

Tissue specificityi

Expressed in neural tissues and in several nonneural tissues of the abdomen. Malpighian tubules contain a circadian pacemaker that functions independently of the brain. Expression oscillates in all tissues studied except for the ovary. PER-A isoforms are mainly expressed in adult's head.

Inductioni

Expression is sensitive to temperature but not to light.

Gene expression databases

BgeeiFBgn0003068.
GenevisibleiP07663. DM.

Interactioni

Subunit structurei

Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi57782. 14 interactors.
DIPiDIP-29426N.
MINTiMINT-1327740.
STRINGi7227.FBpp0070455.

Structurei

Secondary structure

11224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi240 – 245Combined sources6
Turni246 – 248Combined sources3
Beta strandi250 – 254Combined sources5
Helixi258 – 262Combined sources5
Helixi274 – 277Combined sources4
Helixi280 – 282Combined sources3
Helixi283 – 291Combined sources9
Beta strandi310 – 316Combined sources7
Beta strandi326 – 328Combined sources3
Beta strandi335 – 346Combined sources12
Beta strandi352 – 354Combined sources3
Beta strandi364 – 372Combined sources9
Beta strandi390 – 396Combined sources7
Beta strandi400 – 404Combined sources5
Helixi408 – 412Combined sources5
Helixi416 – 419Combined sources4
Helixi424 – 427Combined sources4
Helixi430 – 432Combined sources3
Helixi433 – 446Combined sources14
Beta strandi459 – 462Combined sources4
Beta strandi468 – 479Combined sources12
Turni481 – 483Combined sources3
Beta strandi485 – 497Combined sources13
Beta strandi500 – 502Combined sources3
Beta strandi504 – 507Combined sources4
Helixi516 – 535Combined sources20
Turni544 – 550Combined sources7
Helixi554 – 573Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WA9X-ray3.15A/B232-599[»]
3GECX-ray4.00A232-538[»]
3RTYX-ray2.85A/B/C/D/E/F/G/H236-574[»]
ProteinModelPortaliP07663.
SMRiP07663.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07663.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 373PAS 1PROSITE-ProRule annotationAdd BLAST136
Domaini391 – 497PAS 2PROSITE-ProRule annotationAdd BLAST107
Repeati694 – 69512
Repeati697 – 69822
Repeati699 – 70032
Repeati701 – 70242
Repeati703 – 70452
Repeati705 – 70662
Repeati707 – 70872
Repeati709 – 71082
Repeati711 – 71292
Repeati713 – 714102
Repeati715 – 716112
Repeati717 – 718122
Repeati719 – 720132
Repeati721 – 722142
Repeati723 – 724152
Repeati725 – 726162
Repeati727 – 728172
Repeati729 – 730182
Repeati731 – 732192
Repeati733 – 734202
Repeati735 – 736212
Repeati737 – 738222
Repeati739 – 740232
Repeati741 – 742242
Repeati743 – 744252
Repeati745 – 746262
Repeati747 – 74827; approximate2
Repeati749 – 750282
Repeati751 – 752292
Repeati753 – 754302

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni694 – 75430 X 2 AA approximate tandem repeats of G-[TN]Add BLAST61
Regioni749 – 868Regulates the rhythm of species-specific courtship songAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 79Nuclear localization signalSequence analysisAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 79Poly-Lys6
Compositional biasi143 – 146Poly-Glu4
Compositional biasi223 – 226Poly-Ala4
Compositional biasi872 – 879Poly-Gly8
Compositional biasi898 – 905Poly-Gly8
Compositional biasi906 – 914Poly-Ala9
Compositional biasi1006 – 1013Poly-Ala8
Compositional biasi1035 – 1041Poly-Ala7

Domaini

Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least three types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), and two major variants (Gly-Thr)17 and (Gly-Thr)20. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior.
Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).

Sequence similaritiesi

Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3753. Eukaryota.
ENOG410Y118. LUCA.
InParanoidiP07663.
KOiK02633.
OrthoDBiEOG091G01SQ.

Family and domain databases

InterProiIPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 3 hits.
PROSITEiPS50112. PAS. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform PER-A-long (identifier: P07663-1) [UniParc]FASTAAdd to basket
Also known as: perA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY
60 70 80 90 100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG
110 120 130 140 150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG
160 170 180 190 200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG
210 220 230 240 250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI
260 270 280 290 300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR
310 320 330 340 350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE
360 370 380 390 400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI
410 420 430 440 450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA
460 470 480 490 500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK
510 520 530 540 550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS
560 570 580 590 600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD
610 620 630 640 650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG
660 670 680 690 700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT
710 720 730 740 750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT
760 770 780 790 800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK
810 820 830 840 850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA
860 870 880 890 900
AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA
910 920 930 940 950
GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH
960 970 980 990 1000
STHTAMAQSS FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP
1010 1020 1030 1040 1050
TTSQQAAAAA AQAMPLQYMA GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP
1060 1070 1080 1090 1100
GMANALQIPE RPLGSQSAYN KSVYTTTPAS MTKKVPGAFH SVTTPAQVQR
1110 1120 1130 1140 1150
PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN SDPPCSSSNP
1160 1170 1180 1190 1200
ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL
1210 1220
KSMSTSESKI MEHPEEDQTQ HGDG
Length:1,224
Mass (Da):127,852
Last modified:December 15, 1998 - v2
Checksum:i71FA54ECF3E90F4A
GO
Isoform PER-A-short (identifier: P07663-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Show »
Length:1,162
Mass (Da):121,661
Checksum:i7EF93EDE76EC5A5B
GO
Isoform PER-B (identifier: P07663-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-963: Missing.

Show »
Length:1,128
Mass (Da):119,293
Checksum:iAE924CCDF4C5ADD9
GO
Isoform PER-C (identifier: P07663-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1224: TTPASMTKKV...EEDQTQHGDG → VSQWPVVPHR...SRQQQGMLYE

Show »
Length:1,182
Mass (Da):123,485
Checksum:i434AC9036463909E
GO
Isoform PER-D (identifier: P07663-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.

Show »
Length:1,128
Mass (Da):119,431
Checksum:i5ED88CCD3FEE97B4
GO
Isoform PER-E (identifier: P07663-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.
     1155-1224: KYTDSNGNSD...EEDQTQHGDG → VCYTNEVHW

Show »
Length:1,067
Mass (Da):112,804
Checksum:iBD72A8EC731BFD31
GO

Sequence cautioni

The sequence CAA27285 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211G → V in AAA28777 (PubMed:8436278).Curated1
Sequence conflicti498 – 499GP → A in AAA28777 (PubMed:8436278).Curated2
Sequence conflicti637E → A (PubMed:3087625).Curated1
Sequence conflicti733 – 767Missing (PubMed:3081818).CuratedAdd BLAST35
Sequence conflicti762 – 764TAA → RR (PubMed:3081818).Curated3
Sequence conflicti762 – 764TAA → RR (PubMed:3087625).Curated3
Sequence conflicti1029L → V (PubMed:3087625).Curated1
Sequence conflicti1038A → P (PubMed:3087625).Curated1
Sequence conflicti1075T → TVSQWPV in CAA19677 (PubMed:10731137).Curated1
Sequence conflicti1114S → F (PubMed:3102970).Curated1
Sequence conflicti1215E → D (PubMed:3102970).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti697 – 708Missing in (Gly-Thr)17. Add BLAST12
Natural varianti697 – 702Missing in (Gly-Thr)20. 6
Natural varianti748S → F in strain: U79. 1
Natural varianti762T → S in strain: Berkeley, L18, Oregon-R, SP1 and U79. 1
Natural varianti846A → T in strain: U79. 1
Natural varianti858V → A in strain: L18 and U79. 1
Natural varianti1176S → P in strain: L18. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0046571 – 62Missing in isoform PER-A-short. CuratedAdd BLAST62
Alternative sequenceiVSP_004659863 – 958Missing in isoform PER-D and isoform PER-E. CuratedAdd BLAST96
Alternative sequenceiVSP_004658868 – 963Missing in isoform PER-B. CuratedAdd BLAST96
Alternative sequenceiVSP_0046601076 – 1224TTPAS…QHGDG → VSQWPVVPHRTVLTPTPTPY SSIDHAGVHDEEGAGCIPLG HHSCPGAASLLAERIRQDGA GLQCSGIRSLQEGGAGLLAH SLRDGRLQLRPALQQQQSRQ QQGMLYE in isoform PER-C. CuratedAdd BLAST149
Alternative sequenceiVSP_0046611155 – 1224KYTDS…QHGDG → VCYTNEVHW in isoform PER-E. CuratedAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30114 Genomic DNA. Translation: AAA28752.1.
M30114 Genomic DNA. Translation: AAA28753.1.
M30114 Genomic DNA. Translation: AAA28754.1.
AF033029 mRNA. Translation: AAB87476.1.
X03636 Genomic DNA. Translation: CAA27285.1. Sequence problems.
AE014298 Genomic DNA. Translation: AAF45804.1.
AL024485 Genomic DNA. Translation: CAA19677.1.
AL024485 Genomic DNA. Translation: CAA19678.1.
AL024485 Genomic DNA. Translation: CAA19679.1.
AL024485 Genomic DNA. Translation: CAA19680.1.
AY575847 Genomic DNA. Translation: AAS89667.1.
L07817 Genomic DNA. Translation: AAA28777.1.
L07818 Genomic DNA. Translation: AAA28776.1.
L07819 Genomic DNA. Translation: AAA28775.1.
L07821 Genomic DNA. Translation: AAA28773.1.
L07823 Genomic DNA. Translation: AAA28771.1.
L07825 Genomic DNA. Translation: AAA28769.1.
AB029194 Genomic DNA. Translation: BAB15868.1.
AB029195 Genomic DNA. Translation: BAB15869.1.
AB029196 Genomic DNA. Translation: BAB15870.1.
AB029222 Genomic DNA. Translation: BAB15896.1.
AB029223 Genomic DNA. Translation: BAB15897.1.
AB029224 Genomic DNA. Translation: BAB15898.1.
AB029250 Genomic DNA. Translation: BAB15924.1.
AB029251 Genomic DNA. Translation: BAB15925.1.
AB029252 Genomic DNA. Translation: BAB15926.1.
D00009 Genomic DNA. Translation: BAA00007.1.
AF251241 Genomic DNA. Translation: AAG44573.1.
AY047980 Genomic DNA. Translation: AAN02289.1.
AY047981 Genomic DNA. Translation: AAN02291.1.
AY047982 Genomic DNA. Translation: AAN02293.1.
AY047983 Genomic DNA. Translation: AAN02295.1.
AY047984 Genomic DNA. Translation: AAN02297.1.
AY047985 Genomic DNA. Translation: AAN02299.1.
AY047986 Genomic DNA. Translation: AAN02301.1.
AY047987 Genomic DNA. Translation: AAN02303.1.
AY047988 Genomic DNA. Translation: AAN02305.1.
AY047989 Genomic DNA. Translation: AAN02307.1.
AY047990 Genomic DNA. Translation: AAN02309.1.
AY047991 Genomic DNA. Translation: AAN02311.1.
AY047992 Genomic DNA. Translation: AAN02313.1.
AY047993 Genomic DNA. Translation: AAN02315.1.
AY047994 Genomic DNA. Translation: AAN02317.1.
AY047995 Genomic DNA. Translation: AAN02319.1.
AY047996 Genomic DNA. Translation: AAN02321.1.
AY047997 Genomic DNA. Translation: AAN02323.1.
AY047998 Genomic DNA. Translation: AAN02325.1.
AY047999 Genomic DNA. Translation: AAN02327.1.
AY048000 Genomic DNA. Translation: AAN02329.1.
AY048001 Genomic DNA. Translation: AAN02331.1.
AY048002 Genomic DNA. Translation: AAN02333.1.
AY048003 Genomic DNA. Translation: AAN02335.1.
AY048004 Genomic DNA. Translation: AAN02337.1.
AY048005 Genomic DNA. Translation: AAN02339.1.
AY048006 Genomic DNA. Translation: AAN02341.1.
AY048007 Genomic DNA. Translation: AAN02343.1.
AY048008 Genomic DNA. Translation: AAN02345.1.
AY048009 Genomic DNA. Translation: AAN02347.1.
AY048010 Genomic DNA. Translation: AAN02349.1.
AY048011 Genomic DNA. Translation: AAN02351.1.
AY048012 Genomic DNA. Translation: AAN02353.1.
AY048013 Genomic DNA. Translation: AAN02355.1.
AY048014 Genomic DNA. Translation: AAN02357.1.
AY048015 Genomic DNA. Translation: AAN02359.1.
AY048016 Genomic DNA. Translation: AAN02361.1.
AY048017 Genomic DNA. Translation: AAN02363.1.
AY048018 Genomic DNA. Translation: AAN02365.1.
AY048019 Genomic DNA. Translation: AAN02367.1.
AY048020 Genomic DNA. Translation: AAN02369.1.
AY048021 Genomic DNA. Translation: AAN02371.1.
AY048022 Genomic DNA. Translation: AAN02373.1.
AY048023 Genomic DNA. Translation: AAN02375.1.
AY048024 Genomic DNA. Translation: AAN02377.1.
AY048025 Genomic DNA. Translation: AAN02379.1.
AY048026 Genomic DNA. Translation: AAN02381.1.
AY048027 Genomic DNA. Translation: AAN02383.1.
AY048028 Genomic DNA. Translation: AAN02385.1.
AY048029 Genomic DNA. Translation: AAN02387.1.
AY048030 Genomic DNA. Translation: AAN02389.1.
AY048031 Genomic DNA. Translation: AAN02391.1.
AY048032 Genomic DNA. Translation: AAN02393.1.
AY048033 Genomic DNA. Translation: AAN02395.1.
AY048034 Genomic DNA. Translation: AAN02397.1.
AY048035 Genomic DNA. Translation: AAN02399.1.
AY048036 Genomic DNA. Translation: AAN02401.1.
AY048037 Genomic DNA. Translation: AAN02403.1.
AY048038 Genomic DNA. Translation: AAN02405.1.
AY048040 Genomic DNA. Translation: AAN02407.1.
AY048041 Genomic DNA. Translation: AAN02409.1.
AY048042 Genomic DNA. Translation: AAN02411.1.
PIRiA23932. UMFF.
A26427.
A26588.
B26427.
C26427.
S52943.
RefSeqiNP_001259194.1. NM_001272265.1.
NP_525056.2. NM_080317.2.
UniGeneiDm.65.

Genome annotation databases

GeneIDi31251.
KEGGidme:Dmel_CG2647.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

The tale of a love song - Issue 6 of January 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30114 Genomic DNA. Translation: AAA28752.1.
M30114 Genomic DNA. Translation: AAA28753.1.
M30114 Genomic DNA. Translation: AAA28754.1.
AF033029 mRNA. Translation: AAB87476.1.
X03636 Genomic DNA. Translation: CAA27285.1. Sequence problems.
AE014298 Genomic DNA. Translation: AAF45804.1.
AL024485 Genomic DNA. Translation: CAA19677.1.
AL024485 Genomic DNA. Translation: CAA19678.1.
AL024485 Genomic DNA. Translation: CAA19679.1.
AL024485 Genomic DNA. Translation: CAA19680.1.
AY575847 Genomic DNA. Translation: AAS89667.1.
L07817 Genomic DNA. Translation: AAA28777.1.
L07818 Genomic DNA. Translation: AAA28776.1.
L07819 Genomic DNA. Translation: AAA28775.1.
L07821 Genomic DNA. Translation: AAA28773.1.
L07823 Genomic DNA. Translation: AAA28771.1.
L07825 Genomic DNA. Translation: AAA28769.1.
AB029194 Genomic DNA. Translation: BAB15868.1.
AB029195 Genomic DNA. Translation: BAB15869.1.
AB029196 Genomic DNA. Translation: BAB15870.1.
AB029222 Genomic DNA. Translation: BAB15896.1.
AB029223 Genomic DNA. Translation: BAB15897.1.
AB029224 Genomic DNA. Translation: BAB15898.1.
AB029250 Genomic DNA. Translation: BAB15924.1.
AB029251 Genomic DNA. Translation: BAB15925.1.
AB029252 Genomic DNA. Translation: BAB15926.1.
D00009 Genomic DNA. Translation: BAA00007.1.
AF251241 Genomic DNA. Translation: AAG44573.1.
AY047980 Genomic DNA. Translation: AAN02289.1.
AY047981 Genomic DNA. Translation: AAN02291.1.
AY047982 Genomic DNA. Translation: AAN02293.1.
AY047983 Genomic DNA. Translation: AAN02295.1.
AY047984 Genomic DNA. Translation: AAN02297.1.
AY047985 Genomic DNA. Translation: AAN02299.1.
AY047986 Genomic DNA. Translation: AAN02301.1.
AY047987 Genomic DNA. Translation: AAN02303.1.
AY047988 Genomic DNA. Translation: AAN02305.1.
AY047989 Genomic DNA. Translation: AAN02307.1.
AY047990 Genomic DNA. Translation: AAN02309.1.
AY047991 Genomic DNA. Translation: AAN02311.1.
AY047992 Genomic DNA. Translation: AAN02313.1.
AY047993 Genomic DNA. Translation: AAN02315.1.
AY047994 Genomic DNA. Translation: AAN02317.1.
AY047995 Genomic DNA. Translation: AAN02319.1.
AY047996 Genomic DNA. Translation: AAN02321.1.
AY047997 Genomic DNA. Translation: AAN02323.1.
AY047998 Genomic DNA. Translation: AAN02325.1.
AY047999 Genomic DNA. Translation: AAN02327.1.
AY048000 Genomic DNA. Translation: AAN02329.1.
AY048001 Genomic DNA. Translation: AAN02331.1.
AY048002 Genomic DNA. Translation: AAN02333.1.
AY048003 Genomic DNA. Translation: AAN02335.1.
AY048004 Genomic DNA. Translation: AAN02337.1.
AY048005 Genomic DNA. Translation: AAN02339.1.
AY048006 Genomic DNA. Translation: AAN02341.1.
AY048007 Genomic DNA. Translation: AAN02343.1.
AY048008 Genomic DNA. Translation: AAN02345.1.
AY048009 Genomic DNA. Translation: AAN02347.1.
AY048010 Genomic DNA. Translation: AAN02349.1.
AY048011 Genomic DNA. Translation: AAN02351.1.
AY048012 Genomic DNA. Translation: AAN02353.1.
AY048013 Genomic DNA. Translation: AAN02355.1.
AY048014 Genomic DNA. Translation: AAN02357.1.
AY048015 Genomic DNA. Translation: AAN02359.1.
AY048016 Genomic DNA. Translation: AAN02361.1.
AY048017 Genomic DNA. Translation: AAN02363.1.
AY048018 Genomic DNA. Translation: AAN02365.1.
AY048019 Genomic DNA. Translation: AAN02367.1.
AY048020 Genomic DNA. Translation: AAN02369.1.
AY048021 Genomic DNA. Translation: AAN02371.1.
AY048022 Genomic DNA. Translation: AAN02373.1.
AY048023 Genomic DNA. Translation: AAN02375.1.
AY048024 Genomic DNA. Translation: AAN02377.1.
AY048025 Genomic DNA. Translation: AAN02379.1.
AY048026 Genomic DNA. Translation: AAN02381.1.
AY048027 Genomic DNA. Translation: AAN02383.1.
AY048028 Genomic DNA. Translation: AAN02385.1.
AY048029 Genomic DNA. Translation: AAN02387.1.
AY048030 Genomic DNA. Translation: AAN02389.1.
AY048031 Genomic DNA. Translation: AAN02391.1.
AY048032 Genomic DNA. Translation: AAN02393.1.
AY048033 Genomic DNA. Translation: AAN02395.1.
AY048034 Genomic DNA. Translation: AAN02397.1.
AY048035 Genomic DNA. Translation: AAN02399.1.
AY048036 Genomic DNA. Translation: AAN02401.1.
AY048037 Genomic DNA. Translation: AAN02403.1.
AY048038 Genomic DNA. Translation: AAN02405.1.
AY048040 Genomic DNA. Translation: AAN02407.1.
AY048041 Genomic DNA. Translation: AAN02409.1.
AY048042 Genomic DNA. Translation: AAN02411.1.
PIRiA23932. UMFF.
A26427.
A26588.
B26427.
C26427.
S52943.
RefSeqiNP_001259194.1. NM_001272265.1.
NP_525056.2. NM_080317.2.
UniGeneiDm.65.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WA9X-ray3.15A/B232-599[»]
3GECX-ray4.00A232-538[»]
3RTYX-ray2.85A/B/C/D/E/F/G/H236-574[»]
ProteinModelPortaliP07663.
SMRiP07663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57782. 14 interactors.
DIPiDIP-29426N.
MINTiMINT-1327740.
STRINGi7227.FBpp0070455.

PTM databases

iPTMnetiP07663.

Proteomic databases

PaxDbiP07663.
PRIDEiP07663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31251.
KEGGidme:Dmel_CG2647.

Organism-specific databases

CTDi31251.
FlyBaseiFBgn0003068. per.

Phylogenomic databases

eggNOGiKOG3753. Eukaryota.
ENOG410Y118. LUCA.
InParanoidiP07663.
KOiK02633.
OrthoDBiEOG091G01SQ.

Miscellaneous databases

EvolutionaryTraceiP07663.
GenomeRNAii31251.
PROiP07663.

Gene expression databases

BgeeiFBgn0003068.
GenevisibleiP07663. DM.

Family and domain databases

InterProiIPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 3 hits.
PROSITEiPS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPER_DROME
AccessioniPrimary (citable) accession number: P07663
Secondary accession number(s): O17483
, O76882, O76883, O76884, O76885, Q24446, Q24447, Q24448, Q24449, Q6PVA3, Q8MLY0, Q9GN20, Q9GN51, Q9GQH9, Q9GV48, Q9GV53, Q9GV54, Q9GV55, Q9W4X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: November 30, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.