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P07663

- PER_DROME

UniProt

P07663 - PER_DROME

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Protein

Period circadian protein

Gene

per

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.

GO - Molecular functioni

  1. protein heterodimerization activity Source: FlyBase
  2. protein homodimerization activity Source: FlyBase
  3. signal transducer activity Source: InterPro
  4. transcription cofactor activity Source: FlyBase
  5. transcription corepressor activity Source: FlyBase
  6. transcription factor binding Source: FlyBase

GO - Biological processi

  1. age-dependent response to oxidative stress Source: FlyBase
  2. behavioral response to cocaine Source: FlyBase
  3. circadian behavior Source: FlyBase
  4. circadian rhythm Source: FlyBase
  5. circadian sleep/wake cycle Source: FlyBase
  6. circadian temperature homeostasis Source: FlyBase
  7. copulation Source: FlyBase
  8. courtship behavior Source: FlyBase
  9. determination of adult lifespan Source: FlyBase
  10. eclosion rhythm Source: FlyBase
  11. entrainment of circadian clock Source: FlyBase
  12. entrainment of circadian clock by photoperiod Source: FlyBase
  13. locomotor rhythm Source: FlyBase
  14. long-term memory Source: FlyBase
  15. male courtship behavior, veined wing generated song production Source: FlyBase
  16. mating behavior Source: FlyBase
  17. negative regulation of transcription, DNA-templated Source: FlyBase
  18. negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  19. negative regulation of transcription regulatory region DNA binding Source: FlyBase
  20. regulation of circadian rhythm Source: FlyBase
  21. regulation of circadian sleep/wake cycle, sleep Source: FlyBase
  22. response to light stimulus Source: FlyBase
  23. response to oxidative stress Source: FlyBase
  24. response to temperature stimulus Source: FlyBase
  25. rhythmic behavior Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Enzyme and pathway databases

ReactomeiREACT_180268. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Period circadian protein
Alternative name(s):
Protein clock-6
Short name:
CLK-6
Gene namesi
Name:per
ORF Names:CG2647
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003068. per.

Subcellular locationi

Nucleus. Cytoplasmperinuclear region
Note: Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization.

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12241224Period circadian proteinPRO_0000162596Add
BLAST

Post-translational modificationi

Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP07663.

Expressioni

Tissue specificityi

Expressed in neural tissues and in several nonneural tissues of the abdomen. Malpighian tubules contain a circadian pacemaker that functions independently of the brain. Expression oscillates in all tissues studied except for the ovary. PER-A isoforms are mainly expressed in adult's head.

Inductioni

Expression is sensitive to temperature but not to light.

Gene expression databases

BgeeiP07663.
ExpressionAtlasiP07663. differential.

Interactioni

Subunit structurei

Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer.1 Publication

Protein-protein interaction databases

BioGridi57782. 14 interactions.
DIPiDIP-29426N.
MINTiMINT-1327740.

Structurei

Secondary structure

1
1224
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi240 – 2456
Turni246 – 2483
Beta strandi250 – 2545
Helixi258 – 2625
Helixi274 – 2774
Helixi280 – 2823
Helixi283 – 2919
Beta strandi310 – 3167
Beta strandi326 – 3283
Beta strandi335 – 34612
Beta strandi364 – 3729
Beta strandi390 – 3967
Beta strandi400 – 4045
Helixi408 – 4125
Helixi416 – 4194
Helixi424 – 4274
Helixi430 – 4323
Helixi433 – 44614
Beta strandi459 – 4624
Beta strandi468 – 47912
Turni481 – 4833
Beta strandi485 – 49713
Beta strandi500 – 5023
Beta strandi504 – 5074
Helixi516 – 53520
Turni544 – 5507
Helixi554 – 57320

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WA9X-ray3.15A/B232-599[»]
3GECX-ray4.00A232-538[»]
3RTYX-ray2.85A/B/C/D/E/F/G/H236-574[»]
ProteinModelPortaliP07663.
SMRiP07663. Positions 237-571.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07663.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini238 – 373136PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini391 – 497107PAS 2PROSITE-ProRule annotationAdd
BLAST
Repeati694 – 69521
Repeati697 – 69822
Repeati699 – 70023
Repeati701 – 70224
Repeati703 – 70425
Repeati705 – 70626
Repeati707 – 70827
Repeati709 – 71028
Repeati711 – 71229
Repeati713 – 714210
Repeati715 – 716211
Repeati717 – 718212
Repeati719 – 720213
Repeati721 – 722214
Repeati723 – 724215
Repeati725 – 726216
Repeati727 – 728217
Repeati729 – 730218
Repeati731 – 732219
Repeati733 – 734220
Repeati735 – 736221
Repeati737 – 738222
Repeati739 – 740223
Repeati741 – 742224
Repeati743 – 744225
Repeati745 – 746226
Repeati747 – 748227; approximate
Repeati749 – 750228
Repeati751 – 752229
Repeati753 – 754230

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni694 – 7546130 X 2 AA approximate tandem repeats of G-[TN]Add
BLAST
Regioni749 – 868120Regulates the rhythm of species-specific courtship songAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7914Nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 796Poly-Lys
Compositional biasi143 – 1464Poly-Glu
Compositional biasi223 – 2264Poly-Ala
Compositional biasi872 – 8798Poly-Gly
Compositional biasi898 – 9058Poly-Gly
Compositional biasi906 – 9149Poly-Ala
Compositional biasi1006 – 10138Poly-Ala
Compositional biasi1035 – 10417Poly-Ala

Domaini

Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least three types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), and two major variants (Gly-Thr)17 and (Gly-Thr)20. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior.
Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).

Sequence similaritiesi

Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG253593.
InParanoidiP07663.
KOiK02633.
OrthoDBiEOG7TMZRC.

Family and domain databases

InterProiIPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 3 hits.
PROSITEiPS50112. PAS. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform PER-A-long (identifier: P07663) [UniParc]FASTAAdd to Basket

Also known as: perA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY
60 70 80 90 100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG
110 120 130 140 150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG
160 170 180 190 200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG
210 220 230 240 250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI
260 270 280 290 300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR
310 320 330 340 350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE
360 370 380 390 400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI
410 420 430 440 450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA
460 470 480 490 500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK
510 520 530 540 550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS
560 570 580 590 600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD
610 620 630 640 650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG
660 670 680 690 700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT
710 720 730 740 750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT
760 770 780 790 800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK
810 820 830 840 850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA
860 870 880 890 900
AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA
910 920 930 940 950
GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH
960 970 980 990 1000
STHTAMAQSS FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP
1010 1020 1030 1040 1050
TTSQQAAAAA AQAMPLQYMA GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP
1060 1070 1080 1090 1100
GMANALQIPE RPLGSQSAYN KSVYTTTPAS MTKKVPGAFH SVTTPAQVQR
1110 1120 1130 1140 1150
PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN SDPPCSSSNP
1160 1170 1180 1190 1200
ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL
1210 1220
KSMSTSESKI MEHPEEDQTQ HGDG
Length:1,224
Mass (Da):127,852
Last modified:December 15, 1998 - v2
Checksum:i71FA54ECF3E90F4A
GO
Isoform PER-A-short (identifier: P07663-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Show »
Length:1,162
Mass (Da):121,661
Checksum:i7EF93EDE76EC5A5B
GO
Isoform PER-B (identifier: P07663-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-963: Missing.

Show »
Length:1,128
Mass (Da):119,293
Checksum:iAE924CCDF4C5ADD9
GO
Isoform PER-C (identifier: P07663-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1224: TTPASMTKKV...EEDQTQHGDG → VSQWPVVPHR...SRQQQGMLYE

Show »
Length:1,182
Mass (Da):123,485
Checksum:i434AC9036463909E
GO
Isoform PER-D (identifier: P07663-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.

Show »
Length:1,128
Mass (Da):119,431
Checksum:i5ED88CCD3FEE97B4
GO
Isoform PER-E (identifier: P07663-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.
     1155-1224: KYTDSNGNSD...EEDQTQHGDG → VCYTNEVHW

Show »
Length:1,067
Mass (Da):112,804
Checksum:iBD72A8EC731BFD31
GO

Sequence cautioni

The sequence CAA27285.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111G → V in AAA28777. (PubMed:8436278)Curated
Sequence conflicti498 – 4992GP → A in AAA28777. (PubMed:8436278)Curated
Sequence conflicti637 – 6371E → A(PubMed:3087625)Curated
Sequence conflicti733 – 76735Missing(PubMed:3081818)CuratedAdd
BLAST
Sequence conflicti762 – 7643TAA → RR(PubMed:3081818)Curated
Sequence conflicti762 – 7643TAA → RR(PubMed:3087625)Curated
Sequence conflicti1029 – 10291L → V(PubMed:3087625)Curated
Sequence conflicti1038 – 10381A → P(PubMed:3087625)Curated
Sequence conflicti1075 – 10751T → TVSQWPV in CAA19677. (PubMed:10731137)Curated
Sequence conflicti1114 – 11141S → F(PubMed:3102970)Curated
Sequence conflicti1215 – 12151E → D(PubMed:3102970)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti697 – 70812Missing in (Gly-Thr)17.
Add
BLAST
Natural varianti697 – 7026Missing in (Gly-Thr)20.
Natural varianti748 – 7481S → F in strain: U79.
Natural varianti762 – 7621T → S in strain: Berkeley, L18, Oregon-R, SP1 and U79.
Natural varianti846 – 8461A → T in strain: U79.
Natural varianti858 – 8581V → A in strain: L18 and U79.
Natural varianti1176 – 11761S → P in strain: L18.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6262Missing in isoform PER-A-short. CuratedVSP_004657Add
BLAST
Alternative sequencei863 – 95896Missing in isoform PER-D and isoform PER-E. CuratedVSP_004659Add
BLAST
Alternative sequencei868 – 96396Missing in isoform PER-B. CuratedVSP_004658Add
BLAST
Alternative sequencei1076 – 1224149TTPAS…QHGDG → VSQWPVVPHRTVLTPTPTPY SSIDHAGVHDEEGAGCIPLG HHSCPGAASLLAERIRQDGA GLQCSGIRSLQEGGAGLLAH SLRDGRLQLRPALQQQQSRQ QQGMLYE in isoform PER-C. CuratedVSP_004660Add
BLAST
Alternative sequencei1155 – 122470KYTDS…QHGDG → VCYTNEVHW in isoform PER-E. CuratedVSP_004661Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30114 Genomic DNA. Translation: AAA28752.1.
M30114 Genomic DNA. Translation: AAA28753.1.
M30114 Genomic DNA. Translation: AAA28754.1.
AF033029 mRNA. Translation: AAB87476.1.
X03636 Genomic DNA. Translation: CAA27285.1. Sequence problems.
AE014298 Genomic DNA. Translation: AAF45804.1.
AL024485 Genomic DNA. Translation: CAA19677.1.
AL024485 Genomic DNA. Translation: CAA19678.1.
AL024485 Genomic DNA. Translation: CAA19679.1.
AL024485 Genomic DNA. Translation: CAA19680.1.
AY575847 Genomic DNA. Translation: AAS89667.1.
L07817 Genomic DNA. Translation: AAA28777.1.
L07818 Genomic DNA. Translation: AAA28776.1.
L07819 Genomic DNA. Translation: AAA28775.1.
L07821 Genomic DNA. Translation: AAA28773.1.
L07823 Genomic DNA. Translation: AAA28771.1.
L07825 Genomic DNA. Translation: AAA28769.1.
AB029194 Genomic DNA. Translation: BAB15868.1.
AB029195 Genomic DNA. Translation: BAB15869.1.
AB029196 Genomic DNA. Translation: BAB15870.1.
AB029222 Genomic DNA. Translation: BAB15896.1.
AB029223 Genomic DNA. Translation: BAB15897.1.
AB029224 Genomic DNA. Translation: BAB15898.1.
AB029250 Genomic DNA. Translation: BAB15924.1.
AB029251 Genomic DNA. Translation: BAB15925.1.
AB029252 Genomic DNA. Translation: BAB15926.1.
D00009 Genomic DNA. Translation: BAA00007.1.
AF251241 Genomic DNA. Translation: AAG44573.1.
AY047980 Genomic DNA. Translation: AAN02289.1.
AY047981 Genomic DNA. Translation: AAN02291.1.
AY047982 Genomic DNA. Translation: AAN02293.1.
AY047983 Genomic DNA. Translation: AAN02295.1.
AY047984 Genomic DNA. Translation: AAN02297.1.
AY047985 Genomic DNA. Translation: AAN02299.1.
AY047986 Genomic DNA. Translation: AAN02301.1.
AY047987 Genomic DNA. Translation: AAN02303.1.
AY047988 Genomic DNA. Translation: AAN02305.1.
AY047989 Genomic DNA. Translation: AAN02307.1.
AY047990 Genomic DNA. Translation: AAN02309.1.
AY047991 Genomic DNA. Translation: AAN02311.1.
AY047992 Genomic DNA. Translation: AAN02313.1.
AY047993 Genomic DNA. Translation: AAN02315.1.
AY047994 Genomic DNA. Translation: AAN02317.1.
AY047995 Genomic DNA. Translation: AAN02319.1.
AY047996 Genomic DNA. Translation: AAN02321.1.
AY047997 Genomic DNA. Translation: AAN02323.1.
AY047998 Genomic DNA. Translation: AAN02325.1.
AY047999 Genomic DNA. Translation: AAN02327.1.
AY048000 Genomic DNA. Translation: AAN02329.1.
AY048001 Genomic DNA. Translation: AAN02331.1.
AY048002 Genomic DNA. Translation: AAN02333.1.
AY048003 Genomic DNA. Translation: AAN02335.1.
AY048004 Genomic DNA. Translation: AAN02337.1.
AY048005 Genomic DNA. Translation: AAN02339.1.
AY048006 Genomic DNA. Translation: AAN02341.1.
AY048007 Genomic DNA. Translation: AAN02343.1.
AY048008 Genomic DNA. Translation: AAN02345.1.
AY048009 Genomic DNA. Translation: AAN02347.1.
AY048010 Genomic DNA. Translation: AAN02349.1.
AY048011 Genomic DNA. Translation: AAN02351.1.
AY048012 Genomic DNA. Translation: AAN02353.1.
AY048013 Genomic DNA. Translation: AAN02355.1.
AY048014 Genomic DNA. Translation: AAN02357.1.
AY048015 Genomic DNA. Translation: AAN02359.1.
AY048016 Genomic DNA. Translation: AAN02361.1.
AY048017 Genomic DNA. Translation: AAN02363.1.
AY048018 Genomic DNA. Translation: AAN02365.1.
AY048019 Genomic DNA. Translation: AAN02367.1.
AY048020 Genomic DNA. Translation: AAN02369.1.
AY048021 Genomic DNA. Translation: AAN02371.1.
AY048022 Genomic DNA. Translation: AAN02373.1.
AY048023 Genomic DNA. Translation: AAN02375.1.
AY048024 Genomic DNA. Translation: AAN02377.1.
AY048025 Genomic DNA. Translation: AAN02379.1.
AY048026 Genomic DNA. Translation: AAN02381.1.
AY048027 Genomic DNA. Translation: AAN02383.1.
AY048028 Genomic DNA. Translation: AAN02385.1.
AY048029 Genomic DNA. Translation: AAN02387.1.
AY048030 Genomic DNA. Translation: AAN02389.1.
AY048031 Genomic DNA. Translation: AAN02391.1.
AY048032 Genomic DNA. Translation: AAN02393.1.
AY048033 Genomic DNA. Translation: AAN02395.1.
AY048034 Genomic DNA. Translation: AAN02397.1.
AY048035 Genomic DNA. Translation: AAN02399.1.
AY048036 Genomic DNA. Translation: AAN02401.1.
AY048037 Genomic DNA. Translation: AAN02403.1.
AY048038 Genomic DNA. Translation: AAN02405.1.
AY048040 Genomic DNA. Translation: AAN02407.1.
AY048041 Genomic DNA. Translation: AAN02409.1.
AY048042 Genomic DNA. Translation: AAN02411.1.
PIRiA23932. UMFF.
A26427.
A26588.
B26427.
C26427.
S52943.
RefSeqiNP_001259194.1. NM_001272265.1.
NP_525056.2. NM_080317.2.
UniGeneiDm.65.

Genome annotation databases

GeneIDi31251.
KEGGidme:Dmel_CG2647.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

The tale of a love song - Issue 6 of January 2001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30114 Genomic DNA. Translation: AAA28752.1 .
M30114 Genomic DNA. Translation: AAA28753.1 .
M30114 Genomic DNA. Translation: AAA28754.1 .
AF033029 mRNA. Translation: AAB87476.1 .
X03636 Genomic DNA. Translation: CAA27285.1 . Sequence problems.
AE014298 Genomic DNA. Translation: AAF45804.1 .
AL024485 Genomic DNA. Translation: CAA19677.1 .
AL024485 Genomic DNA. Translation: CAA19678.1 .
AL024485 Genomic DNA. Translation: CAA19679.1 .
AL024485 Genomic DNA. Translation: CAA19680.1 .
AY575847 Genomic DNA. Translation: AAS89667.1 .
L07817 Genomic DNA. Translation: AAA28777.1 .
L07818 Genomic DNA. Translation: AAA28776.1 .
L07819 Genomic DNA. Translation: AAA28775.1 .
L07821 Genomic DNA. Translation: AAA28773.1 .
L07823 Genomic DNA. Translation: AAA28771.1 .
L07825 Genomic DNA. Translation: AAA28769.1 .
AB029194 Genomic DNA. Translation: BAB15868.1 .
AB029195 Genomic DNA. Translation: BAB15869.1 .
AB029196 Genomic DNA. Translation: BAB15870.1 .
AB029222 Genomic DNA. Translation: BAB15896.1 .
AB029223 Genomic DNA. Translation: BAB15897.1 .
AB029224 Genomic DNA. Translation: BAB15898.1 .
AB029250 Genomic DNA. Translation: BAB15924.1 .
AB029251 Genomic DNA. Translation: BAB15925.1 .
AB029252 Genomic DNA. Translation: BAB15926.1 .
D00009 Genomic DNA. Translation: BAA00007.1 .
AF251241 Genomic DNA. Translation: AAG44573.1 .
AY047980 Genomic DNA. Translation: AAN02289.1 .
AY047981 Genomic DNA. Translation: AAN02291.1 .
AY047982 Genomic DNA. Translation: AAN02293.1 .
AY047983 Genomic DNA. Translation: AAN02295.1 .
AY047984 Genomic DNA. Translation: AAN02297.1 .
AY047985 Genomic DNA. Translation: AAN02299.1 .
AY047986 Genomic DNA. Translation: AAN02301.1 .
AY047987 Genomic DNA. Translation: AAN02303.1 .
AY047988 Genomic DNA. Translation: AAN02305.1 .
AY047989 Genomic DNA. Translation: AAN02307.1 .
AY047990 Genomic DNA. Translation: AAN02309.1 .
AY047991 Genomic DNA. Translation: AAN02311.1 .
AY047992 Genomic DNA. Translation: AAN02313.1 .
AY047993 Genomic DNA. Translation: AAN02315.1 .
AY047994 Genomic DNA. Translation: AAN02317.1 .
AY047995 Genomic DNA. Translation: AAN02319.1 .
AY047996 Genomic DNA. Translation: AAN02321.1 .
AY047997 Genomic DNA. Translation: AAN02323.1 .
AY047998 Genomic DNA. Translation: AAN02325.1 .
AY047999 Genomic DNA. Translation: AAN02327.1 .
AY048000 Genomic DNA. Translation: AAN02329.1 .
AY048001 Genomic DNA. Translation: AAN02331.1 .
AY048002 Genomic DNA. Translation: AAN02333.1 .
AY048003 Genomic DNA. Translation: AAN02335.1 .
AY048004 Genomic DNA. Translation: AAN02337.1 .
AY048005 Genomic DNA. Translation: AAN02339.1 .
AY048006 Genomic DNA. Translation: AAN02341.1 .
AY048007 Genomic DNA. Translation: AAN02343.1 .
AY048008 Genomic DNA. Translation: AAN02345.1 .
AY048009 Genomic DNA. Translation: AAN02347.1 .
AY048010 Genomic DNA. Translation: AAN02349.1 .
AY048011 Genomic DNA. Translation: AAN02351.1 .
AY048012 Genomic DNA. Translation: AAN02353.1 .
AY048013 Genomic DNA. Translation: AAN02355.1 .
AY048014 Genomic DNA. Translation: AAN02357.1 .
AY048015 Genomic DNA. Translation: AAN02359.1 .
AY048016 Genomic DNA. Translation: AAN02361.1 .
AY048017 Genomic DNA. Translation: AAN02363.1 .
AY048018 Genomic DNA. Translation: AAN02365.1 .
AY048019 Genomic DNA. Translation: AAN02367.1 .
AY048020 Genomic DNA. Translation: AAN02369.1 .
AY048021 Genomic DNA. Translation: AAN02371.1 .
AY048022 Genomic DNA. Translation: AAN02373.1 .
AY048023 Genomic DNA. Translation: AAN02375.1 .
AY048024 Genomic DNA. Translation: AAN02377.1 .
AY048025 Genomic DNA. Translation: AAN02379.1 .
AY048026 Genomic DNA. Translation: AAN02381.1 .
AY048027 Genomic DNA. Translation: AAN02383.1 .
AY048028 Genomic DNA. Translation: AAN02385.1 .
AY048029 Genomic DNA. Translation: AAN02387.1 .
AY048030 Genomic DNA. Translation: AAN02389.1 .
AY048031 Genomic DNA. Translation: AAN02391.1 .
AY048032 Genomic DNA. Translation: AAN02393.1 .
AY048033 Genomic DNA. Translation: AAN02395.1 .
AY048034 Genomic DNA. Translation: AAN02397.1 .
AY048035 Genomic DNA. Translation: AAN02399.1 .
AY048036 Genomic DNA. Translation: AAN02401.1 .
AY048037 Genomic DNA. Translation: AAN02403.1 .
AY048038 Genomic DNA. Translation: AAN02405.1 .
AY048040 Genomic DNA. Translation: AAN02407.1 .
AY048041 Genomic DNA. Translation: AAN02409.1 .
AY048042 Genomic DNA. Translation: AAN02411.1 .
PIRi A23932. UMFF.
A26427.
A26588.
B26427.
C26427.
S52943.
RefSeqi NP_001259194.1. NM_001272265.1.
NP_525056.2. NM_080317.2.
UniGenei Dm.65.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WA9 X-ray 3.15 A/B 232-599 [» ]
3GEC X-ray 4.00 A 232-538 [» ]
3RTY X-ray 2.85 A/B/C/D/E/F/G/H 236-574 [» ]
ProteinModelPortali P07663.
SMRi P07663. Positions 237-571.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 57782. 14 interactions.
DIPi DIP-29426N.
MINTi MINT-1327740.

Proteomic databases

PaxDbi P07663.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 31251.
KEGGi dme:Dmel_CG2647.

Organism-specific databases

CTDi 31251.
FlyBasei FBgn0003068. per.

Phylogenomic databases

eggNOGi NOG253593.
InParanoidi P07663.
KOi K02633.
OrthoDBi EOG7TMZRC.

Enzyme and pathway databases

Reactomei REACT_180268. BMAL1:CLOCK,NPAS2 activates circadian gene expression.

Miscellaneous databases

EvolutionaryTracei P07663.
GenomeRNAii 31251.
NextBioi 772671.

Gene expression databases

Bgeei P07663.
ExpressionAtlasi P07663. differential.

Family and domain databases

InterProi IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view ]
Pfami PF00989. PAS. 1 hit.
[Graphical view ]
SMARTi SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view ]
SUPFAMi SSF55785. SSF55785. 3 hits.
PROSITEi PS50112. PAS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene."
    Citri Y., Colot H.V., Jacquier A.C., Yu Q., Hall J.C., Baltimore D., Rosbash M.
    Nature 326:42-47(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Oregon-R.
  2. "Genetic, molecular and cellular studies of the period locus and its products in Drosophila melanogaster."
    Baylies M.K., Weiner L., Vosshall L.B., Saez L., Young M.W.
    (In) Young M.W. (eds.); Molecular genetics of biological rhythms, pp.123-153, Marcel Dekker, New York (1993)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PER-A-LONG).
    Strain: Canton-S.
  3. "Product of per locus of Drosophila shares homology with proteoglycans."
    Jackson F.R., Bargiello T.A., Yun S.-H., Young M.W.
    Nature 320:185-188(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Canton-S.
  4. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT (GLY-THR)20.
    Strain: Berkeley.
  5. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Oregon-R.
  7. "Linking phylogenetics with population genetics to reconstruct the geographic origin of a species."
    Dean M.D., Ballard J.W.O.
    Mol. Phylogenet. Evol. 32:998-1009(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-609.
    Strain: Oregon-R.
  8. "DNA sequence variation at the period locus within and among species of the Drosophila melanogaster complex."
    Kliman R.M., Hey J.
    Genetics 133:375-387(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-573.
  9. "Population structure and founder effect in the colonization of D.simulans based on DNA sequence variation in the Drosophila clock gene period."
    Horio A.T., Date A., Noda R., Tajima F., Chigusa S.I., Kondo R.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 243-400; 744-926 AND 1076-1218.
    Strain: L18, SP1 and U79.
  10. "The period clock locus of D. melanogaster codes for a proteoglycan."
    Reddy P., Jacquier A.C., Abovich N., Petersen G., Rosbash M.
    Cell 46:53-61(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 499-1075, VARIANT (GLY-THR)20.
    Strain: Oregon-R.
  11. "Evolutionary novelties in islands: Drosophila santomea, a new melanogaster sister species from Sao Tome."
    Lachaise D., Harry M., Solignac M., Lemeunier F., Benassi V., Cariou M.L.
    Proc. R. Soc. B 267:1487-1495(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 683-932, VARIANT (GLY-THR)20.
  12. "Hitchhiking mapping: a population-based fine-mapping strategy for adaptive mutations in Drosophilamelanogaster."
    Harr B., Kauer M., Schloetterer C.
    Proc. Natl. Acad. Sci. U.S.A. 99:12949-12954(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1155-1224.
    Strain: AF1, AF2, AF3, AF4, K1, K11, K13, K14, K16, K17, K2, K20, K21, K3, K5, K7, K9, Wi1, Wi10, Wi12, Wi13, Wi14, Wi15, Wi16, Wi17, Wi18, Wi19, Wi2, Wi21, Wi22, Wi23, Wi24, Wi25, Wi27, Wi28, Wi29, Wi3, Wi30, Wi31, Wi32, Wi33, Wi4, Wi5, Wi6, Wi7, Wi8, Wi9, ZH1, ZH13, ZH16, ZH18, ZH19, ZH2, ZH20, ZH21, ZH23, ZH25, ZH29, ZH31, ZH33, ZH35 and ZH36.
  13. Cited for: PHOSPHORYLATION.
  14. "Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD."
    Yildiz O., Doi M., Yujnovsky I., Cardone L., Berndt A., Hennig S., Schulze S., Urbanke C., Sassone-Corsi P., Wolf E.
    Mol. Cell 17:69-82(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 232-599, SUBUNIT.

Entry informationi

Entry nameiPER_DROME
AccessioniPrimary (citable) accession number: P07663
Secondary accession number(s): O17483
, O76882, O76883, O76884, O76885, Q24446, Q24447, Q24448, Q24449, Q6PVA3, Q8MLY0, Q9GN20, Q9GN51, Q9GQH9, Q9GV48, Q9GV53, Q9GV54, Q9GV55, Q9W4X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3