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Protein

Calcitonin

Gene

CALCA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Gene namesi
Name:CALCA
Synonyms:CALC
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 7954By similarityPRO_0000004071Add
BLAST
Peptidei82 – 11332Calcitonin1 PublicationPRO_0000004072Add
BLAST
Propeptidei118 – 13821By similarityPRO_0000004073Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi82 ↔ 88
Modified residuei113 – 1131Proline amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP07660.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038811.

Structurei

3D structure databases

ProteinModelPortaliP07660.
SMRiP07660. Positions 82-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7S. Eukaryota.
ENOG4111KS6. LUCA.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP07660.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Calcitonin (identifier: P07660-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMLKISSFL AVYALVVCQM DSFQAAPVRP GLESITDRVT LSDYEARRLL
60 70 80 90 100
NALVKDFIQM TAEELEQASE GNSLDRPISK RCASLSTCVL GKLSQELHKL
110 120 130
QTYPRTDVGA GTPGKKRNVL NDLDHERYAN YGETLGNN
Length:138
Mass (Da):15,308
Last modified:November 1, 1991 - v2
Checksum:i730B618CF724F248
GO
Isoform Calcitonin-gene related peptide (identifier: P10286-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P10286.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:125
Mass (Da):13,729
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561D → E in CAA26796 (PubMed:4054101).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06311 Genomic DNA. Translation: CAA29630.1.
X06312 Genomic DNA. No translation available.
X06313 Genomic DNA. No translation available.
X03012 mRNA. Translation: CAA26796.1.
M27563 mRNA. Translation: AAA48648.1.
PIRiS00153. TCCH.
UniGeneiGga.1232.
Gga.4991.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06311 Genomic DNA. Translation: CAA29630.1.
X06312 Genomic DNA. No translation available.
X06313 Genomic DNA. No translation available.
X03012 mRNA. Translation: CAA26796.1.
M27563 mRNA. Translation: AAA48648.1.
PIRiS00153. TCCH.
UniGeneiGga.1232.
Gga.4991.

3D structure databases

ProteinModelPortaliP07660.
SMRiP07660. Positions 82-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038811.

Proteomic databases

PaxDbiP07660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IX7S. Eukaryota.
ENOG4111KS6. LUCA.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP07660.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Elucidation of the nucleotide sequence of chicken calcitonin mRNA: direct evidence for the expression of a lower vertebrate calcitonin-like gene in man and rat."
    Lasmoles F., Jullienne A., Day F., Minvielle S., Milhaud G., Moukhtar M.S.
    EMBO J. 4:2603-2607(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-138.
  3. "Structure of chicken calcitonin predicted by partial nucleotide sequence of its precursor."
    Lasmoles F., Jullienne A., Desplan C., Milhaud G., Moukhtar M.S.
    FEBS Lett. 180:113-116(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 71-117.
  4. "Isolation and determination of the amino acid sequence of chicken calcitonin I from chicken ultimobranchial glands."
    Homma T., Watanabe M., Hirose S., Kanai A., Kangawa K., Matsuo H.
    J. Biochem. 100:459-467(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 82-113.

Entry informationi

Entry nameiCALC_CHICK
AccessioniPrimary (citable) accession number: P07660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1991
Last modified: December 9, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.